--- Log opened Sat Nov 11 00:00:22 2023
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08:31 < jkhales> Anyone have thoughts on this argument for nicotine from gwern? https://gwern.net/nicotine
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09:07 < muurkha> nicotine patches make me impatient and short-tempered
09:08 < muurkha> I think Gwern is correct that nicotine doesn't damage your body unless it kills you in an overdose
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09:10 < muurkha> generically, though, Algernon's argument (mentioned therein) suggests that if you go around dosing yourself with nicotine, you will have fewer expected descendants, probably because you'll be more likely to die (perhaps due to impaired judgment)
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09:38 < jkhales> @muurkha Algernon's and other evolutionary arguments are interesting. But there is always the loophole that excess energy consumption was maladaptive historically, but is no longer a concern for the first world.
09:48 < muurkha> yes, agreed
09:48 < muurkha> or the second world or most of the third world either, obviously
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10:49 < hprmbridge> kanzure> https://twitter.com/kanzure/status/1723412036288176301/photo/1 https://cdn.discordapp.com/attachments/1064664282450628710/1172971393630097478/16997285495057936472608307084430.png?ex=656241bc&is=654fccbc&hm=32c627d8e3dcceeab843dc13cc4ea4e13449dccd3abbf8eb09b1bd1279afe858&
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13:15 < docl> https://www.nature.com/articles/s41467-019-12916-w // Expanding the limits of the second genetic code with ribozymes
13:18 < docl> apparently ribosomes aren't strictly limited to amino acids. I wonder if there's a plausible route to assemble diamond threads from adamantane this way?
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13:36 < docl> my guess is no, at least not directly, but hmm. maybe from a precursor like Meerwein's ester
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16:33 < fenn> "to be fair, we can mail order botulinum toxin (much worse than sarin), americium (more radioactive than plutonium, used in smoke detectors), and grenade launchers (sold as flare guns but let's be real)."
16:33 < fenn> TIL you can just buy grenade launchers
16:34 < fenn> i mean it seems very easy to DIY but these are professionally built
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16:36 < hprmbridge> kanzure> and flamethrowers
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17:28 < muurkha> you can't mail-order entire milligrams of botulinum toxin or americium
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23:47 < docl> for data storage, I wonder if it would make sense to run two mirrored polymers with side rings (polysterine being an example) and link or fuse the rings where they touch. so it ends up being in a straight line at nanoscale. you could still roll it up like a ribbon mechanically. the basic idea would be to store the bits in terms of whether the given ring pair is inwardly or outwardly oriented.
23:50 < docl> ordinary atactic polystyrene stores a huge amount of random data, but it makes the polymer not be oriented in a straight line
23:50 < docl> https://en.wikipedia.org/wiki/Polystyrene#/media/File:Polystyrene_tacticity_en.svg
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23:53 < jrayhawk> there exists a data-storage polymer with excellent pre-existing packing techniques https://patents.justia.com/patent/11339423
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--- Log closed Sun Nov 12 00:00:23 2023