| --- Log opened Sat Sep 29 00:00:40 2012 | ||
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| @kanzure | you guys are all boring | 05:01 |
|---|---|---|
| chris_99 | i just found out how the little micro-hybdrid rockets work, and they sound kind of nifty. They use nitrous oxide + PVC as the fuel source. | 05:15 |
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| wizzbrah | [08:01] <@kanzure> you guys are all boring | 08:33 |
| wizzbrah | <3 | 08:33 |
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| @kanzure | https://groups.google.com/group/londonbiogeeks | 11:10 |
| @kanzure | this just seems weird: | 11:11 |
| @kanzure | http://2012.igem.org/Team:University_College_London/HumanPractice/DIYbio/DIYbio | 11:11 |
| @kanzure | "Common activities: genetic engineering" | 11:11 |
| @kanzure | "Desired activities (not feasible persently): synthetic biology" | 11:11 |
| @kanzure | what? | 11:12 |
| chris_99 | yeah and then thay say ' No genetic modification possible due to tight European regulations ' | 11:12 |
| chris_99 | er what | 11:12 |
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| chris_99 | does anyone know if http://diybio.madlab.org.uk/ is any good | 11:14 |
| @kanzure | well, they seem to run lots of public outreach sessions at their space in the uk | 11:17 |
| @kanzure | and they seem to have some weird background in television/public outreach/news. | 11:17 |
| chris_99 | hmm, i'm confused if they're still active, as their last blog post seems to be in july | 11:18 |
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| @kanzure | chris_99: yeah they just suck at posting updates | 11:18 |
| @kanzure | i think they post most of their updates through the bbc :P | 11:19 |
| chris_99 | ah hehe | 11:19 |
| @kanzure | pasky: have you met prusa? | 11:39 |
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| gnusha | nanoengineer.git: 1331640 shouldn't list names without the contributors in a README | 12:27 |
| @kanzure | aww "We don't yet support double or triple bonds..." | 12:43 |
| brownies | just like the early universe! | 12:53 |
| @kanzure | brownies: https://github.com/kanzure/nanoengineer/blob/master/cad/src/model/assembly.py#L1663 | 12:55 |
| @kanzure | legacy code is the worst | 12:55 |
| pasky | kanzure: sure, he used to come to brmlab fairly frequently | 13:08 |
| pasky | not so often lately though | 13:08 |
| chido | he gave me a reprap badge | 13:13 |
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| @kanzure | ah neat | 13:19 |
| @kanzure | okay then | 13:19 |
| @kanzure | "Hello, I'm Ki Sang Jung from HK. I wish to introduce to you a profitable deal worth USD $ 98.6M, it's legitimate and may be of appeal to you. I want your consent to enable me provide you with detail." | 13:35 |
| @kanzure | .. and it's sent from a brazilian email provider. | 13:35 |
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| eudoxia | h+ magazine almost had three consecutive articles asking for money | 13:47 |
| eudoxia | i think that's a new record | 13:47 |
| @kanzure | wtf why are you reading that | 13:48 |
| @kanzure | also did you check out the mocking branch in nanoengineer? | 13:48 |
| eudoxia | sometimes my blood pressure gets too low | 13:48 |
| eudoxia | no, what does it do? | 13:49 |
| eudoxia | or, rather, have | 13:49 |
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| @kanzure | eudoxia: it disables all of the graphics libraries and makes nanoengineer run on modern linux with python2.6 | 13:55 |
| eudoxia | what do you mean 'disables the graphics libraries'? | 13:55 |
| @kanzure | https://github.com/kanzure/nanoengineer/commit/697d64c22b457b8470608c7de8d5540785a81c85 | 13:56 |
| eudoxia | kanzure it looks like it couples some of the OpenGL with a python testing library? | 13:59 |
| @kanzure | correct. this way the gui stuff doesn't get in my way. | 13:59 |
| @kanzure | don't pull that branch because it's craptastic. i might make it a mode or something before i start moving things into separable modules. | 14:00 |
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| @kanzure | nmz787: hi | 15:59 |
| nmz787 | hi | 16:22 |
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| nmz787 | so i may get to meet george church at genspace next thurs | 17:47 |
| nmz787 | apparently he's gonna be there in the AM | 17:47 |
| nmz787 | since he's on their scientific board | 17:47 |
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| @kanzure | i wonder how good his memory is | 17:54 |
| @kanzure | sometimes it seems like he's the sort of guy to forget 50 out of 60 of the companies he's invested in | 17:54 |
| yashgaroth | invested? I thought they paid him | 17:56 |
| @kanzure | oh right, yes that too | 17:57 |
| @kanzure | but i'm pretty sure he has his own money that he throws around a little | 17:57 |
| @kanzure | boop beep | 18:25 |
| eudoxia | beep bopity bop | 18:25 |
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| @kanzure | re: pharma costs | 22:48 |
| @kanzure | "it's closer to $1 billion on average." | 22:48 |
| @kanzure | "In the March 2003 edition of the Journal of Health Economics, a trio of economists from the United States wrote about a number. Soon after, that number began popping up all over the place — in newspapers and political speeches, on television and the Internet." | 22:48 |
| @kanzure | "But the figure, despite reaching near-canonical status, drew criticism. Some said it was inflated. Less diplomatic detractors said it was a 9-digit fairy tale." | 22:48 |
| yashgaroth | oh, per drug? yeah | 22:48 |
| @kanzure | "That number was 802,000,000. It was, according to the 2003 study, the number of US dollars that pharmaceutical companies spent, on average, to bring a new drug to market (J Health Econ 2003;22[2]:151-85)." | 22:48 |
| @kanzure | "Now there are new numbers. Some health economists peg the current cost of drug development at US$1.3 billion, others at US$1.7 billion. | 22:49 |
| @kanzure | "... the data used to come up with the original number came from an industry financed source and was not made public." | 22:49 |
| @kanzure | "When I was working at a big pharma company, I heard about a new manufacturing site they had built in anticipation of a really big drug being approved. The cost? Several hundred million dollars." | 22:50 |
| @kanzure | "What happen when the drug got rejected by the FDA? The manufacturing site was written off (couldn't really be used to make anything else)." | 22:50 |
| @kanzure | uh.. someone needs to go hijack those phantom pharma factories. | 22:50 |
| @kanzure | http://www.pharmalot.com/2011/07/clinical-trial-costs-for-each-patient-rose-rapidly/ | 22:50 |
| @kanzure | http://csdd.tufts.edu/research/research_milestones | 22:50 |
| @kanzure | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630351/ | 22:51 |
| @kanzure | http://www.theglobeandmail.com/life/health-and-fitness/drug-rd-costs-are-less-than-estimated---so-why-the-high-prices/article623054/ | 22:51 |
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| yashgaroth | well I'm only gonna read that last article cuz it's late, but they don't seem to consider the cost of the ~90% of drugs that fail in clinical trials | 22:55 |
| @kanzure | well, let's consider commando pharma | 22:56 |
| @kanzure | guerrilla pharma | 22:56 |
| @kanzure | so let's say we ignore the FDA, and uh, ignore phases 3 and 4? | 22:56 |
| @kanzure | and possibly ignoring phase 2 | 22:57 |
| @kanzure | and let's also say that you don't include all your failed terrible decisions in the price of it | 22:57 |
| yashgaroth | 10 mil, maybe 5, which I base on very little | 22:58 |
| yashgaroth | that also depends on a how much basic research has been done on the target | 22:59 |
| yashgaroth | I can neither confirm nor deny that a phase 1 trial's worth of drug will cost approximately 1 mil to produce at GMP specifications, and 5 mil for a phase 2 | 23:00 |
| yashgaroth | and that GMP costs about 5-10x more than quasi-GMP production, ignoring the large equipment capital | 23:02 |
| yashgaroth | by 'quasi' I mean 99% safe, rather than 99.9% | 23:03 |
| yashgaroth | for true underground pharma, or whatever we're calling it, I suppose you could look at certain large asian countries that don't respect foreign patents | 23:04 |
| yashgaroth | for a more accurate portrayal of cost, anyway | 23:04 |
| yashgaroth | not that they do much reliable basic research there, no offense to said countries | 23:05 |
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| yashgaroth | anyway I'm out for the night, here have this http://www.theonion.com/articles/munchstrosity-created-in-fritolayboratory,29587/ | 23:13 |
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| nmz787 | kanzure: awake? | 23:45 |
| --- Log closed Sun Sep 30 00:00:41 2012 | ||
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