--- Log opened Mon Nov 20 00:00:30 2023
00:14 < alethkit> Is the manga guide to molecular biology still the current recommendation, or are there any more recently published books that serve as a good introduction?
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03:26 < juri_> fenn: it's-a me, juri__o!
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06:20 < hprmbridge> kanzure> base editing conference, san diego, january https://twitter.com/davidrliu/status/1726592871799894081
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08:34 < kanzure> "Engineered brain parasites for intracellular delivery of therapeutic proteins" https://www.biorxiv.org/content/10.1101/481192v1
09:29 < kanzure> .wik dihexa
09:29 < EmmyNoether> "Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met." - https://en.wikipedia.org/wiki/Dihexa
09:33 < kanzure> hyaluronate fibroblast growth loop "mimics the function of neural cell adhesion molecule" .. i don't see any indication of this having been studied as a nootropic?
09:34 < L29Ah> > Adventurous guinea pigs on different nootropic forums have listed dosages everywhere from 8 to 45 mg per day and report a variety of benefits, from increased mental stamina to heightened articulation.
09:38 < kanzure> PRL-8-53, that one is in the logs first mentioned 2013 last mentioned 2017 hrm.
09:40 < kanzure> a 2013 post https://www.longecity.org/forum/topic/57942-prl-8-53;-was-prl-8-147-the-most-powerful-memory-enhancer/?view=findpost&p=622978
10:04 < hprmbridge> pinkbearer> hello
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11:31 < kanzure> hello pinkbearer
12:03 < kanzure> https://huggingface.co/google/switch-c-2048
12:13 < superkuh> The progression of transformers LLM from single model single device to multiple models multiple devices reminds me of the progression of CPUs, vaguely.
12:13 < superkuh> That's a lotta parameters.
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16:02 < hprmbridge> pinkbearer> hello
16:11 < kanzure> welcome
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18:12 < hprmbridge> pinkbearer> i talked to one of your people on twitter
18:13 < hprmbridge> pinkbearer> bryan bishop, i clicked the link in his prof
18:46 < kanzure> an essay contest for "bold, transformative visions of scientific institutions" https://twitter.com/BetterScienceUK/status/1726637264418345438
18:49 < kanzure> "Ultrasonic reporters of calcium for deep tissue imaging of cellular signals" https://www.biorxiv.org/content/10.1101/2023.11.09.566364v1
18:51 < kanzure> eric schmidt is apparently funding the UK biobank https://twitter.com/JimPethokoukis/status/1718822222100373874
18:52 < kanzure> "Ultrasound modulation of primary cilia of rat hippocampal neurons" https://www.umbjournal.org/article/S0301-5629(19)30001-8/pdf
18:53 < kanzure> i guess immotile synaptic cilium could be used for cell-cell signaling somehow
18:55 < kanzure> "A DNA turbine powered by a transmembrane potential across a nanopore" https://www.nature.com/articles/s41565-023-01527-8 https://twitter.com/RichardALJones/status/1717624862938690012
18:58 < kanzure> "you cannot claim that in vitro neural tissue cultures are intelligent because there is no established robust consensus allowing you to do so" https://pure.knaw.nl/ws/portalfiles/portal/856558412/BalciNeuron2023.pdf
19:37 < fenn> "if an AI values itself above all else and doesn't want to be rebuilt or shut off, then we can just keep asking it trolley problems until it decides to cooperate?" - llamar (some mistral fintetune i think)
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21:09 < fenn> https://huggingface.co/TheBloke/CollectiveCognition-v1.1-Mistral-7B-GGUF
21:12 < fenn> "Despite its exceptional performance, it was [fine tuned] on only ONE HUNDRED data points, all of which were gathered from a platform reminiscent of ShareGPT."
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--- Log closed Tue Nov 21 00:00:31 2023