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| chris_99 | http://sxm4.uni-muenster.de/stm-en/ | 04:50 |
|---|---|---|
| yoleaux | 00:00Z <nmz787_i> chris_99: nope, they kept telling me they sent it and to wait, and then that they sent a second (and maybe a third) and eventually I had to dispute the sale and got my money back.... not sure how realistic their claims were or if it was just some ebay scam where I essentially loaned them $130 for a few months... | 04:50 |
| chris_99 | anyone seen that | 04:50 |
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| fenn | yes | 05:21 |
| chris_99 | oh i just found this one too, which has got some pretty photos - http://dberard.com/home-built-stm/ | 05:22 |
| kanzure | beep | 05:34 |
| chris_99 | boop | 05:36 |
| chris_99 | theres no reason you couldn't image dies with STM is there? | 05:36 |
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| CaptHindsight | who does your machine work? Does anyone here have a machine shop> | 05:44 |
| CaptHindsight | ? | 05:44 |
| kanzure | well, i have an imaginary/pretend machine shop... does that count? | 05:51 |
| adlai | kanzure: can i give paperbot an isbn? | 05:52 |
| kanzure | you would have to submit a copy of paperbot to the library of congress, but uh sure | 05:52 |
| adlai | ironically, the book i'm looking for was written by the guy who killed english to avoid precisely such miscommunication :P | 05:53 |
| * adlai rephrases: can i feed paperbot an isbn? | 05:53 | |
| kanzure | oh! no, probably not. i don't remember implementing that sort of thing. | 05:53 |
| kanzure | submit a patch? https://github.com/kanzure/paperbont | 05:53 |
| kanzure | oops | 05:53 |
| kanzure | https://github.com/kanzure/paperbot | 05:53 |
| adlai | writing code to do this would imply that i have some algorithm and i just want to get paperbot running it, instead of me | 05:54 |
| kanzure | if you submit a patch then i'll get paperbot to run it | 05:54 |
| adlai | but i don't know how to find fulltext given isbn | 05:55 |
| * adlai is still busy trying to hunt down a digital copy of https://www.goodreads.com/book/show/17436963-the-troika-incident | 05:55 | |
| adlai | .title | 05:55 |
| yoleaux | adlai: Sorry, that command (.title) crashed. | 05:55 |
| adlai | ! | 05:56 |
| kanzure | http://eli.thegreenplace.net/2015/visualizing-matrix-multiplication-as-a-linear-combination/ | 05:56 |
| adlai | fine, i'll replace linguistic dreamery with math | 05:56 |
| CaptHindsight | chris_99: what sort of dies? | 05:59 |
| chris_99 | silicon | 05:59 |
| CaptHindsight | http://dberard.com/home-built-stm/stm-scans/ that graphite scan is ~2nm across, not bad | 06:00 |
| CaptHindsight | sorry 4nm | 06:00 |
| CaptHindsight | would a combo STM, nano-EDM (sinker) be handy? | 06:04 |
| CaptHindsight | http://www.eetasia.com/ART_8800697699_480200_NT_565b6218.HTM this could be made for a few $K or less depending on whats in your junk drawer | 06:08 |
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| kanzure | rates and fees for lab animals http://ular.osu.edu/rates-and-fees/ | 06:41 |
| kanzure | "Beginning in FY 2012, all rodents are now charged by the cage, rather than by the individual animal. " | 06:41 |
| kanzure | http://ular.osu.edu/files/2014/07/ULAR_FY15-Per-Diem-Rates.pdf | 06:42 |
| kanzure | feed costs http://www.bussvc.wisc.edu/purch/contract/wp5082.html | 06:46 |
| kanzure | 06:44 <cpopell7> I'm surprised you haven't hopped on the GDF-11 train | 06:47 |
| kanzure | 06:46 <kanzure> the gdfwho? | 06:47 |
| kanzure | 06:46 <cpopell7> growth differentiation factor 11? | 06:47 |
| kanzure | 06:46 <cpopell7> the whole 'young blood transfusion' thing | 06:47 |
| cpopell7 | yeah | 06:47 |
| kanzure | via eleitl: http://www.lowrisc.org/blog/2015/04/lowrisc-tagged-memory-preview-release/ | 07:06 |
| FourFire | kanzure, how is feed determined to effect the animal's natural health, and what about it's environment: I imagine that a cage isn't very stimulating (not about animal rights, just scientific confounders) | 07:08 |
| kanzure | "We're pleased to announce the first lowRISC preview release, demonstrating support for tagged memory as described in our memo. Our ambition with lowRISC is to provide an open-source System-on-Chip platform for others to build on, along with low-cost development boards featuring a reference implementation. ... The initial motivation for tagged memory was to prevent control-flow hijacking attacks, though there are a range of other ... | 07:08 |
| kanzure | ... potential uses including fine-grained memory synchronisation, garbage collection, and debug tools." | 07:08 |
| kanzure | FourFire: millions of caged animals are used for testing all the time. at this point the strains are probably highly adapted to cagelife. | 07:08 |
| FourFire | ok | 07:09 |
| FourFire | there's special lineages of labrats I suppose | 07:09 |
| kanzure | yep | 07:09 |
| FourFire | like those siberian bred wolves with very petlike characteristics | 07:10 |
| FourFire | I wonder, does the lowRISC arch suffer vulnerability to Rowhammer | 07:10 |
| kanzure | i thought rowhammer was just dram | 07:11 |
| kanzure | https://www.cl.cam.ac.uk/research/security/ctsrd/cheri/ | 07:14 |
| kanzure | "We are developing a prototype of the CHERI ISA using the Bluespec Extensible RISC Implementation (BERI), a 64-bit MIPS FPGA soft core implemented in the Bluespec HDL. The FreeBSD operating system, with Capsicum support, has also been ported to CHERI in order to allow us to compare, side-by-side, traditional software compartmentalisation approaches (based on a translation look-aside buffer (TLB)), with those supported by a capability ... | 07:14 |
| kanzure | ... coprocessor. Using commodity software stacks, such as FreeBSD, LLVM, and the Chromium web browser, allows us to validate our hybrid design, applying capability-based compartmentalisation selectively to support both our most trusted (OS kernel, low-level language runtimes), and least trustworthy (web browsers and servers), software components" | 07:14 |
| cpopell7 | http://www.nature.com/news/ageing-research-blood-to-blood-1.16762 | 07:16 |
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| kanzure | .title | 07:24 |
| yoleaux | Ageing research: Blood to blood : Nature News & Comment | 07:24 |
| kanzure | portable cnc router http://www.michaelwarrendesign.com/grow/Grow_CNC/Home.html | 07:34 |
| kanzure | somewhat portable | 07:35 |
| chris_99 | Patent Pending ey | 08:11 |
| kanzure | and now for your regular dosage of elon musk propaganda http://images.bwbx.io/cms/2012-09-13/features_elonmusk38__01__405inline.jpg | 08:15 |
| chris_99 | haha | 08:15 |
| chris_99 | that'd make a cool poster | 08:15 |
| eudoxia | it looks like he's flying away from an explosion at the launch pad | 08:23 |
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| kanzure | "People who ace standard cognitive tests are in fact slightly more likely to have a "bias blind spot". That is, they are less able to see their own flaws, even when though they are quite capable of criticising the foibles of others. And they have a greater tendency to fall for the "gambler's fallacy" - the idea that if a tossed coin turns heads 10 times, it will be more likely to fall tails on the 11th." | 08:57 |
| kanzure | 08:59 <@gwern> kanzure: ah, I remember that bullshit study. it focused on a tiny tiny subset where the smart people did not seem to perform better, and those were relative biases so it didn't even show that they were wrong | 08:59 |
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| kanzure | https://www.neworgan.org/prize.php "An estimated 35% of all U.S. deaths could be prevented or significantly delayed by organ transplantation. Kidney transplants are $260,000 in the U.S. Immunosuppressants, which must be taken annually, cost $10,000 per year. The New Organ Liver Prize will award $1,000,000 to the first team that creates a regenerative or bioengineered solution that keeps a large animal alive for 90 days without native ... | 09:08 |
| kanzure | ... liver function. Future challenge prizes will cover additional whole organs." | 09:08 |
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| kanzure | "We're also currently exploring a prize focused on organ preservation with the Organ Preservation Alliance, a coalition incubated by Singularity University Labs." | 09:09 |
| kanzure | "In collaboration with the Organ Preservation Alliance, New Organ is investigating an organ preservation prize to advance breakthroughs in the long-term preservation of vital organs." | 09:09 |
| CaptHindsight | my money is one not actually storing but making a digital copy and then printing a new one later | 09:10 |
| CaptHindsight | one/on | 09:10 |
| kanzure | why would it matter whether the copy is digital or not | 09:10 |
| kanzure | and why would it matter whether it is printed or not.... wtf? | 09:10 |
| CaptHindsight | rather than store the original organic material | 09:11 |
| CaptHindsight | it doesn't matter if it's the original or not unless there is some moral issue http://en.wikipedia.org/wiki/The_6th_Day | 09:12 |
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| CaptHindsight | what exactly is organovo selling? http://www.organovo.com/tissues-services/3d-human-tissues-medical-research-therapeutics | 09:17 |
| CaptHindsight | non-working tissues and overpriced printers? | 09:18 |
| nmz787_i1 | CaptHindsight: I'd imagine if they can use your own cells and revert them to i.e. kidney, that the printed organ could be moderately effective at least relative to dialysis treatment... I think the problem at this point is lack of experimentation on people-about-to-die (people who want to try experimental treatment is just gaining some steam it seems) | 09:20 |
| nmz787_i1 | http://www.organovo.com/tissue-service-inquiries | 09:21 |
| CaptHindsight | nmz787: lets say you can print a new kidney now using the exact DNA or with slight mods in case the cause of of failure is genetic... | 09:32 |
| CaptHindsight | is there any clue to how the body reacts long term to those mods? | 09:34 |
| CaptHindsight | I'm just wonder if gene therapy will be the future or if organs will have to be printed and transplanted | 09:35 |
| CaptHindsight | over time what regulates which DNA stays in the cells of an organ? | 09:38 |
| heath | chris_99: google for stm site:gnusha.org/logs for a fun time | 09:44 |
| heath | bettery yet grep for stm and filter links | 09:44 |
| chris_99 | ah cheers | 09:44 |
| chris_99 | heh quite a lot of results | 09:46 |
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| kanzure | CaptHindsight: organ transplants tend to require immunosuppressants so that your immune system doesn't kill yourself | 09:57 |
| CaptHindsight | kanzure: if the organ is from someone else | 09:58 |
| kanzure | that's overly simplistic | 09:58 |
| CaptHindsight | what I'm wondering is if the printed organ only has slight mods to correct a genetic defect | 09:59 |
| CaptHindsight | at sure at some point how much it's been modified triggers an immune system reaction | 09:59 |
| kanzure | well if you define your problem as "it's totally the same organ but one or two things changed" then by definition there's no way anyone could argue with you..... | 09:59 |
| CaptHindsight | at/I/m | 09:59 |
| kanzure | almost everything triggers a reaction | 09:59 |
| chris_99 | paperbot: http://jes.ecsdl.org/content/139/10/2825.abstract | 10:00 |
| CaptHindsight | how well it this understood? | 10:00 |
| paperbot | http://libgen.info/scimag/get.php?doi=10.1149%2F1.2068987 | 10:00 |
| kanzure | there's tens of thousands of organ transplants per year. how do you want to measure understanding? | 10:01 |
| kanzure | (or more) | 10:01 |
| CaptHindsight | down to the molecular level | 10:02 |
| CaptHindsight | why and how does it happen | 10:02 |
| nmz787_i1 | CaptHindsight: depends on where the mod is | 10:07 |
| nmz787_i1 | CaptHindsight: i.e. only protein fragments set off the main concerns around immunoreactions AFAIK | 10:07 |
| nmz787_i1 | stuff that get's presented on the cell surface | 10:07 |
| nmz787_i1 | so if the mod was in a promoter, I doubt there'd be any notice | 10:07 |
| nmz787_i1 | CaptHindsight: http://en.wikipedia.org/wiki/Major_histocompatibility_complex | 10:08 |
| nmz787_i1 | http://en.wikipedia.org/wiki/Major_histocompatibility_complex#In_transplant_rejection | 10:08 |
| archels | I don't think there's an actual microfluidics device here to take photos of | 10:08 |
| * archels will keep looking | 10:09 | |
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| nmz787_i1 | is waag prnounced like 'wag' as in 'the dog wags its tail' or is it like 'waug' as in 'I'm a maug, half man, half dog' | 11:11 |
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| kanzure | http://livestream.com/spacex/events/3959775 | 13:12 |
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| kanzure | .title https://www.youtube.com/watch?v=fs-XI58YeQc | 13:20 |
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| kanzure | .title https://www.youtube.com/watch?v=3ZLG9m1idkI | 13:22 |
| yoleaux | SpaceX's Falcon 9 rocket crash landing on autonomous spaceport drone ship - YouTube | 13:23 |
| yoleaux | SpaceX Barge/ASDS Being Worked On, Fueled, and Towed out of Jacksonville Port on 2015-01-08 - YouTube | 13:23 |
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| heath | hi jdolan | 13:25 |
| jdolan | o/ | 13:25 |
| kanzure | not another jperson | 13:26 |
| heath | kanzure: jdolan is sitting beside me atm | 13:32 |
| heath | https://github.com/jdolan/ | 13:32 |
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| jdolan | and now i go home :) | 13:37 |
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| heath | recommendations on lawyers who can type up a decent `terms and conditions` and `privacy policy`? | 13:48 |
| kanzure | .g site:news.ycombinator.com "terms and conditions" lawyer | 13:59 |
| yoleaux | https://news.ycombinator.com/item?id=2910571 | 13:59 |
| kanzure | .title | 13:59 |
| yoleaux | Poll: Where did you get your site/app's Terms of Service & Privacy Policy? | Hacker News | 13:59 |
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| nmz787_i | heath: I've dealt with Grellas.com | 14:19 |
| nmz787_i | heath: he posts on HN sometimes, pretty decent feedback | 14:19 |
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| kanzure | Joseph_P: hi | 15:11 |
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| Joseph_P | kanzure: hi | 15:18 |
| jrayhawk_ | jrayhawk: hi | 15:19 |
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| nmz787_i | http://seekingalpha.com/news/2423436-bloomberg-disgruntled-altera-shareholders-pushing-for-intel-deal | 16:49 |
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| kanzure | .tw 588144086755999744 | 18:18 |
| yoleaux | If this works, I'm treating myself to a volcano lair. It's time. (@elonmusk) | 18:18 |
| kanzure | http://www.aucklandcivildefence.org.nz/media/48896/2015-03-27-Auckland-Volcanic-Field-Contingency-Plan-Version-2-.pdf | 18:21 |
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| kanzure | "No results found for "Jonathan Pitre" cryonics." seriously? | 18:33 |
| kanzure | wtf is wrong with you people | 18:33 |
| heath | nmz787: ty sir | 18:49 |
| heath | kanzure: oh nice, thanks for the link | 18:50 |
| kanzure | .title https://www.youtube.com/watch?v=TQ6tZtGrShg | 18:54 |
| yoleaux | Elons Tour of SpaceX HD - YouTube | 18:54 |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 19:22 | |
| heath | .title https://www.youtube.com/watch?v=7hvpoLKJHOw | 19:35 |
| yoleaux | How to build a brain with Python - YouTube | 19:35 |
| heath | talking about https://github.com/nengo/nengo | 19:39 |
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| -!- helleshin [~talinck@66.161.138.110] has quit [Quit: Connection reset by bear] | 20:07 | |
| nmz787 | https://hackaday.io/project/5150-arduino-ide-for-esp8266-quickstart-guide | 20:18 |
| nmz787 | .title | 20:18 |
| yoleaux | Arduino IDE for ESP8266 Quickstart Guide • Hackaday.io | 20:18 |
| adlai | nengo's license is fun reading | 20:26 |
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| -!- Quashie [~boingredd@50.14.92.17] has joined ##hplusroadmap | 20:46 | |
| catern | wooo transhumanism | 20:50 |
| kanzure | hm? | 20:50 |
| catern | nothing | 20:51 |
| kanzure | are you sure | 20:51 |
| catern | it's because this is the only transhumanist channel I'm in, what with #lesswrong becoming more and more terrible | 20:52 |
| catern | are there any other good ones? | 20:52 |
| kanzure | no | 20:52 |
| kanzure | this is the island | 20:52 |
| catern | oh | 20:52 |
| kanzure | this is it | 20:52 |
| catern | oh | 20:52 |
| catern | :( | 20:52 |
| kanzure | we have eight years of logs, have fun http://gnusha.org/logs | 20:52 |
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| kanzure | dunno what to tell you, lesswrong just does not seem to incubate the right sort of people | 20:55 |
| catern | well it had a pretty big positive impact on me but the community has degenerated pretty hard | 21:02 |
| Quashie | I keep meaning to go to a meetup | 21:02 |
| Quashie | but it's so easy to just chill with hacker schoolers instead | 21:02 |
| Quashie | who, I must say, are totally the best cult | 21:03 |
| catern | are they? | 21:14 |
| catern | but | 21:14 |
| catern | I have a prejudice against web development | 21:14 |
| nmz787 | what would I use to draw lines that werehighlightable by groups on web? css classes? | 21:20 |
| nmz787 | highlight lines that were drawn* | 21:20 |
| nmz787 | does SVG allow classes that CSS can hook onto? | 21:21 |
| nmz787 | that hovering over would also work into? | 21:21 |
| nmz787 | paperbot: http://www.ingentaconnect.com/content/cog/ct/2014/00000023/00000012/art00013 | 21:35 |
| Quashie | what about web development? | 21:35 |
| nmz787 | http://diyhpl.us/~nmz787/pdf/Functional_Regeneration_of_Supraspinal_Connections_in_a_Patient_With_Transected_Spinal_Cord_Following_T | 21:36 |
| nmz787 | ransplantation_of_Bulbar_Olfactory_Ensheathing_Cells_With_Peripheral_Nerve_Bridging.pdf | 21:36 |
| nmz787 | http://diyhpl.us/~nmz787/pdf/Functional_Regeneration_of_Supraspinal_Connections_in_a_Patient_With_Transected_Spinal_Cord_Following_Transplantation_of_Bulbar_Olfactory_Ensheathing_Cells_With_Peripheral_Nerve_Bridging.pdf | 21:36 |
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| smokeink | !help | 21:48 |
| adlai | paperbot: Common LISP Modules: Artificial Intelligence in the Era of Neural Networks and Chaos Theory | 21:50 |
| smokeink | paperbot: hi | 21:50 |
| catern | Quashie: that it's beneath me and is just unchallenging grunt work | 21:51 |
| Quashie | yeah but how did it come up | 21:53 |
| catern | Quashie: oh, hacker school teaches web development doesn't it? | 21:53 |
| Quashie | no, it doesn't teach anything | 21:53 |
| Quashie | actually they changed the name to recurse centre because people thought they were a school | 21:53 |
| Quashie | also people got the wrong impression from "hacker" | 21:54 |
| catern | oh | 21:54 |
| catern | what impression did they get from hacker? | 21:54 |
| Quashie | it's really more of a writer's retreat, people just work on whatever | 21:54 |
| Quashie | like, black hat | 21:54 |
| catern | lol | 21:54 |
| Quashie | plenty of people post-hacker school are not doing web dev, myself included | 21:55 |
| catern | ok | 21:55 |
| catern | sorry for my misunderstanding | 21:55 |
| Quashie | nah, it's a common misunderstanding, hence the name change (which I'm still taking time to get used to) | 21:56 |
| Quashie | at pycon something like 10 of the talks were by various hacker schoolers | 21:57 |
| nmz787 | web is quite pervasive, and has a ton of standardization behind it (which is more to say than the longest running non-web GUI projects) | 22:02 |
| nmz787 | of course all the security and performance stuff to think about is quite a bit different than end-client/desktop dev | 22:02 |
| Quashie | I guess it depends what you mean by "web dev" | 22:03 |
| Quashie | I mean, I've been working on an analytics engline, but the primary place that it'll be consumed is a web app | 22:04 |
| Quashie | *engine | 22:04 |
| nmz787 | I've been trying to really wrap my head around whether model view controller could make for an easy any-interface app | 22:20 |
| smokeink | paperbot: Common LISP Modules: Artificial Intelligence in the Era of Neural Networks and Chaos Theory | 22:30 |
| nmz787 | smokeink: that isn't how it works | 22:52 |
| nmz787 | you need to give it a link | 22:52 |
| smokeink | paperbot:http://www.markwatson.com/books/lispbook.zip | 22:54 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/8b84fb688204aaab91acc1e7dfa9424c.txt | 22:54 |
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| adlai | smokeink: http://libgen.org/book/index.php?md5=3aa83fe54841ee843ed6aa84a4b7db5e | 23:04 |
| smokeink | thanks | 23:13 |
| nmz787 | bam http://portland.craigslist.org/wsc/ele/4979382883.html | 23:45 |
| nmz787 | .title | 23:46 |
| yoleaux | Electron Microscope SEM Jeol JSM-T200 | 23:46 |
| --- Log closed Wed Apr 15 00:00:53 2015 | ||
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