--- Log opened Thu Sep 07 00:00:15 2023
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12:00 < kanzure> https://www.theguardian.com/science/2023/sep/07/humanised-kidneys-grown-inside-pigs-for-the-first-time
12:13 < kanzure> "Previous attempts to create human-pig hybrids have foundered because pig cells tend to outcompete human cells during development, meaning the resultant chimera is almost entirely pig. The latest work, published in Cell Stem Cell, overcame this by genetically engineering a single-cell pig embryo so that it lacked two genes needed for kidney development. This created a niche within the embryo ...
12:13 < kanzure> ...that could be filled by human embryonic stem cells that were integrated into the pig embryo."
12:14 < kanzure> "Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation" https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00286-2
12:14 < kanzure> "To produce human cells with superior intra-niche competitiveness, we combined optimized pluripotent stem cell culture conditions with the inducible overexpression of two pro-survival genes (MYCN and BCL2). The resulting cells had substantially enhanced viability in the xeno-environment of interspecies chimeric blastocyst and successfully formed organized human-pig chimeric middle-stage kidney ...
12:14 < kanzure> ...(mesonephros) structures up to embryonic day 28 inside nephric-defective pig embryos lacking SIX1 and SALL1."
12:15 < kanzure> wait why only 28 days
13:02 < L29Ah> maybe for ethical reasons
13:02 < L29Ah> i recall arguments for terminating human-containing embryos at 28 days
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15:14 < catern> kanzure: hey are you still recording all your interactions in your stalklog? it's very inspiring to me
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16:50 < hprmbridge> kanzure> https://twitter.com/mechadense/status/1691491558284046353
18:30 < L29Ah> .t https://www.lifespan.io/news/a-metformin-and-galantamine-combination-for-sarcopenia/?utm_source=rss&utm_medium=rss&utm_campaign=a-metformin-and-galantamine-combination-for-sarcopenia
18:30 < EmmyNoether> A Metformin and Galantamine Combination for Sarcopenia
22:24 < fenn> "contribution to other lineages, including the brain and germ cells, raises serious ethical concerns if the pigs were brought to term."  guess i'll just die then
22:26 < fenn> why is china going along with the ethics facade? aren't they still murdering falun gong people and harvesting their organs?
22:29 < fenn> the pig kidney work was done at: CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Sanya Institute of Swine Resource, Hainan Provincial Research Centre of Laboratory Animals; Jilin Provincial Key Laboratory of Animal Embryo Engineering, Key Laboratory
22:29 < fenn> of Zoonosis Research, Jilin University, Changchun; Institute of Stem Cells and Regeneration, Chinese Academy of Sciences, Beijing 
--- Log closed Fri Sep 08 00:00:16 2023