--- Log opened Tue Sep 26 00:00:07 2023
--- Day changed Tue Sep 26 2023
00:00 < kanzure> https://janismac.github.io/ControlChallenges/
00:04 < fenn> didn't the last paper about dyson spheres show that nested structures didn't make thermodynamic senes
00:04 < fenn> sense*
00:12 < fenn> return -20*block.x-7*block.dx;
00:12 < fenn> the simulation has some built in damping apparently
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01:20 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1041909b Bryan Bishop: transcript: hashrate estimation >> http://diyhpl.us/diyhpluswiki/transcripts/proof-of-work-summit/2023/hunting-bitcoin-real-hashrate/
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06:25 < hprmbridge> Eli> https://www.today.com/health/mom-chatgpt-diagnosis-pain-rcna101843?utm_source=tldrai
07:12 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=6d4eed13 Bryan Bishop: transcript: caitlin long >> http://diyhpl.us/diyhpluswiki/transcripts/proof-of-work-summit/2023/caitlin-long/
07:34 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=aadb3ec4 Bryan Bishop: transcript: prime >> http://diyhpl.us/diyhpluswiki/transcripts/proof-of-work-summit/2023/prime/
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07:53 < kanzure> https://silent.link/
08:01 < ike8> > https://silent.link/
08:01 < ike8> I don't trust it. Their stack is not open-source AFAIK. JMP.chat's entire stack is open-source. They offer anonymous phone numbers and esims too.
08:15 < kanzure> https://cloakedwireless.com/
08:15 < kanzure> i confused silent link for someone else, oops
08:39 < L29Ah> sphertext> that's why i really don't understand the hype around AI. why would I want to use a computer if it will make mistakes that I can't even debug? for me, that's the whole entire point in using a machine: verifiable determinism. 
08:39 < L29Ah> there are plenty of tasks that are hard to perform but the result is easy to verify
08:40 < L29Ah> and sometimes 50% success rate is good enough
09:17 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=7e2b99e1 Bryan Bishop: transcript: zimmermann >> 
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10:50 < hprmbridge> nmz787> My usage of chatgpt for coding has been productive in that the prompts end up being something like a "spec document" that managers or other folks just wanting an overview of the project or work can read, and the code output puts me in more of an "expert reviewer" stance which is a nice change from banging the keyboard
10:57  * L29Ah prefers banging the keyboard to banging both his head and keyboard trying to make the LLM produce correct code
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15:30 < hprmbridge> kanzure> planets not megastructures https://arxiv.org/abs/2309.06562
16:17 < sphertext> nuking my immune system with a mega dose of corticosteroids :( 
16:17 < sphertext> for 10 days 
16:19 < sphertext> L29Ah yeah you're right, there can be applications of LLMs in domains where accuracy and precision aren't paramount. i'm just not really used to it and can't come up with many examples. im habituated to the pursuit of maximal precision, at least as far as meaningful work goes
16:19 < fenn> don't die
16:20 < hprmbridge> alonzoc> Always good fun, be wary that first day or so though it can be quite weird making you feel super energised
16:24 < sphertext> yeah this is my first time and i read about the psychological effects. so im actually trying not to think too much about it and placebo myself into a psychosis
16:25 < sphertext> its annoying because i had planned the next 10 days to focus on something really important to me. i really hope they won't affect my cognitive performance 
16:26 < sphertext> if they do, i might just stop. the chance that the treatment will help is vanishingly small anyway
16:29 < hprmbridge> alonzoc> Yeah, it mucked with my mind a bit but if you're aware of it you can slightly change habits. Tbh the day was amazing for the first week or so before I got used to it (got a lot of stuff done), main issue was waking up in the middle of the night with a feeling of doom. If you suffer from that I suggest a brisk night walk with a audiobook or podcasts.
16:29 < hprmbridge> alonzoc>
16:29 < hprmbridge> alonzoc> Mental performancewise I actually did measurements. Slightly impairment of my recall, however baseline speed scores increased. Improvements in focus were also substantial but likely because I was no longer suffering from constant pain and fatigue
16:30 < hprmbridge> alonzoc> I was on a daily 30mg dose for the first week tapering 5mg each week. For the first week or so it felt basically like jitterless caffeine
16:30 < sphertext> oh, interesting. if it mainly affects mood, i may be able to manage it
16:31 < sphertext> 30mg of what tho?
16:31 < hprmbridge> alonzoc> prednisolone
16:32 < sphertext> right, yeah. same. but i started with 50mg 
16:32 < hprmbridge> alonzoc> Prednisolone: Super-Caffeine that just happens to suppress the immune system
16:33 < hprmbridge> alonzoc> Sounds about right, another not is I had finals exams on pred and I aced them so it defenitely isn't a big mental block
16:34 < sphertext> ohh that's very reassuring 
16:34 < hprmbridge> alonzoc> Yeah don't worry, if you don't mind what's it for?
16:35 < sphertext> i lost exactly 4dB of my hearing in one ear for absolutely no reason 
16:35 < hprmbridge> alonzoc> Wow that's a weird one
16:36 < sphertext> it's called idiopathic sudden sensorineural hearing loss
16:36 < sphertext> emphasis on idiopathic 
16:37 < sphertext> it's intractable and the only thing that can vaguely help is megadosing steroids WITHIN TWO WEEKS. it's not known to be effective after that. and i waited months :( 
16:37 < hprmbridge> alonzoc> Healthcare systems do be like that.
16:38 < hprmbridge> alonzoc> Patient: Hello I am suffering this might be urgent!
16:38 < hprmbridge> alonzoc> Doctors secretary: Urgent referral then? Best we can do is two weeks to have a phone consultation with a specialist
16:39 < sphertext> it makes me so sad, because im passionate about music and music has been one of my long term projects in life. not being able to hear a centred stereo image is very debilitating 
16:39 < hprmbridge> alonzoc> (It was not two weeks)
16:40 < hprmbridge> alonzoc> Owch, I can only imagine
16:41 < sphertext> it was partly my fault.. 4dB isn't a lot, so i second guessed myself for a while (i thought it was just in my head). then i blamed it on faulty headphones. i only decided to actually test it 2 weeks ago, and my GP's secretary in first instance just asked me to clear my ear wax, before she would agree to book an appointment (it turned out there wasn't any ear wax at all)
16:43 < sphertext> who even knows when it actually started. i only noticed it on headphones eventually and it was pretty vague 
16:44 < sphertext> it's so ironic that i would suffer from this, considering how emotionally invested i am in music. you know, the beethoven myth 
16:45 < hprmbridge> alonzoc> I guess you could try offset the stereo on headphones? But yeah corticosteroids aren't much to fear mentally apart from minor mood changes.
16:45 < hprmbridge> alonzoc> Oh another one I can't completely speak to because my anecdotes are coloured by the fact my body had been destroying itself for half a year and I wasn't absorbing nutrients properly, but my appetite went a bit over the top. So I suggest if that's an issue tracking calories for a while
16:47 < sphertext> yes, offsetting the headphones is how i measured the 4dB deficit. and i kept that setting, but it's not perfect. there is some mild variation across the spectrum
16:47 < hprmbridge> alonzoc> Beethoven 2.0?
16:48 < sphertext> and thanks for your comments. i read about the effect it has on weight. it's hard to tell which side effects are associated more with long term use. i do practice very strict control over my diet actually 
16:50 < sphertext> did your condition improve eventually? my impression is steroids are not a cure, just a temporary relief from symptoms 
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16:52 < hprmbridge> alonzoc> Well it kept the edge off long enough for long term medication to take effect. I'm not as symptom free as with the steroids (mostly fatigue still follows me around), but I'm way better.
16:52 < hprmbridge> alonzoc>
16:52 < hprmbridge> alonzoc> Sadly there's no cure yet for ulcerative colitis, and I don't have enough of a biolab to DIY one lol
16:52 < sphertext> beethoven's hearing loss was much worse and progressed over time. by the end he was nearly deaf. mine has stabilised at 4dB, at least. i wish i could trigger the same loss in my other ear lol. my hearing is still well within normal range, it's just unbalanced 
16:53 < hprmbridge> alonzoc> I read a while ago that a Japanese team tracked down some interesting immune markers though that might suggest a route forward
16:53 < jrayhawk> Which were those?
16:53 < sphertext> oh that's good then. yeah, seems like steroids can help to pause autoimmune reactions, so that tissue has a chance to repair and reach a more resilient baseline 
16:54 < hprmbridge> alonzoc> I'll need to search for it, can't remember off the top of my head but they found antibodies (iirc) present in patients almost all the time (90+%) and near zero in base population
16:55 < hprmbridge> alonzoc> Yeah, there was defenitely a cumulative element that was offset that greatly helped
16:56 < hprmbridge> alonzoc> Step 1. Purchase gun
16:56 < hprmbridge> alonzoc> Step 2. Put earplug in deafer ear
16:56 < hprmbridge> alonzoc> Step 3. Fire gun.
16:56 < hprmbridge> alonzoc> Step 4. Repeat until dB parity
16:56 < hprmbridge> alonzoc> (this is a BAD plan)
16:56 < sphertext> did you suppress your gastric acid while taking the steroid? my gp prescribed another compound, apparently it helps alleviating stomach upset from the high dose steroid. but im not sure i really want to suppress gastric acid. 
16:57 < hprmbridge> alonzoc> Proton pump inhibitors?
16:57 < sphertext> yes 
16:57 < hprmbridge> alonzoc> Yeah I took them, I think they're almost standard practice. Didn't feel any issues with that. Did they prescribe you vitD and calcium tablets?
16:58 < hprmbridge> alonzoc> I was on a longer dosage period so they might not for you
16:59 < sphertext> no, no supplements. i find it puzzling tho, how can you digest food if your acid is suppressed?
17:00 < hprmbridge> alonzoc> It's just partial it slows digestion down mostly iirc
17:00 < hprmbridge> alonzoc> jaryhawk i think it was this one https://pubmed.ncbi.nlm.nih.gov/34971808/
17:01 < hprmbridge> alonzoc> Oh wait might be wrong one
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17:59 < hprmbridge> nmz787>  https://cdn.discordapp.com/attachments/1064664282450628710/1156394573665423390/PXL_20230925_012401718.jpg?ex=6514cfdf&is=65137e5f&hm=a7643a5993b89a43aa39a74f7c9c2ecd4109cbf412dedc17c37296b5717e6275&
17:59 < hprmbridge> nmz787> Cleared a fallen tree with mini ex and log grapple, found small mushrooms on a broken limb stump
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18:58 < fenn> pancreas secretes a protease that's not acid dependent
18:59 < fenn> also, apparently pepsin activity is only reduced by 50%
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19:10 < NewtonTrendy> what do people think about the coincidence that the year born on the first studies into rapamycin were the first year at school who didnt get the TB vaccine, and thats what rapamycin is licensed to treat
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19:28 < sphertext> fenn gastric acid is required besides just activating enzymes or breaking down the macros. 
19:29 < sphertext> as for the pancreas, yes that is correct and it is active inside the small intestine 
19:29 < sphertext> actually acid doesn't break down macros at all, but _digestion_ is about more than that 
19:47 < jrayhawk> so, like, what, is HCl protein hydrolysis a myth The Man wants you to believe?
19:50 < jrayhawk> damn big chloride for manipulating obvious and ubiquitous chemical reactions
19:52 < sphertext> sorry i could be wrong.. maybe it does play a part in proteolysis, but it's not it's primary purpose 
19:53 < sphertext> and there is obvious redundancy to it
20:02 < jrayhawk> hydrogen donation has a "primary purpose"? is this like a religious thing?
20:04 < sphertext> physiological role is not a religious thing
20:05 < sphertext> trying to figure out why mixing whey and soy protein isolates together results in a far more watery consistency compared to the same amount of soy mixed alone. could it be ph? 
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--- Log closed Wed Sep 27 00:00:34 2023