--- Log opened Fri Feb 02 00:00:47 2024
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02:43 < hprmbridge> kanzure> maybe this is a different lulu and nana foundation? https://twitter.com/Jiankui_He/status/1753307118755877003
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04:00 < hprmbridge> kanzure> ( https://youtu.be/ltv9RnZMN5g )
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09:35 < hprmbridge> kanzure> "Programmable RNA writing with trans-splicing" https://www.biorxiv.org/content/10.1101/2024.01.31.578223v1 https://twitter.com/jgooten/status/1753460179977531429
09:41 < hprmbridge> kanzure> also recently the programmable RNA bridge recombination: https://twitter.com/pdhsu/status/1750316518133694734
09:48 < hprmbridge> kanzure> oh I was thinking of this one https://twitter.com/pdhsu/status/1752725514593382503
09:49 < hprmbridge> kanzure> which is also about programmable RNA through trans-splicing too
09:49 < hprmbridge> kanzure> I thought I saw something similar the other day...
09:50 < hprmbridge> kanzure> "Rewriting endogenous human transcripts with trans-splicing" https://www.biorxiv.org/content/10.1101/2024.01.29.577779v1
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13:39 < kanzure> it's a neat technique, but therapeutically impermanent?
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14:38 < fenn> i used some consumer biotech today: https://www.amazon.com/naturally-clean-24-Gallons-Biodegradable-Eliminates/dp/B007P5YZ36/
14:39 < L29Ah> rinse-free, huh
14:39 < fenn> it actually removes that gunky oil vapor stuff on things around the stove pretty well
14:39 < L29Ah> PSA: frying kills
14:40 < fenn> i think deep frying is worse, but sure
14:40 < L29Ah> lots of things are worse than frying, sure
14:41 < fenn> sitting still and staring at a screen "kills" but i'm still going to do it
14:41 < L29Ah> does it?
14:41 < fenn> that's what the propaganda says
14:42 < L29Ah> pro-longevity exercise effects plateau at some point, and you can even combine them with staring at a screen with some effort
14:42 < fenn> i think effort is the wrong word here
14:43 < fenn> initiative and executive function maybe
14:45 < fenn> huh. you can buy enzymatic toothpaste, but only for dogs and cats
14:45 < fenn> "Remineralizing Veterinarian Grade Toothpaste for Dogs with Nano-Hydroxyapatite"
14:48 < fenn> "All in a delicious flavor, clear, mess free application that your pet will love (try it for yourself – it’s delicious!)." FDA ALERT - AUTHORITY CONTRADICTED!!!
14:49  * L29Ah recalls anarcho-biopunk Meganesia arc about using advanced veterinarian meds for humans
14:58 < fenn> teranesia?
15:01 < fenn> "Catalase Extreme Shampoo"
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15:38 < fenn> USAnians seriously discussing using phage therapy https://www.livescience.com/health/medicine-drugs/could-bacteria-killing-viruses-ever-prevent-sexually-transmitted-infections
15:39 < fenn> actually no, none of the people quoted are USAnians, my bad
16:13 < fenn> "BPC 157 is one of the few peptides that works as well by an oral pill as by an injection under the skin. In fact, in the rat study looking at MCL healing, it worked equally well orally and as a topical cream."
16:14 < fenn> speeds healing of tendon and ligament injuries, supposedly
16:15 < fenn> BPC-157 (also known as PL 14736) is a pentadecapeptide. It has the amino acid sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.
16:16 < fenn> "recently shown to particularly affect dopamine systems. For instance, it blocks the stereotypy produced acutely by amphetamine in rats"
16:20 < fenn> reduction of acute and chronic inflammation, increased wound healing, eart protection,
16:20 < fenn> heart protection following hypoxic and reoxygenation injury
16:21 < fenn> this research is 25 years old
16:27 < fenn> "at least one study noting that this sequence did not register in the Protein BLAST database" - must be extraterrestrial in origin :)
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16:39 < fenn> https://examine.com/supplements/bpc-157/research/
16:45 < L29Ah> not extraterrestrial, just chopped up from a biogenic one, likely for manufacturability
16:55 < fenn> why no BLAST similarity?
16:55 < fenn> i guess i could try to see if it's still not found by searching myself
16:56 < hprmbridge> bootstrap3141> I love BPC-157. It’s helped me a lot with IBS issues
17:03 < fenn> still nuffin https://fennetic.net/irc/bpc-157_blast_results.png
17:05 < fenn> odd that Streptomyces rapamycinicus shows up
17:06 < fenn> bpc-157 is "GEPPPGKPA" and the hypothetical protein from Streptomyces rapamycinicus is GAPPPGRPA
17:10 < fenn> what are the odds of a bacterium containing TWO miracle drugs
17:19 < fenn> ok i ran the non-quick blast and got some more results
17:20 < fenn> no exact matches. this one is interesting: "universal stress protein [Streptomyces sp. NRRL S-118]"
17:21 < fenn> WP_324615801.1
17:43 < fenn> because blast is dumb you have to search for GEPPPGKPADDAGLV
18:04 < fenn> WADA has banned this substance, which helps you heal faster from injuries ... in order to protect athletes
18:05 < fenn> i wonder how many other valid medical interventions they've banned, preventing athletes (and the rest of us) from getting proper medical care
18:39 < fenn> paperclip maximizer https://www.threepanelsoul.com/comics/1702697738-845.png
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--- Log closed Sat Feb 03 00:00:48 2024