--- Log opened Sun Mar 24 00:00:35 2024
00:01 < fenn> https://youtu.be/h9OBbsLYGOE
00:01 < fenn> .t
00:01 < saxo> The Fifth Element an example of future 3D Bio Printing. (For educational purposes) - YouTube
00:01 < fenn> yes, for educational purposes
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00:22 < fenn> is this a different bone growth pattern than in aging?
00:22 < fenn> .wik acromegaly
00:22 < saxo> "Acromegaly is a disorder that results in excess growth of certain parts of the human body. It is caused by excess growth hormone (GH) after the growth plates have closed." - https://en.wikipedia.org/wiki/Acromegaly
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00:30 < hprmbridge> robertmcdougal_73197> Yes! I think acromegaly patients grow the same way!
00:30 < hprmbridge> robertmcdougal_73197> https://x.com/robertbmcdougal/status/1771756888817844341?s=20
00:31 < hprmbridge> robertmcdougal_73197> It's funny I just talked about GH and acromegaly a couple hours ago on Twitter
00:32 < hprmbridge> robertmcdougal_73197> Yes you could say all adult humans have a super form of mild acromegaly
00:44 < fenn> i'd rather be shrek than dead
00:50 < fenn> https://en.wikipedia.org/wiki/Pak_Protector
01:13 < hprmbridge> robertmcdougal_73197> Yeah I guess I'd rather be Shrek than dead, but I don't want to look hideous. I am very much interested in the science of hotmaxxing.
01:24 < fenn> is there anything to "mewing" or is it just confirmation bias?
01:24 < fenn> post-puberty
01:33 < hprmbridge> nmz787> hotmaxxing?
01:41 < hprmbridge> kanzure> https://robertmcdougal.substack.com/p/superintelligence-now
01:42 < hprmbridge> kanzure> https://robertmcdougal.substack.com/p/shrinking-the-skull-with-cell-therapy
01:53 < fenn> please fix the typos "ediding" and "ransyrethrin" because typos actually detract from your point that we can edit DNA without introducing any errors if we are very careful
01:59 < fenn> would it be easier to convince a small country that it's in their interest to have genetically engineered geniuses
02:00 < fenn> surely "international law" already accounts for discrepancies in local legal codes, and multinational corporations seem to get away with murder and worse
02:00 < fenn> is there really a difference between doing something in international waters, vs doing it in a country where it's legal?
02:01 < fenn> i just don't see private yachts scaling very far
02:08 < fenn> i guess that could be the "phase 2" trial
02:28 < fenn> jeez the last time i looked there weren't any good 3d model datasets, now they have 10 million high quality textured models with good metadata https://objaverse.allenai.org/explore
02:42 < fenn> .t https://youtu.be/_FDZzKAFSz4
02:42 < saxo> 3d Printed Radial Pneumatic Engine - YouTube
02:44 < fenn> it uses rubber glove finger tips as the diaphragm material
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02:52 < hprmbridge> robertmcdougal_73197> Fixed the typos lol
02:53 < hprmbridge> robertmcdougal_73197> Fixed the typos lol
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02:53 < hprmbridge> robertmcdougal_73197> Próspera is best bet I guess?
02:54 < hprmbridge> robertmcdougal_73197> Balaji already tweeted something in favor of genetically engineering super genius humans
02:54 < hprmbridge> robertmcdougal_73197> biological intelligence augmentation
02:54 < hprmbridge> robertmcdougal_73197> he shared gene smith's post on lesswrong about gene therapy to raise iq
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03:04 < hprmbridge> robertmcdougal_73197> The problem is a lot of the countries with little regulation on biotech like in Africa or Southeast Asia have corrupt governments and radical religious regimes. But I'm no expert. I mean we can look into Vietnam, Malaysia, Indonesia, or Egypt. I doubt the governments will have any clue about what we want to do. I don't know how safe those jurisdictions are.
03:06 < hprmbridge> robertmcdougal_73197> With Vitalia, its a lot of autist SF rationalists running things so the biomed freedom is intentional, other countries if there is biomed freedom, it is an accidental oversight. They would not understand what we are doing. And if they heard details, they would reject it as "unnatural"
03:07 < hprmbridge> robertmcdougal_73197> I mean the SF rationalist mindset rather. Obvi many are from Europe and midwest US.
03:30 < fenn> i heard first-hand one case where biohackers literally wrote the regulations for a country because the government had no idea where to even start
03:35 < fenn> they were doing longevity treatments for wealthy patrons, preservation ecology... i seem to have lost my notes
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04:03 < hprmbridge> kanzure> lots wrong with that iq post
04:04 < hprmbridge> kanzure> it would be easier if people listened to us instead of having us run around correcting every lesswronger's bag biology
04:04 < hprmbridge> kanzure> uh, bad biology
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04:06 < fenn> sort of worrying that something so simple has remained undiscovered for hundreds of years https://spectrum.ieee.org/electroadhesion-for-better-implants
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09:34 < hprmbridge> kanzure> "Want to get in early at a new animal genetic engineering startup? Looking for a Lab tech to help us out in Austin, TX" from zany zayner
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10:02 < hprmbridge> alonzoc> Lesswrong posts on biology or biotech can be amazing reads, if you're looking for comedy
10:02 < hprmbridge> alonzoc> Some posts that are in-depth on neuroscience can be good though
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10:33 < hprmbridge> nmz787> That Allenai site is terrible on my phone both in mobile and desktop mode
10:34 < hprmbridge> nmz787> Fenn is that similar to anodic bonding? Which has been done for I believe decades in semiconductors
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--- Log opened Sun Mar 24 15:59:30 2024
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15:59 -!- Topic for #hplusroadmap: biohacking, nootropics, transhumanism, open hardware | this channel is LOGGED: http://gnusha.org/logs | https://diyhpl.us/wiki | not quite sponsored by george church | banned by the MIT media lab and the FDA
15:59 -!- Topic set by fenn [~fenn@user/fenn] [Fri Mar 25 06:29:19 2022]
15:59 -!- Irssi: #hplusroadmap: Total of 62 nicks [1 ops, 0 halfops, 0 voices, 61 normal]
16:00 -!- mode/#hplusroadmap [+v gnusha] by ChanServ
16:00 -!- Channel #hplusroadmap created Wed May 19 06:51:36 2021
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16:27 < hprmbridge> kanzure> test
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16:29 < kanzure> test
16:30 < fenn> i had completely forgotten about writing this, but it's good https://fennetic.net/dreams/elsie_and_emony
16:33 < hprmbridge> robertmcdougal_73197> If there are rich people getting longevity therapies why do none of these people look younger?
16:33 < hprmbridge> kanzure> Because longevity is a very hard unsolved problem.
16:34 < hprmbridge> robertmcdougal_73197> I just want my large intestine back. And all the surgery/drains/peritonitis scar tissue to be removed. And then mRNA coding for collagen and dermal fat proteins. That's it. This is not longevity.
16:34 < hprmbridge> robertmcdougal_73197> Reversing scarring is very likely solvable right now.
16:36 < hprmbridge> robertmcdougal_73197> I had a hypertrophic scar that, after a couple years, just become flat all by itself. Like the scar elevation index went from 0.3cm to basically zero.
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16:42 < hprmbridge> robertmcdougal_73197> I want to inject myself with a peptide from tarantula venom. The peptide GsMTx-4 appears to be completely safe.
16:42 < hprmbridge> robertmcdougal_73197>
16:42 < hprmbridge> robertmcdougal_73197> What does "For research use only. We do not sell to patients" mean?
16:42 < hprmbridge> robertmcdougal_73197>
16:42 < hprmbridge> robertmcdougal_73197> Do distributors ship just anywhere? How do they know if they're selling to a "patient" or not? https://cdn.discordapp.com/attachments/1064664282450628710/1221605094965907486/GJeLjvOboAAfoom.png?ex=66132f66&is=6600ba66&hm=e36327c8b69421ee3a33a8365f3075c0f54ce729536dddbc8d3b22396578101c&
16:43 < hprmbridge> bootstrap3141> You’re probably not going to be able to purchase from a site like that. They typically only ship to research labs
16:43 < hprmbridge> bootstrap3141> There are more grey market providers like peptidesciences.com that will happily ship to your house
16:44 < hprmbridge> kanzure> "for research use only" is deeply archaic legalese, indecipherable gibberish
16:44 < hprmbridge> bootstrap3141> They have to say that because the products are not approved for human use
16:44 < hprmbridge> bootstrap3141> Well… some are, but they aren’t licensed to sell them for human use.
16:45 < hprmbridge> bootstrap3141> You can find some peptides like sermorelin at compounding pharmacies
16:45 < hprmbridge> robertmcdougal_73197> Then I'll ask a professor with a research lab (or do they have to document everything they buy and how they used it)
16:45 < hprmbridge> bootstrap3141> I have an account with Carmen Chemicals I use for some research chems but it was a massive pita to setup
16:45 < hprmbridge> robertmcdougal_73197> Then I'll ask a professor with a research lab (or do they have to document everything they buy and how they used it)
16:45 < hprmbridge> bootstrap3141> If you can do that, do it
16:46 < hprmbridge> bootstrap3141> That’s how I got access to cayman chem
16:46 < hprmbridge> bootstrap3141> It’s my corporations account, but I have to ship to profs research lab
16:46 < hprmbridge> yashgaroth> is the spider venom to shrink your skull, or something else
16:48 < hprmbridge> robertmcdougal_73197> I'm not using peptides for the sake of wellness. GsMTx-4 is very specific to what I'm trying to do. I am trying to continuously block the Piezo1 ion channels of cells inside scar tissue so I can completely get rid of scars I have.
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19:14 < hprmbridge> fodagut> @alonzoc “Some posts that are in-depth on neuroscience can be good though” <— Murray Gell-Mann Amnesia effect?
19:58 < fenn> incremental progress, p-B11 fusion boosted electric spacecraft thruster https://rocketstar.nyc/
20:00 < fenn> heh this 10cm cube is basically a space engineers ion thruster
20:09 < fenn> https://dsiac.org/articles/space-travel-aided-by-plasma-thrusters-past-present-and-future/
20:26 < geneh2> once you take the neutrons emitted into account. Fusion reactors as ion engines that multiply input power don't seem very attractive
20:27 < geneh2> an interesting up and coming propulsion tech is magnetic sails: https://www.centauri-dreams.org/2021/11/19/wind-rider-a-high-performance-magsail/
20:44 < fenn> p-B11 emits only 0.1% of the neutrons per mole reacted, it's mostly alpha particles and some hard x-ray and gamma
20:45 < fenn> and they're going away at several km/s
20:50 < fenn> it is a problem for stationary power generation though
21:35 < hprmbridge> robertmcdougal_73197> it's for scar tissue from a bunch of surgeries I got tricked into
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23:08 < hprmbridge> alonzoc> Maybe, they do tend to over-extrapolate *some* of Steven Byrnes is a good read, I mark his speculations with scare quotations. But he provides interesting references which tbh I rate as more important than his actual blog. And sent me down a rabbit whole of computational neuroscience papers on phasic dopamine.
23:11 < hprmbridge> alonzoc> And whenever lesswrong touches on sociology extrapolations from neuroscience that's a sign to *stop reading* unless you want your mind tainted with something that's half-right that you want to see the world through
23:14 < hprmbridge> alonzoc> Tbh one of the posts I like reading the most was https://www.lesswrong.com/posts/ZahzaAXsBatrWNZzE/i-m-confused-about-innate-smell-neuroanatomy which is mostly a confession of confusion with copious references
23:14 < fenn> instincts, how do they work
23:16 < hprmbridge> alonzoc> Yeah. What's a really interesting problem is the morphogensis of the brain, more specifically the morphogensis of the neural circuits that aren't "blank slates". Or simply put "How does genetic information code for 'weight patterns' in the brain to yield instincts"
--- Log closed Mon Mar 25 00:00:07 2024