--- Log opened Thu Feb 15 00:00:59 2024
00:07 < fenn> is there even a place i can send my DNA for safekeeping until it becomes possible to make a clone, if that should be desirable
00:07 < fenn> or better sequencing or whatever
00:07 < hprmbridge> kanzure> like an alcor?
00:08 < hprmbridge> kanzure> who would raise the clone if you are dead?
00:08 < fenn> hopefully not evil clowns
00:09 < fenn> it would be good if the clone had lots of data about the original, to avoid known problems
00:10 < fenn> i'm more just flabbergasted that it's just roaring chaos and there's no sanctioned repository of random DNA samples
00:11 < fenn> forget the long dead nobel prize winners and renaissance men, what about people alive right now?
00:11 < fenn> could we get a sample of DNA to clone them?
00:11 < fenn> like if you get hit by a bus tomorrow, there's a good chance you get cremated because that happens all the time
00:13 < fenn> [REDACTED] but maybe a superintelligence could reconstruct you from vacuum cleaner dust in a landfill
00:13 < fenn> since that hasn't been combusted and it's pretty dry inside a landfill
00:14 < fenn> i just don't want to rely on a superintelligence making everything better
00:17 < hprmbridge> kanzure> the clone would have to be raised by dune kind of godparents
00:17 < hprmbridge> kanzure> Or you can raise your mini-me while you're still alive
00:18 < hprmbridge> kanzure> dune -> some
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00:19 < fenn> actually i can't raise my mini-me because human cloning is banned and i don't go to the right parties
00:20 < fenn> and i don't wanna
00:20 < fenn> also that just kicks the can down the road
00:20 < fenn> what if me and mini me get hit by a bus tomorrow and are cremated?
00:20 < fenn> it wasn't even an off site backup
00:22 < fenn> at best it increases the redundancy factor by 1
00:23 < fenn> there should be 100 copies of every living human's genome, annotated with at least a gigabyte of data
00:23 < fenn> we can do digital copies too, but hard copy is best
00:24 < fenn> i'm not convinced that DNA sequence preserves all the important information
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02:49 < hprmbridge> kanzure> https://twitter.com/kanzure/status/1758080654426714433
02:54 < fenn> .m
02:55 < fenn> .m https://twitter.com/kanzure/status/1758080654426714433
02:55 < AugustaAva> ​twitter: <kanzure> There's a biohacker company selling a gene therapy and hasn't posted details, measurements, or trials. Customers receiving the treatments are posting about all the amazing benefits and and and... And let's make sure there's no fraudulence. If it is fraud, then it could really…
02:56 < fenn> nitter is dying
03:16 < L29Ah> fenn> actually i can't raise my mini-me because human cloning is banned
03:16 < L29Ah> pretty sure raising mini-me's isn't banned, and you just don't tell about the cloning you did on a vacation to that third-world country like you don't tell about your drugged shotacon orgies in Thailand
03:18 < L29Ah> (btw is it "mini-me's" or "mini-mes", or maybe "mini-me-s"?)
03:20 < fenn> cloning requires infrastructure and expertise, so finding a competent cloner will probably require a reputation market of some sort
03:21 < fenn> mini-me's looks best to me, but i'm sure someone on the internet will complain
03:27 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1207649258434600990/share_3162125826334364586.png?ex=65e06a04&is=65cdf504&hm=d46f9bed2c26b4984b68fbc22bb90281635a08514f1933edb372d2cac53ce277&
03:30 < hprmbridge> kanzure> "A grade eight student from Ontario, Canada has helped to settle a long-standing historical debate by proving that a so-called “death ray” designed by the Ancient Greek polymath Archimedes could really have worked."
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05:03 < kanzure> hmph
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06:10 < kanzure> doesn't feel good calling out a clandestine gene therapy, people getting treatments and posting on twitter about the amazing benefits and nobody has posted data.. or the methods.. etc.. yeah.
06:10 < kanzure> lifting 155 lbs a week later when you usually lift 125 lbs is... nothing. any amateur could add that amount of weight with some motivation.
06:11 < kanzure> and running euphoria? what? why would anyone think to attribute that to the treatment a week or two later? in fact, you should want to *not* attribute things to the treatment, because if you over-attribute then you run the risk of over-hyping the treatment which could be very bad for its continued existence and production
06:12 < kanzure> there is not much need to over-hype any gene therapy... if it works, that's going to be enough. don't need to attribute every positive thing that happens to you going forward to the gene therapy.
06:12 < kanzure> wouldn't it be funny if their injection includes something like a small amount of amazing steroids or, like, cocaine
06:14 < kanzure> not saying that's what it is, but on the other hand we currently have little data (except for a slide deck that i received a long time ago that has raised concerns but i haven't expressed those concerns in public yet)
06:21 < L29Ah> i'd be thrilled when receiving some experimental clandestine treatment, perhaps some people would overreact just from that fact, and certain cultures favor overblowing positive things disregarding the probability of bias
06:21 < kanzure> "I wish the intersection of “actual gene therapy specialists” and “people willing to destroy their careers in mainstream academia/industry for the cause of getting therapies out faster” was bigger" https://twitter.com/s_r_constantin/status/1758131446324043905
06:21 < kanzure> L29Ah: yeah..... brian johnson says his team did diligence, so that must mean it's perfect.. right? right?
06:22 < kanzure> er, bryan johnson
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07:32 < hprmbridge> Eli> bryan johnson has a team?
07:32 < L29Ah> he says so
07:32 < L29Ah> and invited people to join it on his Blueprint site
07:49 < kanzure> https://finance.yahoo.com/news/meet-29-old-doctor-leading-120000848.html
07:49 < kanzure> "Pulling the strings behind Johnson’s reportedly $2 million longevity craze is a team of 30-plus doctors and health experts, led by 29-year-old Oliver Zolman"
08:38 < hprmbridge> Eli> Another CRISPR treatment approved by FDA: https://www.fiercepharma.com/pharma/vertex-crispr-win-early-fda-nod-gene-therapy-casgevy-treat-beta-thalassemia
08:54 < hprmbridge> leoht06> hey guys been recently interested in neuromorphic computing but have essentially no background
08:54 < hprmbridge> leoht06> any cool fun beginner type projects you suggest?
08:55 < hprmbridge> leoht06> (open to pretty much anything tbh)
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10:07 < hprmbridge> kanzure> um, no https://twitter.com/farbood/status/1758180816772063536
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10:55 < hprmbridge> gourneau> https://openai.com/sora wow really good text to video from openai
10:56 < hprmbridge> kanzure> @gourneau what kind of prompts would you use it for?
10:58 < hprmbridge> gourneau> infinite videos of puppies playing
11:00 < hprmbridge> gourneau> but as someone with Aphantasia it would be amazing to have videos generated inline with I am reading text ( at least fiction)
11:01 < hprmbridge> kanzure> dream visualization could be a fun application
11:02 < hprmbridge> kanzure> maybe generate video assembly instructions for devices
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11:30 < hprmbridge> gourneau> 'Obesity plus': What’s next for GLP-1s? https://endpts.com/obesity-plus-whats-next-for-glp-1s/
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13:45 < geneh2> video generators can be used as 'universal simulators' to do long term planning for robots and train robots to do tasks
13:45 < geneh2> https://universal-simulator.github.io/unisim/
13:48 < geneh2> it's really hard for robots to pick up objects in clutter. you really need some way to figure out how stuff will move with respect to each other
13:49 < geneh2> solving this has required using a pretty much full physics engine https://www.ri.cmu.edu/publications/physics-based-grasp-planning-through-clutter/
13:50 < geneh2> and that didn't work great because you can only guess about physical properties like friction
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19:06 < hprmbridge> kanzure> is Sora using a physics engine for training?
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--- Log closed Fri Feb 16 00:00:00 2024