--- Log opened Tue Oct 10 00:00:51 2023
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08:44 < kanzure> .gpt4 explain intelligence-linked interesting aspects of SRGAP2C, MCPH1, FOXP2, but mainly SRGAP2C
08:45 < gptpaste> ​SRGAP2C, MCPH1, and FOXP2 are all genes that have been linked to various aspects of human intelligence and cognitive development. 1. SRGAP2C: This gene is particularly interesting because it is a human-specific gene duplication that occurred about 2-3 million years ago, around the same time when the Homo lineage was diverging from other primates. The protein encoded by th - https://bin.gy/micomononk
08:46 < kanzure> .gp4 is SRGAP2C a copy number variation in human
08:53 < kanzure> hm
08:54 < kanzure> "The ancestral copy SRGAP2A limits synaptic density and promotes maturation of both excitatory (E) and inhibitory (I) synapses received by cortical pyramidal neurons (PNs). SRGAP2C binds to and inhibits all known functions of SRGAP2A leading to an increase in E and I synapse density and protracted synapse maturation, traits characterizing human cortical neurons."
09:54 < nsh> .gpt4 -c is SRGAP2C a copy number variation in human
09:54 < gptpaste> ​Yes, SRGAP2C is a result of copy number variation (CNV) in humans. Copy number variations are alterations of the DNA of a genome that results in the cell having an abnormal or, in some cases, normal number of copies of one or more sections of the DNA. In the case of SRGAP2C, it is a partial duplication (copy) of its ancestral gene SRGAP2. This duplication event happened a - https://bin.gy/trivindula
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14:23 < fenn> https://science.nasa.gov/eclipses/future-eclipses/eclipse-2023/where-when/ "In the U.S., the annular solar eclipse begins in Oregon at 9:13 a.m. PDT and ends in Texas at 12:03 p.m. CDT."
14:23 < fenn> on saturday october 14
14:24 < hprmbridge> kanzure> yes we're planning a trip for that.
14:25 < fenn> san antonio is not that far
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14:39 < fenn> there's another total eclipse there on april 8 2024
14:41 < fenn> it will be 1-2 minutes long in austin 
14:41 < fenn> https://images.squarespace-cdn.com/content/v1/53c358b6e4b01b8adb4d5870/1644433681052-OLREISTQSOOTZWEMIP3L/Texas%2Bmap%2B1.jpeg
14:44 < hprmbridge> kanzure> do you want to come out for it?
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15:00 < fenn> "here today and gone tomorrow is passe / for us it's here today and gone today"
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15:10 < sphertext> "openAI is doing all sorts of nasty things to your image generation prompts" isn't google doing the exact same with search results? except google profits from it. so if there was a leak that showed how search results were being manipulated, it could be used to subvert their business. i would call it a security vulnerability then. but openAI isn't making a profit from how they manipulate your prompt results. so sorry, i still don't see what
15:10 < sphertext>  the big deal is
15:10 < sphertext> how come this isn't being discussed more? https://en.wikipedia.org/wiki/Thymosin
15:11 < sphertext> it's apparently a class of hormones secreted by the thymus, which are potent immunomodulators, mobilisers of stem cells, etc. they're available in synthetic form and have a wild range of rejuvenating effects. and they're really safe
15:15 < sphertext> "Those activities include the promotion of cell migration, blood vessel formation, cell survival, stem cell differentiation, the modulation of cytokines, [...] [...] clinical trials evaluating the tissue protective, regenerative and repair potential of Tβ"
15:15 < sphertext> " long been recognized for modifying, enhancing, and restoring immune function. "
15:17 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161427291130314863/image0.jpg?ex=65384274&is=6525cd74&hm=33510639d3bba970f761438e3438631041d6a1a69c5f6508f7a42d5c20c1ea4e&
15:17 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161427353549942956/image0.jpg?ex=65384283&is=6525cd83&hm=c30923cf452b5085aa850aebd496aa679a54a0927034857ed087dd2f16db9816&
15:20 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161428170164158464/image0.jpg?ex=65384346&is=6525ce46&hm=4e79398088b7447bb4ca741362bc02a2415f5813eb4aedacc92988486ee4b073&
15:21 < hprmbridge> kanzure> not sure what the plot is, in that one...
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15:27 < sphertext> "The safety profile of Tα1 is excellent and it is virtually devoid of toxicity."
15:28 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161430049367543920/image0.jpg?ex=65384506&is=6525d006&hm=32b563e5791ff4a9a80299f8b937bdcbe56f6312b954c4a5c5ea1bd769e8113c&
15:28 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161430149137436754/image0.jpg?ex=6538451d&is=6525d01d&hm=faa5a250ee04fcb812b2b531ff981f7af47b47bda00a33bf31630560dc807ff3&
15:34 < sphertext> lol https://pubmed.ncbi.nlm.nih.gov/18752465
15:34 < sphertext> .t
15:34 < EmmyNoether> Expression of thymosin alpha1 concatemer in transgenic tomato (Solanum lycopersicum) fruits - PubMed
15:44 < sphertext> "The lung adenoma number was reduced by 15-45% if animals were daily treated subcutaneously (s.c.) with Talpha1"
15:48 < sphertext> i'm always skeptical when something endogenous appears to have benefits when supplemented in supra-physiological doses.. with no side effects. if we can make it, why wouldn't we just make more of it? 
15:49 < sphertext> but everyone says Ta1 is completely non-toxic and has a ton of benefits 
15:53 < ike8> it degrades quickly at room temperature
15:56 < fenn> openAI isn't making a profit from how they manipulate your prompt results... yet
15:57 < fenn> i'm far less worried about advertising induced corruption than politically motivated corruption of the user's intent
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16:06 < fenn> "tissue-regenerating properties of thymosin β4 may ultimately contribute to repair of human heart muscle damaged by heart disease and heart attack"
16:06 < fenn> "Thymosin beta-4 is considered a performance enhancing substance and is banned in sports by the World Anti-Doping Agency due to its effect of aiding soft tissue recovery and enabling higher training loads"
16:06 < fenn> wouldn't want people to be too healthy
16:08 < fenn> at least there is a black market for it, thanks to sportsball
16:45 < sphertext> note that's tb4, a different chemical from ta1 that i was quoting above (but they're both secreted by the thymus) 
16:47 < sphertext> guys am i dumb for wanting to buy dry apple peel powder? most pythochemicals are concentrated in it anyway, so my idea is to obtain them for 1/4 of the calories 
16:51 < sphertext> and it actually works out cheaper 
16:54 < muurkha> how will you tell if it's contaminated with human-toxic pesticides or endocrine disruptors, and whether the phytochemicals have degraded?
16:54 < muurkha> Feynman famously described psychology as "cargo-cult science" but most nutrition research doesn't even rise to that level
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16:56 < sphertext> well actually, this particular manufacturer complies with the residue limit for pesticides http://www.appleactiv.com/uploads/pdfs/AA_DAPP-RM_AND_FOOD_Spec-Feb_2015.pdf
16:57 < sphertext> and it also reports >2.5% ursolic acid.. which is a really based phytochemical found in apple peels 
17:00 < sphertext> although tbh this COA could have just been fabricated. there's no lot #, no lab name, no date
17:10 < sphertext> anyway i'm more generally interested in getting the non-nutritional benefits of a high caloric diet (i.e phytochemicals) but without the calories. one solution is acarbose, but it's not perfect and has some side effects. another approach is using phytochemical extracts, but the supplement industry is mostly a fraud and you can't trust what's on the label. 
17:10 < sphertext> also extracts are seldom full spectrum 
17:10 < sphertext> and those extracts which are standardised and lab tested tend to be reaaally expensive 
17:11 < sphertext> so yeah, tough problem to crack 
17:12 < muurkha> how would you know if they exceeded the limit one day, or if the residue limit was set too high?
17:12 < sphertext> a third approach is to increase the amount of exercise so you can afford eating more calories, but exercise doesn't actually even spend that many calories, unless you do a lot of it (multiple hours/day) 
17:12 < sphertext> muurkha the limit is set by the USP
17:13 < sphertext> and they're supposed to test each batch 
17:13 < sphertext> but as you can see in that document, they didn't even bother to write which particular batch was tested 
17:13 < sphertext> normally each batch as a lot #. and you can check the COA against the number on your product 
17:14 < sphertext> if you want anything more precise than that, then you don't have it when buying grocery store apples anyway, so it seems a bit pointless to worry about it 
18:08 < sphertext> back to Ta1, this stuff is just insane? hello? how is this not a thing? https://sci-hub.st/10.1016/bs.vh.2016.04.003 
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18:34 < sphertext> ike8 "Lyophilized thymosin alpha 1 may remain stable for up to three weeks at room temperature"
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18:55 < muurkha> sphertext: in the absence of science it's probably better to rely on tradition
18:56 < sphertext>  muurkha context?
19:02 < sphertext> i love it when ppl @ me with cryptic ominous messages 
19:48 < fenn> nutrition probably
19:49 < fenn> the great thing about traditions is there are so many of them!
19:57 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161497813583151166/image0.jpg?ex=65388422&is=65260f22&hm=554b8934b7ca7a0223f64bb0fb14856c2308f561cdd04993f2c702b24e0798f4&
19:57 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161497860978786404/image0.jpg?ex=6538842d&is=65260f2d&hm=99c993318e39ffb7a91c2b1ca28c063d52e126ef1e278f45695a5ab9b5f5630a&
19:58 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161497934307807282/image0.jpg?ex=6538843f&is=65260f3f&hm=46b7b70d1bab9c02bb6fefb07716791a1dc837b44520e12e19f64d3f25c5d82b&
19:58 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161498012384759818/image0.jpg?ex=65388451&is=65260f51&hm=98b20b8c276ad85139307e9b3f8f02806c68d514e76f25cbe73dc7ecf377ce01&
20:03 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161499307082518588/image0.jpg?ex=65388586&is=65261086&hm=062aa96ee4ccb1cf81dc657be3eb7eb96ba96ec1c30961d59f873bd226c876b2&
20:09 < hprmbridge> kanzure> this one seems more practical: https://cdn.discordapp.com/attachments/1064664282450628710/1161500810342055946/image0.jpg?ex=653886ec&is=652611ec&hm=8cd3073fb272a09108557ae4bd10703663d9340d6bf6f9a06278c1f6922cb3af&
20:28 < sphertext> https://old.reddit.com/r/Entomology/comments/ggllrs/where_can_i_buy_insect_venom/
20:28 < sphertext> .t
20:28 < EmmyNoether> Where can I buy Insect Venom? : Entomology
20:29 < sphertext> wondering the same tbh 
20:37 < sphertext> does anybody here have institutional access? would appreciate this paper https://doi.org/10.1016/j.intimp.2023.109952 
20:50 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1161511063766974524/image0.jpg?ex=65389079&is=65261b79&hm=d3b953098b4aeaa76c062c4a3f6bac623a24db2a4ecb59d0de65eea48e219a99&
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21:07 < sphertext> sorted
21:10 < fenn> that was quick
21:15 < sphertext> fortunately 
21:16 < sphertext> does anybody know a reputable vendor of peptides?
21:18 < sphertext> science.bio is out of stock right now. and i don't know if i want to go the hassle of using a reshipper with cuerpoymente 
22:19 < sphertext> hmm ok plot twist. all the review articles on ta1 are from ppl affiliated with the manufacturer and it's never been FDA approved for anything. which is bizarre, considering the number of clinical trials (done mostly abroad) 
22:20 < fenn> most things aren't FDA approved
22:22 < sphertext> they would approve something if it had solid evidence. and this is approved in 30 other countries, so it's strange
22:24 < sphertext> apparently there was a surge in interest in it during covid and fda cracked down on it a bit 
22:28 < sphertext> and apparently this surge in interest was triggered by a presentation given by a dude heading a peptide lab that manufactured it, who happened to be a registered sex offender 
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22:29 < sphertext> man 
22:31 < fenn> selection effects
22:31 < fenn> not the hero we wanted, but the hero we deserved
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23:06 < muurkha> sphertext_: the FDA doesn't approve things on their own initiative; they act on requests submitted to them by manufacturers
23:32 < sphertext_> muurkha yeah which is why it's suspect.. because there's a company who actively manufactures, so presumably they would have attempted to get it approved on the US market. 
23:34 < sphertext_> there should be a tool which retrieves all the literature for a keyword and shows you how much overlap there is in the author names 
23:35 < sphertext_> like for melatonin, all of the trials for its benefits in cancer were run by the same lab, headed by the same supervisor. and never replicated independently 
23:35 < sphertext_> i feel like ta1 might be similar 
23:36 < sphertext_> because the most recent two literature reviews were both published by ppl affiliated with the company who manufactures it.. and one of them was even co-authored by the person who originally discovered it. 
23:36 < sphertext_> also a lot of the trials seem to have been done in italy 
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--- Log closed Wed Oct 11 00:00:03 2023