| --- Log opened Tue Jun 23 00:00:49 2015 | ||
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| eleitl | Why just the entire galaxy. If you got that, you can got for a cluster or supercluster. | 01:28 |
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| kanzure | well, it's important to not be too ambitious | 04:16 |
| kanzure | and i worry that not too many people know about superclusters | 04:16 |
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| kanzure | and nobody knows about filaments | 04:35 |
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| kanzure | http://richardelwes.co.uk/2015/06/18/the-top-10-mathematical-achievements-of-the-last-5ish-years-maybe/ | 05:19 |
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| kanzure | "geomagnetic storm hits earth" "oh.. superkuh probably knows something about thi--- oh https://news.ycombinator.com/item?id=9763536 " | 05:21 |
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| eleitl | What is superkuh doing professionally? | 05:22 |
| superkuh | Nothing. | 05:23 |
| eleitl | By design? | 05:23 |
| kanzure | eleitl: stuff like http://superkuh.com/spiralantenna.html | 05:25 |
| eleitl | Nice, but how do you pay for that without a dayjob? | 05:26 |
| eleitl | Ok, he says "without a budget". | 05:27 |
| eleitl | Too bad about your data loss, superkuh. | 05:28 |
| superkuh | Yeah. It wasn't fun. | 05:28 |
| kanzure | pesky pigs | 05:28 |
| eleitl | They took the backup, too? | 05:29 |
| eleitl | Bastards. | 05:29 |
| eleitl | Another reason to backup to the cloud. | 05:30 |
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| eleitl | Hail eudoxia. | 05:33 |
| eudoxia | hi eleitl | 05:33 |
| eudoxia | that trubrain thing didn't kill me, phew | 05:33 |
| eleitl | Did you notice anything? | 05:34 |
| eudoxia | no, but i did settle on a solution to a problem that had been bouncing around my head for a while | 05:35 |
| eudoxia | another coworker reports having vomited | 05:36 |
| eleitl | That high concentration is probably hard on the stomach. | 05:36 |
| eudoxia | so ¯\_(ツ)_/¯ | 05:36 |
| eleitl | My stack gives me trouble at times. | 05:36 |
| kanzure | .title http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042731/ | 05:38 |
| yoleaux | Co-Culture of Neurons and Glia in a Novel Microfluidic Platform | 05:38 |
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| kanzure | i am having difficulty finding an online source for comparative neuroanatomy between adult human brains | 06:09 |
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| kanzure | "Host Performance as a Target of Manipulation by Parasites: A Meta-Analysis" | 06:39 |
| kanzure | "Eric McElroy, Andrew George and Isaure de Buron. (2015) The muscle dwelling myxozoan, Kudoa inornata, enhances swimming performance in the spotted seatrout, Cynoscion nebulosus. Parasitology Research." | 06:39 |
| kanzure | neat.. https://en.wikipedia.org/wiki/Myxozoa | 06:40 |
| kanzure | "many have a two-host lifecycle, involving a fish and an annelid worm or bryozoan. The average size of a myxosporean spore usually ranges from 10 μm to 20 μm[4] whereas that of a malacosporean spore can be up to 2 mm. ... Infection occurs through valved spores. These contain one or two sporoblast cells and one or more polar capsules that contain filaments which anchor the spore to its host. The sporoblasts are then released as a motile ... | 06:41 |
| kanzure | ... form, called an amoebula, which penetrates the host tissues and develops into one or more multinucleate plasmodia. Certain nuclei later pair up, one engulfing another, to form new spores." | 06:42 |
| kanzure | "Relationships between myxosporeans and their hosts are often highly evolved and do not usually result in severe diseases. Infection in fish hosts can be extremely long-lasting, potentially persisting for the lifetime of the host" | 06:42 |
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| archels | most of these parasite-induced changes in performance are just going to be tradeoffs, don't you think? | 06:47 |
| archels | get better at A, but worse at B | 06:47 |
| kanzure | symbiotic lifeforms are just like, a myth or something | 06:49 |
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| archels | one cool thing that they could do is region-specific targetting | 06:55 |
| kanzure | .title http://www.scielo.org.za/scielo.php?pid=S0038-23532013000100017&script=sci_arttext&tlng=pt | 06:55 |
| yoleaux | South African Journal of Science - Effect of toxoplasmosis on personality profiles of Iranian men and women | 06:55 |
| kanzure | archels: hm? | 06:56 |
| kanzure | "Infection of male rats with Toxoplasma gondii results in enhanced delay aversion and neural changes in the nucleus accumbens core" http://www.researchgate.net/profile/Lee_Wei_Lim2/publication/277078037_Infection_of_male_rats_with_Toxoplasma_gondii_results_in_enhanced_delay_aversion_and_neural_changes_in_the_nucleus_accumbens_core/links/556161d708ae86c06b64ab56.pdf | 06:57 |
| kanzure | "Concomitantly, T. gondii infection causes reduction in dopamine content and neuronal spine density of the nucleus accumbens core, but not of the nucleus accumbens shell. These results are consistent with a role of the nucleus accumbens dopaminergic system in mediation of choice impulsivity and goal-directed behaviours." | 06:58 |
| archels | well, let's say there's a bacterium that likes to exocytose dopamine. If it additionally likes to hang out only in the striatum, and not, say, the NAcc, its effects could be very specific | 06:59 |
| kanzure | indeed | 06:59 |
| archels | much more so than systemically administered pharamaceuticals | 06:59 |
| kanzure | did you happen to read my rants in here yesterday | 06:59 |
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| archels | not really, I've been kinda busy | 06:59 |
| kanzure | http://gnusha.org/logs/2015-06-22.log | 06:59 |
| * archels reads up | 06:59 | |
| kanzure | 07:44 < kanzure> also, if i was doing a bacteria/microbe selection experiment for brain infections, i would also include some basic neural growth factor genes, and have them expressed at some base rate with some common promoter probably | 06:59 |
| kanzure | 07:44 < kanzure> and then mutations are slightly more likely to cause things that might be neuronally-relevant | 07:00 |
| kanzure | 07:16 < kanzure> another selection project i want to try eventually is infecting mice with brain-dwelling bacteria, then select populations of bacteria that correlate with mice that have better smartness test scores (and breed/mutate those bacteria) | 07:00 |
| kanzure | 07:45 < kanzure> also i think you could make strains that target only specific brain regions | 07:00 |
| kanzure | so anyway, i'm glad you agree heh | 07:00 |
| kanzure | i'd probably choose to dump all sorts of neuronally-relevant genes into those bacteria before mutating the crap out of them, i think this would make it more likely that microbes would cause neuronally-relevant changes over time | 07:01 |
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| archels | yah, it's just that those smartness tests need to be very comprehensive, to make sure that increased performance in one task does not go at the cost of a decrease in another | 07:01 |
| kanzure | perhaps.. but even a /decrease/ in performance would be interesting. | 07:02 |
| kanzure | like something on the order of "suddenly these mice are incapable of recognizing a flower" would be a neat trick. | 07:02 |
| archels | breaking stuff isn't hard | 07:03 |
| kanzure | overall i think this is easier than attempting to rationally design chemical nootropics | 07:04 |
| kanzure | what was greg egan's idea? something about retroviruses? http://greg-egan.wikia.com/wiki/White_Knights | 07:11 |
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| kanzure | hmm mimivirus and megavirus infect acanthamoeba which is capable of living in human brain tissue | 07:46 |
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| fenn | i can't tell if this is a joke or not http://StrangeSounds.org/strange-sounds | 08:05 |
| JayDugger | Did Greg Egan disown his early horror short stories? | 08:09 |
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| kanzure | i don't think it would be surprising that there are sounds in the earth's atmosphere | 08:13 |
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| CaptHindsight | kanzure: did you want to move the printhead or move the samples around under the printhead? | 10:42 |
| yoleaux | 22 Jun 2015 17:23Z <kanzure> CaptHindsight: you should call me on the phone when you have a few minutes to talk about machine plans, 512-203-0507 | 10:42 |
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| kanzure | CaptHindsight: no preference | 11:04 |
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| FourFire | Hello, has anyone in here done fun things with KVM? | 12:01 |
| chris_99 | as in kernel virtual machine? | 12:03 |
| maaku | FourFire: containers are the hot shit now | 12:04 |
| FourFire | maaku, how are containers superior? | 12:05 |
| FourFire | I need my application to be 1. Portable 2. High performance 3. highly automated in setup on new physical hardware | 12:05 |
| FourFire | 2 includes as native as possible GPGPU acceleration | 12:06 |
| maaku | google will find you lots of reasons why containers are better than virtualization | 12:06 |
| maaku | containers are closer to the hardware -- it's not virtualized | 12:07 |
| FourFire | ooh | 12:08 |
| FourFire | I don't know anything about any of this stuff yet | 12:08 |
| kanzure | you should just use amazon aws ec2 gpu instances | 12:20 |
| kanzure | that should be sufficiently portable for your purposes | 12:20 |
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| FourFire | kanzure, I'm afraid I don't want to entrust my data to it | 13:15 |
| FourFire | but perhaps I am too paranoid for my own good | 13:15 |
| kanzure | "your data" | 13:16 |
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| maaku | also, amazon is expensive | 13:19 |
| maaku | are the scarequotes on "your" or "data"? | 13:19 |
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| FourFire | kanzure, thinking about the simulation, I mean I'm all for open sourcing the results and code and such once I've proven it to work, but before I've done that I'd rather not just give it away | 13:31 |
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| kanzure | maaku: scarequotes were because i doubt he has any unique data, and even if he did, it's not much of a concern | 13:35 |
| kanzure | FourFire: using amazon does not mean that your results are "open source" (also, it's not right to use the term "open source" like this- open source refers to some software copyright licensing schemes; you might be thinking of creative commons licenses or something else) | 13:36 |
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| FourFire | kanzure, yeah, perhaps I am too paranoid (namely that Amazon will keep a copy of every interesting instance run on AWS and check it to see if they can sell it) | 13:54 |
| kanzure | you hsould read the contract terms | 13:55 |
| kanzure | and if you are truly paranoid about that then save a copy of the contract | 13:55 |
| kanzure | i also think that you should still use ec2 for figuring out gpgu things | 13:55 |
| FourFire | ok | 13:56 |
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| kanzure | hi knobuddy | 16:18 |
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| knobuddy | hi | 16:22 |
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| kanzure | bloop | 18:05 |
| kanzure | .tw https://twitter.com/socrates1024/status/612861470829776896 | 18:07 |
| yoleaux | Jeff Garzik's crazy space company released a design document for a Bitcoin space satellite http://dunveganspace.com/assets/bitsat-design-pdr.pdf (@socrates1024) | 18:07 |
| kanzure | http://dunveganspace.com/assets/bitsat-design-pdr.pdf | 18:07 |
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| kanzure | hi gene_hacker | 20:01 |
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| kanzure | https://github.com/kanzure/nanoengineer/pull/3 | 21:42 |
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| --- Log closed Wed Jun 24 00:00:50 2015 | ||
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