--- Log opened Fri Dec 01 00:00:41 2023
00:11 < fenn> more efficient fine tuning of QLoRAs https://old.reddit.com/r/LocalLLaMA/comments/188197j/80_faster_50_less_memory_0_accuracy_loss_llama/
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03:59 < alethkit> Oh, I cannot read the date on the arxiv paper
04:02 < hprmbridge> kanzure> https://huggingface.co/Qwen
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05:02 < docl> hadn't seen that 2001 paper, interesting. time to deep dive polyketides
05:02 < hprmbridge> kanzure> as usual, check the logs first.
05:11 < kanzure> .gpt4 what are some other names that "polyketide synthase" might have gone by in the logs?
05:15 < docl> https://www.youtube.com/watch?v=WWKvn9Dk_Z8 // Engineering Polyketide Synthases for Synthetic Chemistry
05:16 < kanzure> maybe NRPS in the logs.
05:17 < docl> you mentioned it in https://gnusha.org/logs/2014-06-17.log but I can't tell who you were quoting from the context
05:18 < docl> the talk I linked describes them as "modular enzymes"
05:20 < kanzure> there was another name for this... lots of links in the logs for things like molecular factories for non-ribosomal peptides, different modular sections chained together in an enclosed space.
05:20 < kanzure> anyway, that 2001 paper is the best looking treatment i've seen tho. it is the sort of obvious thing to do once you discover a thing like this.
05:21 < docl> is the author someone who has come around here? bryan chow
05:22 < kanzure> nah
05:25 < docl> going by the paper it's an mit media arts and sciences guy
05:26 < docl> https://news.seas.upenn.edu/brian-chow-joins-bioengineering-faculty/
05:42 < docl> https://scholar.google.com/citations?user=uyOgLygAAAAJ
05:48 < L29Ah> asked mistral-7b-finetuned-orca-dpo-v2/ggml-model-q5_k_m.gguf: https://0x0.st/HxQ9.txt
05:48 < L29Ah> how does it compare against gpt4?
06:01 < kanzure> mistral did a bit better, chatgpt-4 says PKS, polyketide synthetase, multifunctional enzyme complex, megasynthase, and NRPS analog
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06:10 < nsh> .gpt4 what are some other names that "polyketide synthase" might have gone by in the logs?
06:10 < nsh> hmm, should play with the API now to see how much logs it can actually meaningfully process
06:11 < nsh> what might help is to do statistically improbable phrase parsing of the logs and create a compact data representation of that with timestamps
06:11 < nsh> then we can probably get it into context to give pointers to previous discussions on any topic 
06:12 < gptpaste> ​Polyketide synthase may also be referred to as PKS, polyketide synthetase, or polyketide synthase enzyme in the logs.# Fri  1 Dec 15:10:08 CET 2023 - what are some other names that "polyketide  - https://bin.gy/palpanting
06:17 < kanzure> no
06:17 < kanzure> nsh: semantic search over the logs <3
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07:58 < muurkha> nsh: maybe use FAISS?
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09:00 < L29Ah> i wonder if mammals live much longer at low core temperatures and artificial breathing/circulation/TPE
09:00 < L29Ah> could be a good option for wealthy advanced cancer patients to win some time for targeted immunotherapy at least
09:02 < muurkha> sounds like a recipe for opportunistic infections, but there are measures to take against those
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12:00 < hprmbridge> Eli> Anyone here ever done an SBIR grant?
12:01 < hprmbridge> elimohamad> Yes, many
12:04 < kanzure> we should do more
12:15 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=6a903b0a Bryan Bishop: welcome remarks >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/welcome/
12:38 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=
12:38 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=38a05775 Bryan Bishop: more words >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/end-of-men/
12:41 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=d9d92e11 Bryan Bishop: birthgap documentarian >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/stephen-shaw/
13:01 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=bd600ad6 Bryan Bishop: transcript: collins and defending cultures >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/collins/
13:04 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=cd8dc746 Bryan Bishop: transcript: collins and defending cultures >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/collins/
13:15 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=a58353be Bryan Bishop: a few more words >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/collins/
13:42 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=bfb172b3 Bryan Bishop: transcript: ben braddock >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/ben-braddock/
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14:32 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=d735ace8 Bryan Bishop: transcript: indian bronson >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/michael-anton/
14:55 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=
14:58 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=48bd2249 Bryan Bishop: more words >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/religion-panel/
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15:39 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=2ce53a74 Bryan Bishop: transcript: children and resilience >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/religion-panel/
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16:38 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=cd803130 Bryan Bishop: transcript: peachy keenan >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/peachy-keenan/
17:53 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1ecbd4b8 Bryan Bishop: transcript: charles haywood >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/charles-haywood/
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18:21 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=daf9558a Bryan Bishop: transcript: razib khan >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/razib-khan/
18:33 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=06cd0dc4 Bryan Bishop: transcript: balaji >> http://diyhpl.us/diyhpluswiki/transcripts/natalism/2023/balaji/
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20:49 < hprmbridge> kanzure> hello @transisto
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22:53 < hprmbridge> Eli> I’m trying to get money for an RCT for a substance for the military. I’ll DM you on your experiences if that’s ok?
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--- Log closed Sat Dec 02 00:00:42 2023