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| jrayhawk_ | http://en.wikipedia.org/wiki/McLaren_MP4-25#F-duct outstanding | 09:34 |
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| kanzure | hrm | 10:36 |
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| ||0_-_0|| | paperbot http://www.nature.com/nbt/journal/v32/n1/full/nbt.2786.html | 12:58 |
| paperbot | http://libgen.org/scimag/get.php?doi=10.1038%2Fnbt.2786 | 12:58 |
| kanzure | .title http://www.nature.com/nbt/journal/v32/n1/full/nbt.2786.html | 13:00 |
| yoleaux | Clinical development success rates for investigational drugs | 13:00 |
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| ||0_-_0|| | I'm building an axe, kanzure | 13:13 |
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| ||0_-_0|| | seeking to quantify the pattern by which pharma R&D is getting steadily worsening returns and in doing so figure out the R&D investment::clinical advancement limit | 13:14 |
| kanzure | ||0_-_0||: i suggest going the opposite direction, presenting a question like "if our target is 1 new drug per $1 million, what would have to change to make the system this efficient?" | 13:15 |
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| FourFire | ||0_-_0||, kanzure's suggestion sounds like an admirable goal | 13:24 |
| ||0_-_0|| | FourFire + kanzure you've hit the other part of the analysis spot-on; the above is about determining total opportunity size | 13:24 |
| FourFire | alright | 13:25 |
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| kanzure | what does "total opportunity size" have to do with "how would we achieve a goal of a $1 million pipeline?" ? | 13:47 |
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| kanzure | various photoresist datasheets http://diyhpl.us/~bryan/papers2/curing/datasheets/ | 15:49 |
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| kanzure | .title https://www.youtube.com/watch?v=8SkdfdXWYaI#t=558 | 17:18 |
| yoleaux | Using Python to Code by Voice | 17:18 |
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| nsh | because what software needs most is more ways to misinterpret your intentions | 17:24 |
| kanzure | well, everyone else does that anyway | 17:26 |
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| kanzure | not sure what this is: "Esterline Instrument Corp 201CE" | 19:55 |
| kanzure | "Made by Esterline Instrument Corp for Bio-Rad. Part Number 201CE. Unit consists of a Deuterium Lamp, Beam splitter, Lens that couples to sample chamber, (not included). and stepper motor driven mirror assembly which balances the sample output to the reference output and produces a measurable value" | 19:55 |
| kanzure | something about light.. but then there's a chamber because ?? | 19:55 |
| kanzure | and then you are measuring something because why not? | 19:55 |
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| kanzure | ugh microscope adapters http://www.microscopy-uk.org.uk/mag/artmar13/gm-digital.pdf | 20:53 |
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| kanzure | an okay list: http://en.wikipedia.org/wiki/Genetically_modified_crops#Examples_of_genetically_modified_crops | 21:57 |
| dingo | i turned 0x1f earlier this week | 21:59 |
| dingo | happy birthday me! | 21:59 |
| gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=0c5aa24a Bryan Bishop: things that have been done with custom DNA >> http://diyhpl.us/diyhpluswiki/dna/projects/ | 22:05 |
| kanzure | i was asked what could be done with custom dna, so i thought i should at least write down a list | 22:06 |
| kanzure | ParahSailin: i know i am forgetting lots of really important stuff, perhaps you could recommend a few.. | 22:06 |
| kanzure | especially non-commercial non-implemented stuff | 22:08 |
| kanzure | gah, i forgot about all the igem projects | 22:13 |
| kanzure | and i forgot how awful their site is for figuring out which ones did any gene stuff: | 22:14 |
| kanzure | http://igem.org/Results?year=2012®ion=All&division=igem | 22:14 |
| ebowden | Oh, kanzure, I heard something about rare codons, if the start of a sequence that codes for a protein has a rare codon, endpoint protein production was increased. Have you heard about this? | 22:14 |
| kanzure | "spider silk gfp fusion protein" http://2012.igem.org/Team:Utah_State | 22:14 |
| kanzure | "arachnicoli" with someone dressed up in a spiderman suit holding a petri dish :shakes head: | 22:17 |
| ebowden | Damn it. I can only find the press release. | 22:24 |
| ebowden | http://wyss.harvard.edu/viewpressrelease/125/a-hidden-genetic-code-for-better-designer-genes- | 22:24 |
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| ebowden | paperbot http://link.springer.com/article/10.1007%2Fs10969-013-9163-9 | 22:33 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/New%20LIC%20vectors%20for%20production%20of%20proteins%20from%20genes%20containing%20rare%20codons.pdf | 22:33 |
| ebowden | God damn it I love you paperbot. | 22:36 |
| gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f92a78ff Bryan Bishop: various igem projects >> http://diyhpl.us/diyhpluswiki/dna/projects/ | 22:43 |
| kanzure | https://ia801509.us.archive.org/18/items/al_saleel_4/SaleelSawarim.mp4 | 22:57 |
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| -!- kumavis [~kumavis@24-196-137-155.static.ftbg.wi.charter.com] has joined ##hplusroadmap | 23:34 | |
| -!- ebowden [~ebowden@CPE-60-231-182-1.lns4.dav.bigpond.net.au] has joined ##hplusroadmap | 23:35 | |
| --- Log closed Sat Jun 14 00:00:34 2014 | ||
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