| --- Log opened Fri Dec 09 00:00:19 2011 | ||
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| Lucas_ | good morninging | 07:53 |
|---|---|---|
| Lucas_ | morning* | 07:53 |
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| kanzure | "usceptibility to lung cancer due to smoking is at least partly genetic. If you have certain variants of a specific gene (don't have time for the lit search right now), smoking won't significantly increase your chances of lung cancer." | 09:53 |
| kanzure | anyone know the allele or genes of interest? | 09:53 |
| Lucas_ | I have no clue | 09:58 |
| Lucas_ | where did you find the gene? | 09:58 |
| kanzure | "Although cigarette smoking is the dominant risk factor for several epithelial cancers, only a small fraction of individuals with tobacco exposure develop cancer." | 09:58 |
| kanzure | of course- cigs have much more than tobacco.. | 09:58 |
| kanzure | Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 http://www.nature.com/ng/journal/v40/n5/abs/ng.109.html | 09:59 |
| kanzure | "we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking cases of European ancestry and 1,137 frequency-matched, ever-smoking controls from Houston, Texas." | 09:59 |
| kanzure | god damn it houston :( | 09:59 |
| kanzure | "Two SNPs, rs1051730 and rs8034191, mapping to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets" | 09:59 |
| kanzure | "We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk." | 10:00 |
| Lucas_ | interesting stuff | 10:02 |
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| Lucas_ | too bad we can't leverage that to our advantage now042 | 10:11 |
| kanzure | it looks like it increases nicotine addiction, causing more smoking and causing more damage | 10:12 |
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| archels | kanzure: rofl | 11:30 |
| archels | kanzure: How far along are we in simulating protein-protein interactions? | 11:40 |
| kanzure | there's lots of software released for that | 11:41 |
| archels | How decent is it? | 11:52 |
| archels | I'm asking for your personal opinion | 12:06 |
| kanzure | yeah i know | 12:07 |
| kanzure | it's been a long time so it's gonig to take me a while to remember anything good | 12:07 |
| kanzure | ligand-ligand stuff tends to be good.. | 12:07 |
| kanzure | http://now.tufts.edu/news-releases/researchers-discover-changes-bioelectric-sign | 12:30 |
| superkuh | Hm. Applying that in general to other organs and tissues probably will not work. Lots of animal eyes have a well known dipole, otherwise EOG wouldn't work. But not other tissues. | 12:43 |
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| JayDugger | http://quantifiedself.com/2011/12/fenn-lipkowitzs-amazing-lifelog/ | 22:24 |
| JayDugger | Congratulations, Fenn! | 22:24 |
| JayDugger | Now, if only QS would provide transcripts. | 22:24 |
| JayDugger | Oh, and good evening, eveyone. | 22:25 |
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| kanzure | huh, professional lab relocation service | 23:54 |
| kanzure | http://www.perkinelmer.com/pages/010/onesource/lab_inst_relocation_services.xhtml?utm_source=LabrelocationRedirect&utm_medium=Redirect | 23:54 |
| --- Log closed Sat Dec 10 00:00:21 2011 | ||
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