--- Log opened Mon Mar 18 00:00:30 2024
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01:40 < fenn> "I'm sorry, I don't have access to information about what 2+2 is. Feel free to ask about any other questions or topics you're interested in!"
01:40 < fenn> this is what happens when you teach machines to refuse
01:53 < fenn> https://github.com/albertan017/LLM4Decompile asm to C
02:41 < hprmbridge> fodagut> @fenn send anyone working on replicating 3d printers my way
02:55 < fenn> @fodagut well you can talk to brianm and atymes without me getting in the way, as far as they know i don't exist
03:08 < fenn> omg do not upgrade tree style tabs
03:25 < fenn> whew downgrading fixed it
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05:36 < kanzure> "Greatness comes from character and character isn't formed out of smart people -- it's formed out of people who suffered." - jensen huang, nvidia
05:36 < kanzure> not a doomer, but yeah pretty cool that the CEO of AI is out there saying "go forth and suffer"
05:41 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1219264329438990416/jensen.jpg?ex=660aab64&is=65f83664&hm=47ed5347a1a156fed141fd44afe4e518a6216a719304473d28da5ef526cb21c9&
05:56 < kanzure> https://twitter.com/kanzure/status/1769708205444141248
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06:33 < gwillen> I am about to watch Jensen's keynote at Nvidia GTC today 
06:34 < gwillen> perhaps it will be about the singularity or some shit.
06:34 < gwillen> he is quite the celebrity for how little of a household name he is
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10:51 < hprmbridge> nmz787> chatGPT is lazy like it's trying to 'slow quit' their job
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13:41 < superkuh> Oof. "<egobot> Intermittent fasting linked to a 91% higher risk of cardiovascular death [2 geox] https://www.eurekalert.org/news-releases/1037544 https://news.ycombinator.com/item?id=39749647 "
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15:42 < gwillen> already flagged off HN, all the comments are about the apparent failure to control for any confounders
15:43 < superkuh> Ah, good.
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17:37 < hprmbridge> nmz787> What does "flagged off" mean?
17:37 < hprmbridge> nmz787> .ud flagged off
17:41 < hprmbridge> nmz787> flagged off
17:41 < hprmbridge> nmz787> Wrongly used term by mongs meaning flipped off
17:41 < hprmbridge> nmz787> Mong - a person who is very clueless and has no idea what is going on.
17:43 < hprmbridge> nmz787> Mongs.. not to be confused with Hmongs.
17:43 < superkuh> When HN users "flag" an submission by clicking "flag" to report it for being inappropriate. It is not clear the process, but things that get flagged a lot drop off the front page of HN.
18:01 < hprmbridge> Eli> I mean like in the cow generating human insulin paper. Gene trait added => NT => profit. The gene imprinting issues make it seem immoral to me though
18:01 < hprmbridge> Eli>
18:01 < hprmbridge> Eli> ```
18:01 < hprmbridge> Eli> In vitro fertilisation, including ICSI, is associated with an increased risk of imprinting disorders, with an odds ratio of 3.7 (95% confidence interval 1.4 to 9.7).```
18:02 < hprmbridge> Eli> Definitely is an interesting idea to use animals as a bioreactor for useful proteins tho
19:25 < fenn> @Eli that's not just cloning though, it's genetic engineering. they only needed to clone the insulin cow embryo because of low yield
19:25 < fenn> 9/10 embryos didn't make it. it would be a waste of time to do the same genetic engineering 10 times
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20:06 < hprmbridge> nmz787> NT?
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20:45 < fenn> "Last week a group at MIT managed to make a 20-tesla magnet out of high temperature superconductor. https://phys.org/news/2024-03-high-temperature-superconducting-magnets-ready.html This was an unexpectedly large advance made possible because it turns out you don’t actually have to insulate superconductors. :)"
20:47 < fenn> i was a little worried that the ukraine war would mess that up. glad to hear there's still progress being made on SPARC fusion
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21:21 < geneh2> inertial confinement fusion's doing pretty well. The two best performing fusion experiments are ICF
21:22 < hprmbridge> alonzoc> Out of interest which types of inertial confinement?
21:23 < geneh2> both are using lasers. NIF and this https://www.rochester.edu/newscenter/spark-plug-direct-drive-inertial-confinement-fusion-591822/
21:25 < geneh2> the recent work removed the need for a fancy hohlraum
21:25 < hprmbridge> alonzoc> Really? Huh, that's neat
21:27 < hprmbridge> alonzoc> Id seen some cool stuff on Z-pinch scaling and stabilisation via sheared flos, however laser fusion is definitely promising and avoids the complexities of stabilisation and expensive confinement.
21:27 < hprmbridge> alonzoc> Last time I checked though the issue was laser efficiency was it not?
21:33 < geneh2> yeah shear flow stabilized zpinch is pretty promising. Zap energy may even demonstrate they could hit break even soon
21:33 < geneh2> NIF uses lasers that were cheap to build, but were inefficient. laser tech is better now
21:33 < geneh2> that and ion beams might be able to do the same thing
21:54 < hprmbridge> Eli> I probably should have been more clear in my statement. The insulin cows use a viral vector to implant gene => NT => cloning => implantation? (I don’t know the correct scientific term for this part?) => newborn cow is bioreactor. In my mental model, there would be less genetic imprinting issues if they used the viral vector for a young cow due to less methylation?
21:54 < hprmbridge> Eli> Also, I’m wondering if IPSC would reduce or remove methylation issues? The closest I’ve ever done to gene mods is with bacteria and p glo.
21:56 < hprmbridge> Eli> https://en.m.wikipedia.org/wiki/Nuclear_transfer
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23:49 < fenn> IPSC would erase all methylation which would be bad in a different way
--- Log closed Tue Mar 19 00:00:31 2024