--- Log opened Wed Feb 14 00:00:58 2024
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02:12 < hprmbridge> kanzure> no hardcopies of KSRM are currently available anywhere
02:23 < hprmbridge> kanzure> "hyperstition"
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05:13 < kanzure> "... plasma proteins, GFAP, NEFL, GDF15 and LTBP2 consistently associated most with incident all-cause dementia (ACD), Alzheimer’s disease (AD) and vascular dementia (VaD), and ranked high in protein importance ordering." https://www.nature.com/articles/s43587-023-00565-0
06:10 < geneh2> the bunny book? I knew someone who bought it
06:10 < kanzure> i wonder where all the copies went
06:11 < kanzure> all but nanodust now
06:15 < geneh2> all bought up probably. Better set up an ebay alert.
06:16 < geneh2> really regret not getting advanced automation for space missions on ebay when I saw it
06:16 < kanzure> oh that one had a physical form?
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07:09 < kanzure> hello WiredSoul
07:10 < WiredSoul> Hi all
07:12 < WiredSoul> Im interested in nootropic regimens, research into intelligence and improving intelligence through medication, lifestyle changes and technology
07:13 < WiredSoul> I'm interested in anyones current mind/body enhancement methodologies or projects
07:13 < WiredSoul> Body implants too.
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07:35 < L29Ah> WiredSoul: what's your current aerobics routine?
07:38 < WiredSoul> I do hit training twice a week, weightlifting 3 times a week and yoga/stretching daily currently, I haven't tried aerobics.
07:38 < L29Ah> hit training?
07:39 < WiredSoul> High Interval Training for cardio
07:40 < WiredSoul> 1 minute intense effort 1 minute moderate effort alternated over 15 mintutes
07:40 < L29Ah> ah, HIIT, great
07:40 < WiredSoul> or some variation
07:40 < WiredSoul> Ah sorry HIIT :)
07:41 < WiredSoul> What's the benefit of Aerobics?
07:43 < L29Ah> nvm, seems like i used "aerobics" as a synonym of "aerobic/cardio training" that it isn't
08:29 < WiredSoul> No worries, do you dable in nootropics at all?
08:32 < WiredSoul> Anyone have any experience with TMS? Transcranial magnestic stimulation? 
08:32 < WiredSoul> *magnetic
08:33 < hprmbridge> kanzure> ASML deets https://twitter.com/8teAPi/status/1757665086783807879
08:33 < hprmbridge> kanzure> > why do you have 5k suppliers ?
08:33 < hprmbridge> kanzure> > each with sporadic and small volume?
08:33 < hprmbridge> kanzure> > why didn’t you pull an SpaceX and vertically integrate
08:33 < hprmbridge> kanzure> > are you really managing the suppliers and quality as well as you could?
08:33 < hprmbridge> kanzure>
08:33 < hprmbridge> kanzure> > software..
08:33 < hprmbridge> kanzure> > 20 million lines of code without test cases?
08:33 < hprmbridge> kanzure> > only senior folks can touch code
08:34 < hprmbridge> kanzure> software at ASML: https://cdn.discordapp.com/attachments/1064664282450628710/1207364228407627856/image0.jpg?ex=65df608f&is=65cceb8f&hm=df7be9611f72868acc7bb89b9e11e93680a38e1fb8c4e8d779ef26651c5e98e4&
08:34 < hprmbridge> kanzure> "There doesn’t seem to be a Wright’s law optimization at work here and the 5k suppliers and 20 million lines of code with no test cases are clear red flags.
08:34 < hprmbridge> kanzure>
08:34 < hprmbridge> kanzure> This sounds very similar to Lockheed-Boeing pre SpaceX.  You can sense the previous engineering milieu.. the large systems integrator buying parts from many firms, without good cost control and a surplus of extraneous parts because no one is certain what is really necessary and what is not.
08:34 < hprmbridge> kanzure>
08:34 < hprmbridge> kanzure> So far only Elon has been able to unentangle old school engineering through sheer dint of will and large amounts of capital.
08:34 < hprmbridge> kanzure>
08:34 < hprmbridge> kanzure> If you can’t add test cases.. do you really think they’ll allow you to delete parts and steps ?"
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11:02 < hprmbridge> Eli> Um, ya, don’t do it without a doctor who knows what they’re doing
11:03 < hprmbridge> Eli> Focus on optimizing sleep, diet, and exercise first; in that order
11:07 < hprmbridge> alethkit> fenn: The issue is presumably developing the right type theory/constraints system given physical laws
11:08 < hprmbridge> alethkit> apparently ab initio materials science is just not a thing
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15:24 < L29Ah> https://www.lifespan.io/news/patrick-linden-describes-why-death-is-bad/
15:24 < L29Ah> tfw the anti-deathist propaganda pamphlet starts from $31 a file
15:30 < L29Ah> at least it's present on libgen
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18:21 < fenn> i dont understand the point he's trying to convey here:
18:22 < fenn> "One of the most striking, yet most self-evident ideas is that population growth, the anti-longevity crowd’s favorite scarecrow, has almost everything to do with fertility and very little to do with longevity. Even if people will live infinitely longer than they do today, but will keep having around two children per woman, we will only see an initial bump in population numbers, when the first
18:22 < fenn> “immortal” cohort doesn’t die. There will be no overpopulation."
18:23 < fenn> without a death rate to counteract the birth rate, instead of leveling off, the population would continue to grow linearly at whatever the fertility rate is
18:24 < fenn> i say linear because the breeding fraction of the population decreases
18:24 < fenn> it's technically wrong but meh
18:26 < fenn> anyway, the old people accumulate, the young people breed and eventually add to the old people. that seems to be an increasing population, so i'm confused by what the "self-evident idea" is
18:27 < fenn> is he saying the death rate will eventually catch up again to the birth rate, because our anti-aging tech sucks in the long term? that's not really what i signed up for
18:30 < fenn> saying stuff like "Japan is actually at risk of being underpopulated" is not helping the case
18:30 < fenn> japan's geezers rely on young people to care for them, because they're disabled by aging
18:31 < fenn> that doesn't mean we need more children, it means we need to stop people being disabled!
18:32 < fenn> japan is crammed to the gills with people, it's comical
18:33 < fenn> there are now "free house" programs in rural japanese villages, not because the population has decreased but because there is no economic opportunity in rural villages
18:33 < fenn> i'm not sure how japan missed out on remote work
18:37 < fenn> population projection for different regions in japan https://c1.staticflickr.com/5/4315/35276650454_20a5a94386_b.jpg
18:38 < fenn> and on a longer timeline https://www.statista.com/graphic/1/1066956/population-japan-historical.jpg
18:41 < fenn> map view of population change in japan 2010-2017 https://i.redd.it/nf2x783suwa31.png
19:13 < fenn> japan population graph on an even longer timescale https://en.wikipedia.org/wiki/File:Historical_population_of_Japan.svg
19:15 < fenn> if the tokugawa period (1600-1868) was so stable and good for development and progress and so on, then why was the population declining?
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--- Log closed Thu Feb 15 00:00:59 2024