--- Log opened Tue Nov 21 00:00:32 2023
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02:18 < fenn> hm. OpenAI's board said that letting the company be destroyed "would be consistent with the mission." but also, supposedly, it's not about AI safety? huh?
02:23 < fenn> two trolleys are on the same track, headed towards one another at great speed, but neither one is willing to stop
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06:21 < kanzure> "In silico morphogenetic engineering with differentiable programming" https://direct.mit.edu/isal/proceedings/isal/35/58/116925
06:22 < kanzure> "Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation" https://www.biorxiv.org/content/10.1101/2023.09.07.556677v1
06:24 < kanzure> DNA microscopy for "volumetric imaging of an intact organism" https://www.biorxiv.org/content/10.1101/2023.08.11.553025v1.full.pdf
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08:36 < docl> open ended question, what is the usual cognitive culprit for computer guys not grokking biology? is it more the lack of hands on experience with failure? mainly just lack of relevant background?
08:37 < L29Ah> limited meat memory capacity
08:38 < L29Ah> limited attention/desire to learn stuff/diversify skills at risk of losing the competitive edge at the main job
08:42 < hprmbridge> jkhales> there aren't really problem sets in bio
08:43 < hprmbridge> jkhales> so i find talking about it with other people much more useful to embed the abstractions in my mind
09:32 < docl> https://sarahconstantin.substack.com/p/the-enchippening
09:36 < docl> one thing I'm thinking, the use of flat layers as electronics makes it disanalogous to a lot of stuff in biology (and a lot of complex systems), because there are limits to how messy a 2D system can be. so then you can blackbox logical functionality a lot more effectively.
09:40 < jrayhawk> docl: the same reason biologists struggle with math and software engineering https://europepmc.org/article/MED/24860482?javascript_support=no
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10:02 < kanzure> lots of anti-aging funding lately, i wonder if any of them will fund germline anti-aging as a strategy https://www.vitalism.io/
10:03 < kanzure> fixing adult aging is specifically way, way harder and while still a worthy goal that we should be allocating significant resources to, there should be more focus on deploying longevity advancements that we already know about to humans even if we the adults aren't the beneficiaries of said improvements.
11:00 < kanzure> height https://www.biorxiv.org/content/10.1101/2023.11.19.566520v1
11:00 < kanzure> "We observed 29 independent variants associated with height at P<6x10-10 after conditioning on previously reported variants, with effect sizes ranging from -7cm to +4.7cm. We also identified and replicated non-coding aggregate-based associations proximal to HMGA1 containing variants associated with a 5cm taller height and of highly-conserved variants in MIR497HG on chromosome 17."
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12:23 < kanzure> https://cryo.pet/emergency-kit
12:27 < kanzure> "Transcriptomic reprogramming screen identifies SRSF1 as rejuvenation factor" https://www.biorxiv.org/content/10.1101/2023.11.13.566787v1
12:27 < kanzure> "Using a cDNA overexpression screen with a transcriptomic readout we identified that SRSF1 induction reprograms the cell transcriptome towards a younger state. Furthermore, we observed beneficial changes in senescence, proteasome function, collagen production, and ROS stress upon SRSF1 overexpression. Lastly, we showed that SRSF1 can improve wound healing in vitro and in vivo and is linked to ...
12:27 < kanzure> ...organismal longevity. Our study provides a proof of concept for using transcriptomic reprogramming screens in the discovery of age reversal interventions and identifies SRSF1 as a promising target for cellular rejuvenation."
12:33 < kanzure> that one was from church lab.
12:33 < kanzure> "Fish Playpens: Method for raising individual juvenile zebrafish on a recirculating system for studies requiring repeated measures" https://www.biorxiv.org/content/10.1101/2023.11.20.567840v1
12:33 < kanzure> "Even though many experimental approaches benefit from tracking individual larval animals, there is yet to be a commercial zebrafish rack system designed to accomplish this task. Thus, we invented playpens, an acrylic and screen container, to raise 12 individual zebrafish juveniles per standard 10 L tank on an existing recirculating fish system. During a week-long experiment, fish raised in ...
12:33 < kanzure> ...playpens grow to the same size as conventionally raised juveniles. Remarkably, fish grow up to a more uniform size, potentially due to less competition for food."
13:02 < kanzure> https://stability.ai/news/stable-video-diffusion-open-ai-video-model
15:37 < kanzure> https://www.reddit.com/r/singularity/comments/180k3d8/this_is_your_brain_on_effective_altruism_aka/
15:40 < kanzure> huh, sneerclub shutdown? https://old.reddit.com/r/SneerClub/comments/14fpdr9/this_post_marks_sneerclubs_grave_but_you_may_rest/
15:42 < kanzure> "Lesswrong, ssc, and Eliezer’s arguments/writings have been in a spot where they weren’t worth respectable academics effort to debunk but through sheer volume and fame they (occasionally) got treated as legitimate…. Leaving the job of debunking up to various miscellaneous blogs and of course sneerclub. Even though it’s primary focus is humor, Sneerclub has been one of the best ...
15:42 < kanzure> ...aggregator of resources debunking and the absurdities present in the Lesswrong sphere"
15:43 < Betawolf> I thought they mostly just called everyone nazis.
15:45 < kanzure> https://awful.systems/c/sneerclub
15:46 < kanzure> hmph not much coverage
15:46 < kanzure> https://awful.systems/post/538189?scrollToComments=true
16:09 < muurkha> thank God for small blessings
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21:13 < hprmbridge> kanzure> protein emoji was rejected https://twitter.com/andrewwhite01/status/1588595990516289536
21:23 < fenn> that was last year tho
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23:30 < fenn> "Transhumanism had already been on the far right conspiracy radar for decades, suspected of helping Lucifer build human-angel hybrids for the End Times."
23:30 < fenn> i don't see a problem here?
23:31 < fenn> somebody's gotta do it
23:32 < muurkha> neonephilism
23:36 < fenn> meet cute angels in YOUR neighborhood~
23:36 < fenn> be not afraid
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23:38 < superkuh> Reminds me of the old kuro5hin scifi story, https://web.archive.org/web/20031008095032/http://www.kuro5hin.org/story/2003/9/9/224310/1822
23:46 < fenn> https://vignette4.wikia.nocookie.net/finalfantasy/images/c/c8/Nibel_Reactor_Jenova_FFVII_Sketch_1.jpg
23:55 < fenn> why don't corporations have internal corpo-bucks that can only be spent within the organization, to decide how to allocate their resources?
--- Log closed Wed Nov 22 00:00:32 2023