--- Log opened Tue Mar 26 00:00:08 2024
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01:07 < fenn> ^ that was re: L29Ah> is there a personal longevity roadmap that synthesizes the best proven interventions and isn't trying to sell you some product at the same time?
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04:01 < L29Ah> Eli: i'm well aware of the practical limitations, hence "kinda"
05:21 < kanzure> hmph
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07:59 < hprmbridge> Eli> Sleep, diet, exercise and in that order. Blood testing and genomic testing to catch malnutrition/diseases or weird mutations. Probably you shouldn’t eat too much but eat more vegetables. You can attempt to look at the ITP data but there is absolutely no guarantee that their interventions will work in humans. I take supps that pretty much no one would disagree with: creatine, magnesium, potassium,
07:59 < hprmbridge> Eli> and I ensure vitamin d is good. There are other supps I take but I won’t share them because they don’t have as much data or because the risk/reward ratio is something I consider beneficial for myself based on the data I have of myself. You can also follow Dr Michael lusgarten at defeat aging or die trying. He’s not a shill and uses blood testing. It’s not a guarantee that his stuff will work, just
07:59 < hprmbridge> Eli> because we know so little about the body.
08:02 < hprmbridge> Eli> There is tremendous money and interest in longevity, but the field started to become big and more scientific only a few years ago, so it’s going to take some time before we can really flesh out the hype vs the science. But I believe that with the money being poured in now that there will be a rapid uptick in longevity knowledge
08:06 < hprmbridge> Eli> A general trend is that animals with a slow metabolism and a later age of puberty live longer. Also, animals that live in a steady and stable environment tend to live longer. And many of the animals we see tee tend to have a similar number of heartbeats before death. A mouse a dog and a human tend to have had a same number of heartbeats at death. So my a priori bias would be that getting your
08:06 < hprmbridge> Eli> heart rate down would be beneficial. I won’t get into the science, but maximizing VO2 max and grip strength seem to be excellent markers of longer lifespan.
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08:34 < kanzure> hello boxy
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08:53 < L29Ah> Eli: the question is is there a neat article anywhere?
08:54 < L29Ah> the knowledge seems quite common among the longevity crowd but i couldn't find it well-summarized for linking
09:17 < hprmbridge> Eli> There’s a huge number of books, podcasts, YouTube’s, and academic articles on the subject now. There’s so much info that it would be impossible to summarize everything.
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09:37 < hprmbridge> Eli> You could start with Peter Attila’s Outlive book. It’s pretty science based and has a good summary of science based longevity methods.
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15:30 < fenn> heart rate is an easy to measure proxy for metabolism
17:01 < hprmbridge> robertmcdougal_73197> I don't know enough about microneedling as it is currently done today. I have read papers about using microneedle patches to deliver mRNA packaged in stuff. And the needles dissolve. I think for dermal delivery of therapeutics, microneedles are great. But this is a very broad term.
17:04 < hprmbridge> robertmcdougal_73197> Anyway, I mentioned that I need help getting this peptide GsMTx-4. The reason is that I have a lot of scar tissue from surgeries and drains and I'm hoping a drug cocktail can make them remodel back to normal. The peptide mixed in PBS was injected into mouse wound daily for 14 days and reduced hypertrophic scar and scar elevation index.
17:04 < hprmbridge> robertmcdougal_73197> https://cdn.discordapp.com/attachments/1064664282450628710/1222335413650194544/IMG_6780.jpeg?ex=6615d790&is=66036290&hm=bb2419cb55f631ec25f2c96c01d0f952a6e280650fce7ec157279543f44ce9ff&
17:10 < hprmbridge> robertmcdougal_73197> As you can see it wasn't perfect. So I might add a Rho kinase inhibitor. GH could also speed up cell cycle and ECM turnover.
17:12 < hprmbridge> robertmcdougal_73197> Paper if you're interested: https://www.nature.com/articles/s41419-021-03481-6
17:42 < hprmbridge> yashgaroth> those injections were done during healing so I'd expect a much lesser effect in pre-existing scars. Have you considered scar-maxxing? Scars are badass and you can always make up a story about them if the origin bothers you. I recommend 'alien embryo extraction'
17:55 < hprmbridge> fodagut> I thought he was talking about internal scar tissue?
18:01 < hprmbridge> yashgaroth> hopefully not, if he's trying to target it with injections
18:01 < hprmbridge> yashgaroth> and the talk of "hotmaxxing"
18:11 < hprmbridge> Eli> Did you say these scars were causing problems? I wouldn’t take experimental peptides based on one paper if it’s just aesthetic. I don’t like the FDA, but you should probably explain what you think will happen and see if it’s been done in humans first. Or even just underground anecdotes. Also you should figure out the side effects and ask what the teleological reason for scars is. Also, scars
18:11 < hprmbridge> Eli> formation is completely different in elderly vs children. What is the teleological reason for that?
18:13 < hprmbridge> Eli> By I’m understanding why evolution did things we can at least make hypothesis of potential treatments in lieu of human trials
18:29 < hprmbridge> alonzoc> Has this any relation to the work in age reversal using yamanaka factors?
18:30 < hprmbridge> alonzoc> As iirc their research healed scar tissue along with the target metrics such as reducing cell senescence etc
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18:38 < fenn> https://www.yalemedicine.org/conditions/microneedling
18:41 < hprmbridge> robertmcdougal_73197> They are there because a surgeon lied to my face and did an emergency surgery and used elective reasons behind my back. I do not tolerate being lied to.
18:44 < hprmbridge> robertmcdougal_73197> It is true in the paper the peptide was injected before scarring formed in the first place.
18:45 < hprmbridge> robertmcdougal_73197> To remodel pre-existing scars, I plan to inject consistently for 6 to 12 months. Inhibiting Piezo does reverse scarring: https://pubmed.ncbi.nlm.nih.gov/37066136/
18:47 < hprmbridge> robertmcdougal_73197> To understand why it should be possible to reverse an existing scar, one must know about why a scar remains a scar if tissue is constantly being degraded and relaid down (tissue turnover). https://cdn.discordapp.com/attachments/1064664282450628710/1222361395383762954/IMG_4387.jpg?ex=6615efc3&is=66037ac3&hm=6d74d2d788eb96a49eacbce7aabd6fde4c6d425ee3076f00ff1614f12e047411&
18:53 < hprmbridge> robertmcdougal_73197> Basically scar tissue is very stiff. Elastic modulus is 3 MPa (Mega Pascals) and normal tissue is 0.2 to 0.5 MPa. This stiff ECM applies mechanical forces onto the cells contained inside. Cells can sense the stiffness (by things such as cilia or ion channels). These mechanical forces are converted into chemical signals and passed down by secondary messengers inside the cytoplasm. You then have
18:53 < hprmbridge> robertmcdougal_73197> master regulator genes turned on like En1 and gene expression that is pro-fibrotic and so the tensile homeostatis is a positive feedback loop where cells continue maintaining the scar forever. So you could block any of these (FAK, Rho, ROCK, mTOR, YAP) and you would reduce scarring as you would block the ability for cells to "sense" that they are inside scar tissue.
19:23 < geneh2> I am personally not a big fan of the FLI: https://www.politico.com/news/2024/03/25/a-665m-crypto-war-chest-roils-ai-safety-fight-00148621
19:29 < hprmbridge> robertmcdougal_73197> The teleological reason for healing with scarring is basically animals did not have time to regenerate because this took a long time and they could get infection as there were not antibiotics or sterile bandaging 100 million years ago obviously. Scarring is a means to heal a wound as fast as possible to prevent infection. This is the universally agreed up explanation for human scarring and mammals
19:29 < hprmbridge> robertmcdougal_73197> not being able to regenerate limbs etc. If you lose a limb, you have a scarred stump where the amputation occured. The company Morphoceuticals is working on regenerating limbs in humans by resetting the bioelectric state.
19:30 < hprmbridge> robertmcdougal_73197> From their website https://cdn.discordapp.com/attachments/1064664282450628710/1222372192826822676/Screenshot_2024-03-26_at_7.30.31_PM.png?ex=6615f9d1&is=660384d1&hm=8f12f3181112807e73bcbabaaf813138845ec552e4224f562bad340351b318f6&
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--- Log closed Wed Mar 27 00:00:09 2024