--- Log opened Sun Sep 10 00:00:18 2023
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14:19 < kanzure> "Frequent, infinitesimal bottlenecks maximize the rate of microbial adaptation" https://www.biorxiv.org/content/10.1101/2023.08.10.552848v1.full
14:19 < kanzure> "Serial passaging is a fundamental technique in experimental evolution. The choice of bottleneck severity and frequency poses a dilemma: longer growth periods allow beneficial mutants to arise and grow over more generations, but simultaneously necessitate more severe bottlenecks with a higher risk of those same mutations being lost. Short growth periods require less severe bottlenecks, but ...
14:20 < kanzure> ...come at the cost of less time between transfers for beneficial mutations to establish. The standard laboratory protocol of 24-hour growth cycles with severe bottlenecking has logistical advantages for the experimenter but limited theoretical justification. Here we demonstrate that contrary to standard practice, the rate of adaptive evolution is maximized when bottlenecks are frequent and ...
14:20 < kanzure> ...small, indeed infinitesimally so in the limit of continuous culture."
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