2012-06-05.log

--- Log opened Tue Jun 05 00:00:31 2012
Utopiahhttp://barabasilab.neu.edu/projects/tedmed/00:01
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Utopiahhttp://www.brepettis.com/blog/2009/3/3/the-cult-of-done-manifesto.html02:20
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archelskanzure: What is LUF, TMP?04:41
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chris_99anyone read 'Human Enhancement'05:37
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archelschris_99: URL?06:03
chris_99http://www.amazon.co.uk/Human-Enhancement-Julian-Savulescu/dp/0199594961/ref=sr_1_1?ie=UTF8&qid=1338901443&sr=8-106:04
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@kanzurearchels: LUF is a weird "501c3" (not really?) built around savage's book, TMP is 'the millineal project'06:33
@kanzurearchels: http://tmp2.wikia.com/06:33
@kanzurechris_99: haha i see you're still trying to not follow my advice about reading 'transhumanist' books.06:33
@kanzurechris_99: you'll be disappoint.06:33
Mariu:p06:35
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chris_99heh06:37
@kanzurehttps://bitbucket.org/iorodeo/transilluminator_enclosure/src06:42
@kanzureOn Tue, Jun 5, 2012 at 5:43 AM, Cathal Garvey <cathalgarvey@gmail.com> wrote:06:43
@kanzure> The problem is, there are great methods out there, but they're patented06:43
@kanzure> just use cold (insoluble) potato starch to purify proteins. But, it's06:43
@kanzure> patented in the EU for another few years at least, and possibly in the06:43
@kanzure> US for the time being, too.06:43
@kanzure> to oblivion. Consider Maltose-Binding Protein: You could, in principal,06:43
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@kanzure"The Assange Show on RT tonight, June 5, covers Cypherpunks as source of WikiLeaks:"  http://www.rt.com/news/julian-assange-internet-war-cypherpunk-989/06:45
@kanzurewell at least he's admitting it now06:46
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@kanzuremaybe he will also admit its origins with extropy-chat06:46
@kanzurefun fact: extropy-chat was good for something once (wikileaks)06:46
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@kanzurewhois Srdjan Gavrilovic <sasvimlogicno@gmail.com>08:27
UrchinI have no clue08:37
Urchinthough he sounds like he's from my region08:38
Urchinthough his name sounds serbian08:39
@kanzure"The second class will be BIOCAMP 101, which is targeted at people with little to no biology experience, or those who want to get hands on with biology.  This is the the bootcamp version of the original biotech 101 class, in that it is condensed into one weekend to make it more convenient- let me know if this is not a good way to do it.  This will be on Friday 22 and Sunday 24."08:40
@kanzure"On Saturday, we will go practice aseptic technique, learn about different kinds of media, and then put new genes (DNA) into bacteria!  On Sunday 24, we will extract DNA or protiens from transformed bacteria and visualize it on an agarose gel.  Sign up HERE."08:41
@kanzurehow about a non-beginner bootcamp :|08:41
@kanzure"3rd postdoc bootcamp"08:41
Urchinlol08:42
UrchinI'm guessing these things are a bit advanced08:42
Urchin*I haven't talked to biologists in a while now08:43
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@kanzurenew! subscribe to ##hplusroadmap log digests by emailing sadrobot@gnusha.org09:08
Urchinwhy?09:24
@kanzuresorta kidding.09:26
UrchinI was actually considering putting my version of this log online09:27
Urchinit's a single file log that has the past 26 days at least09:27
@kanzurego for it09:28
Urchinjust a moment09:33
Urchinhttp://transhumanizam.fizika.org/hplusroadmap.log09:34
Urchinthere you go09:34
Urchin5.6 MB09:35
Urchinjust a warning09:35
Urchinand growing in real time09:35
Urchinand it starts in February09:36
@kanzureUrchin: if you want the previous years you could grab them from http://gnusha.org/logs/09:38
UrchinI have an older log somewhere09:39
Urchinat one point I had a couple of hundred MB of chat logs that I had to get off the server due to user quota09:41
Urchinand it's in a tarball somewhere09:41
Urchinmy current collection of logs is running at 100+ MB09:41
Urchinand that's from every channel I'm on09:42
archels"how to tell if you're an ircaddict"09:42
@kanzurei have a few gigs of various logs.09:42
Urchinthey don't let me have a few gigs here09:43
ThomasEgimy tar.gz'd logs are already 44megs09:43
@kanzureprison?09:43
Urchinshell server09:43
Urchin800 MB quota09:43
@kanzurewhen was that quota set? 1998?09:44
Urchinmore like 200809:44
Urchinthey got fed up with people downloading 20GB+ of stuff09:44
Urchinsoft limit is a bit over DVD size09:45
Urchinthere are hundreds of users (though most don't use it)09:46
Urchinthe quota could use a bit of expanding, truth be told09:49
Urchinthe disk seems to have grown09:49
Urchinbut, I do get the service for free, so...09:50
Mariuoh, nice09:53
Mariudownloading hardware09:53
Mariu@ Gnusha09:53
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thekoranbeltfuture civilization should have a barrier of entry11:01
thekoranbeltyou must be at least this + to enter11:01
Mariuwhat does + stand for ?11:02
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thekoranbeltthats the kicker11:17
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@kanzure"In August 2006, the United States Patent and Trademark Office (USPTO) ordered examiners to stop using Wikipedia as a source of information for determining the patentability of inventions."12:45
@kanzure"However, according to The Patent Librarian's Notebook's blog, examiners continue to cite it, and the number of United States patents issued in 2008 that cited Wikipedia articles nearly doubled to 477, compared to 2007.[20] It increased to 809 citations in 2009.[21]"12:46
not_unoriginalblobjectivity?12:46
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@kanzuregfp dinoflagellates at biocurious http://www.meetup.com/BioCurious/events/65346872/13:36
@kanzureoh nevermind13:38
@kanzurethey are naturally bioluminescent. how disappointing :P13:38
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@kanzurefuck udacity :(16:28
@kanzurehttp://www.youtube.com/watch?feature=player_embedded&v=5LrTUeawyfI16:28
@kanzurefriend of mine is learning python16:28
@kanzurethis is *not* how you parse html16:28
@kanzureraaawwwrr :V16:28
chris_99?16:29
Mariulol16:30
browniesto be fair, most people just flat out shouldn't parse HTML16:35
chris_99how do you parse html16:36
chris_99oh theres a video16:36
@kanzureyou should parse html with a library, like lxml or beautifulsoup16:38
@kanzureyou should never find yourself writing your own html parser16:38
@kanzureif that happens, you have done something terribly wrong16:38
chris_99it depends what your doing, if you want something simple you could hack up a regex16:38
@kanzureno! never use a regexp to parse html.16:39
chris_99for a simple script its ok16:40
chris_99html is a kludgy mess anyway16:40
@kanzureyou know what's even simpler? "import beautifulsoup"16:40
browniesbsoup is really quite nice16:41
chris_99ideally we should be able to use a nice xml parser16:41
@kanzurethat's what it is.16:41
chris_99not exactly16:41
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browniesthe problem is that there is a lot of HTML out there that is not well-formed16:42
browniesbrowser-makers correct for it in the rendering process, so it happily goes on existing16:42
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chris_99some of you guys use django/rails right?17:08
@kanzureyes17:09
@kanzurei use both.17:09
chris_99do those have a way to compile all files to bytecode?17:10
@kanzurepython has its own bytecode format (".pyc")17:14
@kanzurebut that's probably not what you mean?17:14
chris_99sort of i mean is there a way to bundle all the bytecode together, without needing any source files17:16
@kanzurewhy would you want to do that17:18
chris_99well i'm sort of curious, as if it's not dependant on the source, why can't it do that17:19
chris_99but maybe it is dependant on the source17:19
chris_99to put it more clearly17:20
chris_99i want to see if all my source can be compiled cleanly17:20
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ParahSailinyou want to distribute something without the source?17:32
chris_99no17:35
chris_99i want to compile all source17:35
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delinquentmeanyone else started reading theils #17 class notes?17:52
delinquentmeI think some of his thoughts on AI development are very very large ( ? ) steps.17:53
yashgarothwhat/where17:53
@kanzurechris_99: in general, you shouldn't think about compiling python or ruby source code17:57
@kanzureinternally, there's a byte code for their VMs but that's not particularly useful for you17:58
chris_99guess i'll stick to java for the time being18:00
@kanzurewhy?18:01
@kanzurei don't understand.18:01
@kanzuremaybe i've misrepresented something to you.18:01
chris_99i like the idea of being able to know all my source files are syntactically correct18:03
@kanzureit will tell you if it's wrong.18:04
chris_99for all files? even if you don't execute that specific method?18:05
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@kanzurechris_99: correct18:07
chris_99cool18:07
@kanzureif you load it into the environment, then yes it will check it18:07
@kanzurebut if you load code later, like "randomfile.rb" randomly, it will only check that at runtime18:07
@kanzurei mean.. erm.18:07
@kanzureif in one of your methods, you include a file..18:07
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chris_99ah, so django or rails will compile all files to bytecode for you?18:10
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chris_99when they change18:10
chris_99time for bed, cheers for the heads up18:14
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@kanzureruby/python both have to interpret the source code somehow, this is how interpreters work18:17
@kanzurei am probably making this too complicated for chris_9918:18
@kanzuremost django/rails users aren't expected to care about these things18:18
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delinquentmeyashgaroth,  A leading candidate for an invisible barrier in AI is the complexity of the code. The might be some limit where the software becomes too complicated as you produce more and more lines of code.19:08
delinquentmeare we at the point now where codebases are too complex?19:08
yashgarothis this peter thiel or some other thiel19:08
delinquentmeOk then what do we do with them19:08
delinquentmepeter thiel19:08
delinquentmeI say the code base is then replaced with something manageable19:09
delinquentmeor refactored19:09
delinquentmeand better tools are developed19:09
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delinquentme" codebase too big " is too absolute19:09
delinquentmealso his take on biotech being heavily regulated19:10
delinquentmesure once you're into clinical19:10
delinquentmebut literally you can put anything in a lab and run it19:10
delinquentmehence why people are biohacking19:10
yashgarothehh not so much, biohackers haven't done much beyond glowing bacteria...on the wetwork side at least19:11
notunoriginalAFKare you serious?19:11
yashgarothwho, me?19:11
notunoriginalAFKcheck out a forum devoted to body building or nootropics19:12
notunoriginalAFKpeople are buying strange powders or peptide molecules and injecting them or otherwise ingesting them19:12
yashgaroth1 that's not in a lab 2 it's not genetic engineering, which I'd consider to be biohacking; if you want to take that angle, drinking coffee is "biohacking"19:13
yashgarothpeptides/proteins, with the exception of the rare genuine HGH, are a scam19:14
notunoriginalAFKokay so biohacking refers to a very small sliver of human biological experimentation19:14
yashgarothsomething beyond steroids and stimulants, yes19:15
atumlsd19:15
atumdmt19:15
atumthat sort of stuff?19:15
yashgaroththough of course the people at grindhouse seem to think anything subdermal is automatically "bio"hacking19:15
notunoriginalAFKnootropics.19:15
yashgarothyes, commonly available drugs19:15
yashgaroththere's no DIY science in those, beyond measuring dose response and other banal shit19:16
yashgarotheveryone seems to have a different opinion of biohacking's definition, much like with transhumanism19:17
notunoriginalAFKI mean tabletop home pcr is neat I guess19:18
notunoriginalAFKlab-on-a-chip under $n is going to be the turning point19:18
yashgarothoh totally, but I can buy some old used PCR machine off ebay, sometimes for less than whatever kickstarter is manufacturing one19:18
notunoriginalAFKand then what.19:19
notunoriginalAFKbbl dog walk time19:19
yashgarothwell sure with accessible microfluidics you lower a lot of a barriers19:19
yashgarothbut back to delinquentme, you can't really do 'anything' in a lab...it's just that clinical GMP manufacturing is so tightly regulated as to be absurd19:20
delinquentmeyashgaroth, when I say 'anything'19:21
delinquentmei mean that theres no regulation19:21
delinquentmeyou dont need to be UL tested19:21
yashgaroththere are theoretically inspections by the fire dept., and if you're receiving 'hazardous' materials there is another level of requirements19:22
delinquentmewell yeah thats employee health19:22
delinquentmeI mean you're not going through FDA approval to make a machine that you can use commerially in a lab19:23
yashgarothand environmental protection - I was annoyed to find that triton x-114 is technically hazmat19:23
delinquentmecommercially **19:23
yashgarothmachinery is much less strict19:23
yashgarothok I found his class notes19:24
yashgarothfor those following along at home, http://blakemasters.tumblr.com/post/24464587112/peter-thiels-cs183-startup-class-17-deep-thought I guess19:25
atumif you want noots get em from hong kong19:25
atummayeb set up somethign to test them on arrival19:25
yashgarothI don't have a problem sourcing them locally19:26
delinquentmesonicator is the instrument i was gonna say19:26
delinquentmelike you rig up a back massager into a sonicator19:26
delinquentmeno one is stopping you .. unless you've got clearly ghetto rigged wires and obviously bad priactices19:27
delinquentmeyashgaroth, yeah it looks like i failed w the link19:27
yashgarothsure but you're not working with any sort of chemicals, so the government doesn't give a fuck19:27
delinquentmebut thats HUGE19:27
delinquentmeHUUUGGGEEE19:27
delinquentmeeveryone and their stupid ass group think " biotech takes long time "19:27
delinquentmepharma and the FDA take along time19:27
yashgaroththe equipment doesn't19:28
delinquentme=]19:28
delinquentme<319:28
atumwerd, and pharma and the fda are part of the problem19:28
atumnot the solution19:28
yashgarothwaiting for a significant clinical outcome does, at least according to the FDA19:28
atumregulation is for commies19:28
atumi want to throw science at the wall and see what sticks19:29
yashgarothhey man I'm a commie and I still think clinical trials are a massive overexpense19:29
yashgarothten years, a billion dollars each...and most of them fail anyway19:29
yashgarothR&D is expensive, but not compared to human testing19:29
atumso let people compete for a chance to become test subjects19:30
atummaybe they already do19:31
yashgarothsure, if they have the disease19:31
atumwell, theres the first come first serve clinical trials19:31
yashgaroththe regulation around running the clinical trial is what takes the expense, you're not paying the test subjects19:31
atumwhere they pay the subjects19:31
delinquentmeatum, lolol19:31
yashgaroththey only pay for the phase 1 safety testing in healthy people19:32
delinquentmei too feel that these regulations are put forth by fascists19:32
atumi was thinking about portal, and then remembered ppl do go to these trials19:32
@kanzurei haven't seen any proposals for an alternative to the FDA19:32
delinquentmeLets just bomb some of it on the islands that still have feral people19:32
delinquentmesee what happens19:32
@kanzureyou don't want snakesoil salesmen like "reasonattl" from fightaging.org19:32
atumwerd19:33
atumhey america was built on snake oil19:33
yashgarothjust like I haven't seen an alternative to the patent system :/19:33
atumwasnt that rockefellers first gig19:33
atumor carnagie19:33
atumone of the maganates19:33
delinquentmeOh no im just saying that biotech != FDA and the pharma approval times19:33
atumwerd19:34
yashgarothit's = for biopharma19:34
atumregulation is only for ppl that want to play in the system19:34
@kanzureyashgaroth: the patent system isn't to protect you from snakeoil19:34
atumbiotech can easily be done underground and have much faster results19:34
delinquentmeits to ensure proper pricing and margins on snakeoil19:34
yashgarothno, patents provide a way to get funding for research19:34
@kanzureok, so again, i don't see why "just like I haven't seen an alternative to the patent system" is relevant19:35
atumits quite likely that there are clandestine facilities where research is advanced and not regulated19:35
@kanzureand plus, sure you have (no patets at all)19:35
@kanzure*patents19:35
atumblack budget facilities or something19:35
atummaas biotech19:35
@kanzureatum: i haven't seen any.19:35
yashgarothbecause you can't just replace either system because it'd be good to do so19:35
@kanzuremost of the clandenstine drug labs are barely operational19:35
atumand youve been around a bit you say kanzure19:35
@kanzurebut this is because of economic incentivizes to not be large19:36
@kanzure(i.e. if you're too large it's much easier to be found by authorities, unless you're not selling anything of course..)19:36
atumwerd, because there is no benifite to making a secret drug unless its designed to kill19:36
@kanzurewhat?19:36
@kanzurewtf?19:36
@kanzurewho are you anyway19:36
atumie; race specific bioweapons failure19:36
yashgarothuhhh19:37
delinquentmehttp://vimeo.com/4343103519:37
delinquentmetactus .. tactile buttons from your smartphone screen19:37
@kanzuremeh19:38
@kanzuretactus was spamming the open manufacturing list19:38
@kanzurei blocked them.19:38
yashgarothdat narrator19:38
atumno ones going to let you use a chemical weapon in conventional theatre., so theres no point in developing it in secret. so --- as you say this is because of economice incentives to not be large19:38
@kanzureno, i wasn't talking about weapon development19:38
@kanzurei was talking about meth labs.19:38
atumoh19:39
@kanzurethe larger your economic footprint, the easier it is to be found out.19:39
atumsame thing19:39
atumamirite19:39
@kanzurenope.19:39
atumwell thanks to the war on drugs meth production has moved into mexico19:39
atumnow its a cia business19:39
atumproblem solved19:39
atumOUTSOURCE19:39
@kanzureit hasn't all moved into mexico, no.19:39
atummethtowns are aweful19:39
atumsort of like crack is weaponized cocaine - bad for some people, but otherwise good for business19:40
-!- mode/##hplusroadmap [+o yashgaroth] by kanzure19:41
@kanzureyou deal with this19:41
* kanzure goes back to coding19:41
@yashgaroththe power19:41
atumive done enough meth to know how bad it is19:41
atumwhen i lived in arkansas the bomb squad and hazmat would go by once a month or so19:41
atumbusting up a lab19:41
@yashgarothI lost the thread of this conversation a while ago19:42
@kanzurefff19:42
delinquentmekanzure, so i sent a message to the genome compiler guy and basically told him that I dont think he wants a photoshop for synthetic biology but instead a automation pipeline19:43
atumthere was a misunderstanding about the nature of the labs initially19:43
atumbut otherwise like new19:43
@yashgarothI don't wanna do it19:43
delinquentmehe replied that we basically lack the hardware integration19:43
@kanzuredelinquentme: that guy isn't very bright. he built his whole company around Adobe Air19:43
@kanzureyeah, he's not a hardware guy if he's using adobe air19:43
delinquentmelol kanzure i mean its a tool19:43
@kanzurei don't have a lot of respect for him19:43
delinquentmeit works and he likes UIs because hes a scientist19:43
@kanzurei think he's a non-hardware non-software person19:43
@kanzureno he's not19:43
delinquentmea scientist?19:44
@kanzureyes, it seems all superficial19:44
@kanzurehe's trying to sell you something anyway (proprietary, crappy UI software)19:44
delinquentmei thought hes got a PHD19:44
@kanzuredoesn't seem to do him much good man19:44
delinquentmewell i like the idea19:44
delinquentmehow about you?19:44
@kanzureyou just like it because it has 'compiler' in the name19:44
@kanzurejust because it's called compiler doesn't mean it's an actual compiler19:44
@kanzuremost of those tools already exist as open source software out there19:44
delinquentmeabsolutely thats the hardware part19:44
@kanzureevery year the 'clotho' guy pops up and starts spamming people about how amazing his UI is19:45
delinquentmehes got a genome autocad or something like that19:45
@kanzurenot really19:45
@kanzurei mean, he claims it is, but who cares19:45
@kanzureif it's any good, it means i have to rewrite it anyway since it's proprietary19:45
@kanzurefuck that19:45
@kanzurehe's just increasing the amount of work i have to do later19:45
@kanzurebleh19:46
delinquentmewell the point was19:46
delinquentmehardware19:46
atumyout a couple protiens in a petrii dish and have them do math19:46
@kanzuredelinquentme: he's not a hardware person, i don't trust his opinion about hardware19:46
atumhow hard would it be to take a couple really long strings and dip them in the pool of life19:46
@kanzuredelinquentme: all sorts of hardware is hackable. he's lying to you.19:47
delinquentmekanzure, lets step away from the ad hominem19:47
delinquentmeok i get it you dont like *HIM*19:47
@kanzureif he's telling you that hardware interfaces are impossible, he's still ying to you19:47
@kanzure*lying19:47
delinquentmebut if hes got thourough mappings of metabolic pathways?19:47
delinquentmeno19:47
delinquentmewhere are you getting this?19:47
delinquentmeslow down19:47
@kanzureyou said it19:47
@kanzure19:43 < delinquentme> he replied that we basically lack the hardware integration19:47
delinquentmelacking != impossible19:48
@kanzureare you saying that his /company/ is lacking it19:48
delinquentmeim saying that I think the market wants it19:48
@kanzurewants what?19:48
delinquentmeOOC are metabolic pathways out there?19:48
@kanzureand what is "the market"19:48
delinquentmelike can I get a codified version of ecoli metabolic pathways?19:49
@kanzurei'm just trying to get you to be more precise about your thinking19:49
@kanzure"the market" is a vague way of waving your hands aimlessly19:49
@kanzureyes, people in general like computers to be hooked up, it's true19:49
delinquentmeyeah so I mean if hes building a software package for 1 off ecoli modifications19:50
@kanzurebut what you need to do- like we've been telling you for months now- is get a number of people to sign statements saying they will pay $X,000 for your hardware19:50
delinquentmethats not the end goal19:50
delinquentmethe end goal is specify inputs and outputs and the model organism and to have machines crunch, sequence, synthesize, insert incubate test and quantify19:50
delinquentmeover and over until we've got candidates we're interested in19:50
delinquentmehence why I told him I think he should be less interested in a UI and more interested in a software pipeline for these processes19:51
@kanzurei don't think he's a software guy, he probably doesn't understand that.19:51
atumfox p219:51
atum-that gene alone is responsible for language19:52
@kanzureatum: not really. foxp2 is responsible for many things.19:52
atumoh im repeating the television, watching some show about ... genes and what not19:52
@kanzurelike in lung/gut19:52
@kanzureok television is probably not the most accurate source of biology knowledge :P19:53
atumobv :P19:53
delinquentmeok but back to the metabolic pathways19:53
@kanzureare you describing software you're writing?19:53
delinquentmeis there some kind of codified map of the ecoli metabolic pathways19:53
@kanzurethis is what ncbi is for. go look up kegg or the other kegg-replacements.19:53
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delinquentmeOHHHH kanzure did i tell you about the busted NCBI data?19:54
delinquentmeI found a number of papers which had missing information and I emailed them with completed information sets and cites19:54
delinquentme" If we dont get it from the publisher it doesn't go in there "19:54
delinquentmeso yeah theres are a number of papers in there with missing DOIs which have them but only outside of NCBI19:55
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