--- Log opened Sun Feb 25 00:00:09 2024
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09:10 < hprmbridge> kanzure> https://entertainment.ha.com/itm/movie-tv-memorabilia/props/jurassic-park-universal-1993-wayne-knight-dennis-nedry-hero-dinosaur-embryo-cryogenic-smuggling-d/a/7356-90094.s
11:20 < jrayhawk> apt install tdfsb
11:22 < hprmbridge> kanzure> hm?
11:23 < hprmbridge> kanzure> oh the unix system interface
11:27 < jrayhawk> Uh-uh-uh! You didn't say the magic word!
11:30 < geneh2> https://jurassicsystems.com/
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13:18 < hprmbridge> Eli> I read a lot of biology books, but somehow I was unaware of “geeps”, the chimeric combination of sheep and goats. They have 4 parents. Has anyone else heard of these? https://cdn.discordapp.com/attachments/1064664282450628710/1211422090398539827/IMG_0988.png?ex=65ee23bd&is=65dbaebd&hm=4edc6c9fb71dddd53e3cbbece6faf2b38d76459e9b97b19915116d045a0aed5a&
13:20 < hprmbridge> Eli> Conceivably you could do this with all sort sorts of animals. Maybe humans? I’m curious how well it would propagate its DNA with a mitochondrial mismatch though
13:21 < hprmbridge> Eli> Probably you would have to do a lot of genetic engineering to cross a human with a bonobo
13:33 < nsh> they aren't viable as a rule, due to chromosomal mismatch primarily
13:34 < nsh> no idea what you mean by four parents
13:34 < nsh> oh i see
13:35 < nsh> yeah direct hybrids are usually nonviable but a chimera produced from a combination of embryos can be 
13:35 < nsh> this is because organs with different chromosomes are more broadly compatible than DNA strands
13:35 < nsh> they will be infertile however
13:37 < nsh> the issue is primarily that of nucleic DNA. i would expect mitochondrial DNA to be more universal
13:37 < nsh> dunno any specifics though
13:38 < nsh> it's probably beyond us to directly experiment with creating chimera with solely mitochrondial DNA replacement. hmm maybe idk
13:38 < nsh> it would be a chore
13:40 < nsh> .wik Cytoplasmic hybrid
13:40 < saxo> "A cytoplasmic hybrid (or cybrid, a portmanteau of the two words) is a eukaryotic cell line produced by the fusion of a whole cell with a cytoplast." - https://en.wikipedia.org/wiki/Cytoplasmic_hybrid
13:40 < nsh> i think mainly in cell lines
13:42 < nsh> .t https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693707/
13:42 < saxo> Interspecies mitochondrial fusion between mouse and human mitochondria is rapid and efficient - PMC
13:43 < nsh> this is whole mitochrondial fusion so i think the constituent DNA molecules would replicates independently, though perhaps one would win out over another
13:43 < nsh> but better to ask someone working in the field
13:44 < nsh> but again this is asking a different question - whether the mouse and human mitochondrial DNAs retain functional compatibility, not whether mitochrondria from the one species is compatible with cells from the other
13:45 < nsh> i'd expect the general rule that the more distantly diverged the species the less compatibility there would be
13:45 < nsh> but it's also a question of complexity. nobody cares where the animo acid comes from
13:45 < nsh> unless it's irradiated
13:50  * TMA has read a report of three-parent IVF child -- egg cytoplasm & mitochondria from female #1, nucleus female #2, sperm male #3 [m/f designations are sex designations, not gender designations which were undisclosed]
13:51 < L29Ah> le disclaimer
14:01 < TMA> a hypothetical pan x homo hybrid would need to address the fact that two chromosomes are fused in one but not the other species. perhaps it would be possible to treat those as a unit and select either the fused or both of the unfused from one ancestor species only
14:02 < TMA> L29Ah: I have been made aware of the sensitivity of the topic by reading the definition of 'tribbing', which did not mention women at all.
14:03 < TMA> [it resorted to using 'humans with vulva' instead]
15:25 < hprmbridge> Eli> Yeah, hybrids and three parent babies are pretty standard topics in any undergrad genetics class. But I’ve never heard of four parent chimeras. I’m not sure if any of my profs have heard of this either. I need to do some research on the topic. I was thinking how it might be interesting to remake The Island of Dr Moreau but with actual scientific knowledge we have today. Things are getting really
15:25 < hprmbridge> Eli> weird with how far technology is pushing the gray area of embryology. It’s just going to get weirder.
15:27 < jrayhawk> fenn: re: cloak and dagger about AI training: copyright threats are mostly hollow, but the CFAA is a legitimate threat to data aggregation projects https://www.google.com/search?q=%22the+worst+law+in+technology%22
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21:16 < hprmbridge> Katylase> Hi! How are you?
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22:41 < hprmbridge> Eli> From my understanding, mitochondria and DNA mismatch is a huge problem. Even in humans. Over time, mitochondria have passed nearly every gene possible to the DNA in order to be able to replicate as fast and efficiently as possible. From my understanding, a lot of spontaneous abortions are due to the mismatch between the DNA and mtDNA. If the embryo can't create enough ATP early on, spontaneous
22:41 < hprmbridge> Eli> abortion prevents the energy and time costs of pregnancy for what will be a newborn that has extreme difficulty surviving due to ATP production difficulty. Basically if genes in mtDNA and DNA don't align well for whatever reason, it's a problem. And because there are so few genes in mtDNA, mismatch is not difficult.
22:41 < hprmbridge> Eli>
22:41 < hprmbridge> Eli> ```We were, however, unable to maintain human mitochondrial DNA in the mouse cells. These results indicate that mitochondrial fusion proteins in mouse and human cells have enough functional homology to mediate efficient cross-species mitochondrial fusion, but mouse nuclear and human mitochondrial genomes have not retained functional compatibility with one another.```
--- Log closed Mon Feb 26 00:00:10 2024