| --- Log opened Sat Aug 06 00:00:12 2011 | ||
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| kanzure | ok i've settled on arghparser | 09:00 |
|---|---|---|
| foucist | kanzure: for parsing what | 09:10 |
| kanzure | arghparser is a wrapper around argparse for python command line parsing | 09:28 |
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| kanzure | https://github.com/tbuser/openscad.tmbundle | 10:49 |
| kanzure | for textmate lusers | 10:49 |
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| kanzure | hi Tyrant_ | 11:18 |
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| delinquentme | uniqanomaly, thanks for the heads up on the human metabolic pathways | 11:55 |
| delinquentme | kanzure, so seriously whos making the big progress in aging research? | 11:56 |
| uniqanomaly | just and idea but I think it can have really enormous applications | 11:57 |
| uniqanomaly | can/will | 11:57 |
| delinquentme | i just looked up the article and the girl thiel sponsored for 100g ... but I think its gonna need to be a bit more than that... her name is " Laura Deming " | 11:57 |
| uniqanomaly | delinquentme: especially in the world where human experimentation is illegal ;) | 11:58 |
| delinquentme | uniqanomaly, i got a little sister im volunteering | 11:59 |
| delinquentme | and a puppy | 11:59 |
| delinquentme | oh, wait.. | 11:59 |
| uniqanomaly | delinquentme: ok but I mean like testing *any possible* chemical compound | 12:00 |
| delinquentme | Tyrant_, so im looking at this Gilson machine you were talking about .. definitely seems a little more robust... The focus of the one i built was around an open protocol ... as in i wanted it to be able to "teather" up against another machine and have that machine run it | 12:00 |
| uniqanomaly | something goes wrong, you reset simulation and start again with something else | 12:00 |
| uniqanomaly | well, you can even test combinations of drugs | 12:00 |
| uniqanomaly | like 5 drugs acting on different stuff | 12:01 |
| delinquentme | uniqanomaly, so this is kind of like ... take model of human ... endocrine system? toss a few drugs into the model | 12:01 |
| delinquentme | and using physical / chemical models | 12:01 |
| uniqanomaly | yeah | 12:01 |
| delinquentme | attempt to predict the effects | 12:01 |
| delinquentme | derp not endocrine system .. but yeah biological system | 12:02 |
| uniqanomaly | simulating different feedbacks etc | 12:02 |
| uniqanomaly | and you can do with it anything as far as human related biological knowledge goes without limitations of human testing | 12:04 |
| delinquentme | uniqanomaly, just out of curiosity .. for the model to represent an actual human model correctly .. wouldnt we need to test it on one ? | 12:37 |
| delinquentme | or are we just talking about chemical reactions which we've studied sufficiently indepth that they're kind of .. standard / static chemical reactions? | 12:38 |
| uniqanomaly | you can use actual know data as tests for systems reaction | 13:00 |
| uniqanomaly | known* | 13:00 |
| uniqanomaly | of course it won't be 100% accurate human model from start | 13:01 |
| uniqanomaly | you add more and more stuff thats missing and at some point you supposedly get results very similar to actual drug action | 13:02 |
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| delinquentme | ohhhh i seeee | 14:12 |
| delinquentme | uniqanomaly, what do you do for a living? | 14:12 |
| * delinquentme currently watching transcendent man | 14:12 | |
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| delinquentme | open question to all: are there any labs / business which are openly studying the pursuit of aging with high power computing? | 14:33 |
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| Tyrant_ | delinquentme, sorry I was afk. I'll be making mine with an open interface as well but mine is geared more towards reducing the cost of the equipment for biotechs | 16:39 |
| Tyrant_ | thats why im going for the three axis gantry | 16:39 |
| Tyrant_ | What was the accuracy on your LH001 liquid wise? | 16:39 |
| delinquentme | untested | 16:39 |
| delinquentme | i was aiming for .1 uL | 16:40 |
| Tyrant_ | ah. how did you pump the liquid? | 16:40 |
| delinquentme | peristaltic pump with pull compression | 16:40 |
| delinquentme | bad idea | 16:40 |
| -!- Tyrant_ is now known as Tyrant | 16:40 | |
| delinquentme | do direct compression | 16:40 |
| delinquentme | i mean sandwitch that tube between two hard objects | 16:40 |
| delinquentme | i swear to god to get it pump it took like 100 lbs of force | 16:40 |
| Tyrant | I'm looking at using a linear actuator pumping a glass tube ala tecans | 16:41 |
| Tyrant | actuators with .1mm precision are pretty cheap and using a sealed piston gives you great control | 16:42 |
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| delinquentme | Tyrant, yeah my design off the biotek liquid handler peristaltic pump was bc i thought it was novel | 17:07 |
| delinquentme | and if you want really cheap .. you can go with regular syringes | 17:08 |
| Tyrant | delinquentme, cheap but difficult to control and not as long lasting | 17:33 |
| delinquentme | yeah just a suggestion .. i was looking at the pumps used in tecans as well | 17:37 |
| delinquentme | however i did have a really big question as to how the "flow thru" technology actually removed all the biological particulate | 17:37 |
| delinquentme | basically they some how wash and blow out the pipette tips which allow them to jump between different substances | 17:38 |
| delinquentme | AND if you want to get REALLYYY nuts | 17:38 |
| delinquentme | .... | 17:38 |
| delinquentme | http://www.labcyte.com/Acoustic_Droplet_Ejection_ADE/Default.270.html | 17:39 |
| delinquentme | the technical term for this is "the tits" | 17:39 |
| delinquentme | aka AED .. AKA acoustic droplet ejection | 17:39 |
| delinquentme | Tyrant, ^^ hah | 17:44 |
| kanzure | http://www.letsremake.info/PDFs/inflatocookbook.pdf | 18:03 |
| Tyrant | You mean for their fixed tips? | 18:03 |
| Tyrant | delinquentme, I'm going to just add in the feature to pick up and drop disposable tips | 18:04 |
| delinquentme | Tyrant, yeah but what about high volume | 18:05 |
| Tyrant | how high? | 18:06 |
| Tyrant | having a system that flushes if necessary isn't too difficult | 18:06 |
| Tyrant | ill figure that out once the major functions are working | 18:07 |
| Tyrant | right now my linear stage is giving me a lot of trouble. off the shelf stepper controllers kinda suck | 18:07 |
| delinquentme | what're u using? | 18:31 |
| delinquentme | so im thinking they have flow through of liter capacity | 18:41 |
| delinquentme | but the magic is in how does flushing it ... make it sterile .. or pretty close to sterile? | 18:42 |
| delinquentme | i dont know ? | 18:42 |
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| Tyrant | You mean they can hold a liter of a sample? No way. Not a single one I've seen has that capability. Usually only the expensive LHs have anything about milli | 19:45 |
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| ybit | weeee! | 20:19 |
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| --- Log closed Sun Aug 07 00:00:14 2011 | ||
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