--- Log opened Fri Nov 10 00:00:21 2023
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06:48 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1172548352261500968/image0.png?ex=6560b7c0&is=654e42c0&hm=dbf53f00a85f0ee5c93b41b184f24773860d52f9c25167303930e67b571066c8&
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10:56 < docl> for a thermocycler like denaturing effect, I wonder if you could use an LED that warms the strand itself. with specific strand length and one of the strand being immobilized on a surface, there could be an antenna like effect to exploit
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11:00 < docl> it's generally hard to warm/cool a molecule without the whole solution being warmed/cooled, but hmm. an ultra brief pulse might translate to something more mechanical
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12:38 < hprmbridge> kanzure> "Live birth of chimeric monkey with high contribution from embryonic stem cells" https://www.cell.com/cell/fulltext/S0092-8674(23)01087-5
12:58 < alethkit> kanzure: Not sure why he doesn't go for amphetamines Erdos style
12:58 < alethkit> also, interesting that the smear campaign on him worked
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13:02 < hprmbridge> kanzure> smear campaign on erdos?
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15:16 < hprmbridge> nmz787> https://www.nejm.org/doi/full/10.1056/NEJMoa2300792
15:16 < hprmbridge> nmz787> Actionable Genotypes and Their Association with Life Span in Iceland
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16:00 < fenn> tomorrow 11/11 at 11 AM https://www.aaronswartzday.org/
16:24 < fenn> amphetamines can impair judgement and encourage snap decisions, which would seem to be a bad idea for a professional investor
16:25 < fenn> when i looked into nicotine substitutes, i may have learned that nicotine stimulates a receptor that directly promotes cancer, but i could be wrong
16:27 < jrayhawk> "directly"?
16:30 < jrayhawk> yes but, OTOH, white people are bred for neuroticism and gout
16:32 < jrayhawk> or gout tolerance, rather
17:26 < muurkha> maybe neuroticism helps make them obedient to their hereditary monarchs
17:28 < jrayhawk> and religious scruples
17:29 < muurkha> not sure how religious scruples increase the numbers of copies of a gene
17:29 < muurkha> except for Mormons
17:30 < jrayhawk> it is when you exile, torture, and/or kill anyone who is insufficiently scrupulous
17:33 < muurkha> that sounds like a lot of effort that could be better spent exiling, torturing, and killing people whose eyes aren't the same color as yours
17:33 < muurkha> to a selfish gene
17:33 < muurkha> (or just raising food and children)
18:12 < fenn> or chasing women/men
18:13 < fenn> TIL there are only 400k tRNA per bacterial cell
18:14 < fenn> 3 million per yeast cell
18:14 < fenn> ~10 per ribosome
18:14 < fenn> somehow i imagined there were more
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18:15 < L29Ah> me too, since they meet ribosomes by pure chance
18:22 < fenn> in 2023 biophysicist Sunney Xie renounced his U.S. citizenship in order to reclaim his Chinese citizenship
18:34 < fenn> https://sunneyxielab.org/research/single_cell_genomics/malbac_babies/
18:34 < fenn> it's pretty rare to see a biophysicist posing with a baby from his lab
18:36 < fenn> "We have recently developed a technique for whole genome amplification that enables sequencing the genome of a single cell with high coverage. The technique—Multiple Annealing and Looping-Based Amplification Cycles (MALBAC)—uses a uniform, linear pre-amplification of DNA prior to exponential amplification by PCR. The unprecedented uniformity provided by MALBAC allows accurate detection of
18:36 < fenn> both single point mutations and copy number variations of individual cells."
19:02 < hprmbridge> kanzure> no way it's 10 tRNA per ribosome
19:05 < hprmbridge> yashgaroth> https://bionumbers.hms.harvard.edu/files/Number%20of%20tRNA%20molecules%20and%20ribosomes%20in%20yeast%20cells%20growing%20in%20different%20media1.pdf
19:05 < hprmbridge> yashgaroth> they're recycled fairly fast by tRNA synthetases, but even so it seems low
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19:39 < docl> https://bionumbers.hms.harvard.edu/KeyNumbers.aspx
21:08 < fenn> RemoveDebris cubesat test https://www.youtube.com/watch?v=RvgctXXzIYA 
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--- Log closed Sat Nov 11 00:00:22 2023