--- Log opened Sat Aug 05 00:00:19 2023
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03:57 < hprmbridge> Eli> not sure it has been studied enough. L-Theanine relaxes me, but can make me spacy if i take too much. Makes me wonder what impact green tea had on the development of asian cultures.
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06:27 < fenn> the future has high dynamic range
06:29 < fenn> muurkha: chat on blockchain?
07:00 < L29Ah> https://tinystash.undef.im/il/3Mbcvuqx7546Ap3h3xRcJrAVmDxSF7yr9unPcMus2MjtfYEnEmxzm4W3Vrbz2e4fv6PgJpyQ8Ea9BcYFoukbea3YGiWZcTKk1CzkFupahxHzix.jpg
07:02 < fenn> also good for decorating rat cakes
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09:27 < muurkha> fenn: I guess potentially there could be conflicting updates in, like, channel ownership?
09:49 < nsh> https://twitter.com/floates0x/status/1687859912133779456
10:00 < fenn> that guy is gonna get spammed so hard
10:03 < fenn> is there any argument in favor of patents in a situation like this, where buttloads of engineers and scientists are scrambling to refine and develop a formula for a new scientific phenomenon
10:07 < hprmbridge> alonzoc> I guess to incentivise them, but tbh not really
10:07 < hprmbridge> alonzoc> Like if I had the tools with me I'd be on the whole replication race right now, and I don't care about patents I just want a cool floaty rock
10:09 < hprmbridge> Katylase> HisIlePheArgIleGluAsnAspSer! HisArgSec?
10:28 < fenn> SerSecProLysAlaThrTyr
10:40 < fenn> IleMetAlaSerGluArgIlePylSecSerProGluArgSerPylAsn
10:41 < fenn> seen on the interwebs: "Japanese man who identifies as a dog goes for a walk in public and enjoys being stroked by strangers."
10:42 < fenn> "I haven't told anyone about my transformation into a dog," he said in one of his videos. "I am still afraid that my friends will find my hobby bizarre."
10:58 < hprmbridge> Katylase> IleMetPylLysAlaTyr! (AlaAsnAspHisAlaProProTyr)🙂
11:05 < hprmbridge> kanzure> MetGluThrPylPylCysAlaAsnIle(PylIleAsn
11:07 < hprmbridge> kanzure> @Katylase Can you identify the errors in this very funny video https://youtu.be/W1_KEVaCyaA
11:07 < Muaddib> [W1_KEVaCyaA] Origin: Probability of a Single Protein Forming by Chance (9:28)
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12:25 < hprmbridge> alonzoc> Is there a meaning to this?
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12:36 < hprmbridge> alonzoc> https://www.science.org/doi/10.1126/science.ade6967
12:36 < hprmbridge> alonzoc> Looks interesting
12:39 < docl> such a silly movie. doesn't mention catalysts
12:39 < L29Ah> This website requires cookies to function properly. Please enable cookies in your browser and try again.
12:39 < L29Ah> very scientific
12:40 < hprmbridge> alonzoc> Yeah don't we love modern journals
13:05 < fenn> "In vivo hematopoietic stem cell modification by mRNA delivery - Messenger RNA was delivered to bone marrow stem cells by intravenous injection in lipid nanoparticles, facilitating both gene editing and bone marrow transplantation"
13:06 < hprmbridge> alonzoc> New delivery mechanisms are always good
13:06 < fenn> "this platform could be the basis of in vivo genome editing to cure genetic disorders, which would abrogate the need for HSCT."
13:06 < fenn> what about a lipid nanoparticle specifically targets bone marrow cells?
13:12 < hprmbridge> Eli> Is it gene editing or rna editing? Or are those terms used interchangeably?
13:13 < fenn> presumably there's a reverse transcriptase involved
13:14 < hprmbridge> Eli> are there any risks/downsides to using reverse transcriptase?
13:14 < fenn> "Delivery of the anti–human CD117/LNP–based editing system yielded near-complete correction of hematopoietic sickle cells."
13:14 < fenn> based
13:15 < fenn> these dashes have gotten out of control
13:15 < hprmbridge> Eli> seems like it might be difficult to correct the exact base. But, my experience with gene editing in the lab is mostly confined to putting p glo into ecoli
13:16 < fenn> ok i parsed that wrong
13:17 < hprmbridge> Eli> looks like mojibake coming through. Try using Clipy if you're on a mac to paste in the correct format
13:18 < fenn> when i take over the world we're going back to ASCII
13:18 < fenn> fuck all this nonsense
13:20 < fenn> like why can't wikipedia just put "-" in the URL instead of %E2%80%93
13:22 < hprmbridge> Eli> character encoding is stupidly overcomplicated
13:24 < fenn> there was this one guy "Noetica" who basically bullied all of wikipedia into putting en-dashes everywhere
13:26 < fenn> why is sci-hub still broken?
13:31 < hprmbridge> Eli> https://annas-archive.org/
13:33 < fenn> says its search index is updated monthly
13:33 < fenn> i'm doubtful they host journal articles anyway
13:34 < fenn> aside from sci-hub, which is "included" whatever that means
13:37 < docl> finally have my chemicals. time to try some reactions
13:38 < fenn> could you explain again what you're going to do?
13:38 < fenn> i didn't really understand the electrochemistry part
13:42 < docl> I think I've narroed it down to: electroplate the two metals onto a substrate to make 2 thin layers, then react phosphoric acid and hydrogen peroxide to that
13:48 < fenn> won't that just dissolve the electroplayed layer?
13:48 < fenn> and probably the substrate too
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13:58 < docl> likely depends on process parameters. if I use dilute solution and run current such that the metal is positively charged, PO4- should be attracted to it. I'm also thinking low current might help avoid the metal going into solution in that context. the phosphates / apatites aren't very soluble in water
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18:58 < kanzure> hmph
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19:56 < kanzure> "Chemically induced reprogramming to reverse cellular aging" https://www.aging-us.com/article/204896/text
19:57 < kanzure> "... To screen for molecules that reverse cellular aging and rejuvenate human cells without altering the genome, we developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay."
19:57 < kanzure> .gpt what is nucleocytoplasmic compartmentalization
20:02 < fenn> bot went MIA
20:02 < fenn> along with its server admin
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20:25 < kanzure> wut? "However, with such reliance on AI, some critics raise concerns about the potential ethical implications of using advanced technology in the realm of sperm banking. They question the possible commodification of human genetic material and the extent to which AI could be used to engineer "designer babies." Gilia Project must address these concerns head-on and assure the public that their ...
20:26 < kanzure> ...use of AI is strictly focused on enhancing compatibility and promoting successful conceptions, without compromising individual autonomy and dignity"
20:27 < kanzure> "We are committed to creating the world’s most selective and highest-quality cryobank, the first of its kind in the industry. As part of our mission, we provide a platform for individuals with exceptional genetic traits to explore their heritage while using our expertise to help those in needs with the latest technology"
20:27 < kanzure> https://www.giliaproject.com/
20:29 < hprmbridge> nmz787> Fenn what do you use for video chat?
20:31 < fenn> uh i don't really. meet.jit.si is almost tolerable 
20:32 < kanzure> oh come is zayner really the best we can offer young people https://www.reddit.com/r/transhumanism/comments/14vm9bg/how_do_i_get_into_biohacking_as_a_17yearold/
20:32 < kanzure> *oh come on
20:34 < kanzure> nvidia now funding george's GPU cravings https://www.genomeweb.com/informatics/nvidia-pushes-forward-cloud-based-hardware-acceleration-genome-analysis
20:42 < hprmbridge> nmz787> Fenn meet?
20:42 < kanzure> some organic synthesis tool.. things: https://askcos.mit.edu/
20:42 < hprmbridge> nmz787> Click the following link to join the meeting:
20:42 < hprmbridge> nmz787> https://meet.jit.si/ArchitecturalChildhoodsLoveAlways
20:42 < hprmbridge> nmz787>
20:42 < hprmbridge> nmz787> =====
20:42 < hprmbridge> nmz787>
20:42 < hprmbridge> nmz787> Just want to dial in on your phone?
20:42 < hprmbridge> nmz787>
20:42 < hprmbridge> nmz787> Dial-in: +1.512.647.1431 PIN: 1063463794#
20:42 < hprmbridge> nmz787>
20:42 < hprmbridge> nmz787> Click this link to see the dial in phone numbers for this meeting
20:42 < hprmbridge> nmz787> https://meet.jit.si/static/dialInInfo.html?room=ArchitecturalChildhoodsLoveAlways
20:47 < hprmbridge> nmz787> You're about to miss me angle grinding...
20:59 < kanzure> are we to want to watch you grinding your angles?
21:08 < hprmbridge> nmz787> I wanted to small talk mostly while I'm alone
21:15 < jrayhawk> twitch's "Science & Technology" and "Hobbies & Crafts" categories are okay for that sort of thing
21:17 < jrayhawk> and OBS is generally fun to play around with
21:19 < jrayhawk> or i guess it's "Makers & Crafting" now
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21:42  * RoyBatty extended his 4 year lifespan
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22:00 < kanzure> some rather dry, but not overly annoying, text about trading https://astralcodexten.substack.com/p/your-book-review-the-laws-of-trading
22:28 < kanzure> pet intelligence competition v2 proposal: guinness book of records style where you have pet food sponsors and prize money, and you go to each claimaint and verify/broadcast, but it's not a single olympics event.
22:28 < kanzure> s/pet/animal
22:29 < kanzure> most of competitive dog sports are focused on obedience, there is literally no category for border collie vocabulary size
22:35 < kanzure> everyone complains about cycle times for animal intelligence breeding projects but ain't nobody actually doing it; i feel like the complaint would only be justified by someone who has tried it and isn't getting anywhere. we don't actually know.
23:30 < kanzure> wonder who or what is doing these later ones https://btctranscripts.com/lightning-specification/
--- Log closed Sun Aug 06 00:00:20 2023