--- Log opened Thu Jun 15 00:00:31 2023
00:14 < hprmbridge> InquilineKea> organoid intelligence professors at JHU might be transhumanism friendly.. im gonna visit today
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02:27 < fenn> COMT inhibitors for cognitive enhancement? val158met mutants have better performance across a range of metrics. also more pain and anxiety though.
02:29 < fenn> Entacapone and opicapone are peripheral inhibitors, unable to cross the blood-brain barrier. Tolcapone is able to cross the blood-brain barrier, but associated with at least three fatal cases of acute liver failure and is thus only rarely prescribed.
02:30 < fenn> the met/met genotype is only a 45% reduction in enzyme activity in vivo
02:31 < fenn> these drugs are prescribed for parkinson's, so presumably for enhancement use you'd be using a lot less, and the side effects would be proportionally reduced
03:26 < hprmbridge> kanzure> @InquilineKea let me know if you would like to meet other organoid intelligence people too...
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03:39 < alethkit> kanzure: Do you have insider info?
03:43 < hprmbridge> kanzure> well that's an odd question
03:44 < hprmbridge> kanzure> I know people, and things. Am I inside? I dunno. Maybe?
05:45 < hprmbridge> kanzure> http://apm.bplaced.net/w/index.php?title=Digital_control_over_reversibly_composable_units_of_matter
05:46 < hprmbridge> kanzure> https://sci-nanotech.com/index.php?thread/45-preparatory-experimental-component-r-d-reprec-and-rechain/
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06:44 < hprmbridge> ml3> I‘d love to!
06:46 < hprmbridge> ml3> I‘m in Boston and not Baltimore but happy with any intros or suggestions
06:52 < hprmbridge> kanzure> well in boston there is sergeeva and she is working on cortical organoids
06:52 < hprmbridge> lachlan> She was in Austin, right?
06:52 < hprmbridge> kanzure> yes for our conference
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09:01 < docl> she's a staff scientist at levin lab https://as.tufts.edu/biology/levin-lab/people/current-lab-members
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10:24 < kanzure> this seems to be where the ex utero lamb stuff went https://www.vitara.com/
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11:23 < alethkit> Ah, good to know
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11:51 < hprmbridge> kanzure> "Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naive PSCs" https://www.biorxiv.org/content/10.1101/2023.06.14.544922v1
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17:40 < hprmbridge> kanzure> snpedia person recently emailed me. he is still around. if you have a particular question let me know.
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18:24 < hprmbridge> kanzure> https://twitter.com/jacob_hanna/status/1669368828436918272
18:30 < hprmbridge> kanzure> and https://twitter.com/vlad_bndk/status/1669385951397675020
19:09 < hprmbridge> ml3> Awesome, thanks
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22:52 < fenn> was it ever possible to just edit snpedia directly as an anonymous user?
22:53 < fenn> on snpedia i'm getting this "your IP is blacklisted because it's an open proxy" and then shows an IP that is not my IP, and at least one other user is having this issue
22:53 < fenn> i'm wondering if it's some sort of "quiet quitting" way of saying snpedia is read-only now
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--- Log closed Fri Jun 16 00:00:32 2023