--- Log opened Thu Nov 16 00:00:27 2023
00:09 < docl> https://www.sciencedirect.com/science/article/pii/S1369702112700457 // Defects and impurities in graphene-like materials
00:11 < docl> relevant to data storage. c13 affects the bond length and phonon frequencies
00:12 < docl> and a given c-c bond is only 1.4 angstroms, so that beats DNA bases by a considerable margin
00:14 < docl> I wonder if the difference could be detected by a biologically compatible mechanism
00:20 < docl> like, do you have to chill to cryogenic temperatures to be able to observe it? or can you run a polymer next to it and sense the resonant changes in a warm aqueous solution??
00:25 < docl> maybe you could have a side chain that's NH2 and one that's N on a different polymer, and have a hydrogen bond that crosses the cell. it could be stronger or weaker based on the difference in carbon bond length.
00:26 < docl> wait, it's NH2-O or NH-N
00:28 < docl> the 5-7-7-5 and 5-8-5 clusters could be easier to detect with a hydrogen bonding probe, as it's a bigger difference in aperture size
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07:23 < hprmbridge> kanzure> chroma protein diffusion https://twitter.com/AndrewLBeam/status/1724838193042784399
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16:59 < hprmbridge> jkhales> oh nice to see I'm not the only increasingly obsessed with organoids unlocking the future 🙂
17:00 < hprmbridge> kanzure> just biological brains generally
17:07 < docl> hmm. reading up on the nucleus I don't see any obvious dealkillers for a cybernetic replacement idea. it looks like you'd still need nucleoli to produce ribosomes, but replacing the chromosomes/chromatin with a computer controlled synthesizer still seems doable. I think the function of sNRPs can maybe just be abstracted out, as you'd target the mRNA profile of the healthy cell directly. you could 
17:07 < docl> incorporate sNRPs into the synthesis route, but it'd be optional
17:09 < hprmbridge> Eli> Organoids seem likely to be apart of it. It seemed like the idea of using vast amounts of data before conducting trials would allow a better ROI. I've been reading a lot of historical medicine history books and I'm struck by how much of it was completely accidental. So many of the medicine Nobel prizes were like, "This dude left a window open and discovered antibiotics" whereas you look at physics
17:09 < hprmbridge> Eli> Nobel prizes and it's like "A really smart dude derived an elegant math equation in his brain that was confirmed years later with a groundbreaking physics experiment which completely altered how humans viewed their place in the universe".
17:09 < kanzure> docl: there are things in the logs about adding a microchip into every cell as a ~near term alternative
17:11 < docl> nice! did they discuss reengineering the nucleus specifically, or are we talking an organelle in the cytoplasm?
17:28 < docl> I think replacing the nucleus would work better than adding a separate mRNA factory alongside it, because you can avoid cascade effects. bad signals? just ignore them and continue to express healthy function
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22:26 < fenn> starship delayed to 18th
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22:36 < fenn> Restrictions. Licensee may only Use the Chroma Parameters and/or any Output solely for good, and not for evil.
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22:40 < fenn> chroma diffusion is 2 GB
22:40 < fenn> in case anyone was wondering
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22:55 < fenn> eesh... "Received: 20 December 2022"
22:55 < fenn> took a year to get published
22:55 < fenn> springer is holding us back :(
23:27 < fenn> ProCap uses natural language captions to condition samples [generative protein structure]
23:35 < fenn> that's the biggest model. i wonder if it's mostly language model to deal with the english natural language descriptions
--- Log closed Fri Nov 17 00:00:28 2023