--- Log opened Sat Mar 02 00:00:15 2024
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03:27 < jrayhawk> what the fuck
03:27 < jrayhawk> advising a gout-prone species to take a gout precursor is fucking insane
03:28 < jrayhawk> mice are not humans
03:29 < jrayhawk> it's just another hormetic Nrf2 upregulator like every other hormetic Nrf2 upregulator
03:39 < jrayhawk> oh, no, i am wrong, looks like it is competing with and upregulating the transporters for that pathway https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759838/
03:41 < jrayhawk> biology is always more complicated than i anticipate
03:45 < jrayhawk> i rescind my incredulity, but i do question if a lifespan effect would be achieved by some other nrf2 upregulator on rodents not being fed a significant percentage of their calories as fructose
04:45 < kanzure> hmph
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07:14 < hprmbridge> Eli> Anecdotally it has a nice anti inflammatory effect. Strange that a supplement can provide an actual noticeable impact. I take it when I’m inflamed.
07:29 < jrayhawk> what kind of inflammation? do other nrf2 upregulators fail to produce the same anti-inflammatory effect?
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07:41 < hprmbridge> Eli> I’ve taken multiple types of sulphoraphane and curcumin supplements, including curcumin supplements that have actual human RCTs. Anecdotally, I feel astaxanthin beats them. But there may be a psychological effect to it. It can have a slight antidepressant effect for me. Everyone is different so who knows. I didn’t have good reactions to sulphoraphane or curcumin and a lot of people love them.
07:55 < jrayhawk> cytokines are among the many ways to induce depression, so that's not too surprising
07:56 < jrayhawk> curcumin is also an MAOI
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08:15 < fenn> "Locus is currently in the middle of a Phase II trial for its lead bacteriophage therapy, LBP-EC01, an engineered fixed cocktail of CRISPR-Cas3-enhanced bacteriophages targeting drug-resistant urinary tract infections caused by E. coli. The company also has preclinical programs targeting Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus"
08:15 < fenn> https://www.genengnews.com/topics/infectious-diseases/antimicrobial-resistance-multiple-threats-multiple-responses/
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10:48 < hprmbridge> Katylase> Hi guys! What y'all up to?
10:49 < hprmbridge> Katylase> I'm trying to make a sewing pattern for a Cas9 plushie RN...
10:50 < hprmbridge> Katylase> (I always wanted to have a Cas9 as a pet, you know...🤭)
11:11 < fenn> do you have a highlight for "Cas" or something?
11:31 < hprmbridge> Katylase> What do you mean by "highlight"?👀
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11:36 < hprmbridge> nmz787> Can these embryos-are-people be claimed as dependents on taxes this year?
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11:57 < fenn> technically the IVF storage facility is caring for them
12:05 < fenn> https://www.reuters.com/business/environment/safety-fears-stall-un-bid-examine-sun-blocking-climate-change-tech-2024-02-29/
12:05 < fenn> "don't come up with a solution, it might let those responsible off the hook"
12:05 < fenn> "don't do research, because the risks are unknown"
12:06 < fenn> -_-
12:07 < fenn> and they wonder why we want to go to mars
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12:13 < hprmbridge> nmz787> I'm not sure the caretaker matters as much as who pays for the care. I'm pretty sure kids in boarding school are still legally dependents
12:22 < fenn> @katylase: most chat interfaces have a way to notify you when a certain word or pattern is mentioned, and it usually defaults to your username. i don't know about discord
12:22 < hprmbridge> nmz787> I never knew that, aside from mentions of my username
13:52 < hprmbridge> kanzure> wherein @richardfuisz gets a reply from elon https://twitter.com/ID_AA_Carmack/status/1763747234284237150
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14:31 < fenn> also funny to see marek rosa (space engineers dev) in the comments
14:33  * fenn mutters about copy number variations, insertions, deletions
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16:51 < hprmbridge> richardfuisz> yeah, i added these caveats in the original thread but then it blew up and they kind of got lost. I kind of just figured it was fine -- any biologist who might act on the information would know to just read the graph caption which obviously says this is only talking about SNVs.
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17:47 < hprmbridge> soul_syrup> @fenn why not just analyze for emotion
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18:37 < fenn> analyze what? you've got a stream of text. it could be as little as a single word, or none
18:39 < fenn> somehow EMO does a great job of facial expression from just audio of real speech
18:39 < fenn> whatever it's using as the data source to drive that emotion expression is missing from a text-only transcript
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--- Log closed Sun Mar 03 00:00:15 2024