--- Log opened Sun Oct 15 00:00:56 2023
01:25 < hprmbridge> Eli> They use fentanyl patches
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02:48 < hprmbridge> kanzure> https://twitter.com/nerijs/status/1713286086078652858
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10:10 < docl> fentanyl patches only last 72 hours. I think that has some downsides compared to a 6 month implant, like now sourcing patches is part of your day to day routine. also it's less discreet. so there's a social contagion factor to consider
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10:33 < hprmbridge> nmz787> Also patches can be abused
10:33 < hprmbridge> nmz787> Implant seems less likely for someone to extract, crush, get high
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11:53 < TMA> wikipedia suggests that synthesis is very easy (compared to other drug types, which the "substance abuse industry" is already capable to produce in large volumes)
12:22 < hprmbridge> nmz787> Fentanyl's potency might mean it's an environmentally "green" choice?
13:11 < TMA> in a technical sense. the source of non-greenness lies solely with humans. anything that serves to reduce the number of humans is indirectly "green" in this sense
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13:35 < hprmbridge> nmz787> I mean more like, less carbon involved (micrograms vs milligrams per dose per human)
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15:06 < ike8> The extraction/synthesis process is a better measure of carbon intensity than human dose.
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15:40 < fenn> it probably comes from russian chemical weapons, as it's a potent less-lethal incapacitant
15:43 < fenn> pff chatgpt doesn't like my theory
15:43 < fenn> "clandestine labs in china and mexico"
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16:46  * L29Ah recommends bromo-dragonfly as the green dope/less-lethal incapacitant of choice
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17:39 < kanzure> hello world
17:51 < sphertext_> and what a world indeed 
18:07 < sphertext_> ike8 hi
18:08 < sphertext_> ike8 tbh there isn't definitive research on how selegiline benefits longevity
18:08 < sphertext_> knoll originally demonstrated in a lot of mouse, rat, even dog and fly studies that selegiline extends lifespan
18:08 < sphertext_> that's about it
18:09 < sphertext_> we also know that selegiline modestly delays the progression of early onset dementia 
18:09 < sphertext_> and we know that in mice it is neuroprotective against anticholinergics 
18:13 < sphertext_> partly because it significantly inhibits the acetylcholinesterase enzyme
18:13 < sphertext_> more of a nootropic thing, unless you consider longer lifespan to be downstream of cognitive function 
18:17 < sphertext_> selegiline also helps control drug addiction in rodents (alcohol, morphine, cocaine)
18:22 < sphertext_> in vitro studies also showed that selegiline modulates cytokine biosynthesis in blood cells, suggesting a potential effect on the immune system. but it's hard to judge how it translates in vivo 
18:25 < sphertext_> there is also one study in rabbits with chronic heart failure, where selegiline protected their heart cells from dying, which resulted in improved cardiac function 
18:34 < sphertext_> and then there are the in vitro studies on various types of neurones, where selegiline protected them from many toxins, whether they targeted dopaminergic, adrenergic, serotonergic or cholinergic neurones 
18:35 < sphertext_> it also rescued neurones whose axons have been cut off, in a similar manner to how the endogenous brain neurotrophic factors would
18:38 < sphertext_> oh and there's something in the cerebrospinal fluid of dementia patients that is toxic to dopaminergic neurones (we don't know what), and selegiline was able to protect neurones being cultured in that fluid. and it did so at a concentration below what would be needed for MAOB inhibition 
18:46 < sphertext_> but it's very hard to translate this in vitro stuff in vivo 
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19:50 < sphertext_> just as an example, while that one study found decreased AChE expression in vitro after selegiline, actually a lot of in vivo studies, in rodents as well as primates, found that AChE levels are modulated differentially in various regions of the brains by selegiline: it goes both up and down. and ACh levels also vary differentially. 
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19:54 < sphertext_> which ok, because in all cases the cholinergic modulation correlated with increased performance. and in dementia, AChE levels in the cortex actually go down, which is a bit counter-intuitive. 
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21:35 < sphertext_> fenn i suppose you've seen this https://botharetrue.substack.com/p/every-app-that-adds-ai-looks-like
21:37 < fenn> ✨thanks✨
21:44 < sphertext_> man i really can't enjoy shit stuff anymore
21:44 < sphertext_> it's a problem 
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21:48 < sphertext_> 2 days ago i decided to nuke my cognition with 35mg of a decarboxylated cannabis oil extract. stocked up on lots of random food using the too good to go app. including cookies, pastries, lots of sushi, deep fried stuff. made a play list of braindead tv shows. i said let's see what im missing out on.. half way through, all i could think about was having one of my usual apples lol 
21:49 < fenn> but why
21:49 < sphertext_> because from a distance, the "other" stuff starts to feel exotic.. and you start wondering if you're missing out 
21:50 < sphertext_> but it was pretty disappointing 
21:50 < fenn> there's a lot more actually exotic things in the world than mainstream things
21:50 < fenn> the blurse of dimensionality
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21:51 < sphertext_> the what
21:51 < fenn> blessing/curse
21:52 < sphertext_> the dimensionality of what?
21:55 < sphertext_> oh this is actually thing https://en.wikipedia.org/wiki/Curse_of_dimensionality
22:02 < fenn> snacks, drugs, tv shows, micronutrients...
22:04 < fenn> each of which is somewhat high dimensional
22:05 < fenn> i didn't really have a point i guess
22:05 < fenn> don't be surprised that boring things are boring, when there is so much non-boring stuff out there
22:11 < sphertext_> nah it's an interesting reference and it makes sense.. higher dimensionality increases the available degrees of freedom, conditionality and therefore adaptability of your behaviour. conversely, it increases the perceived distance and differentiation between the available options, which can foster renewed curiosity in those that were being selected against
22:19 < sphertext_> in other news, puberty was a mistake 
22:19 < sphertext_> >  Since the immune system must compete with other bodily systems, notably reproduction, for limited physiological resources, the body must invest in the immune system differentially at different stages of life. There is high immunological investment in youth since immunological memory is low.
22:20 < sphertext_> https://journals.aai.org/jimmunol/article/175/4/2741/74731/Activation-of-Thymic-Regeneration-in-Mice-and
22:20 < sphertext_> .t
22:20 < EmmyNoether> Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade | The Journal of Immunology | American Association of Immunologists
22:22 < sphertext_> also i've made a bomb tempeh. what makes it special is that instead of boiling the beans before the fermentation, i steam cooked them. which retained all the nutrients! you won't find this kind of tempeh anywhere 
22:22 < sphertext_> that's a great business idea right there 
22:23 < sphertext_> it's a solid asf USP 
22:25 < sphertext_> "TempehPlus – unique preparation that retains the full spectrum of phytonutrients"
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23:14 < sphertext> i wouldn't even know how to start a food business. i wonder if someone would outsource the manufacturing? or build the facility themselves first? in that case the upfront investment becomes really prohibitive. plus all the food safety certifications you have to obtain. i hope i'm wrong, but it seems really complicated to do this, even tho the product idea is really simple 
23:19 < fenn> there are contract manufacturers but it's still complicated
23:19 < fenn> getting a product on the shelf at a grocery store is a monumental endeavor
23:22 < sphertext> yeah i know the competition for shelf space is huge 
23:23 < sphertext> and selling a fresh product online is somewhat complicated logistics too, although i guess mainly for the storage part, because you outsource the shipping to a shipping company and the cost is paid by the customer (if they can afford it) 
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--- Log closed Mon Oct 16 00:00:57 2023