| --- Log opened Sun Apr 28 00:00:10 2013 | ||
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| @kanzure | http://medsforbitcoin.com/ has modafinil and armodafinil | 01:50 |
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| @kanzure | ParahSail1n: wanna do a black market antibody service | 01:50 |
| @kanzure | also.. with apologies for linking to io9, http://io9.com/5899339/the-science-behind-counterfeit-cancer-drugs | 01:55 |
| @kanzure | "This week, U.S. officials intercepted 120 vials of fake Avastin, created by devious individuals looking to make a quick buck. It's easy to see why the crooks targeted this drug: A single year of therapy with a monoclonal antibody, like Avastin, can cost upwards of $100,000 a year in many cases." | 01:55 |
| @kanzure | "The high cost of monoclonal antibody therapies makes vials a bizarre target for counterfeiting. Turkish counterfeiters replicated the packaging for bevacizumab (marketed by Roche as Avastin), a monoclonal used in cancer therapy, and sold the vials to hospitals." | 01:55 |
| @kanzure | "February 2012 reports of the counterfeit monoclonal therapies centered around vials found in the U.S., while a second batch of fake vials Avastin landed in North America via the United Kingdom in April 2012. The thieves made a large amount of money in the process, while depriving patients of care, as the bottles inside the packaging likely contained saline instead of lifesaving antibodies." | 01:55 |
| @kanzure | wait.. what? that's not counterfeiting. | 01:55 |
| @kanzure | i'm really disappointed by the turks now. | 01:55 |
| @kanzure | also i meant to add a question mark after service. | 01:57 |
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| @kanzure | pfft the biotech industry is arguing that because isolated dna isn't wrapped around histones that it's a novel molecule. | 02:02 |
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| Mokstar | anybody got a vertical float tank design? | 03:59 |
| Mokstar | either that or I'm gonna have to learn to do math | 04:00 |
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| ParahSail1n | kanzure, im reading up on ranibizumab vs bevacizumab | 06:57 |
| ParahSail1n | r..ab isproduced in e coli | 06:57 |
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| ParahSail1n | great, they give you the peptide sequences for the variable domains http://www.google.com/patents/US7375193?dq=genentech+vegf&hl=en&sa=X&ei=Tyt9UYPzNcTL2QWk4IFY&sqi=2&pjf=1&ved=0CFEQ6AEwCQ | 07:04 |
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| ParahSail1n | thats pretty cool http://wiki.gekgasifier.com/w/page/6123754/How%20to%20Build%20and%20Run%20the%20GEK%20Gasifier | 07:22 |
| ParahSail1n | they also sell units | 07:22 |
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| ParahSail1n | paperbot, http://www.nature.com/nbt/journal/v28/n9/full/nbt0910-883a.html | 07:48 |
| paperbot | HTTP 401 unauthorized http://www.nature.com/nbt/journal/v28/n9/pdf/nbt0910-883a.pdf | 07:48 |
| ParahSail1n | "Enbrel is marketed as a lyophylized powder in 25 mg vials which must be reconstituted with a diluent and then injected subcutaneously, typically by the patient at home." | 07:54 |
| ParahSail1n | i wonder if avastin could be administered this way | 07:54 |
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| @kanzure | ParahSail1n: so that's a yes? | 12:14 |
| ParahSail1n | which? | 12:15 |
| @kanzure | selling some antibodies | 12:17 |
| ParahSail1n | i think that would be pretty cool | 12:17 |
| @kanzure | i don't have a priority list but i think it would be pretty easy to make one up | 12:17 |
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| Mokstar | ThomasEgi, there you are! | 12:18 |
| ParahSail1n | i have a couple co2 incubators in my friend's garage | 12:18 |
| ThomasEgi | Mokstar, and.. who may you be? | 12:18 |
| Mokstar | the guy who went on an on about tDCS in ##biohack about six months ago, then disappeared | 12:18 |
| ParahSail1n | im trying to figure out whether to do cell culture to make native antibodies or express Fab in e coli | 12:18 |
| ParahSail1n | its weird how the Fab E coli version is more expensive | 12:19 |
| Mokstar | I used to pester you with ignorant questions about electronics | 12:19 |
| Mokstar | anyway, I'm back with more ignorant questions about electronics | 12:20 |
| Mokstar | I came up with what I think is a neat design for a tactile feedback device, and I wanted to get your thoughts on it, and if you had any alternative ideas | 12:20 |
| @kanzure | how about ultrasound :( | 12:21 |
| @kanzure | also why are you doing tactile feedback? | 12:21 |
| Mokstar | kanzure, you first! :p | 12:21 |
| Mokstar | northpaw, plus some other ideas | 12:21 |
| @kanzure | uh, how about "blocks of meat" first, instead of a person? | 12:21 |
| Mokstar | ultrasonic distance sense | 12:21 |
| @kanzure | you must not like me much | 12:21 |
| Mokstar | oh alright | 12:21 |
| Mokstar | as long as I can turn it into pemmican afterwards | 12:21 |
| Mokstar | I have some ultrasonic elements, also a set of 1mhz and a 3mhz therapy-grade units | 12:22 |
| Mokstar | ThomasEgi, anyway, here's my idea: an earbud voice coil wrapped around a cylinder of hard plastic containing a spherical magnet | 12:23 |
| Mokstar | or maybe a cylinder magnet, so it'd be... locked into an axis of travel? | 12:24 |
| Mokstar | not sure what the correct way to put that is | 12:24 |
| Mokstar | way less power than a pager motor, but very sense-able | 12:24 |
| ThomasEgi | so you want to build a vibrating unit, with a magnet + coil | 12:36 |
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| Mokstar | pretty much | 12:36 |
| Mokstar | instead of the voice coil moving a diaphragm, I want the magnet to move | 12:37 |
| Mokstar | sort of like a tiny solenoid | 12:37 |
| Mokstar | all it has to do is smack against the inside of the cylinder though | 12:37 |
| ThomasEgi | you do realize that a pager motor is just coils moving magnets,too right? | 12:37 |
| Mokstar | right, but I can't drive one right from my arduino's digital pin | 12:37 |
| Mokstar | it's less efficient for the purpose | 12:38 |
| ThomasEgi | you can add a simple transistor to do that | 12:38 |
| Mokstar | right, but when I've got 10 of them, the part count goes up a bit | 12:38 |
| ThomasEgi | transistor and a freewheeling diode | 12:38 |
| Mokstar | and also lower current = lower usage = smaller battery required | 12:39 |
| Mokstar | wouldn't the transistor use up a bit of juice as well? | 12:39 |
| ThomasEgi | neglectable | 12:40 |
| Mokstar | fair enough, but the difference between the motor and micro-solenoid is enough to justify it | 12:40 |
| ThomasEgi | compared to the current you send through your coil. it is in the 0.something percent range | 12:40 |
| Mokstar | plus complexity | 12:41 |
| Mokstar | do you know offhand what awg wire they use in these things? | 12:41 |
| Mokstar | it's about as fine as a relatively fine human hair | 12:42 |
| ThomasEgi | awg as american wire gauge? | 12:42 |
| Mokstar | yes | 12:42 |
| Mokstar | that's how I buy wire, anyway | 12:42 |
| Mokstar | I suppose ify ou know the metric unit I can convert | 12:42 |
| ThomasEgi | well the diameter pretty much depends on what current you want to send through | 12:42 |
| ThomasEgi | which determines the resistance (given the working voltage). and that determines the lenght and diameter | 12:43 |
| Mokstar | I can get 44awg, or 0.05080mm | 12:43 |
| ThomasEgi | you have to know what current and voltage you want to apply. and the length of your wire | 12:44 |
| ThomasEgi | with that, you can calculate the neccessary diameter | 12:44 |
| Mokstar | I guess if I wanted to get really fancy I'd figure out that value based on the force with which I'd like to move the ... what woul dyou call it? | 12:44 |
| Mokstar | core | 12:44 |
| Mokstar | which would be based also on its weight and magnetic strength | 12:45 |
| ThomasEgi | you can calculate field strengthes and magnetic flux | 12:45 |
| Mokstar | but that sounds like too much work | 12:45 |
| ThomasEgi | and forces etc. but those usualy are very math heavy | 12:45 |
| Mokstar | so I'm just going to get ear bud voice coils and cheap cylinder magnets | 12:45 |
| Mokstar | or maybe just get some iron bar and magnetize it | 12:45 |
| Mokstar | and put it in an aluminum tube... hmmm | 12:45 |
| Mokstar | or maybe I could put a smaller disc magnet inside the tube held loosely in place | 12:46 |
| Mokstar | perpendicular to the coil | 12:46 |
| Mokstar | so it'd rattle when you pulse the coil | 12:47 |
| Mokstar | it'd be easier to figure out the width of the wire they use in them and buy some of that, then wind it on the cylinder | 12:48 |
| Mokstar | tube | 12:48 |
| Mokstar | or heck, I wouldn't need to use a cylinder at that point | 12:48 |
| ThomasEgi | why not simply use two coils? | 12:50 |
| ThomasEgi | probably less weight, so less mass to accelerate | 12:50 |
| Mokstar | hmm | 12:51 |
| Mokstar | in what physical configuration? | 12:51 |
| ThomasEgi | just wind them in different directions. | 12:51 |
| ThomasEgi | or. same direction and reverse current direction for one | 12:51 |
| Mokstar | would that cause movement? | 12:51 |
| ThomasEgi | they'd repell each other. | 12:51 |
| Mokstar | ahh | 12:51 |
| ThomasEgi | so if you make it possible for them to move slighty, sure | 12:51 |
| Mokstar | so maybe secure one of them to an Al plate | 12:52 |
| Mokstar | which would be loose | 12:52 |
| Mokstar | and another plate benhind it | 12:52 |
| ThomasEgi | don't you want to implant that? | 12:52 |
| Mokstar | no | 12:52 |
| Mokstar | this is for sensebridge | 12:52 |
| ThomasEgi | why bother with energy demand then? | 12:52 |
| Mokstar | because I'd be wearing this thing | 12:54 |
| Mokstar | and would prefer to keep the battery as small as possible | 12:54 |
| Mokstar | but that makes sense for internal usage too | 12:54 |
| ThomasEgi | a pager motor doesnt eat that much | 12:54 |
| Mokstar | 90ma | 12:54 |
| ThomasEgi | it's not running all the time i guess? | 12:55 |
| Mokstar | yes, all the time | 12:55 |
| Mokstar | at elast one | 12:55 |
| Mokstar | the northmost one | 12:55 |
| Mokstar | I want to run this with an arduino pro mini | 12:56 |
| ThomasEgi | how bout getting smaler pager motors instead? | 12:57 |
| Mokstar | harder to source | 12:58 |
| Mokstar | magnet wire is pretty easy | 12:59 |
| Mokstar | cheaper, too | 12:59 |
| ThomasEgi | an onlineshop in germany is selling pager motors that have a max current rating of 40mA | 12:59 |
| Mokstar | url? | 12:59 |
| ThomasEgi | http://www.pollin.de/shop/dt/MzY1OTg2OTk-/Motoren/Gleichstrommotoren/Vibrationsmotor.html | 12:59 |
| @fenn | Mokstar: have you considered piezo speaker diaphrams | 13:00 |
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| Mokstar | I have, I got a tiny one but I couldn't drive it strongly enough to feel it | 13:00 |
| Mokstar | a larger one might work, but I haven't gotten around to prying one out of something | 13:01 |
| @kanzure | https://btcnootropics.com/ | 13:01 |
| @fenn | shouldnt the prices be in btc? | 13:01 |
| @fenn | Mokstar: the tactile sense receptors in your skin each have a certain frequency window they respond to, so it's not entirely about the power | 13:06 |
| @fenn | from first principles it would seem that higher frequencies are more efficient because there is less displacement | 13:06 |
| @fenn | also keep in mind that the AVR chips have an overall power rating of something like 30mA, so you can't drive all the pins at once | 13:07 |
| Mokstar | They are the most sensitive of the four main types of mechanoreceptors to vibrations at low frequencies, around 5 to 15 Hz. | 13:07 |
| Mokstar | right, I won't need to | 13:08 |
| Mokstar | just one | 13:08 |
| Mokstar | at a time, at least for the northpaw application | 13:08 |
| Mokstar | I had the thought of using it as a general purpose transmission method | 13:08 |
| ThomasEgi | Mokstar, piezo speakers need rather high voltages to move noticably | 13:08 |
| ThomasEgi | depending on how they are build, you may need to mount them in a special way. or you won't notice anythang | 13:09 |
| Mokstar | fenn, are you familiar at all with the work of Dr. Paul Bach-y-Rita? | 13:09 |
| @fenn | i've heard the name but i'm no neuroscience student | 13:09 |
| Mokstar | the northpaw is based on his research | 13:09 |
| Mokstar | he's passed on, sadly, but his projects live on | 13:10 |
| Mokstar | http://www.youtube.com/watch?v=xNkw28fz9u0 | 13:10 |
| Mokstar | Brainport Vision Device helps a blind man "see" | 13:10 |
| gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=cc1bca97 Bryan Bishop: article about los angeles biohackers | 13:10 |
| @kanzure | yes yes, we all know about brainport | 13:11 |
| @fenn | ah, 200mA max output power per chip, not 30 | 13:11 |
| ThomasEgi | for driving loads i recommend a designated chip. like the uln 2003 | 13:11 |
| @fenn | what he said | 13:12 |
| ThomasEgi | if you are running a low voltage system. a mosfet based sollution might be better | 13:12 |
| ThomasEgi | as the darlington causes quite a voltage drop already | 13:12 |
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| delinquentme | anyone good with container ships? | 14:10 |
| delinquentme | erm shipping containers? | 14:10 |
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| ThomasEgi | delinquentme, i guess companies that are into container business ;) | 14:12 |
| delinquentme | ThomasEgi, I'm tyring to get a place where I can stash one and call it home | 14:13 |
| ThomasEgi | like for storage? | 14:13 |
| delinquentme | ThomasEgi, Nah to live in. | 14:14 |
| ThomasEgi | ah | 14:14 |
| ThomasEgi | so you are looking for like.. a container appartement? | 14:14 |
| delinquentme | yeah! essentially right now I want a cheap place to live ... and then I can think about modding it out later | 14:15 |
| ThomasEgi | http://www.tempohousing.com/products/housing-solutions/professor.html | 14:15 |
| delinquentme | shit shower shave the gym | 14:15 |
| ThomasEgi | oh i see | 14:15 |
| ThomasEgi | so you basically just want like.. a container office then. | 14:16 |
| ThomasEgi | the above link might give you good inspiration tho. | 14:16 |
| ThomasEgi | you can get used containers on ebay | 14:16 |
| ThomasEgi | if you add some insulation, floor etc yourself | 14:16 |
| ThomasEgi | you may be able to find office containers,too | 14:17 |
| Mokstar | I want to find some 36" HDPE sewer conduit | 14:17 |
| superkuh | That'd be bigger than my current apartment | 14:17 |
| Mokstar | vertical float tank | 14:18 |
| Mokstar | bbl | 14:18 |
| delinquentme | No they're totally a fucking awesome idea. | 14:19 |
| delinquentme | and you can KEEEP them | 14:19 |
| ThomasEgi | the tempohousing? | 14:21 |
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| delinquentme | ThomasEgi, wow. this is awesome. | 14:24 |
| delinquentme | tempohousing | 14:24 |
| delinquentme | KANZ what work on | 14:27 |
| delinquentme | did i tell you about the awesome conflict of interest @ jebi? | 14:28 |
| delinquentme | JBEI? | 14:28 |
| @kanzure | work on paperbot.. it needs some loving. | 14:28 |
| @kanzure | https://github.com/kanzure/paperbot | 14:28 |
| @kanzure | refactoring the download_url() method would be cool. it should be classes of plugins instead of that cruft. and it should use unit tests. | 14:28 |
| @kanzure | that would be very helpful. | 14:28 |
| @kanzure | alternatively.. pdfparanoia things. | 14:28 |
| @kanzure | no you didn't mention any conflict of interest at jbei. | 14:28 |
| delinquentme | so I go in ready to program on this: | 14:39 |
| delinquentme | https://github.com/JBEI/prpr | 14:39 |
| delinquentme | hot-swappable code on tecan freedoms right? | 14:40 |
| delinquentme | Note: got an estimate on the total utilitzation of their tecan @ jbei < 50% | 14:40 |
| delinquentme | and so im ready to work on it ... get handed off to some dude ... and hes like " Actually I'm gonna have you work on a translation table for this euro startup who works with microfluidics " | 14:41 |
| * delinquentme facepalm | 14:41 | |
| delinquentme | so! | 14:41 |
| delinquentme | I've not talked to nathan about fixing THAT little issue yet but its on the plate | 14:41 |
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| @kanzure | i have no idea what you're talking about | 14:48 |
| delinquentme | hot swappable code on tecan freedom evos right? | 14:49 |
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| delinquentme | so transcriptic is working with these guys ... but they've got their own set of ways to change the functionality of the robot instantly | 14:49 |
| delinquentme | drag / drop code ( once the function has been programmed ) | 14:49 |
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| @kanzure | transcriptic is working with jbei? | 14:52 |
| @kanzure | why would i want to drag and drop code? wtf | 14:52 |
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| @kanzure | so what is it.. is it just an api, or do they implement the protocol too? https://github.com/JBEI/prpr/blob/master/prpr_tecan.py | 14:54 |
| @kanzure | looks like a custom recipe format https://github.com/JBEI/prpr/blob/master/prpr_sample.par | 14:54 |
| @kanzure | not sure why they would use dashes in python file names.. that never works for importing. https://github.com/JBEI/prpr/blob/master/tests/prpr-test.py | 14:55 |
| delinquentme | no transcriptic isnt working w jbei | 14:55 |
| delinquentme | kanzure, you want to hot-swap machine functionality | 14:55 |
| delinquentme | the downtime is the reprogramming | 14:55 |
| @kanzure | and i'm unconvinced that this is a sufficient grammar for recipe representation https://github.com/JBEI/prpr/blob/master/developer/prpr_bnf.txt | 14:55 |
| delinquentme | again conflicts of interest | 14:56 |
| delinquentme | a team of two | 14:56 |
| @kanzure | what conflict of interest? | 14:56 |
| delinquentme | one girl is a UI designer with no science background | 14:56 |
| delinquentme | and the dude with any science wants to work on microfluidics | 14:56 |
| delinquentme | im tempted to ask nathan about it ... however im almost sure he doesnt give a shit either | 14:57 |
| @kanzure | conflict of interest is when you can't sign a document because it would violate another agreement you have with another entity | 14:57 |
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| @kanzure | for example, an attorney can't run both sides of litigation because that's a conflict of interest | 14:57 |
| delinquentme | sure sure semantics | 14:57 |
| delinquentme | I mean " bad incentive structure " | 14:57 |
| delinquentme | IE they're not motivated to do the shit they're supposed to be doing | 14:57 |
| @kanzure | "This software was developed under funding from the U.S. Department of Energy. As such, the U.S. Government has been granted for itself and others acting on its behalf a paid-up, nonexclusive, irrevocable, worldwide license in the Software to reproduce, prepare derivative works, and perform publicly and display publicly. Beginning five (5) years after the date permission to assert copyright is obtained from the U.S. Department of Energy, and ... | 14:59 |
| @kanzure | ... subject to any subsequent five (5) year renewals, the U.S. Government is granted for itself and others acting on its behalf a paid-up, nonexclusive, irrevocable, worldwide license in the Software to reproduce, prepare derivative works, distribute copies to the public, perform publicly and display publicly, and to permit others to do so. | 14:59 |
| @kanzure | uh this is not open source. | 14:59 |
| @kanzure | or maybe it is.. https://github.com/JBEI/prpr/blob/master/license.txt not sure which license this is closest to. | 15:01 |
| delinquentme | prpr is open source | 15:03 |
| delinquentme | however theres a j5 lib which isnt | 15:03 |
| delinquentme | which does some cool things | 15:03 |
| @kanzure | how do you know it's open source? i don't think that's an OSI-approved license.. | 15:04 |
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| abetusk | Just got back. I was actually attending the GET conference, that's why I was in Boston. I managed to get a quick tour of Bosslab while I was there. They showed me their light thermocycler machine | 15:45 |
| @kanzure | ah, then i should have told you to find patrik. | 15:46 |
| @kanzure | he either works at or used to work at jbei | 15:46 |
| abetusk | I met a Patrik who tagged along for the Bosslab tour | 15:46 |
| @kanzure | ah, then the system works | 15:47 |
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| @kanzure | http://biocurious.org/projects/ | 17:49 |
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| @kanzure | 12.75 characters/min EEG typing http://www.youtube.com/watch?v=fxr9yhOG-c0 | 19:01 |
| @kanzure | lame :( | 19:01 |
| @kanzure | i guess that's 1-2 words/minute if you use small words | 19:02 |
| @kanzure | s/small/short/ | 19:02 |
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| juri_ | that's a lot of bandwidth, compared with 0. | 20:53 |
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| @kanzure | juri_: is ocropus usable? | 21:36 |
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| juri_ | i just heard of it myself today. | 22:05 |
| juri_ | i really need to do an evaluation of the market, was it were. probably take me a month. | 22:08 |
| juri_ | s/was/as/ | 22:08 |
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| @kanzure | ParahSail1n: drchrono is spamming hacker news for android/ios people.. quick, throw together a demo app. | 23:29 |
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| --- Log closed Mon Apr 29 00:00:11 2013 | ||
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