| --- Log opened Tue Jul 02 00:00:13 2013 | ||
| -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap | 00:01 | |
| -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Ping timeout: 240 seconds] | 00:05 | |
| -!- monkeynipples_ [monkeynipp@gateway/shell/xzibition.com/x-yicirlggpkeehflv] has joined ##hplusroadmap | 00:40 | |
| -!- monkeynipples [monkeynipp@gateway/shell/xzibition.com/x-rfdxwsuzmjptbgvz] has quit [Ping timeout: 240 seconds] | 00:40 | |
| nmz787_ | paperbot: http://journals.sfu.ca/rncsb/index.php/csbj/article/download/csbj.201304003/271 | 01:19 |
|---|---|---|
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/f2c5005dd99d30dd7f38e07214cb91b0.pdf | 01:19 |
| nmz787_ | 'The biological microprocessor, or how to build a computer with | 01:19 |
| nmz787_ | biological parts' | 01:19 |
| nmz787_ | "Systemics, a revolutionary paradigm shift in scientific thinking, with applications in systems biology, and synthetic | 01:20 |
| nmz787_ | biology, have led to the idea of using silicon computers and their engineering principles as a blueprint for the engineering of a | 01:20 |
| nmz787_ | similar machine made from biological parts. Here we describe these building blocks and how they can be assembled to a general | 01:20 |
| nmz787_ | purpose computer system, a biological microprocessor. Such a system consists of biological parts building an input / output | 01:20 |
| nmz787_ | device, an arithmetic logic unit, a control unit, memory, and wires (busses) to interconnect these components. A biocomputer can | 01:20 |
| nmz787_ | be used to monitor and control a biological system." | 01:20 |
| -!- Juul [~Juul@208.87.217.74] has quit [Ping timeout: 252 seconds] | 01:37 | |
| -!- Juul [~Juul@208.87.217.74] has joined ##hplusroadmap | 01:47 | |
| -!- Juul [~Juul@208.87.217.74] has quit [Ping timeout: 246 seconds] | 02:25 | |
| -!- eleitl [~eugen@v8.ativel.com] has joined ##hplusroadmap | 02:32 | |
| eleitl | paperbot: http://dx.doi.org/10.1016/j.theriogenology.2008.11.005 | 02:33 |
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/9a4cf4bf851a85a22d956075bbb6c77c.txt | 02:33 |
| @archels | hoi eleitl | 02:34 |
| @archels | http://turingbirds.com/temp/1-s2.0-S0093691X08007784-main.pdf | 02:35 |
| eleitl | Hi archels -- can you access that journal? | 02:35 |
| eleitl | Ah, that was just a test paper. | 02:36 |
| eleitl | Paperbot doesn't seem to be able to. | 02:36 |
| @archels | yep, I have access | 02:37 |
| eleitl | Institutional? | 02:37 |
| @archels | nod | 02:38 |
| eleitl | As a matter of personal favor, I might have to ask you for some articles in future. | 02:38 |
| @archels | sure | 02:38 |
| -!- Charlie [~quassel@74.63.212.44] has quit [Ping timeout: 256 seconds] | 02:39 | |
| eleitl | We're about to form a startup, and evaluating what particular biological system to cryopreserve. | 02:39 |
| @archels | this is an offshoot of that lab space you guys were setting up? | 02:40 |
| @archels | I thought you were working on cryopreserving L. stagnalis | 02:40 |
| eleitl | Yes. | 02:40 |
| eleitl | Sorry, phone. | 02:42 |
| eleitl | No, the L. stagnalis is a project which is difficult to get investors to pay for. | 02:42 |
| eleitl | We'll probably try to weaselt that in via way of nonprofit, via donations. | 02:42 |
| eleitl | We have a first internal round of investors which are interested in human cryopreservation, but can't pay for it all, especially if it's not a sustainable business. | 02:43 |
| eleitl | First funding round is small just about 55 kEUR, for the first 12 months. | 02:44 |
| @archels | ah. This is focused at advancing the necessary technology, rather than actually setting up long-term human cryo storage? | 02:44 |
| eleitl | We do aim for a provider in Switzerland, but that's more long-term. | 02:45 |
| eleitl | Our first priority is to start cryopreserving something already useful, and produce enough results to be able to raise a lot more money in the second round. | 02:46 |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 02:47 | |
| eleitl | We're investigating several potential candidates, but unfortunately this is all for-profit business plan, so hush-hush. | 02:47 |
| @archels | I guess the return-on-investment on fundamental research cannot be expected to be very high | 02:48 |
| eleitl | It's more a teaser, to raise serious cash in the second round. | 02:48 |
| @archels | right | 02:48 |
| eleitl | We do have some interesting candidates, but research is intrinsically uncertain. You can work 1-2 years and only run into a wall. | 02:49 |
| eleitl | We're going to have a specific exit clause in the contract in case we run into a wall. | 02:49 |
| @archels | sure, but cryopreservating is already a commercially successful business, so you're not starting from square one | 02:50 |
| @archels | unless you're planning on doing something radically different | 02:50 |
| eleitl | yes, we're trying to improve existing methods, or we're trying to do something reasonably radical | 02:50 |
| eleitl | so we'll spend next 2-3 months reading papers, trying to figure out where our chances are better | 02:51 |
| eleitl | currently there are 3 options, ideally I want to have a few more | 02:51 |
| eleitl | what would you try to do if you were me? | 02:52 |
| @archels | beats me, I have no intuition for business =) | 02:53 |
| @archels | generally I would argue for doing one thing and doing it well, but if you're just working up towards attracting more capital, then doing a few things in parallel could be beneficial | 02:54 |
| @archels | because it gives you more things to show to potential investors | 02:55 |
| eleitl | we will be focusing on one thing, but we try it to be the right thing | 02:55 |
| eleitl | if you want to raise, say 1-10 MEUR in the next round it better be something slightly exciting | 02:56 |
| @archels | not sure what is a reasonable target given 55k€ and 12 months | 02:59 |
| eleitl | I hesitate to say more, as archives are public | 03:00 |
| eleitl | we have something hot, but quite uncertain | 03:01 |
| eleitl | if we go that route, 12 months will be just getting competent with that system | 03:01 |
| eleitl | if results are not a total failure, you can prolong the phase, or up the ante | 03:01 |
| eleitl | it might make sense to become a licensed animal research facility | 03:02 |
| eleitl | I understand it's easier if you order animals from a commercial supplier, and don't hold them longer than 12 hours in your research facility | 03:03 |
| eleitl | this is US law, it might be different in the EU | 03:03 |
| eleitl | slaughterhouse is easy, but not really reproducible | 03:03 |
| @archels | hum, how fresh is the tissue you can get from there, anyway? | 03:07 |
| eleitl | if you pick it up yourself, very fresh | 03:08 |
| @archels | hope you have one nearby the lab, then :) | 03:09 |
| @fenn | cats and dogs seems like a reasonable place to start; there's demand for it after all | 03:09 |
| @fenn | mice are convenient | 03:09 |
| eleitl | in case of slaughterhouse, it will be pigs and cows | 03:10 |
| @fenn | but they are so big | 03:10 |
| eleitl | in case of commercial animals, rabbits or tats | 03:10 |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] | 03:10 | |
| eleitl | big is a plus, actually | 03:10 |
| @archels | .wa volume of pig brain | 03:12 |
| yoleaux | pig brain: amount: 3 oz (ounces): serving volume: (data not available); Physical properties: mass: 3 oz (ounces) | 03:12 |
| @archels | canhazmetric? | 03:12 |
| @fenn | yum yum | 03:12 |
| @fenn | that was serving size from a food database | 03:12 |
| eleitl | unfortunately, brains are not transplanted, and slaughterhouse methods tend to ruin your brain | 03:12 |
| eleitl | removing the brain is also very difficult, and time-consuming | 03:13 |
| @fenn | i dont suppose you could get dead dolphins | 03:14 |
| eleitl | even fixated brains are difficult, needle-nose pliers removing pieces of skull, etc. | 03:14 |
| -!- Charlie [~quassel@74.63.212.44] has joined ##hplusroadmap | 03:14 | |
| eleitl | I see no point in dolphins, and in general I'd rather stay away from the smarter critters | 03:14 |
| @archels | so pigs about 0.1L, compared to human ~1L? | 03:14 |
| @archels | dolphins, haha | 03:15 |
| eleitl | in case of brains, I would still like to look at snails | 03:15 |
| eleitl | but, sales proposition to investors: zero | 03:15 |
| eleitl | ditto whole body transplants, for that matter | 03:16 |
| @fenn | looks like a pig brain is 180g | 03:16 |
| eleitl | I'd hate working with live pigs | 03:16 |
| @fenn | from http://mste.illinois.edu/malcz/DATA/BIOLOGY/Animals.html | 03:17 |
| @fenn | mountain beaver? | 03:17 |
| @archels | eleitl: I take it you've considered rats? | 03:17 |
| @archels | not sure what you're trying to do; if working on perfusion methods then small brains like these are probably useless | 03:18 |
| eleitl | yes, in case we go animal research route rats and rabbits | 03:18 |
| eleitl | but, first year we'll be doing fresh cadaver tissue | 03:18 |
| eleitl | strictly no live critters on the premises | 03:18 |
| @archels | except for the scientists | 03:18 |
| eleitl | was thinking that as well ;) | 03:19 |
| eleitl | human research is less regulated, probably | 03:19 |
| eleitl | sacrifice a few lab assistants... | 03:19 |
| eleitl | nobody going to notice... | 03:19 |
| gradstudentbot | Have you read this paper? | 03:19 |
| @archels | I think we got ourselves a volunteer | 03:21 |
| eleitl | codo derecho se objetiva fractura de cupula radial <- fracture of the radial head | 03:26 |
| eleitl | correct? | 03:26 |
| eleitl | http://qz.com/99413/first-ever-human-head-transplant-is-now-possible-says-neuroscientist/ | 03:26 |
| heath | http://www.bu.edu/abl/publications.html | 03:30 |
| heath | .title | 03:30 |
| yoleaux | Boston University: Collins Lab | 03:30 |
| heath | publications from the lab | 03:30 |
| -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 03:32 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 252 seconds] | 03:33 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 03:39 | |
| -!- Charlie [~quassel@74.63.212.44] has quit [Ping timeout: 252 seconds] | 03:40 | |
| nmz787_ | paperbot: http://www.sciamdigital.com/index.cfm?fa=Products.ViewIssuePreview&ISSUEID_CHAR=E94E8DBF-C927-4DCD-B32C-221B7832ABB&ARTICLEID_CHAR=AB980A62-605D-4562-8CA1-360E43FA131 | 04:15 |
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/dfa8eec7860d311a26224758562e0d10.txt | 04:15 |
| nmz787_ | paperbot: http://solidstate.um.ac.ir/parameters/solidstate/filemanager/Scientific.American.Special.Edition.1997-12_Solid_State_Century.pdf | 04:21 |
| paperbot | ConnectionError: [Errno 110] Connection timed out (file "/usr/local/lib/python2.7/dist-packages/requests/models.py", line 625, in send) | 04:24 |
| -!- Viper168_ [~Viper@unaffiliated/viper168] has quit [Ping timeout: 256 seconds] | 04:41 | |
| -!- Charlie [~quassel@74.63.212.44] has joined ##hplusroadmap | 04:47 | |
| -!- makoLime [~mako@103-9-42-152.flip.co.nz] has quit [Read error: Operation timed out] | 04:54 | |
| -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap | 05:07 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 05:12 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Remote host closed the connection] | 05:12 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 05:15 | |
| -!- archels [~neuralnet@sascha.esrac.ele.tue.nl] has quit [Changing host] | 05:42 | |
| -!- archels [~neuralnet@unaffiliated/archels] has joined ##hplusroadmap | 05:42 | |
| -!- ServerMode/##hplusroadmap [+o archels] by pratchett.freenode.net | 05:42 | |
| -!- mode/##hplusroadmap [-o archels] by ChanServ | 05:42 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 256 seconds] | 05:49 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 06:10 | |
| -!- yorick [~yorick@oftn/member/yorick] has joined ##hplusroadmap | 06:12 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 260 seconds] | 06:21 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 06:34 | |
| -!- marciogm [~textual@177.106.60.46] has joined ##hplusroadmap | 06:55 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Ping timeout: 252 seconds] | 07:03 | |
| -!- marciogm [~textual@177.106.60.46] has quit [Ping timeout: 276 seconds] | 07:06 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap | 07:07 | |
| -!- Gue______ [~textual@177.106.60.46] has joined ##hplusroadmap | 07:15 | |
| -!- Gue______ is now known as marciogm | 07:16 | |
| -!- marciogm [~textual@177.106.60.46] has quit [Changing host] | 07:16 | |
| -!- marciogm [~textual@unaffiliated/marciogm] has joined ##hplusroadmap | 07:16 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 264 seconds] | 07:22 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 07:34 | |
| -!- ianmathwiz7 [~chatzilla@ip65-46-170-6.z170-46-65.customer.algx.net] has joined ##hplusroadmap | 07:56 | |
| -!- kajetan [122@unaffiliated/kmo] has quit [Remote host closed the connection] | 08:14 | |
| -!- rk[zZz] is now known as ryankarason | 08:22 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 246 seconds] | 08:22 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 08:35 | |
| @ParahSailin | wasted 15 minutes because i pasted a command where - was replaced by – | 08:37 |
| @ParahSailin | fucking code point U0x2013 | 08:38 |
| chris_99 | yeah that's a PITA | 08:40 |
| @kanzure | it seems my phone is unable to charge unless i am directly staring at it | 08:41 |
| @kanzure | something about the micro usb connection not making full contact when i am not looking | 08:41 |
| @kanzure | and rebooting changes the charge from 2% to 40% | 08:44 |
| -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap | 08:49 | |
| -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Ping timeout: 256 seconds] | 08:54 | |
| -!- yorick [~yorick@oftn/member/yorick] has quit [Remote host closed the connection] | 09:10 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 240 seconds] | 09:22 | |
| balrog | kanzure: ya there? | 09:26 |
| @kanzure | maybe | 09:27 |
| balrog | wanna add support for IOP to pdfparanoia? | 09:27 |
| balrog | I can provide a sample | 09:27 |
| @kanzure | balrog: https://github.com/kanzure/pdfparanoia | 09:27 |
| @kanzure | i think iop is already supported | 09:28 |
| @kanzure | or there is an open bug report | 09:28 |
| balrog | also the version in pip is busted | 09:28 |
| @kanzure | ah, iop is not supported | 09:28 |
| @kanzure | why is it busted? | 09:28 |
| balrog | --verbose doesn't work | 09:28 |
| balrog | -o doesn't work | 09:28 |
| @kanzure | can you fix? :( | 09:28 |
| @kanzure | i am really busy right now | 09:28 |
| balrog | it doesn't specify pdfminer as a prereq | 09:28 |
| balrog | ah :| | 09:28 |
| @kanzure | pdfminer is not a prerequisite | 09:28 |
| @kanzure | oh wait, it is | 09:29 |
| @kanzure | https://github.com/kanzure/pdfparanoia/blob/master/requirements.txt | 09:29 |
| balrog | IOP seems to be "strip first page if contains certain text" | 09:30 |
| balrog | of course there may be additional watermarks | 09:30 |
| @kanzure | sure | 09:31 |
| @kanzure | one of the other plugins does that right now | 09:31 |
| gradstudentbot | Friends don't let friends go to super school. | 09:31 |
| @kanzure | but it has a lot of checks | 09:31 |
| balrog | alternatively the ip and timestamp could be removed | 09:31 |
| @kanzure | because stripping the first page when it's not iop would be deadly | 09:31 |
| -!- marciogm [~textual@unaffiliated/marciogm] has quit [Quit: Computer has gone to sleep.] | 09:33 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 09:36 | |
| balrog | I wonder if a becton-dickinson facscalibur PCI interface card would be of use to anyone | 09:39 |
| balrog | I don't have any other hardware or software | 09:39 |
| -!- ianmathwiz7 [~chatzilla@ip65-46-170-6.z170-46-65.customer.algx.net] has quit [Ping timeout: 240 seconds] | 09:49 | |
| -!- pads [~not@100.43.114.90] has quit [Ping timeout: 268 seconds] | 09:50 | |
| -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap | 09:54 | |
| -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Ping timeout: 256 seconds] | 09:59 | |
| -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Read error: Connection reset by peer] | 09:59 | |
| -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap | 10:00 | |
| -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap | 10:03 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 276 seconds] | 10:24 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 10:36 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 276 seconds] | 11:13 | |
| -!- EnLilaSko- [~Nattzor@host-85-30-145-65.sydskane.nu] has joined ##hplusroadmap | 11:22 | |
| -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Ping timeout: 256 seconds] | 11:23 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 256 seconds] | 11:24 | |
| -!- delinquentme [~asdfasdf@66.233.132.203] has joined ##hplusroadmap | 11:24 | |
| @ParahSailin | any way to write "def derp(x): return (x, dict())" as a lambda or is this just language smell | 11:25 |
| @kanzure | [(x, dict()) for x in whatever] | 11:27 |
| @kanzure | oops, that's a list comprehension | 11:28 |
| brownies | heh | 11:28 |
| brownies | i think you have to be careful about when the dict() gets evaluated... | 11:28 |
| @ParahSailin | yeah thats the referential transparency thing that python lacks | 11:30 |
| @ParahSailin | is there list comprehension sugar for making itertools generators? | 11:32 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 11:37 | |
| -!- ThomasEgi [~thomas@185.5.8.81] has joined ##hplusroadmap | 11:56 | |
| -!- ThomasEgi [~thomas@185.5.8.81] has quit [Changing host] | 11:56 | |
| -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap | 11:56 | |
| -!- EnLilaSko- is now known as EnLilaSko | 11:58 | |
| -!- EnLilaSko [~Nattzor@host-85-30-145-65.sydskane.nu] has quit [Changing host] | 11:59 | |
| -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has joined ##hplusroadmap | 11:59 | |
| delinquentme | kanzure, EYE MISS YEWWWW | 12:01 |
| -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Read error: Connection reset by peer] | 12:09 | |
| -!- padz [~not@100.43.114.90] has joined ##hplusroadmap | 12:14 | |
| -!- cogitokat [~kat@ip70-171-6-179.ga.at.cox.net] has quit [Quit: Lost terminal] | 12:22 | |
| -!- marciogm [~textual@177.106.60.46] has joined ##hplusroadmap | 12:22 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 240 seconds] | 12:24 | |
| -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap | 12:29 | |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has joined ##hplusroadmap | 12:33 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 12:37 | |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has quit [Quit: Leaving] | 12:44 | |
| -!- delinquentme [~asdfasdf@66.233.132.203] has quit [Ping timeout: 252 seconds] | 12:44 | |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has joined ##hplusroadmap | 12:57 | |
| @ParahSailin | coworker is using ^I's for tabs instead of spaces; told to help him with project; time to quit | 12:59 |
| @ParahSailin | repo master refuses to learn what pull request is on github; have to email diffs; time to quit | 13:05 |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has quit [Remote host closed the connection] | 13:07 | |
| @kanzure | ParahSailin: why are you bothering | 13:10 |
| @kanzure | "Jonathan Rothberg has resigned from Life Technologies, amid Life's attempted $13.6 billion merger with Thermo Fisher Scientific. | 13:10 |
| @kanzure | Rothberg's Ion Torrent business unit was cited by Thermo as a motivating factor behind the acquisition." | 13:10 |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has joined ##hplusroadmap | 13:11 | |
| -!- kmo [~kmo@apn-46-169-138-228.dynamic.gprs.plus.pl] has joined ##hplusroadmap | 13:16 | |
| -!- kmo [~kmo@apn-46-169-138-228.dynamic.gprs.plus.pl] has quit [Changing host] | 13:16 | |
| -!- kmo [~kmo@unaffiliated/kmo] has joined ##hplusroadmap | 13:16 | |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has quit [Quit: Leaving] | 13:20 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 13:20 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 264 seconds] | 13:25 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 13:37 | |
| -!- makoLime [~mako@103-9-42-152.flip.co.nz] has joined ##hplusroadmap | 13:42 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 268 seconds] | 13:57 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Read error: Connection reset by peer] | 14:07 | |
| Burninate | http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2013;volume=4;issue=2;spage=335;epage=342;aulast=Canavero;type=0 | 14:09 |
| Burninate | so Goertzel lives near me 0.o | 14:11 |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap | 14:12 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Client Quit] | 14:15 | |
| @kanzure | Burninate: i think he has a few kids. one is probably still in high school. | 14:19 |
| Burninate | his face looks like someone I know the first name of, but not hte last | 14:20 |
| Burninate | in college | 14:20 |
| Burninate | *just graduated I guess | 14:20 |
| @kanzure | not the amelious zarathustra one | 14:23 |
| @kanzure | the other one | 14:23 |
| -!- padz [~not@100.43.114.90] has quit [Read error: Connection reset by peer] | 14:24 | |
| -!- padz [~not@100.43.114.90] has joined ##hplusroadmap | 14:25 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 252 seconds] | 14:26 | |
| -!- smeaaagle [~smeaaagle@2002:6ca6:4fb1::6ca6:4fb1] has quit [Ping timeout: 256 seconds] | 14:27 | |
| -!- smeaaagle [~smeaaagle@2002:6ca6:4fb1::6ca6:4fb1] has joined ##hplusroadmap | 14:29 | |
| -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection] | 14:36 | |
| -!- Reverse_dog [~I@c-71-201-142-136.hsd1.il.comcast.net] has joined ##hplusroadmap | 14:38 | |
| @kanzure | Reverse_dog: hi | 14:40 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 14:40 | |
| @kanzure | does anyone have recommendations for which sdr things to buy? | 14:40 |
| @kanzure | maybe i should also pick something out from http://www.aircrack-ng.org/doku.php?id=compatibility_drivers | 14:42 |
| -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Remote host closed the connection] | 14:50 | |
| -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap | 14:50 | |
| -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Ping timeout: 264 seconds] | 14:55 | |
| jrayhawk_ | broadcasting or receiving? | 15:06 |
| @kanzure | how about both! | 15:07 |
| @kanzure | i just feel morally bad that i do not have this hardware laying around | 15:07 |
| @kanzure | i expect superkuh to have an idea or two except for whatever reason he is not actually here | 15:10 |
| chris_99 | bladerf looks pretty nifty to me | 15:12 |
| -!- Reverse_dog [~I@c-71-201-142-136.hsd1.il.comcast.net] has quit [Quit: Leaving] | 15:14 | |
| -!- Juul [~Juul@static.3.202.4.46.clients.your-server.de] has joined ##hplusroadmap | 15:18 | |
| -!- phillyj [~Thunderbi@c-68-80-251-160.hsd1.pa.comcast.net] has joined ##hplusroadmap | 15:23 | |
| -!- weles [~mariusz@c-71-234-3-169.hsd1.ct.comcast.net] has joined ##hplusroadmap | 15:25 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 252 seconds] | 15:27 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 15:38 | |
| -!- pads [~not@100.43.114.90] has joined ##hplusroadmap | 15:43 | |
| -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap | 15:44 | |
| -!- yorick [~yorick@oftn/member/yorick] has joined ##hplusroadmap | 15:45 | |
| -!- padz [~not@100.43.114.90] has quit [Ping timeout: 246 seconds] | 15:45 | |
| -!- ParahSailin_ [~ropoctl@99-25-202-211.lightspeed.hstntx.sbcglobal.net] has joined ##hplusroadmap | 15:48 | |
| -!- ParahSailin_ [~ropoctl@99-25-202-211.lightspeed.hstntx.sbcglobal.net] has quit [Changing host] | 15:48 | |
| -!- ParahSailin_ [~ropoctl@unaffiliated/parahsailin] has joined ##hplusroadmap | 15:48 | |
| -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has quit [Remote host closed the connection] | 15:52 | |
| -!- marciogm [~textual@177.106.60.46] has quit [Quit: Computer has gone to sleep.] | 16:01 | |
| -!- phillyj [~Thunderbi@c-68-80-251-160.hsd1.pa.comcast.net] has quit [Quit: phillyj] | 16:07 | |
| balrog | what was that zotero auto-import plugin? | 16:16 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 256 seconds] | 16:27 | |
| @kanzure | balrog: zotero translators | 16:29 |
| @kanzure | balrog: https://github.com/zotero/translators | 16:29 |
| @kanzure | balrog: https://github.com/zotero/translation-server | 16:29 |
| -!- ParahSailin_ [~ropoctl@unaffiliated/parahsailin] has quit [Quit: ParahSailin_] | 16:38 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 16:39 | |
| -!- jrayhawk_ is now known as jrayhawk | 16:49 | |
| -!- yorick [~yorick@oftn/member/yorick] has quit [Remote host closed the connection] | 17:00 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] | 17:21 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap | 17:22 | |
| -!- joehot [~not@100.43.114.90] has joined ##hplusroadmap | 17:26 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 246 seconds] | 17:28 | |
| -!- pads [~not@100.43.114.90] has quit [Ping timeout: 256 seconds] | 17:29 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 17:41 | |
| superkuh | paperbot: http://proceedings.aip.org/resource/2/apcpcs/664/1/194_1?isAuthorized=no | 17:47 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/Ablative%20Laser%20Propulsion%3A%20A%20Study%20of%20Specific%20Impulse%2C%20Thrust%20and%20Efficiency.txt | 17:47 |
| @kanzure | i wonder if i am stripping out isAuthorized=no | 17:47 |
| superkuh | paperbot: http://proceedings.aip.org/resource/2/apcpcs/664/1/194_1 | 17:48 |
| paperbot | error: HTTP 500 http://diyhpl.us/~bryan/papers2/paperbot/Ablative%20Laser%20Propulsion%3A%20A%20Study%20of%20Specific%20Impulse%2C%20Thrust%20and%20Efficiency.txt | 17:48 |
| superkuh | paperbot: http://scitation.aip.org/getpdf/servlet/GetPDFServlet?filetype=pdf&id=APCPCS000664000001000194000001&idtype=cvips&doi=10.1063/1.1582108&prog=normal | 17:48 |
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/User%20Authentication.txt | 17:48 |
| @kanzure | archels: maybe you have access? | 17:48 |
| gradstudentbot | I have to read all these articles. | 17:49 |
| -!- Juul [~Juul@static.3.202.4.46.clients.your-server.de] has quit [Ping timeout: 252 seconds] | 17:52 | |
| -!- balrog [~balrog@discferret/developer/balrog] has quit [Ping timeout: 256 seconds] | 17:53 | |
| streety | I think some selection process would be necessary | 17:56 |
| -!- Charlie_ [~quassel@74.63.212.44] has joined ##hplusroadmap | 17:57 | |
| -!- Charlie [~quassel@74.63.212.44] has quit [Write error: Connection reset by peer] | 17:57 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Excess Flood] | 17:57 | |
| -!- Charlie_ is now known as Guest61414 | 17:57 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap | 17:58 | |
| -!- balrog [~balrog@discferret/developer/balrog] has joined ##hplusroadmap | 17:58 | |
| -!- yashgaroth [~ffffff@cpe-66-27-118-94.san.res.rr.com] has joined ##hplusroadmap | 17:59 | |
| -!- padz [~not@100.43.114.90] has joined ##hplusroadmap | 18:00 | |
| -!- jrayhawk [~jrayhawk@nursie.omgwallhack.org] has quit [Ping timeout: 246 seconds] | 18:01 | |
| -!- jrayhawk [~jrayhawk@nursie.omgwallhack.org] has joined ##hplusroadmap | 18:01 | |
| -!- joehot [~not@100.43.114.90] has quit [Ping timeout: 246 seconds] | 18:01 | |
| -!- klafka_ [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap | 18:01 | |
| -!- hehelleshin [~talinck@69-61-156-24.ubr1.dyn.lebanon-oh.fuse.net] has joined ##hplusroadmap | 18:02 | |
| -!- Netsplit *.net <-> *.split quits: gradstudentbot, helleshin, klafka | 18:10 | |
| -!- Netsplit over, joins: gradstudentbot | 18:11 | |
| jonathan__ | how do I explain genetic algorithm seo optimization in order to pick the name of a new product, to a friend of mine who knows absolutely nothing about math or science and also thinks their opinion is usually the best...? | 18:18 |
| jonathan__ | it's like explaining evolution to a catholic priest.. | 18:19 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 276 seconds] | 18:29 | |
| @kanzure | jonathan__: i don't think genetic algorithms are the best way to do seo optimization. you should start from the other-end of the spectrum by looking at google search keyword tools that tells you how many people search for a given term. | 18:36 |
| jonathan__ | sure, same thing | 18:36 |
| jonathan__ | the reply I got back was something like "well I like my name better so what does it matter what other people think" ... ummm yea | 18:37 |
| jonathan__ | google adwords is just a manual simplistic way of doing genetic algorithm really | 18:38 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 18:42 | |
| @kanzure | google adwords forces you to increase your margins so you can dump more of it into adwords | 18:43 |
| -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 264 seconds] | 18:48 | |
| -!- Juul [~Juul@static.3.202.4.46.clients.your-server.de] has joined ##hplusroadmap | 19:05 | |
| -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap | 19:23 | |
| -!- pads [~not@100.43.114.90] has joined ##hplusroadmap | 19:27 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 276 seconds] | 19:29 | |
| -!- padz [~not@100.43.114.90] has quit [Ping timeout: 240 seconds] | 19:30 | |
| -!- ianmathwiz7 [~chatzilla@68-115-57-210.static.eucl.wi.charter.com] has joined ##hplusroadmap | 19:34 | |
| jonathan__ | oh, like cocaine. "cocaine makes me work better. so I can make more money. so I can buy more cocaine. so I can work better. so I can make more money. so I can buy more cocaine. ..." | 19:41 |
| -!- ianmathwiz7 [~chatzilla@68-115-57-210.static.eucl.wi.charter.com] has quit [Quit: ChatZilla 0.9.90 [SeaMonkey 2.17.1/20130410205058]] | 19:41 | |
| jonathan__ | angelina jolie will now remove her ovaries to prevent future cancer. ... | 19:41 |
| jonathan__ | so what body parts can I remove to reduce my cancer risk? | 19:42 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 19:43 | |
| yashgaroth | three, but you're not gonna like it | 19:43 |
| jonathan__ | oh, says who? maybe I enjoy self mutilation | 20:02 |
| jonathan__ | let me see, my esophogus? | 20:03 |
| -!- rk[imposter] [~rkimposte@stallman.cse.ohio-state.edu] has joined ##hplusroadmap | 20:04 | |
| yashgaroth | hell if you go on soylent you can safely remove most of your digestive tract | 20:05 |
| jonathan__ | i hope that stuff is tasty | 20:26 |
| jonathan__ | i saw they were hiring for lab techs | 20:26 |
| jonathan__ | to make the stuff.. | 20:27 |
| jonathan__ | yum! cant wait to have my soylent chicken mcnuggets | 20:27 |
| yashgaroth | 'lab tech' is a little optimistic | 20:27 |
| jonathan__ | ok, factory worker | 20:28 |
| yashgaroth | artisan manual labor | 20:28 |
| jonathan__ | not so arty artisan | 20:29 |
| jonathan__ | glorified stirring rod ok | 20:29 |
| yashgaroth | I'm waiting for the choco-soylent | 20:29 |
| jonathan__ | speaking of job opps I've now seen cybercoder ad for lead android engineer, listed $130K-$200K DOE | 20:30 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 252 seconds] | 20:30 | |
| jonathan__ | now thats what i'm talkin bout yo | 20:30 |
| jonathan__ | maybe that $200K is fake tho, I dunno | 20:30 |
| jonathan__ | I dunno about soylent but I would love some hemp burger | 20:30 |
| yashgaroth | mm, lentil steak | 20:31 |
| jonathan__ | so there was a lab meetup today at 1pm | 20:31 |
| yashgaroth | damn I was busy for some reason | 20:31 |
| jonathan__ | I was there at 1pm with some dude who came in off the street to help | 20:31 |
| jonathan__ | but.... no you know who | 20:32 |
| yashgaroth | like literally just walked in? | 20:32 |
| jonathan__ | new dude was basically sitting around staring at the wall while I attempted to revive my babies | 20:32 |
| jonathan__ | some way to treat free labor :-( | 20:32 |
| jonathan__ | yea | 20:32 |
| jonathan__ | well there was a carpenter dude there working on lab benches so lab was unlocked | 20:33 |
| yashgaroth | I went and saw it on sunday, new benches have a distinct lack of ergonomics for people with legs | 20:33 |
| jonathan__ | yea well, maybe you're just too tall ha | 20:33 |
| jonathan__ | evolve yourself | 20:33 |
| yashgaroth | man you gotta put your knees somewhere | 20:33 |
| jonathan__ | this is the era of downsizing | 20:33 |
| jonathan__ | the lab will only be rented out to paraplegics | 20:34 |
| yashgaroth | also the display rack of big test tubes with colored liquid inside | 20:34 |
| yashgaroth | I should make some skittles vodka in some of those for the opening | 20:34 |
| jonathan__ | I'm gonna have a special treat for the opening day, wanna know what it is | 20:34 |
| jonathan__ | oh it will be so cool | 20:35 |
| jonathan__ | for me, anyway lol | 20:35 |
| -!- eudoxia [~eudoxia@r190-135-66-107.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap | 20:35 | |
| yashgaroth | no don't tell me it'll be a surprise | 20:35 |
| yashgaroth | yes | 20:35 |
| jonathan__ | since I'm still the only one with an experiment, is that right? | 20:35 |
| yashgaroth | teeeechnically | 20:35 |
| jonathan__ | I mean, something actually living breathing bio with genes and stuff | 20:35 |
| jonathan__ | "lets have a computer with fold it" ummm come onnnnnn | 20:36 |
| jonathan__ | that must be the "beyond" in btnb.. like, beyond believability that it will fly | 20:36 |
| yashgaroth | kinda hard to start experiments when we still can't order shit to the lab address | 20:36 |
| -!- Adifex [~Adifex@75-148-41-126-Colorado.hfc.comcastbusiness.net] has joined ##hplusroadmap | 20:36 | |
| jonathan__ | geez kind of hard to get work done in a meetup to do work if there's no one to direct the work, eh? | 20:37 |
| gradstudentbot | Dropped my sample. | 20:37 |
| jonathan__ | dropped the ball more like dude | 20:37 |
| yashgaroth | yeah I mentioned to joseph that I'd be to the one next sunday and he was like 'oh yeah I just set up the repeating meetings' | 20:37 |
| jonathan__ | presumably there's a work list, not | 20:38 |
| jonathan__ | anyways I hope to turn a profit for the grand opening, that is MY measure | 20:38 |
| yashgaroth | job 1: make sure the machines go 'bing!' in time for opening day | 20:39 |
| yashgaroth | or was it 'ping!' damnit we're screwed | 20:39 |
| jonathan__ | i dunno what HIS measure is, maybe most number of rookies asking for help over and over? | 20:39 |
| yashgaroth | wait are you gonna be selling wine at the opening or kombucha | 20:39 |
| jonathan__ | my job 1: measure progress via $$$ earned. period | 20:39 |
| jonathan__ | what do you think.. I'm a friggin CAPITALIST cause I live in the U.S.A. not commie china | 20:40 |
| yashgaroth | it's not usually my first, but until we can actually support the lab I'm okay with that | 20:40 |
| jonathan__ | $$ just is a really good yardstick of success. | 20:41 |
| jonathan__ | in this country, anyways | 20:41 |
| yashgaroth | in pretty much any country, including china these days | 20:41 |
| jonathan__ | not that the definition of success makes any sense. other than that's what people want at the time. | 20:42 |
| jonathan__ | the new dude today is apparently a yeast grower. | 20:42 |
| jonathan__ | currently at a brewing supply co. | 20:42 |
| yashgaroth | maybe he just hadn't showered | 20:42 |
| yashgaroth | oh | 20:43 |
| jonathan__ | he was... fascinated... by my (your) glassware | 20:43 |
| jonathan__ | it made me somehow understand his career choices. | 20:43 |
| yashgaroth | brb buying lockbox | 20:43 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 20:44 | |
| jonathan__ | gradstudentbot, do you know any hot postdocs? | 20:44 |
| gradstudentbot | Yeah, but his project was so easy. | 20:44 |
| -!- weles [~mariusz@c-71-234-3-169.hsd1.ct.comcast.net] has quit [Ping timeout: 252 seconds] | 20:58 | |
| -!- randallagordon [~randall@75-175-52-220.ptld.qwest.net] has quit [Ping timeout: 252 seconds] | 21:05 | |
| -!- randallagordon [~randall@71-38-144-220.ptld.qwest.net] has joined ##hplusroadmap | 21:07 | |
| -!- Juul [~Juul@static.3.202.4.46.clients.your-server.de] has quit [Ping timeout: 264 seconds] | 21:10 | |
| -!- eudoxia [~eudoxia@r190-135-66-107.dialup.adsl.anteldata.net.uy] has quit [Quit: leaving] | 21:13 | |
| -!- Juul [~Juul@199-188-193-9.PUBLIC.monkeybrains.net] has joined ##hplusroadmap | 21:21 | |
| -!- ParahSailin [~Rob@50-194-178-148-static.hfc.comcastbusiness.net] has quit [Ping timeout: 256 seconds] | 21:24 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 21:30 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 264 seconds] | 21:30 | |
| -!- ParahSailin [~Rob@50-194-178-148-static.hfc.comcastbusiness.net] has joined ##hplusroadmap | 21:37 | |
| audy | <3 gradstudentbot | 21:42 |
| gradstudentbot | Who has the latest version of the paper? | 21:42 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 21:43 | |
| * brownies pokes gradstudentbot | 21:53 | |
| gradstudentbot | I think the centrifuge is broken. | 21:53 |
| brownies | .meow | 21:53 |
| yoleaux | http://moar.edgecats.net/cats/5NrgZ.gif | 21:53 |
| heath | http://parts.igem.org/Part:BBa_R0051 | 22:02 |
| heath | what does the SS AND DS acronyms stand for? | 22:02 |
| heath | i'm guessing DS = dna sequence? | 22:02 |
| heath | ss = _ sequence | 22:02 |
| yashgaroth | single and double stranded | 22:02 |
| heath | um, that makes complete sense | 22:03 |
| * heath blushes' | 22:03 | |
| heath | yashgaroth: do you know what OR1 and OR2 stand for? | 22:04 |
| ParahSail1n | occipital reticulin 1 and 2 | 22:04 |
| yashgaroth | binding sites for cI, apparently | 22:05 |
| yashgaroth | or is that cl, damn alphabet | 22:05 |
| yashgaroth | oh nope it's cI | 22:05 |
| yashgaroth | so if the cI protein is being expressed in the cell, the promoter is repressed | 22:06 |
| jonathan__ | bryan - about that paper you asked about, ultrasonic rug delivery | 22:08 |
| heath | ParahSail1n: if you don't mind me askin,g how'd you know that? i'm trying to learn to put together my first assembly of these parts | 22:09 |
| heath | i'm reading the RFCs and also noticing that some of these parts aren't as well characterized as others have already pointed out | 22:10 |
| ParahSail1n | er, i just bs'd | 22:10 |
| ParahSail1n | yashgaroth's cro operon fits a lot better than my made up words | 22:11 |
| yashgaroth | my response was actually true but y'know whatever ignore me | 22:11 |
| jonathan__ | I guess the question was about the driving circuitry. well Im not sure why it takes a whole paper to describe differential signaling, anyways, it is relatively straightforward what they are doing, there is no need for an FPGA etc etc | 22:11 |
| ParahSail1n | in general, if you give two letters and a number for a gene, you're usually not going to have a useful time finding what that is without more context | 22:12 |
| gradstudentbot | The paper got rejected. | 22:12 |
| ParahSail1n | so i didnt even bother googling | 22:12 |
| yashgaroth | I thought it was just one of those technically correct answers | 22:13 |
| jonathan__ | kanzure: so in essence just use a TI 6x DSP chip | 22:13 |
| ParahSail1n | http://www.uniprot.org/uniprot/?query=or1&sort=score 170 pages of or1 to choose from | 22:14 |
| jonathan__ | the bigger problem is that the piezo element they created is 100% custom fabrication | 22:15 |
| jonathan__ | can't get that off the shelf | 22:15 |
| jonathan__ | also I thought that acoustic delivery systems had a habit of destroying whatever was being delivered | 22:17 |
| jonathan__ | there's huge pressures at play, at micro sizes | 22:17 |
| heath | yashgaroth: heh, i'm sorry | 22:17 |
| yashgaroth | no worries | 22:19 |
| jonathan__ | It's a pretty meaty paper so I'd have to give it a more careful reading. | 22:19 |
| heath | slightly under the influence of things affecting my discernment :) | 22:19 |
| jonathan__ | I just skimmed around here & there. | 22:19 |
| jonathan__ | suppose you guys had 5 undergrads at your 100% disposal right now to work on whatever you want. What would you have them work on? | 22:23 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 252 seconds] | 22:31 | |
| heath | depends on their qualifications | 22:33 |
| jonathan__ | I think I would have them work on cloning micheal jackson. | 22:34 |
| heath | i'm wondering which papers are associated with this guy: http://parts.igem.org/wiki/index.php?title=Part:BBa_J45004 | 22:36 |
| heath | jonathan__: where are you located btw? | 22:36 |
| heath | kanzure: you know of anyone else here that's in the southeast? | 22:36 |
| jonathan__ | i have no location, on a public channel | 22:37 |
| * heath thinks he recalls TX | 22:37 | |
| heath | http://www.amazon.com/Synthetic-Biology-Part-Volume-Characterization/dp/0123850754 | 22:37 |
| heath | .title | 22:38 |
| yoleaux | Synthetic Biology, Part A, Volume 497: Methods for Part/Device Characterization and Chassis Engineering (Methods in Enzymology): Chris Voigt: 9780123850751: Amazon.com: Books | 22:38 |
| heath | i want this | 22:38 |
| heath | http://libgen.info/view.php?id=723808 | 22:38 |
| heath | that works | 22:38 |
| jonathan__ | oh, perfect, subject Техника | 22:40 |
| jonathan__ | Hm let me file this under Техника | 22:40 |
| jonathan__ | Техника: One morning, as Gregor Samsa was waking up from anxious dreams, he discovered that in his bed he had been changed into a monstrous verminous bug. He lay on his armour-hard back and saw, as he lifted his head up a little, his brown, arched abdomen divided up into rigid bow-like sections. From this height the blanket, just about ready to slide off completely, could hardly stay in place. His numerous legs, pitifull | 22:43 |
| jonathan__ | in comparison to the rest of his circumference, flickered helplessly before his eyes. | 22:43 |
| jonathan__ | That's one for the undergrads too. | 22:44 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 22:44 | |
| yashgaroth | very Техникаesque | 22:44 |
| jonathan__ | yes quite | 22:45 |
| -!- marciogm [~textual@177.106.60.46] has joined ##hplusroadmap | 22:48 | |
| -!- joehot [~not@100.43.114.90] has joined ##hplusroadmap | 22:49 | |
| jonathan__ | many of the supposed projects I come up with are fine for undergrads or postdocs and often PI's claim it is worth pursuing, but the grad students, man they are never believers | 22:49 |
| jonathan__ | ok maybe here's a better question | 22:50 |
| gradstudentbot | You know they keep the mice in better conditoins than us. | 22:51 |
| jonathan__ | what should the undergrads have to be experienced with in order to be valuable | 22:51 |
| -!- pads [~not@100.43.114.90] has quit [Ping timeout: 256 seconds] | 22:51 | |
| -!- jrayhawk [~jrayhawk@nursie.omgwallhack.org] has quit [Remote host closed the connection] | 22:53 | |
| -!- jrayhawk [~jrayhawk@nursie.omgwallhack.org] has joined ##hplusroadmap | 22:53 | |
| -!- marciogm [~textual@177.106.60.46] has quit [Quit: Computer has gone to sleep.] | 22:57 | |
| jonathan__ | paperbot: http://www.wiley.com/WileyCDA/WileyTitle/productCd-1118610733.html | 23:01 |
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/b8435a6877fa587c45d8c700aa10b471.txt | 23:01 |
| jonathan__ | max, I'm gonna need some of this http://www.abmgood.com/APOE-siRNA-Lentivectors-7-APOE.html | 23:02 |
| yashgaroth | don't we all | 23:05 |
| jonathan__ | paperbot http://www.nature.com/nrg/journal/v3/n10/pdf/nrg908.pdf | 23:07 |
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/a5e9fa2a7db16690a87bfcfcca66db31.pdf | 23:07 |
| jonathan__ | do you know if that is really viable? | 23:08 |
| yashgaroth | it's not really | 23:08 |
| yashgaroth | RNAi has a lot of problems, lentiviruses have a lot of them too | 23:09 |
| jonathan__ | "Abstract | RNA interference (RNAi) is a powerful approach for reducing expression of endogenously expressed proteins. It is widely used for biological applications and is being harnessed to silence mRNAs encoding pathogenic proteins for therapy. Various methods — including delivering RNA oligonucleotides and expressing RNAi triggers from viral vectors — have been developed for successful RNAi in cell culture and in vivo. | 23:10 |
| jonathan__ | Recently, RNAi-based gene silencing approaches have been demonstrated in humans, and ongoing clinical trials hold promise for treating fatal disorders or providing alternatives to traditional small molecule therapies. " | 23:10 |
| jonathan__ | so what's the problem? | 23:11 |
| yashgaroth | mostly everything about it | 23:11 |
| yashgaroth | people got all hyped because it was the first novel regulatory system discovered in a decade | 23:11 |
| yashgaroth | to get use out of knocking down a gene, you'll probably need to knock it down in a significant fraction of the cells | 23:12 |
| yashgaroth | low duration of expression | 23:12 |
| yashgaroth | and viral vectors are usually attacked by the immune system | 23:12 |
| yashgaroth | in a few years it may play an important part in select therapies | 23:14 |
| -!- Juul [~Juul@199-188-193-9.PUBLIC.monkeybrains.net] has quit [Ping timeout: 276 seconds] | 23:14 | |
| jonathan__ | hmmmm | 23:15 |
| yashgaroth | you will often find that people who bank their entire academic career on a specific niche will be biased toward its relevancy | 23:15 |
| jonathan__ | well sounds like regular injections are just required right | 23:16 |
| jonathan__ | you know, bioshock style | 23:16 |
| yashgaroth | the advantage of gene therapy is theoretically that you only need one, or maybe a few injections | 23:16 |
| yashgaroth | there's some promising work in morpholinos, which are synthetic RNAi's with modified backbones that give them a much better half-life | 23:16 |
| yashgaroth | since the half-life of RNAi is absurdly short in vivo | 23:17 |
| jonathan__ | well suppose that problem is solved... lets say a microinjector is surgically sewn in like an insulin pump | 23:17 |
| yashgaroth | not recommended to take viral gene therapy without immunosuppressants | 23:18 |
| yashgaroth | if you don't get the dose you need, you've immunized yourself against the medicine | 23:18 |
| yashgaroth | it's hard to find a condition that's easily treated by RNAi alone, it's not like you often have Bad Gene X that if you could only turn it off you'd be fine | 23:20 |
| yashgaroth | usually you just have two shitty recessive versions of Normal Gene X | 23:21 |
| jonathan__ | paperbot http://www.tandfonline.com/doi/pdf/10.1081/E-EBAF-120043002 | 23:22 |
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/8a72c68cef5e51ac07e4bcffccce4b44.txt | 23:22 |
| yashgaroth | "RNAi technology promising to create safe and effective models that may in fact reach the herds in the future" right | 23:22 |
| jonathan__ | paperbot http://www.tandfonline.com/doi/abs/10.1081/E-EBAF-120043002 | 23:22 |
| paperbot | no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/d6bf4314aa10356701bbc9d4def39774.txt | 23:23 |
| jonathan__ | ah you're such a pessimist | 23:24 |
| yashgaroth | nah just accurate | 23:25 |
| -!- Adifex [~Adifex@75-148-41-126-Colorado.hfc.comcastbusiness.net] has quit [Quit: Adifex] | 23:25 | |
| jonathan__ | I read it in Nature, it has to be true! | 23:26 |
| jonathan__ | paperbot http://www.annualreviews.org/doi/pdf/10.1146/annurev-biophys-083012-130404 | 23:26 |
| paperbot | error: HTTP 200 http://diyhpl.us/~bryan/papers2/paperbot/b15aa335bb7be028b24757b21d4efe33.pdf | 23:26 |
| yashgaroth | add that one to gradstudentbot's cache | 23:26 |
| gradstudentbot | Hey, does anyone have an extra undergrad? | 23:26 |
| -!- kmo [~kmo@unaffiliated/kmo] has quit [Quit: Leaving] | 23:28 | |
| jonathan__ | what happened to that journal supposed to be for publishing papers that don't work... | 23:28 |
| yashgaroth | journal of negative results? same thing that happened to everyone going to open access journals...'well not everyone's doing it so I'll look bad by publishing there' | 23:29 |
| yashgaroth | my impact factoru~~ | 23:30 |
| yashgaroth | oh you published in JNR? you must be terrible at experiments, unlike me who burns all results that don't fit my worldview/grant | 23:31 |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 252 seconds] | 23:31 | |
| jonathan__ | hm | 23:32 |
| yashgaroth | I exaggerate for comedic and pessimistic effect, but not by much | 23:32 |
| jonathan__ | "Use and abuse of RNAi to study mammalian gene function" | 23:33 |
| jonathan__ | WG Kaelin - Science, 2012 | 23:33 |
| yashgaroth | heh | 23:34 |
| jonathan__ | My poor APOE | 23:35 |
| jonathan__ | will never be silenced :-( | 23:35 |
| jonathan__ | paperbot http://www.nature.com/mt/journal/vaop/ncurrent/full/mt2013124a.html | 23:37 |
| paperbot | HTTP 401 unauthorized http://www.nature.com/mt/journal/vaop/ncurrent/pdf/mt2013124a.pdf | 23:37 |
| jonathan__ | oh you just need to add NANO particles! | 23:38 |
| jonathan__ | "Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics" | 23:38 |
| jonathan__ | zzzzz | 23:40 |
| yashgaroth | eurgh and also zzzz | 23:40 |
| -!- yashgaroth [~ffffff@cpe-66-27-118-94.san.res.rr.com] has quit [Quit: Leaving] | 23:42 | |
| -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap | 23:43 | |
| -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap | 23:56 | |
| -!- klafka_ [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Ping timeout: 256 seconds] | 23:58 | |
| --- Log closed Wed Jul 03 00:00:14 2013 | ||
Generated by irclog2html.py 2.15.0.dev0 by Marius Gedminas - find it at mg.pov.lt!
