| --- Log opened Thu Nov 25 00:00:08 2010 | ||
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| kanzure | Bill Paspaliaris, adistem, stem cells + LEDs? | 00:45 |
|---|---|---|
| dbolser | Select Biosciences is delighted to announce the inaugural European Lab Automation congress | 01:00 |
| dbolser | http://www.technologynetworks.net/email/r/redirect.aspx?id=314138&contentid=116935&url=http://www.selectbiosciences.com/conferences/ELA2011/ | 01:00 |
| dbolser | btw, anyone go for the 23 and me sale? | 01:07 |
| dbolser | This code is only valid until Friday, 11/26 | 01:07 |
| dbolser | http://shirleywho.wordpress.com/2010/11/24/get-it-while-its-hot-23andme-for-99/ | 01:07 |
| dbolser | You may have already heard the rumors floating around and they're all true: 23andMe is having another sale -- the whole thing for $99! | 01:08 |
| dbolser | Use discount code UA3XJH at checkout to get $400 off the regular price. (This code is only valid until Friday, 11/26.) | 01:08 |
| Utopiah | US only? | 01:09 |
| dbolser | nope | 01:10 |
| dbolser | big shipping charge though | 01:10 |
| dbolser | and an extra $60 for 'subscription' | 01:10 |
| dbolser | but still a big saving | 01:10 |
| dbolser | cost me £107 | 01:11 |
| dbolser | is that like ... 10,000 eruo ;-) | 01:11 |
| dbolser | The DNA chip that we use genotypes hundreds of thousands of SNPs at one time. It actually reads 1,000,000 SNPs that are spread across your entire genome. Although this is still only a fraction of the 10 million SNPs that are estimated to be in the human genome, these 1,000,000 SNPs are specially selected "tag SNPs." | 01:13 |
| dbolser | can we have a channel genome pool? | 01:17 |
| dbolser | They even ship to the vatican... | 01:17 |
| dbolser | I need to dig up that 'blood of christ' | 01:18 |
| Utopiah | (naive med question) are there strokes or brain tumor leading to major memory loss highly correlated to some if the SNPs read by 23&me? | 01:23 |
| Utopiah | in fact anything that could sudden major memory loss | 01:23 |
| dbolser | Utopiah: not sure off the top of my head... | 01:44 |
| dbolser | I spoke to a guy in 'clinical sequencing' who was talking about this... | 01:45 |
| dbolser | (genetics of neur-cognative disfunction) | 01:45 |
| dbolser | actually, he kind of babbled... | 01:45 |
| dbolser | lemmy see... | 01:45 |
| dbolser | http://www.sciencedaily.com/releases/2009/04/090415172235.htm | 01:45 |
| dbolser | Genetic Variant Tied To Increased Stroke Risk | 01:46 |
| dbolser | www.acnr.co.uk/pdfs/volume4issue4/v4i4reviewartstroke.pdf | 01:46 |
| Utopiah | sounds like a good starting point, thank you | 01:48 |
| Utopiah | if you are curious it's for http://fabien.benetou.fr/Slideshows/MemoryLoss?action=slideshow ;) | 01:48 |
| dbolser | ty | 01:53 |
| dbolser | here is the guy, I think... | 01:53 |
| dbolser | Identification of individuals within study cohorts with unusual intermediate phenotypes | 01:53 |
| dbolser | Vicky E Cho¹, Rohan B Williams¹ | 01:53 |
| dbolser | 1 | 01:53 |
| dbolser | JCSMR, The Australian National University, Genome Biology Program, Canberra, | 01:53 |
| dbolser | 2601, Australia | 01:53 |
| dbolser | Whole-genome sequencing on individuals is offering a powerful new approach to | 01:53 |
| dbolser | dissecting genotype-phenotype architecture in human health and disease. Recent studies | 01:53 |
| dbolser | have highlighted the difficulties in identifying genomic (or epigenomic) correlates of | 01:53 |
| dbolser | physiological- or behavioural-level phenotypes, suggesting that more detailed phenotypic | 01:54 |
| dbolser | characterisation of individuals may improve the utilisation of re-sequencing technologies. | 01:54 |
| dbolser | Intermediate phenotypes, namely mRNA, protein or metabolite levels, offer an ideal | 01:54 |
| dbolser | phenomenological level for more targeted phenotyping. Here, we address this issue by | 01:54 |
| dbolser | developing methodology for identifying individuals that demonstrate unusual | 01:54 |
| dbolser | characteristics in global mRNA levels, and illustrate this approach using expression | 01:54 |
| dbolser | microarray data from CNS-tissue in 135 normal human subjects (Myers et al, 2007). To | 01:54 |
| dbolser | characterise inter-individual differences in gene expression, we measure inter-individual | 01:54 |
| dbolser | co-variance using a robust version of the Mahalanobis distance statistic. Rather than | 01:54 |
| dbolser | attempt to analyse global expression differences between individuals, we focus on | 01:54 |
| dbolser | analysing inter-individual differences that are present in gene-sets, (i.e. a set of genes that | 01:54 |
| dbolser | share some common properties, e.g. co-regulation, membership of a known signaling | 01:54 |
| dbolser | pathway, etc). We then adapt multivariate outlier methods to identify individuals that | 01:54 |
| dbolser | demonstrate unusual patterns of expression in a given gene set with respect to the rest of | 01:54 |
| dbolser | the cohort. Due to the complex co-variance structure of microarray data, we have | 01:54 |
| dbolser | developed procedures to distinguish whether an individual's status as an "outlier" is not | 01:54 |
| dbolser | simply related to unusual distributional properties of the underlying microarray data. Our | 01:54 |
| dbolser | approach could be used to target individuals in large study cohorts, in which molecular | 01:54 |
| dbolser | phenotypic data have been assayed, for aberrant expression of either known or putative | 01:54 |
| dbolser | pathways or functional gene sets. The ability to identify such individuals could be critical | 01:54 |
| dbolser | in pinpointing subjects for further, more targeted assessment: for example, more | 01:55 |
| dbolser | extensive genotyping or resequencing, assessment of subject-specific environmental | 01:55 |
| dbolser | influences or more intensive clinical phenotyping. | 01:55 |
| dbolser | genetics of sleep? | 01:55 |
| dbolser | Genetic Basis of Human Sleep Behaviors -Studies from Familial Sleep Phase Syndromes | 01:55 |
| dbolser | Angela L Huang¹, Christopher R Jones², Ying-Hui Fu¹, Louis J Ptacek¹ | 01:55 |
| dbolser | ageing | 01:57 |
| dbolser | The application of genome-wide association studies of aging in a patient-driven clinical | 01:57 |
| dbolser | trial. | 01:58 |
| dbolser | Melanie Swan¹, Aaron Vollrath¹, Raymond McCauley¹ | 01:58 |
| dbolser | 1 | 01:58 |
| dbolser | DIYgenomics, Personalized Genome Research, Palo Alto, CA, 94306 | 01:58 |
| QuantumG | wall of text | 01:58 |
| dbolser | sorry, I figure ... well.. sorry | 01:59 |
| QuantumG | meh, not like anyone else was saying anything | 01:59 |
| dbolser | can we make a 'genome scoring game' and see who on the channel gets the highest score? | 02:01 |
| Utopiah | ? | 02:02 |
| QuantumG | of everyone with a 23 and me account? I think you'd win :P | 02:02 |
| dbolser | lowest disease risk? | 02:02 |
| dbolser | $99 :-) | 02:03 |
| QuantumG | .. I was just thinking.. quite a number of towns in Australia have construction (of housing) as their primary industry. | 02:03 |
| QuantumG | talk about your self-perpetuating economy | 02:04 |
| dbolser | when is it not? | 02:05 |
| QuantumG | most places don't have housing construction as the primary industry.. there's usually some economic reason that brings people to the area. | 02:05 |
| QuantumG | like, a mining town or a mill town or even a technology center | 02:06 |
| dbolser | ic | 02:06 |
| dbolser | its particularly clear in this case | 02:06 |
| QuantumG | but I imagine there are people who move to "housing towns" :P | 02:06 |
| QuantumG | s/people/builders/ | 02:07 |
| QuantumG | "hey, there's lots of building going on over here, we should move there to get a job building houses." | 02:07 |
| QuantumG | a town of builders.. building houses for more builders to move into. | 02:08 |
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| dbolser | QuantumG: right, but is the big picture really different? it's more diverse, but... | 02:19 |
| QuantumG | well, I imagine the bubble of a building town will burst eventually | 02:20 |
| QuantumG | but yes, that's similar to the wider economy | 02:20 |
| dbolser | you're right though, canibalism is not a long term ecological strategy | 02:20 |
| QuantumG | monoculture | 02:22 |
| dbolser | monoculture monoculture | 02:23 |
| QuantumG | :) | 02:37 |
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| fenn | gah | 03:10 |
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| kanzure | dbolser: thanks for the abstract.. i noticed it was written by melanie swan / diygenomics | 06:05 |
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| kanzure | "The application of genome-wide association studies of aging in a patient-driven clinical trial" oh wait i might have heard of this one before | 06:05 |
| dbolser | sorry, did you find it online? | 06:14 |
| dbolser | http://hplus.pastebin.com/WY9Q2A3R | 06:14 |
| dbolser | kanzure: genotyped? | 06:16 |
| kanzure | they told me i have too many base pairs to be human :( | 06:17 |
| dbolser | orly? | 06:25 |
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| kanzure | http://en.swpat.org/wiki/Publishing_information_is_made_dangerous | 07:04 |
| dbolser | a big field of research is dedicated to predicting this kind of patent | 07:11 |
| dbolser | michael schroder, my old colleague, worked on that | 07:12 |
| kanzure | does anyone have access to this? http://www.sciencebusiness.net/info/get_sciencebusiness.php | 07:16 |
| kanzure | http://www.earto.eu/nc/service/news/details/article/innovation-and-the-economy/ | 07:16 |
| dbolser | what in particular? | 07:24 |
| kanzure | the article "Innovation and the economy: innovation bonds" | 07:25 |
| kanzure | "Two kinds of innovation bonds are under consideration." | 07:30 |
| kanzure | "The more radical approach would see the formation of a knowledge bank where people with an innovative idea could trade certain rights in return for money to develop the idea." | 07:30 |
| kanzure | "A more conventional approach would be to provide state loan guarantees, offering lower returns to private investors of maybe 25 to 50 percent, but with a lower risk." | 07:30 |
| kanzure | all of the search results for "klaus gretschmann" are pdf files.. this must be what europe is like | 07:32 |
| dbolser | This page requires a subscription | 07:32 |
| dbolser | sorry | 07:32 |
| dbolser | (trying MPI) | 07:32 |
| dbolser | kanzure: tried that 'password' plugin for firefox? | 07:33 |
| dbolser | allows you to share logins... prolly unlikely here | 07:33 |
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| dbolser | http://www.scribd.com/National-Innovation-Funds-Act-of-2011/d/31629907 ? | 07:35 |
| kanzure | http://ec.europa.eu/invest-in-research/pdf/download_en/gretschmann.pdf | 07:35 |
| kanzure | dbolser: wtf why are you using scribd | 07:36 |
| kanzure | can you just link me to the pdf instead | 07:37 |
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| dbolser | kanzure: no clue, random google hit | 07:59 |
| dbolser | sorry | 07:59 |
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| wrldpc2 | Obligatory greeting. | 09:17 |
| kanzure | obligatory retort | 09:36 |
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| archels | obligatory sigh | 10:00 |
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| wrldpc2 | predetermined reaction to obligatory sigh. | 10:02 |
| Utopiah | so lively those scripts looked like real chat | 10:07 |
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| archels | http://arstechnica.com/tech-policy/news/2010/11/adam-savage-tsa-saw-my-junk-missed-12-razor-blades.ars | 10:39 |
| archels | I didn't know Adam Savage is doing stand-up comedy now. | 10:39 |
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| archels | Or, well, stand-up /something/. | 10:49 |
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| uniqanomaly | http://www.urbandictionary.com/define.php?term=gate+rape | 11:01 |
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| Ybit | Love the latest slashdot story where hong kong researchers stored 90gb of data in bacteria | 11:50 |
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| Ybit | http://science.slashdot.org/story/10/11/25/1824252/Hong-Kong-Team-Stores-90GB-of-Data-In-1g-of-Bateria?from=rss | 11:53 |
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| QuantumG | http://www.diginfo.tv/2010/11/24/10-0135-r-en.php | 16:38 |
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| klafka | you guys see about the glowing trees? | 17:26 |
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| joshcryer | QuantumG, "science TV" is no longer educational or informative. | 17:52 |
| joshcryer | It's utter freaking garbage. | 17:52 |
| joshcryer | Scientists should boycott these idiots who invite them to be on TV. | 17:52 |
| joshcryer | I would simply say "No, your platform is embarrassing to the scientific process and I will have no part of it." | 17:52 |
| joshcryer | Consider "Through the Wormhole." They were going to do a spot on Garrett Lisi's ESTOE. They spent all of 5 minutes actually talking about it and absoultely nothing was said. Nothing. I am not joking. | 17:57 |
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| mayko | heh yeah i got the History Channel's take on astronomy as a 5 DVD set for christmas a few years ago | 18:47 |
| mayko | it was.... lulzy. | 18:47 |
| mayko | 1,000 WAYS THAT THE UNIVERSE CAN KILL YOU | 18:48 |
| mayko | BLACK HOLES ARE 'PROWLING THE GALAXY' IN SEARCH OF PLANETS JUST LIKE EARTH | 18:48 |
| mayko | i miss the heyday of the discovery channel; it used to have decent programming before everyone decided that reality tv is the wave of the future | 18:49 |
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| kanzure | lee uploaded http://bio.cc/Bioinformics/papers/AFM/ to http://www.thingiverse.com/technologiclee/things | 20:29 |
| kanzure | of course, the plastic parts are not really the meat-and-potato of what's going on | 20:29 |
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| epitron | mmm... meat and potatoes.... | 20:57 |
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| Utopiah | http://sigbovik.org | 22:33 |
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| joshcryer | http://spectrum.ieee.org/robotics/artificial-intelligence/moneta-a-mind-made-from-memristors | 23:07 |
| QuantumG | nice | 23:08 |
| joshcryer | Low quality article for those who have been keeping track, but yeah, I was entertained. | 23:09 |
| QuantumG | here's what we need to do: knock out the gene(s) in mice that produce the cerebellum.. test 'em to make sure they suck at all experiments that require memory/reasoning/etc. Wire in an artificial cerebellum. Profit! | 23:10 |
| joshcryer | I like their virtual technique, just artifically evolve animats, until you have one that performs adequately at tasks. | 23:14 |
| QuantumG | yeah, but if you had a mouse that stored its memories in a removable device you could plug it into another knockout mouse and prove that it could perform similarly to the first. | 23:15 |
| QuantumG | hello neuromancer, I'm home. | 23:15 |
| joshcryer | Lots of learning about processing algorithms can be done that way. Throw a problem at an animat, figure out which one solves the problem the quickest and most effectively (doesn't have to be perfect, as we humans are by no means perfect), and you really start to understand how these algorithms work. Might not necessarily be a human-analog, could be better. | 23:16 |
| joshcryer | But then you're limited to mouse-architecture. :( | 23:16 |
| QuantumG | no.. the next step is higher mammals and eventually humans | 23:16 |
| QuantumG | when you die we'll clone you, pull the crystal memory from the base of your skull and reboot your new body. - with apologies to Peter F. Hamilton | 23:19 |
| joshcryer | Take optical character recognigtion, we got a lot of that from analyzing how humans do it, while mediocre at best, if you discovered an algorithm that did it with half as many neural pathways with twice as much accuracy you may as well say "screw trying to figure out how humans do it." | 23:19 |
| joshcryer | And are you sure you're not thinking of Richard Morgan? :P | 23:20 |
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| QuantumG | nah, Peter F. Hamilton did it better.. introducing that technology in like 2 paragraphs so he could tell a story spanning a few hundred years without having to invent new characters all the time | 23:21 |
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| joshcryer | Fair enough, Takeshi Kovacs did seem to go downhill after Altored Carbon. | 23:23 |
| joshcryer | I'll have to check his stuff out. | 23:23 |
| joshcryer | DARPA loves to go with crazy shit though, we'll have damn drones that can do really accurate facial recognition and assasinate people individually with 99.99% accuracy with no collateral damage or something. | 23:26 |
| joshcryer | kanzure, joshcryer #memristor | 23:40 |
| joshcryer | :) | 23:40 |
| * joshcryer goes to sleep for real now | 23:40 | |
| --- Log closed Fri Nov 26 00:00:07 2010 | ||
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