--- Log opened Wed Dec 27 00:00:11 2023
00:00 < nmz787_> (maybe it's C++, yeah probably)
00:00 < fenn> arduino is C++
00:00 < fenn> it tries really hard to hide this fact
00:01 < nmz787_> I mean the Python extension code
00:01 < fenn> oh libmagicrf is c with python bindings
00:04 < fenn> writing a card catalog TUI in C doesn't sound fun
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00:06 < fenn> can you "lock" an RFID card with a password to make it unreadable/unwritable?
00:06 < nmz787_> I think so
00:06 < nmz787_> I see "password" in the code and the mostly-chinese manual
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00:12 < fenn> the most straightforward way to do this, in my n00b opinion, is to port the libmagicrf C code to esp32, then talk to it over bluetooth serial with the arduino bluetooth serial app
00:12 < fenn> if you want a prettier interface you can run a webserver on the esp32
00:13 < fenn> that way you never have to touch android, and anyone can access it from any phone
00:15 < nmz787_> this other github repo has arduino code, which I haven't tried or reviewed other than seeing it has the set RF Channel function implemented https://github.com/Xinyuan-LilyGO/RFID-UHF-reader/blob/main/src/RF_Commands.cpp#L415
00:17 < nmz787_> in fact that repo already seems to be targetting esp32 on arduino
00:17 < nmz787_> so I guess I'd just have to rip out the OLED display GUI and swap in ad-hoc wifi and HTML GUI
00:18 < nmz787_> presumably there's some sort of jinja2-like templating engine for arduino
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00:23 < nmz787_> https://techtutorialsx.com/2021/09/13/esp32-inja-html-template-engine/#Rendering_and_serving_an_HTML_page
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01:05 < fenn> nmz787_: i finished the UI mockup for the RFID locator device https://www.youtube.com/watch?v=iV59X3GgAC4&t=4m45s
01:13 < nmz787_> :D
01:13 < nmz787_> I just showed Ben some Ren and Stimpy in the past month
01:13 < nmz787_> one was "Space Madness" and I can't remember the other
01:17 < fenn> ah here's the full spectrum of RF strength signifiers https://www.youtube.com/watch?v=1UniUkUIzEM&t=3m
01:17 < fenn> sorry for the earlier thing, you know how it is these days
01:19 < fenn> "stuck in space" instead of "marooned"
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03:01 < hprmbridge> Eli> So, previously, I was in the aging from a biochemistry camp. I still think that antagonistic pleiotropy and mutation accumulation have a place in the aging process. For example, things like mTOR are highly conserved. In fact, I think we no longer call it mammalian target of rapamycin explicitly because we've seen it in so many organisms. It makes sense to me that evolution would have all creatures
03:01 < hprmbridge> Eli> be anabolic in times of plenty and catabolic in times of hardship. The hypothesis being that anabolism is more likely to cause mutations, which then cause cancer. While, catabolism would not lead to mutations and organisms would live longer so they could reproduce when the period of hardship ended.
03:01 < hprmbridge> Eli>
03:01 < hprmbridge> Eli> However, I'm starting to really come around to the computational biologist/ecologist view of aging. The reality is that there are dramatic differences in fertility windows and lifespan. Some organisms live a few days, some thousands of years, and some are effectively immortal. In other words, if there is some sort of universal biochemical law of aging, it is not clearly apparent to me.
03:05 < hprmbridge> Eli> Now, if we look at the computational biologist/ecologist view of aging, things get interesting. You can basically see aging as a way to solve the tragedy of the commons. In the same way that viruses burn out if they kill their host too rapidly, or the Rocky Mountain locust died out because it reproduced so successfully, we can create a model where age, fertility,  and ecosystem are related in a
03:05 < hprmbridge> Eli> way that allows species to reproduce and survive without going extinct by destroying it's prey. In other words, a species in an ecosystem needs to evolve in a way that maintains a homeostatic set point in it's dynamic system. From this, we can start to make a lot of hypotheses.
03:08 < hprmbridge> Eli> Here is a model of rabbit fertility vs grass in an ecosystem. If the rabbits don't have very many babies, the system is completely stable and the rabbits won't eat and reproduce to famine and extinction. However, when we get to three babies per rabbit, the system becomes highly unstable and the entire population collapses due to the collapse in grass as food. We don't normally think of rabbits as
03:08 < hprmbridge> Eli> predators, but in the eyes of grass they clearly are. https://cdn.discordapp.com/attachments/1064664282450628710/1189525202724470825/image.png?ex=659e7aac&is=658c05ac&hm=b5f71ad294cc898bd3a915371bdb8b6063be7a9987d6ceaad21f7f5ced497a04&
03:15 < hprmbridge> Eli> In times of stress, organisms stop reproducing as much, thus, preventing the youth from overeating the reduced food that is available in the system. In times of plenty, organisms reproduce more and die sooner. These positive and negative feedback loops help to maintain the set point.
03:34 < hprmbridge> Eli> I haven't read this paper yet, but it's making the argument that telomere shortening acts as a biological clock. And that telomere shortening is actually a cause of cancer. https://cdn.discordapp.com/attachments/1064664282450628710/1189531757473701888/Telomerase-Cancer-Clock.pdf?ex=659e80c7&is=658c0bc7&hm=fcaf75af02d4cdd7b6d7e1754d8dd4e2d672474000632bddbaf92550fa6a1fb6&
03:34 < hprmbridge> Eli> I have lots of reading to do. 🤓
06:08 < kanzure> out-of-distribution generalizations in retrosynthesis predictions https://arxiv.org/abs/2312.10900
07:14 < hprmbridge> kanzure> this is not a "nano fabricator" with that kind of line width https://www.atlant3d.com/nanofabricators
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07:42 < hprmbridge> docl> welcome!
07:42 < docl> ah, the bridge doesn't show who I'm replying to
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08:11 < docl> https://en.wikipedia.org/wiki/English_coffeehouses_in_the_17th_and_18th_centuries
08:11 < docl> > Historians often associate English coffeehouses, during the 17th and 18th centuries, with the intellectual and cultural history of the Age of Enlightenment: they were an alternate sphere, supplementary to the university. Political groups frequently used coffeehouses as meeting places.
08:15 < docl> I'm recalling a talk where they mentioned this and associated it with the agglomeration effects of large cities, ideas cross pollenating due to proximity, that sort of thing
08:17 < docl> https://www.youtube.com/watch?v=0af00UcTO-c // Where good ideas come from | Steven Johnson
08:22 < docl> hmm. cross pollinating different strains of idea-stuff might be at its most powerful when you have two inbred strains come together. inbreeding causes the worse mutations to come to the front and die out, aka genetic purging. so it's not like being a lone introvert hyperfocused without distractions isn't a valid form of work here
08:23 < docl> .wik Genetic_purging
08:23 < EmmyNoether> "Genetic purging is the reduction of the frequency of a deleterious allele, caused by an increased efficiency of natural selection prompted by inbreeding. /  Purging occurs because many deleterious alleles only express all their harmful effects when homozygous, present in two [...]" - https://en.wikipedia.org/wiki/Genetic_purging
08:44 < docl> https://publicdomainreview.org/essay/the-lost-world-of-the-london-coffeehouse/ // The Lost World of the London Coffeehouse
08:49 < docl> cross pollination is part of my theory for how scenius erupts
08:49 < docl> https://kk.org/thetechnium/scenius-or-comm/ // Scenius, or Communal Genius
11:25 < docl> .m https://twitter.com/eshear/status/1668057708896088066
11:25 < AugustaAva> ​twitter: <eshear> @goblinodds The basic formula was a little like coaching. Both people I was very close to. Every time they said something in victim mindset I’d challenge, and ask more or less the same series of questions. “What’s the stupidest easiest one thing you could do to make even a little progress?”
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13:33 < hprmbridge> nmz787> it's nano because it's ALD
13:33 < hprmbridge> nmz787> I wonder if they have demonstrated DRIE
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16:43 < Ashstar> agh, just hit a deep hole in the road which damaged my right suspension, Called my insurance, it's not covered
16:43 < Ashstar> shit
16:48 < Ashstar> I just have the average required insurance
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17:39 < hprmbridge> nmz787> Like your control arm?
17:40 < hprmbridge> nmz787> Those can be pretty easy to replace, if you're ok with wrenching on things and have 4-8 hours
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18:03 < hprmbridge> fodagut> Are the PartCAD people on here?
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18:09 < hprmbridge> kanzure> not yet... let's get them.
19:09 < hprmbridge> nmz787> jrayhawk and fenn https://www.theculinarygym.com/blog/peanut-butter-jelly-potato-sandwich
19:09 < hprmbridge> nmz787> I haven't tried it yet, but the onions and garlic and pepper seem like they'd clash with the pb&j
19:10 < hprmbridge> nmz787> But i guess jam isn't uncommon on savory meat dishes, and peanut butter or peanuts are common enough in stuff like Thai or Indian food
19:27 < Ashstar> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831340/
19:28 < Ashstar> only problem with some peanut, bean products, especially in humid climates, is aflotoxin
19:29 < Ashstar> b
19:30 < Ashstar> a mycotoxin
19:33 < fenn> jrayhawk has convinced me that peanuts are bad because of CXCR3 adhesion, basically the same pathway as wheat gluten
19:37 < Ashstar> perhaps, lots of people jumping on the gluten free bandwaggon, unless you got ciliacks diseae
19:38 < Ashstar> disease, Im not convinced it is such an issue
19:39 < Ashstar> Celiac disease is an illness caused by an immune reaction to eating gluten.
19:39 < Ashstar> maybe it is
19:39 < Ashstar> common
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20:08 < hprmbridge> Eli> Is that pathway inerently bad @fennfoot ? Wasn't the paper showing that peanut allergies are almost entirely caused by lack of exposure to peanuts early in life posted in this discord?
20:09 < hprmbridge> Eli>  https://cdn.discordapp.com/attachments/1064664282450628710/1189782217925333032/image.png?ex=659f6a09&is=658cf509&hm=c62890dfe27033821ba389ed846dd8aa4c34a5e8de77c0b2162b2cc9a736681e&
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20:58 < fenn> yes that's what the graph shows, but it doesn't imply that peanuts are harmless
21:01 < Ashstar> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409992/
21:02 < fenn> .t
21:02 < EmmyNoether> Assessing Aflatoxin Exposure Risk from Peanuts and Peanut Products Imported to Taiwan - PMC
22:39 < fenn> huh that's the same emmett shear isn't it
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23:30 < muurkha> by coincidence I am currently eating peanuts whose possible aflatoxin contents I was worrying about
23:53 < jrayhawk> .t https://academic.oup.com/carcin/article/42/8/1079/6315265
23:53 < EmmyNoether> Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines | Carcinogenesis | Oxford Academic
23:53 < jrayhawk> the cancer angle on this paper is dumb, but it's otherwise a good read
23:55 < jrayhawk> fenn: i didn't know about CXCR3; do you have a paper on that?
23:56 < jrayhawk> with regards to peanut, that is
23:57 < fenn> p_p
23:57 < fenn> am i going senile
--- Log closed Thu Dec 28 00:00:12 2023