| --- Log opened Wed May 16 00:00:11 2012 | ||
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| fenn | hehe exercise mimetics http://www.fightaging.org/archives/2012/01/development-of-exercise-mimetics-will-recapitulate-the-development-of-calorie-restriction-mimetics.php | 01:06 |
|---|---|---|
| fenn | take a pill that has the biochemical effect of a triathlon | 01:06 |
| fenn | i'd like to see more mouse studies with multiple simultaneous treatments, with the goal of increasing mouse lifespan indefinitely | 01:09 |
| fenn | seems like there should be an x-prize for the 10 year mouse, 20 year mouse, etc | 01:09 |
| fenn | if you have 10 different treatments that all target the same pathways, there's no point in doing all of them at once | 01:11 |
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| Utopiah_ | is there a dedicated QuantifisedSelf IRC channel? | 01:40 |
| fenn | no | 02:17 |
| fenn | they exclusively communicate by blog comments :\ | 02:17 |
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| @kanzure | juul: lavaamp got run into the ground by rob | 07:06 |
| @kanzure | and then they all went to startupchile for some reason | 07:06 |
| @kanzure | "Weill Cornell Medical College scientists have discovered that single protein alpha 2 delta controls the volume of neurotransmitters and other chemicals that flow between the synapses of brain neurons." | 07:07 |
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| bkero | lmao, copeenhagen hackerspace is randomly 2 blocks away from where I'm staying | 07:24 |
| bkero | win | 07:24 |
| @kanzure | hijack the submarine! | 07:24 |
| bkero | lul | 07:30 |
| bkero | perhaps | 07:31 |
| bkero | They haven't updated their site since last september, I want to know if it's still active. | 07:31 |
| Utopiah_ | CFP http://agi-conf.org/2012/call-for-papers/ | 07:31 |
| Utopiah_ | bkero: and the ML? | 07:32 |
| bkero | Utopiah_: dunno f it has a ml | 07:35 |
| Utopiah_ | the wiki looks quite active https://labitat.dk/wiki/Special:RecentChanges | 07:38 |
| bkero | not that one | 07:51 |
| bkero | The other one | 07:51 |
| bkero | Illutron | 07:51 |
| bkero | Labitat is quite active and I need to make somet ime to go see them one of these weekends | 07:52 |
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| bkero | Wrote Copenhagen Suborbitals an email asking to attend their rocket test this sunday | 08:37 |
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| @kanzure | i found this old "neuropsychopharmacology" textbook of mine on a shelf | 09:47 |
| @kanzure | filled with hand-written notes from 2007-2008 | 09:48 |
| jrayhawk | note 1: "EAT ALL THE DRUGS" | 09:48 |
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| ThomasEgi | note 2: disregard note 1 | 09:50 |
| @kanzure | jrayhawk: that would be an appropriate comment if the book was pikhal | 09:50 |
| @kanzure | *pihkal | 09:50 |
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| @kanzure | Resolution doubling in live, multicellular organisms via multifocal structured illumination microscop | 11:37 |
| @kanzure | http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.2025.html | 11:37 |
| @kanzure | *microscopy | 11:37 |
| @kanzure | "We demonstrate three-dimensional (3D) super-resolution in live multicellular organisms using structured illumination microscopy (SIM). Sparse multifocal illumination patterns generated by a digital micromirror device (DMD) allowed us to physically reject out-of-focus light, enabling 3D subdiffractive imaging in samples eightfold thicker than had been previously imaged with SIM." | 11:37 |
| @kanzure | "We imaged samples at one 2D image per second, at resolutions as low as 145 nm laterally and 400 nm axially. In addition to dual-labeled, whole fixed cells, we imaged GFP-labeled microtubules in live transgenic zebrafish embryos at depths >45 μm." | 11:38 |
| @kanzure | "Our method uses commercially available parts and open-source software and is simpler than existing SIM implementations, allowing easy integration with wide-field microscopes." | 11:38 |
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| jrayhawk | bkero: if you like rockets you should hang out with http://psas.pdx.edu/ | 12:02 |
| bkero | jrayhawk: I've been invited to some of the meetings | 12:07 |
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| Utopiah | robot arm and BCI http://www.youtube.com/watch?v=ogBX18maUiM (braingate) | 13:24 |
| @kanzure | braingate is still around? they took down their original tongue display page and i am sad | 13:24 |
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| chevbird | long day in the lab. save me with some stimulating conversation before i hit the bar | 14:18 |
| * jrayhawk farts | 14:18 | |
| chevbird | well played | 14:19 |
| Mariu | lol | 14:21 |
| @kanzure | chevbird: there's some stuff in the backlog about the google/oracle and the sage/press cases | 14:24 |
| @kanzure | chevbird: http://gnusha.org/logs/2012-05-16.txt | 14:24 |
| chevbird | saved again by kanzure | 14:25 |
| chevbird | thanks buddy | 14:25 |
| @kanzure | http://www.xconomy.com/seattle/2012/05/03/virtual-biotech-companies-built-on-solid-bedrock-or-unstable-landfill/ | 14:25 |
| @kanzure | "it's virtually a business!" | 14:26 |
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| @kanzure | singularity comedy bit: http://www.youtube.com/watch?v=IFe9wiDfb0E | 14:59 |
| mensch | haha | 15:00 |
| mensch | just saw that | 15:00 |
| @kanzure | hrm, well that's not very funny actually | 15:02 |
| mensch | Depends on your mood, I guess. | 15:05 |
| @kanzure | what's ironic about it? | 15:06 |
| mensch | Sinister, nonetheless. | 15:06 |
| @kanzure | i guess it might qualify to be "dry observational humor" | 15:06 |
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| delinquentme | https://gist.github.com/2714505 << why | 15:35 |
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| @kanzure | delinquentme: because you are using gsub! instead of gsub | 15:57 |
| delinquentme | kanzure, good call | 16:02 |
| delinquentme | jrayhawk, intermittent fasting stimulated cell apoptosis right? | 16:26 |
| delinquentme | stimulates ** | 16:26 |
| delinquentme | also.. what do you normally consume post fast? | 16:26 |
| jrayhawk | Protein fasting for more than 18 hours does that. | 16:27 |
| jrayhawk | Usually I'm fasting by circumstance; if I'm sated enough to not eat for that long, it's because I'm eating a high-fat diet, so fat is what'll bring me out of it. | 16:29 |
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| jrayhawk | fwiw i am not a big believer in the power of intermittent fasting. keto-adaptation and apoptosis are handy, but thyroid downregulation sucks and longevity studies all use garbage calorie sources dubious animal models. | 16:38 |
| jrayhawk | garbage calroie sources and dubious animal models | 16:38 |
| jrayhawk | and i can get those upsides by other means | 16:40 |
| delinquentme | wait I thought you said you're into fasting? | 16:40 |
| delinquentme | and what other ways are there to stimulate apoptosis? | 16:40 |
| jrayhawk | I do occasional carbohydrate and protein fasting versus, like, general caloric restriction | 16:43 |
| jrayhawk | Cold is another way of causing all sorts of interesting apoptotic effects | 16:44 |
| delinquentme | yeahh cold showers | 16:44 |
| delinquentme | they're rough to get through but i feel awesome once I get out | 16:44 |
| jrayhawk | Baths are a bit less awful, and you can get some of the same effects just by dunking your face as long as you can. | 16:45 |
| jrayhawk | mind you a cold shower is better at hammering you metabolicly. it's a good workout. | 16:45 |
| jrayhawk | i just ordered a five gallon bucket of saturated fat this morning :) | 16:47 |
| delinquentme | jrayhawk, you did what? | 16:47 |
| delinquentme | lol wait how why ? | 16:48 |
| jrayhawk | 150,000 largely innocuous calories for $135 seems like a good deal to me | 16:48 |
| jrayhawk | http://www.tropicaltraditions.com/expeller-pressed_coconut_oil.htm | 16:48 |
| delinquentme | lolol | 16:49 |
| delinquentme | jrayhawk, do you not like food? or cooking? | 16:49 |
| jrayhawk | I'm not really motivated by taste reward like some people are; I assume some of that's genetic and some of it's based on leptin/insulin resistance. | 16:50 |
| jrayhawk | And yes, I find cooking irritating. I tend to just shove most of my shopping list in a 3-gallon pot and cook it for 24 hours to provide meals I can pad out with raw greens and fat for the rest of the week. | 16:51 |
| jrayhawk | This cuts my cooking time down substantially. | 16:51 |
| jrayhawk | When you cook a chicken for 24 hours, you don't need to bother disarticulating it! | 16:52 |
| jrayhawk | aum nyaum bones | 16:52 |
| jrayhawk | for a while i could get beef fat for a dollar per pound; that was pretty cool | 16:54 |
| jrayhawk | it was grain-fed, though, which kinda sucked | 16:55 |
| jrayhawk | Not, like, scary CAFO grainfed, though. | 16:55 |
| delinquentme | jrayhawk, you've got backing for liking grass fed beef? | 17:03 |
| jrayhawk | micronutrient density, lipid profile | 17:04 |
| delinquentme | grass fed = lower fat im guessing? | 17:05 |
| delinquentme | Ohh and whats the butter in the coffee thing again | 17:05 |
| delinquentme | i need to youtube this | 17:05 |
| @kanzure | jrayhawk: you are my favorite chef | 17:07 |
| delinquentme | http://quantifiedself.com/2011/01/results-of-the-buttermind-experiment/ | 17:07 |
| jrayhawk | It usually is lower fat, but that's not all that important to me. Human-safe omega-3-to-omega-6 ratio, and not-insignificant levels of conjugated linoleic acid. | 17:07 |
| delinquentme | so if I eat cupcakes with that much butter | 17:09 |
| jrayhawk | And I suppose there's the issue of bacterial overgrowth and attendent health risks to grain-fed beef, but those are pretty marginal risks. | 17:09 |
| delinquentme | will I get the same effects even though im digesting it along w carbs? | 17:09 |
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| delinquentme | bc I've ate some delicious cupcakes | 17:10 |
| delinquentme | and I'd love to be able to do that for brain health | 17:10 |
| jrayhawk | Cupcakes, huh? Have neither the Taubesians or the paleoites gotten to you yet? | 17:10 |
| delinquentme | lol i know carbs | 17:10 |
| delinquentme | but like butter in coffee doesnt sound awesome | 17:11 |
| delinquentme | cupcakes do | 17:11 |
| jrayhawk | well, i don't think inflammation from fructose metabolism, insulin spiking, or gliadin will be good for your brain, no | 17:14 |
| delinquentme | so the sugar is the issue | 17:14 |
| jrayhawk | technically i suppose the wheat is more disastrous, but probably not on a marginal basis | 17:16 |
| * delinquentme sad kid raised on cupcakes | 17:18 | |
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| jrayhawk | err, everywhere i said apoptosis, i meant autophagy | 22:24 |
| @kanzure | this is why you could never pass your chef certification test | 22:25 |
| jrayhawk | there's a lot of overlap | 22:25 |
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| --- Log closed Thu May 17 00:00:12 2012 | ||
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