| --- Log opened Mon Feb 25 00:00:10 2013 | ||
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| archels | If you are a member of an underrepresented ethnicity in science, please indicate below: | 00:25 |
|---|---|---|
| archels | fucking postive discrimination. this pisses me off | 00:25 |
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| archels | paperbot: http://prl.aps.org/pdf/PRL/v66/i25/p3229_1 | 02:07 |
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/bbcaf06ae8c579b591a35716bb40f247.txt | 02:07 |
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| archels | "Effect of micronisation of pre-conditioned cowpeas on cooking time and sensory properties of cooked cowpeas" | 04:25 |
| archels | science. | 04:25 |
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| ThomasEgi | http://xkcd.com/54/ | 04:28 |
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| @fenn | that paper on kidney selling practices is pretty grim | 08:53 |
| @fenn | i wonder how much a child goes for wholesale | 08:54 |
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| @fenn | padz: please fix your connection | 09:07 |
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| ielo | how many different ways are there of arranging nothing, or an empty set (if they are equiv)? is it 0 or 1? | 15:32 |
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| @kanzure | yashgaroth: hi. | 16:40 |
| yashgaroth | yo | 16:40 |
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| cpopell | yashgaroth : See the news about the solid state sequencer? | 17:17 |
| yashgaroth | nope | 17:17 |
| cpopell | Nabsys claims 1m nucleotides/s for targeted sequences | 17:18 |
| cpopell | http://www.technologyreview.com/news/511311/solid-state-sequencer-debuts-at-genome-conference/ | 17:18 |
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| yashgaroth | sounds interesting, so they detect binding to an oligo and then somehow pinpoint that to a specific part of the sequence being read, then do that a million times | 17:21 |
| nsh | yoleaux! | 17:40 |
| yoleaux | nsh! | 17:40 |
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| nmz787 | jrayhawk: http://www.nytimes.com/2013/02/24/opinion/sunday/what-really-causes-celiac-disease.html?src=me&ref=general&_r=0 | 18:03 |
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| nmz787 | kanzure: so what's your opinion on what country to get transplant work done in? | 18:05 |
| nmz787 | kanzure: any stats on thailand? | 18:05 |
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| nmz787 | kanzure: I was in a mod hospital there once, they simply had a flip book of the different before/after pics at their front desk with prices | 18:06 |
| nmz787 | it seemed very professional and straightforward | 18:06 |
| @kanzure | the flipbook seemed professional? | 18:10 |
| @kanzure | obv. they used LaTeX | 18:11 |
| @kanzure | no i don't have any specific countries to recommend | 18:11 |
| @kanzure | apparently, not china. | 18:11 |
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| nmz787 | the whole place was professional | 18:11 |
| nmz787 | seemed india wasn't too bad pricewise | 18:12 |
| nmz787 | from just what you wrote | 18:12 |
| @kanzure | i have no idea how those people decided how to price their organs | 18:12 |
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| nmz787 | jrayhawk: "In rats, the E. coli again intensified inflammation to gluten, prompting whats sometimes called a leaky gut the milieu suspected of contributing to celiac disease. Conversely, bifidobacteria protected the intestinal barrier. Microbes, it seemed, could influence the immune response to gluten." | 18:23 |
| nmz787 | "Bifidobacteria occur naturally in breast milk, which, along with protective antibodies and immune-signaling proteins, conveys hundreds of prebiotic sugars. These sugars selectively feed certain microbes in the infant gut, particularly bifidobacteria. Breast-fed infants tend to harbor more bifidobacteria than formula-fed ones." | 18:23 |
| nmz787 | my mom says I was breastfead til I was 3 | 18:24 |
| nmz787 | "Dr. Ivarsson found that, during the epidemic, the longer children breast-fed after their first exposure to gluten, the more protected they were." | 18:25 |
| nmz787 | "Dr. Fasano of Boston has made another potentially important find. He followed 47 at-risk newborns, regularly collecting microbes from 16 of them, which he analyzed after two years. Like Dr. Sanz, he found these genetically at-risk children to accumulate a relatively impoverished, unstable microbial community." | 18:27 |
| nmz787 | But its a secondary observation that has Dr. Fasano particularly excited. Two of these children developed autoimmune disease: one celiac disease, another Type 1 diabetes, which shares genetic susceptibility with celiac disease. In both cases, a decline of lactobacilli preceded disease onset. | 18:28 |
| nmz787 | "The caveats here are numerous: the tiny sample size in Dr. Fasanos study; Dr. Sanz hasnt yet revealed who actually developed celiac disease in her cohort; and even if these microbial shifts reliably precede disease onset as they do in larger studies on allergic disease theyre still bedeviled by the old chicken or the egg question: Which comes first, the aberrant microbial community, or the aberrant immune response?" | 18:29 |
| nmz787 | "Not all breast milk is the same. It varies according to diet and other factors. One study found that milk from overweight mothers had fewer of those bifidobacteria than milk from thinner mothers. Another observed that breast milk from farming mothers, who inhabit a microbially enriched environment, carried more anti-inflammatory proteins compared with urban mothers milk. All these things are going to matter, Dr. Jabri says. And theyre all potential | 18:29 |
| nmz787 | "We could probably prevent celiac disease if we just give the same environment to the Finnish children as they have in Karelia, says Dr. Hyoty. But theres no way to do it now, except to move the babies there. | 18:30 |
| nmz787 | " | 18:30 |
| nmz787 | sooo | 18:30 |
| nmz787 | you don't like celiac, go to russia | 18:30 |
| nmz787 | seems going to russia is a great excuse anytime you don't like something | 18:31 |
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| jrayhawk | IIRC there's a certain parasite that can trigger anti-gliadin antibodies, too. | 19:27 |
| jrayhawk | Giardia | 19:28 |
| jrayhawk | antitransglutaminase specifically. | 19:30 |
| jrayhawk | http://scholar.google.com/scholar?q=giardia+celiac The literature on the subject is kinda interesting. | 19:31 |
| jrayhawk | They're cystic intestinal parasites; it would kinda make sense for the immune system to learn to attack the enterocytes as a result. | 19:33 |
| @kanzure | when are we going to capitalize on eric hunting's piles of text? | 19:33 |
| @kanzure | i suppose he might not appreciate that, hrm | 19:33 |
| @kanzure | https://groups.google.com/group/openmanufacturing/browse_thread/thread/2b6794b51f9a8209 (cigarette vending machines) | 19:33 |
| jrayhawk | But yeah, increasing susceptibility to gut pathologies pissing off the adaptive immune system would certainly explain the enormous increases in celiac prevalance. | 19:35 |
| nmz787 | ahh so you'r ont saying celiacs patients should go get giardia to cure their celiacs | 20:06 |
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| @kanzure | "I know some local biotech companies have snack machine turned freezer machine with DNA ladders, plasmids, buffer, etc etc" | 20:17 |
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| nsh | which is to say "i made this thing up but it sounded plausible enough that i thought i'd pretend it was real" | 20:21 |
| nmz787 | kanzure: NEB has lots of freezer programs, which /wants/ to be as cool as that sounds | 20:23 |
| nmz787 | but unfortunately they only allow purchasing within the institution where the freezer is located | 20:24 |
| @kanzure | i know, it's disappointing. | 20:24 |
| nmz787 | so U of R had an NEB freezer, but as an RIT researcher I couldn't buy supplies from the local freezer and avoid shipping costs, I had to mailorder from Massachusetts | 20:24 |
| klafka | what is NEB | 20:25 |
| yashgaroth | new england biolabs, they sell enzymes | 20:25 |
| @kanzure | evil organization bent on planetary conquest | 20:25 |
| yashgaroth | are you sure you were formerly a biologist klafka | 20:25 |
| klafka | aah | 20:25 |
| klafka | nope | 20:26 |
| @kanzure | he was a bioinformaticist, it's the lesser type of biologist | 20:26 |
| klafka | i was formerly a computational biologist | 20:26 |
| @kanzure | :P | 20:26 |
| klafka | or bioinformaticist | 20:26 |
| yashgaroth | heh | 20:26 |
| @kanzure | "lesser" | 20:26 |
| klafka | lol | 20:26 |
| klafka | i would never want to be a real biologist | 20:26 |
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| yashgaroth | they're the default source for restriction enzymes, and restriction enzyme accessories | 20:27 |
| @kanzure | and gibson assembly mix | 20:27 |
| @kanzure | maybe paperbot should get a friend, reagentbot | 20:28 |
| klafka | aah | 20:29 |
| nsh | you're being americocentric | 20:33 |
| nsh | jus' sayin. | 20:33 |
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| yashgaroth | who is and what about | 20:35 |
| nsh | kanzure, about reagent sources. | 20:36 |
| nmz787 | kanzure: i'd have some code for reagentbot | 20:36 |
| nmz787 | for scraping prices from promega (if they haven't changed too much) | 20:36 |
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| @kanzure | because of the planetary conquest comment? | 20:38 |
| nmz787 | klafka: think you'll need a bioinformatician with a B.S. only in the next 6 mos? | 20:44 |
| klafka | no | 20:44 |
| klafka | i don't work in biology at all anymore | 20:44 |
| nmz787 | klafka: i know a guy who might be looking for something around the bay | 20:44 |
| nmz787 | klafka: i thought you work at a bioinformatics company | 20:44 |
| klafka | nah i work for a mobile gaming startup | 20:44 |
| nmz787 | oh | 20:45 |
| nmz787 | geeze | 20:45 |
| klafka | money is way better and the data is way cleaner | 20:45 |
| @kanzure | it's ParahSailin that works at a bioinformatics company | 20:45 |
| nmz787 | i should have directed that to someother digital handle then | 20:45 |
| nmz787 | :P | 20:45 |
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| @kanzure | "Jython 2.7beta 1 Has Been Released (February 10, 2013)" | 21:11 |
| @kanzure | so uh.. jython seems a little behind? | 21:11 |
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| jrayhawk | paperbot: http://ajcn.nutrition.org/content/95/5/1238.full | 22:48 |
| paperbot | error: HTTP 500 http://diyhpl.us/~bryan/papers2/paperbot/Protection%20of%20LDL%20from%20oxidation%20by%20olive%20oil%20polyphenols%20is%20associated%20with%20a%20downregulation%20of%20CD40-ligand%20expression%20and%20its%20downstream%20products%20in%20vivo%20in%20humans.pdf | 22:48 |
| nmz787 | is there a 3D scanning channels? | 22:49 |
| @kanzure | irc channel? | 22:49 |
| @kanzure | there's #makerscan but i bet #reprap would be more helpful | 22:50 |
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| --- Log closed Tue Feb 26 00:00:11 2013 | ||
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