| --- Log opened Thu Sep 22 00:00:21 2011 | ||
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| joshcryer | Anyone know if Singularity Summit 2011 will be covered on a stream? | 01:31 |
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| joshcryer | kanzure, I'd be interested in seeing how you'd get around modern patents. Theoretically you could pretend that you're in perpetual 'research' (as patents allow use of the patent for research), but I wonder if it would really work. | 01:34 |
| QuantumG | that video is gold joshcryer | 01:48 |
| joshcryer | Isn't it? | 01:52 |
| joshcryer | I seriously almost went insane debating those idiots in the mid 2000s. Now it's just, a laugh for me. | 01:52 |
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| joshcryer | players playing foldit solve shit: http://www.cs.washington.edu/homes/zoran/NSMBfoldit-2011.pdf | 03:03 |
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| joshcryer | lol names of players in a Nature article | 03:05 |
| joshcryer | win | 03:05 |
| joshcryer | Another teammate, grabhorn, was able to improve spvincent’s model (magenta), particularly in the core of the protein, and another teammate, mimi, was able to generate an even more accurate model (green) by correctly tucking in the loop at the top left. | 03:06 |
| joshcryer | Although much attention has recently been given to the potential of crowdsourcing and game playing, this is the first instance that we are aware of in which online gamers solved a longstanding scientific problem. | 03:07 |
| joshcryer | took that right out of Star Gate Universe. ;P (note really, foldit really predates that by a year). | 03:08 |
| kanzure | why am i awake | 03:08 |
| joshcryer | go to sleep | 03:09 |
| joshcryer | 36/12 is a bad schedule | 03:09 |
| kanzure | 36/7ish | 03:10 |
| joshcryer | ouch | 03:10 |
| joshcryer | there are some people who can do without any sleep whatsoever | 03:11 |
| joshcryer | have some weird gene | 03:11 |
| joshcryer | perhaps you should try to acquire it | 03:11 |
| joshcryer | http://www.webmd.com/sleep-disorders/news/20090813/gene-cuts-sleep-need | 03:12 |
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| QuantumG | and here we go http://www.youtube.com/watch?v=vNGEK6YYCxA | 04:24 |
| kanzure | who is this catering to? | 04:28 |
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| kanzure | "beneficiary of civilization" is the only possibly new line in that whole thing, the rest seems to be hype? | 04:33 |
| kanzure | or angry youtube-posting-clips-of-people-being-angry-at-you | 04:33 |
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| QuantumG | did ya read the description? | 05:08 |
| joshcryer | wait wtf | 05:49 |
| joshcryer | can't watch the whole thing now but lol | 05:49 |
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| QuantumG | like you're too busy to spare 9 minutes | 05:51 |
| JayDugger | Who's the jackass at 00:45? | 05:52 |
| JayDugger | Nice clip from Texas Chainsaw Massacre, too. | 05:55 |
| QuantumG | Derrick Jensen, ecocrazy. | 05:57 |
| JayDugger | Professional ecocrazy? | 05:57 |
| QuantumG | published | 05:57 |
| JayDugger | Wonderful... | 05:57 |
| JayDugger | Digging through most of those clips must have been like gargling raw sewage. | 05:58 |
| QuantumG | I had to cut the scariest shit | 05:59 |
| JayDugger | I don't care to imagine what you omitted. | 06:00 |
| QuantumG | There's a bit where a woman says "these trees are like our mother to us.. they're raping our mother.. what would you do if someone was raping your mother." That was a little *too* powerful for this audience. | 06:00 |
| JayDugger | Does Jeff Greason actually quote Buckminister Fuller's s"Utopia or Obilvion?" | 06:00 |
| QuantumG | http://www.youtube.com/watch?v=m8PlzDgFQMM is the full video.. I didn't cut much. | 06:03 |
| JayDugger | I'll look later. Greason certainly seems to sing from the same sheet music. | 06:09 |
| JayDugger | Thank you for the link. | 06:10 |
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| delinquentme | kanzure: any idea if magnetic pulses could be used to separate out solids from liquids? | 07:29 |
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| dbolser | any DIYBio ppl around? | 07:49 |
| dbolser | anyone running a bioreactor? | 07:49 |
| dbolser | I came up with a fun project (perhaps it's old news). | 07:50 |
| delinquentme | dbolser: diybio heeere! | 07:50 |
| delinquentme | bio reactos are the tits man | 07:50 |
| dbolser | 1) get a cell culture from a plant that produces a low yield of your desired (expensive to manufacture compound) | 07:50 |
| delinquentme | theres a company here in PGH whos made a pretty sucessful one | 07:51 |
| dbolser | 2) randomly modulate the gene expression in the plants using rnai against it's genome | 07:51 |
| dbolser | 3) measure yield, 4) repat | 07:51 |
| dbolser | repeat | 07:51 |
| dbolser | try to 'learn' the trajectory in the search space that gets you to increased yield | 07:52 |
| dbolser | I think this could be a neat way to just 'create appropriate biology' | 07:52 |
| dbolser | the first issue that comes to mind is, how to modulate the gene set of the cells, assuming that's needed | 07:53 |
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| dbolser | and 2, how to increase expression levels of genes, because RNai typically knocks down a gene | 07:53 |
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| dbolser | assuming your initiaL cell line has the right genes, you could use such a 'learning' system to make cells that are easy to transform, easy to handle, easy to maintain and produce a high yield... all assuming you can drive the cells in high throughput in this way | 07:55 |
| dbolser | or rather, apply many rounds (or continious) learning | 07:55 |
| dbolser | by using rnai, you simplify the molbio significantly, but you still need easy / quick / cheap DNa synth | 07:56 |
| kanzure | delinquentme: sure, magnetic solids from liquids or magnetic liquids | 08:18 |
| kanzure | dbolser: doesn't have to be random dude... that shit is well known | 08:19 |
| delinquentme | kanzure: anything with a charge right? | 08:19 |
| delinquentme | and just build a hunking pulse magnet or some shit | 08:19 |
| kanzure | maybe you are thinking of electric fields and point charges | 08:19 |
| delinquentme | @_@ SHOULDA BOUGHT PARTS OF NAVY RAILGUN | 08:19 |
| * delinquentme facepalm | 08:19 | |
| kanzure | i don't know what's going on so i think i'll go sleep for an hour | 08:20 |
| kanzure | cya | 08:20 |
| delinquentme | kanzure: | 08:28 |
| delinquentme | is it open source if only people who BUY it .. get the source? | 08:28 |
| delinquentme | its more open .. maybe not fully though | 08:28 |
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| kanzure | bleh why would you do that | 08:43 |
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| delinquentme | kanzure: does everyone need a medical liquid handler? | 08:59 |
| delinquentme | honestly theres quite a bit of BAD that can be done with this | 09:00 |
| delinquentme | paywalls serve a purpose to filter out a bit of the sketch | 09:00 |
| kanzure | now is not the time for me to help you through your personal crisis of ethics | 09:00 |
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| dbolser | kanzure: right, the 'learning algo' would have the background knowledge to make the next step, but importantly, it wouldn't be restricted to 'known' biology | 09:26 |
| dbolser | i.e. if mirna x enhances the effect of mirna y, add it! | 09:26 |
| dbolser | kanzure: can I shedule a time with you to help me through my personal crisis of ethics? | 09:27 |
| dbolser | I'm dying here! | 09:27 |
| dbolser | ;-) | 09:27 |
| dbolser | so... best way to synthesize miRNa | 09:28 |
| dbolser | ?? | 09:28 |
| dbolser | bleaH, dumb kbd | 09:28 |
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| Utopiah | http://projectgado.org | 13:07 |
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| --- Log closed Fri Sep 23 00:00:23 2011 | ||
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