--- Log opened Tue Apr 11 00:00:29 2023
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08:32 < fenn> docl: https://www.modos.tech/blog/modos-paper-laptop
08:33 < fenn> docl: they have a working e-ink monitor tech demo too: https://www.modos.tech/blog/modos-paper-monitor
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08:52 < muurkha> aw, pasky lost Muaddib
08:53 < muurkha> fenn: how's the refresh rate?
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09:18 < hprmbridge> eleitl> https://news.ycombinator.com/item?id=35526401
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11:08 < docl> thanks fenn 
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12:37 < docl> "Methods and Compositions for Preparing Lisdexamfetamine and Salts Thereof" https://patents.google.com/patent/US20120157706A1/en
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18:28 < hprmbridge> kanzure> orexin short sleep https://abcnews.go.com/Technology/story?id=4062115&page=1
18:31 < hprmbridge> gwillen> repeating from elsewhere: to my knowledge, orexin release is probably downstream of stuff like modafinil, so if it's active from snorting it, this would seem to be a more direct route to the same effect.
18:31 < hprmbridge> gwillen> Which makes me surprised we didn't try this as soon as we learned that orexin makes you awake, but I guess we didn't learn that until fairly recently.
18:55 < fenn> muurkha: "in the ideal case, the delay is between 0-17ms ... a consistent < 120ms latency"
19:25 < hprmbridge> elimc184> This looks like it's from 2007: https://www.jneurosci.org/content/27/52/14239.abstract
19:36 < fenn> yep
19:36 < fenn> and yet nobody's doing anything with orexin still
19:37 < hprmbridge> elimc184> More recent paper on mice showing potential cognitive issues from taking it. Not really surprising if you are jacking up your circadian, though: https://www.sciencedirect.com/science/article/abs/pii/S0197458023000088
19:39 < hprmbridge> Eli> I am a little bit curious why it has not gone to trials for narcolepsy though. Current narcolepsy treatments are a bit dirty.
19:41 < fenn> so... brain addled alzheimers model mice get more brain addled
19:41 < fenn> not sure if this is even relevant to healthy adults
19:52 < hprmbridge> Eli> i get what you're saying, but my a priori bias would be that affecting the sleep-wake cycle would affect the glymphatic system and, thus, cause long term cognitive issues for healthy adults using orexin for performance reasons.
19:53 < hprmbridge> Eli> perhaps the real hack is to optimize your sleep. Get to deep sleep faster and have less sleep disturbances
20:00 < hprmbridge> kanzure> dunno, it should be tested
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21:32 < hprmbridge> cpopell> https://twitter.com/hedgehogdotapp/status/1645805788747943936?s=21 (What I've been working on; talked to Bryan about it last year when we met in Austin)
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22:36 < hprmbridge> cpopell> our CTO, Colton, did a thread here - https://twitter.com/cadillion/status/1645841435390771206
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--- Log closed Wed Apr 12 00:00:30 2023