--- Log opened Wed Jul 26 00:00:10 2023
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00:41 < hprmbridge> Eli> Why does the government say folic acid fortification is so good at reducing neural tube defects?
01:46 < jrayhawk> Because there's a mesh network of feedback cycles between each of the political epistemology ("standard of care"), liability, political authority, funding, training, and licensure that ensures bad ideas take at least two generations to die.
01:51 < jrayhawk> Usually there's also a revolving door with commercially monopolized treatments making things worse, but I don't think there's a Big Pterin is at work in this particular case for once.
01:52 < jrayhawk> Don't get me wrong, I think there's billions of dollars being made on deranged th1/th2 ratios, but I don't think the beneficiaries are smart enough to organize around that.
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03:05 < hprmbridge> Eli> i think I lost you. Are the claims about folic acid helping with neural tube defects wrong? Or simply suboptimal?
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04:07 < jrayhawk> At least suboptimal. Unclear if it improves or worsens the general population. The two RCTs were based on pathological subpopulations.
04:10 < jrayhawk> I don't actually know much about the mechanisms of neural tube defects in particular, but legitimate tetrahydrofolate doseage is tricky enough to balance in highly genetic- and context-dependent ways even using "intended" enzymatic infrastructure.
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10:15 < docl> I wonder if high pressure low temperature superconductors would be useful enough as small threads. you could take sheets of diamond under tension and sandwich them together to make tiny high pressure channels maybe
10:22 < fenn> sounds like a major pain in the ass to be avoided by any means possible
10:23 < fenn> i assume you mean high pressure high temperature
10:23 < docl> er yes
10:24 < docl> maybe you could just use steel. cut a cylinder lengthwise, heat it up, apply the thread, weld back together, then cool to room temp
10:26 < docl> macro approaches are going to be a pain compared to what nanofactories could make, of course
10:40 < docl> https://twitter.com/fodagut/status/1666978677102637056
10:41 < docl> https://twitter.com/fodagut/status/1684251724700348418
10:42 < docl> hmm. maybe they are on to a way to stabilize the atoms at room temperature with lattice energy alone
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16:10 < fenn> maybe we should feed the lab rats big macs and soda until they die, it would be more humane: https://www.lesswrong.com/posts/ghtsPkTQ7JhZtjjsB/mike-darwin-on-animal-research-moral-cowardice-and-reasoning
16:20 < L29Ah> BORING
16:22 < darsie> Hyperloop
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--- Log closed Thu Jul 27 00:00:11 2023