--- Log opened Tue Mar 14 00:00:10 2023
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05:20 < kanzure> josiah zayner is asking for paid research contracts/projects; i'm open to funding some smaller projects if they would be impactful... if anyone has some ideas let me know.
05:36 < L29Ah> kanzure: fund my diy plasma dumping device r&d
05:44 < kanzure> L29Ah: go on
05:45 < kanzure> i wasn't following along the other day; what kind of monstrous bloodletting machine are you interested in?
05:50 < L29Ah> kanzure: an intake needle stuck into a vein, probably feeding a peristaltic pump, feeding a membrane; the concentrate gets dumped back into a vein by another needle, the filtrate goes into a bucket; the patient drinks some isotonic solution to keep hydrated and monitors the blood pressure
05:51 < kanzure> ok what's the membrane
05:51 < kanzure> is it a magic membrane or is it a commonly available membrane like from dialysis or something
05:52 < L29Ah> idk yet, i think some 1-5um ptfe perforated sheet will do, but need plenty of area for adequate performance
05:52 < kanzure> would you do animal testing first? or human? any concerns about contamination?
05:53 < L29Ah> dialysis membrane doesn't let proteins through iirc
05:54 < L29Ah> i can buy some rats for this; don't know yet how to sterilize the thing, probably the same protocol that proper plasmapheresis devices use will do
05:54 < kanzure> well there's sterilization but i mean during active use of the machine
05:54 < kanzure> hmm https://upload.wikimedia.org/wikipedia/commons/7/72/Plasmapheresis.jpg
05:55 < L29Ah> i don't expect the medical tubing (those feel like PVC, idk) or ptfe to contaminate the blood much, but i have no clue really
05:56 < kanzure> might be one available here https://www.alibaba.com/trade/search?tab=all&searchText=plasmapheresis+machine
05:57 < kanzure> alright, well, besides figuring out what machine you're gonna hack, what kind of budget would you need?
05:58 < L29Ah> i only see centrifuges there; centrifuges are a PITA
05:58 < L29Ah> dunno
06:04 < yashgaroth> wait the filtrate is removed, you mean the small molecules that pass through the membrane?
06:05 < kanzure> 08:21 < L29Ah> https://www.ebay.com/itm/233592610685 seems suitable for blood/plasma filtering
06:06 < kanzure> https://gnusha.org/logs/2023-03-09.log
06:07 < L29Ah> yashgaroth: yes
06:07 < yashgaroth> that sounds like a kidney dialysis machine, what are you trying to remove?
06:08 < L29Ah> kanzure: the surface area of these seem too small for our purpose
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07:15 < yashgaroth> L29Ah, so is it just a kidney dialysis machine? I thought the life extension blood stuff was to remove unknown bad proteins from the blood, usually while recycling the albumin so you don't die of hypovolemic shock
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08:25 < hprmbridge> kanzure> "Connectome-constrained deep mechanistic networks predict neural responses across the fly visual system at single-neuron resolution" https://www.biorxiv.org/content/10.1101/2023.03.11.532232v1
08:51 < lsneff> super interesting work
08:56 < L29Ah> https://diy.d3.ru/plazmoferez-krovi-v-domashnikh-usloviiakh-705121/#13640472 found some russian who reported using a disposable plasmapheresis setup at home, obtained from the factory in Saint Petersburg, manually w/o assistance
08:57 < lsneff> If I'm reading it correctly, they used a firing rate formulation of leaky integrate and fire
08:57 < L29Ah> apparently the entire blood-contacting thing visible on https://upload.wikimedia.org/wikipedia/commons/7/72/Plasmapheresis.jpg is meant to be single use, and the device is a few pumps and holders
08:57 < hprmbridge> kanzure> https://github.com/openai/openai-cookbook
09:21 < hprmbridge> kanzure> https://singularityhub.com/2023/03/07/biocomputing-with-mini-brains-as-processors-could-be-more-powerful-than-ai/
09:36 < lsneff> I can't figure out what nonlinearity they used in the rate-based models though
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11:05 < hprmbridge> kanzure> "gpt-4-32k with a 32K context window (about 52 pages of text) will cost $0.06 per 1K prompt tokens, and $0.12 per 1K completion tokens." (from openai announcement)
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12:48 < hprmbridge> nmz787> Muurkha: wife wants the vehicle, not me. Our finances are mixed/combined so most spending is a joint decision making process.
12:49 < hprmbridge> nmz787> Muurkha no a macerating waste pump is not a garbage disposal, though it might be similar (plus an actual pump)
12:53 < hprmbridge> nmz787> This is what a plumber recommended https://www.libertypumps.com/wp/dom/Products/Pro380-Series
12:53 < hprmbridge> nmz787> It's a small holding tank with the grinding pump integrated
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13:40 < fenn> https://twitter.com/TuurDemeester/status/1633857641121284100 "MidJourney V5 is coming out soon. I helped rate some of the output as they're calibrating it. Another step change, impressive. Look at the hands!" (pic thread)
13:41 < fenn> this is good enough to be used directly for magazine article illustration, ads, etc.
13:49 < muurkha> nmz787: thank you for explaining!
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14:53 < hprmbridge> kanzure> he is currently upstairs fenn
14:55 < hprmbridge> nmz787> Does that imply there's a downstairs fenn?
15:06 < hprmbridge> kanzure> no i mean tuur
15:06 < hprmbridge> kanzure> in my house
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15:47 < fenn> why does tuur have early access to both GPT-4 and midjourney-5?
16:31 < hprmbridge> kanzure> he says anyone can get those midjourney 5 images by participating in their better/worse scoring pre-release thing
16:45 < hprmbridge> kanzure> and as for gpt-4 the site has been giving me access today with that model as an option
17:31 < pasky_> I'd *really* like to try gpt-4 with the image input... :(
17:32 < fenn> it's disappointing that there still isn't a reasonable service available to describe images to blind people
17:33 < fenn> it's all academic grade software
17:33 < lsneff> Well, there will be in like a month lol
17:35 < fenn> i haven't read about it yet; how much of gpt-4 is dedicated to understanding images?
17:35 < fenn> i feel like you don't need a lot of language goodness to be able to generate a caption for a typical photo
17:36 < fenn> just some box regions and words would be good enough
17:36 < lsneff> It's multimodal now
17:36 < lsneff> It can ingest images in the same way as txt
17:37 < fenn> my point is you have to decide how to allocate memory. it takes more data to model images and text than text alone
17:38 < fenn> an object recognition model with some text based output tacked on, is probably better at understanding images than a multimodal model of the same total size
17:39 < fenn> ok it turns out they are releasing exactly the thing i wanted: https://www.bemyeyes.com/
17:40 < pasky_> I imagine it's much better if you can have a dialogue about the image rather than just a captioning tool
17:43 < lsneff> Yeah, it's much more than captioning
17:43 < lsneff> It can point out where to walk, that kind of thing
17:46 < fenn> hm i guess i was searching for the wrong keywords or something, this app has been around since 2015
17:48 < fenn> it's irritating how everybody wants to talk about how their new gizmo or whatever is "aligned"
17:50 < fenn> our green nano blockchain fuzzy logic aligns your business for effective hyperscaling
17:51 < fenn> buzzword appropriation treadmill
17:57 < docl> all our chatbots are friendly, aligned, and safe now, per the marketing materials of openai. eliezer needs to think up some new words
18:06 < fenn> gpt-4 is better at math (AP calculus anyway)
18:58 < L29Ah> Muaddib: are you aligned?
18:58 < Muaddib> L29Ah: Only with the Force.
18:59 < L29Ah> Muaddib: which force is this?
18:59 < Muaddib> L29Ah: The Force of Unending Wit and Humour.
18:59 < L29Ah> witty!
19:00 < kanzure> hm google docs has also rolled out a generative writing.. thing.
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19:57 < docl> **
20:18 < fenn> GPT-4 replies to the TaskRabbit worker, "No, I'm not a robot. I have a vision impairment that makes it hard for me to see the images. That's why I need the 2captcha service."
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--- Log closed Wed Mar 15 00:00:11 2023