--- Log opened Thu Sep 28 00:00:35 2023
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02:24 < fenn> hot off the GPUs: https://mistral.ai/news/announcing-mistral-7b/ https://huggingface.co/TheBloke/Mistral-7B-Instruct-v0.1-GGUF  
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05:17 < hprmbridge> kanzure> https://www.scottaaronson.com/democritus/lec9.html
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06:18 < hprmbridge> kanzure> "Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes" https://www.nature.com/articles/s41467-023-39888-2
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08:12 < hprmbridge> nmz787> Hmm  chatgpt says tnf-a is 5nm... if true, the 10nm pores must be excluding it with surface charge
08:48 < hprmbridge> Eli> The preprint only came out in may 2023 😁
08:48 < hprmbridge> Eli> https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbmoycnBHc18tZ2hURFNDdFB4TGFjdTBGejRFd3xBQ3Jtc0tuX3gyNERTbmU2LVlHaDlSV0NwX25uaUh0Sllmdm9wVklyT3Z0ZnYzZXBCUU9mTXgtUVo5cGxpNWg4SklRcE0xaXpKdjJOZV91clFQVlBJQU5FbVZNRzY5M0ozeTYwTnNYRzFIYVFicEVDakZDMlRVRQ&q=https%3A%2F%2Farxiv.org%2Fabs%2F2305.16291&v=uTg39rNMojo
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08:49 < hprmbridge> Eli> I should have posted the blog post. It's a big advance: https://voyager.minedojo.org/
08:51 < hprmbridge> Eli> You can start to see how this would lead to an AI assistant in real life that picks up skills and masters them on it's own.
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09:46 < hprmbridge> kanzure> Architecture 1: A molecular “printer” by Christian Schafmeister, Boris Fain, Jonathan Ackley, Lillian Chong, Tad Hogg, Adam Braunschweig
09:46 < hprmbridge> kanzure>
09:46 < hprmbridge> kanzure> Architecture 2: A molecular “breadboard” by William Shih, Anastasia Ershova, Jacob Majikes, Fei Zhang, Shucong Li, Mandal N, Si-ping Han
09:46 < hprmbridge> kanzure>
09:46 < hprmbridge> kanzure> Architecture 3: Molecular legos / solid phase synthesis of molecular machines by David Forrest, Yuanning Feng, Chris Wintersinger, Rachel Shi, Caleb Meredith, Bill Efcavitch
09:46 < hprmbridge> kanzure>
09:46 < hprmbridge> kanzure> Architecture 4: Scanning-Tunneling Microscope / Atomic-Force Microscope based assembly by Mark Friedenbach, Brenda Rubenstein, Philip Moriarty, Iqbal Utama, HP, Eduardo Beltrame
09:46 < hprmbridge> kanzure>
09:46 < hprmbridge> kanzure> Architecture 5A: Meta-protein 1D thing: META-C by Julian, Petr, Erik Benson, Carlos, Alexis Courbet, Haichao Wu, Jim S, Ted Kaehler
09:46 < hprmbridge> kanzure>
09:46 < hprmbridge> kanzure> Architecture 5B: Small Molecule Approach by Zoe Ashbridge, Stefan Borsley, Irene Regeni, Marco Ovalle, Max Ledent
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10:25 < hprmbridge> kanzure> https://twitter.com/AnnaArchivist/status/1707256578649284890
10:26 < superkuh> Excellent.
10:26 < L29Ah> public release when?
10:37 < superkuh> I'm using it now.
10:37 < superkuh> It just links to libgen and scihub.
10:38 < superkuh> I didn't realize libgen had so many papers.
10:38 < superkuh> So, still, neat.
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12:57 < hprmbridge> nmz787> where are these from?
12:58 < kanzure> https://foresight.org/molecular-workshop/
12:59 < kanzure> oh there are videos now.
13:00 < kanzure> https://foresight.org/summary/msep/
13:08 < kanzure> https://www.youtube.com/watch?v=mKo1VPvfXOE
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16:27 < kanzure> "I do have some early role models. I recall wanting to be a real-life version of the fictional "Sandor Arbitration Intelligence at the Zoo" (from Vernor Vinge's novel A Fire Upon the Deep) who in the story is known for consistently writing the clearest and most insightful posts on the Net. And then there was Hal Finney who probably came closest to an actual real-life version of Sandor at the ...
16:27 < kanzure> ...Zoo"
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19:47 < hprmbridge> kanzure> TKTL1 mutation https://twitter.com/cremieuxrecueil/status/1707464864304635966
19:49 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1157147047099641876/image0.png?ex=65178caa&is=65163b2a&hm=d397758cec01cf1c34d47a095843ecb268f8a11c5949773b54ae4b8312cd6861&
19:49 < hprmbridge> kanzure> https://www.science.org/doi/10.1126/science.abl6422
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21:39 < sphertext_> fenn finally got around to reading the section you linked in dawkin's book. thanks for sharing, it was very interesting and related to several ideas i had been reflecting on. 
21:44 < sphertext_> "bottlenecked reproduction is what keeps us from degenerating into amorphous blobs" --> there are caveats.. although curtailing bottlenecked reproduction would have normally come at the cost of halting the evolution of advanced and precise phenotypes, in humans those adaptations would instead continue to come from indirect cognitive interventions (i.e technology).
21:48 < sphertext_> second, regarding the issue of loss over time in phenotypic organisation and of the uniformity in survival interests, due to the accumulation of mutated cells and inexorable entropy in the same body – well, yes, that's cancer, unfortunately. hope can only come from finding a way to consistently eliminate those aberrations quickly from the body, whenever they arise, so that uniformity can be maintained 
21:49 < sphertext_> and so that phenotypic integrity can be preserved
21:53 < sphertext_> so yeah, idk. provided we can optimise the elimination of genetic divergence + leverage cognition to carry on with evolutionary progress without underlying genetic changes => we can halt bottlenecked reproduction without adverse consequences. 
21:54 < sphertext_> * of genetic divergence that leads to cancer
21:56 < sphertext_> in fact, i dare say this is probably where we (life) are headed 
22:00 < fenn> redundant backup systems are good
22:01 < fenn> it's not obvious to me that we need germ cells once we have base editors and genomes stored in computer databases
22:02 < fenn> but hey, the machinery is there already, you might as well use it
22:03 < sphertext_> @kanzure haha very interesting. it's rare that a gene mutations is found which nicely turns out to be the single determinant of a highly salient phenotypic trait. usually such traits are the result of the interaction of many genes, some of them even being redundant, etc. 
22:03 < sphertext_> * mutation 
22:04 < sphertext_> but it's also really interesting that this particular mutation is shared by virtually all homo sapiens
22:05 < sphertext_> fenn yeah, we might as well use it, but.. don't you have any sympathy for the soma that must carry this machinery on its shoulders? hahaha 
22:27 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=074ed5cc fenn: TKTL1 >> http://diyhpl.us/diyhpluswiki/images/TKTL1_corticogenesis.png
22:28 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=14823a47 fenn: fix image path >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
22:30 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f0353ede fenn: fix markdown whitespace stupidity >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
22:37 < hprmbridge> kanzure> man i really just don't care about polygenics
23:12 < sphertext_> yeah no, im just saying, it's nice when biology gives us a break from intractable complexity... 
23:15 < hprmbridge> kanzure> check the wiki. there's a number of things you can do with genetic engineering unrelated to polygenics.
23:15 < hprmbridge> kanzure> (meaning the diyhpl.us wiki)
23:33 < sphertext_> by polygeny, do you mean the fact 1 phenotypic trait may be determined by a combination of multiple interacting genes? or the theory of different human races?
23:33 < sphertext_> because my point was about the former aspect. and im not sure what the latter has anything to do with it.. 
23:34 < hprmbridge> kanzure> everyone uses polygenic traits to explain why they won't do anything. there are many genetic interventions that are possible, and no it's not just single polymorphisms.
23:34 < hprmbridge> kanzure> there's a whole field of genetic engineering. repressor elements! methylation! promoters! regulatory elements... multi gene circuits.
23:35 < sphertext_> ah ok
23:38 < sphertext_> yeah, for sure. shouldn't let polygenic traits paralyse us from doing what is afforded by those interventions 
23:39 < hprmbridge> kanzure> http://diyhpl.us/wiki/genetic-modifications/
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23:45 < sphertext_> i think the problem with single gene interventions is that you also cannot rule out their pleiotropic contribution to polygenic traits... 
23:46 < sphertext_> (polygenic traits that are unrelated to the one you're interested in)
--- Log closed Fri Sep 29 00:00:36 2023