| --- Log opened Mon Aug 24 00:00:50 2015 | ||
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| CaptHindsight | the long-sought-after structure of a yeast spliceosome at 3.6 angstrom resolution determined by single particle cryo-electron microscopy (cryo-EM), and the molecular mechanism of pre-messenger RNA splicing. | 05:04 |
|---|---|---|
| CaptHindsight | http://news.tsinghua.edu.cn/publish/newsen/6054/2015/20150821223956974989009/20150821223956974989009_.html | 05:04 |
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| archels | .gc spliceosome | 06:03 |
| yoleaux | archels: Sorry, that command (.gc) crashed. | 06:03 |
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| kanzure | cryo-EM is p. okay in my book | 07:08 |
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| kanzure | "Recall that, in over 80 years since modern basic aging research started at Cornell (1933; CR-DR in mice & rats). there have been less than 12 aging companies most of which have gone bankrupt. Only 3 were monetized (IKARIA, Fold Rx & Sirtris). Sirtris was an original investor's dream (GSK paid $720 million but, it was a scientific-business failure. It was a very bad precedent to set for the aging research community & for the investment ... | 08:08 |
| kanzure | ... world. We lost credibility on Wall Street & do not get any significant financial support from them. ... Recall , Art Levinson ( Calico Chairman-CEO & investing founder) was Chairman-CEO of the largest & most successful Biotech (Genentech) which he built up & sold to Roche for about $100 billion. That's why I'll bet on Calico. Your doubts are not at all warranted nor consistent with history & the emerging facts." | 08:08 |
| kanzure | http://xkcd.com/1567/ | 08:32 |
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| kanzure | http://academictorrents.com/ | 09:01 |
| chris_99 | neat | 09:04 |
| JayDugger1 | xkcd's humor again escapes me. | 09:17 |
| kanzure | he is pointing out that i should stop flushing entire rolls of toilet paper | 09:18 |
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| xrr | http://www.explainxkcd.com/wiki/index.php/1567 | 09:18 |
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| kanzure | or alternatively, that cueball was the one who was flushing entire rolls of toilet paper | 09:19 |
| kanzure | and perhaps this is his community service sentencing | 09:19 |
| kanzure | also it's a parody of useless household advice | 09:20 |
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| kanzure | http://www.jamiecraig.com/de-encapsulating-ics-with-a-laser-cutter/ | 11:14 |
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| chris_99 | that's very cool, i recently ordered some microprobing equipment, i'm thinking of using fuming nitric, but that looks a lot safer | 11:17 |
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| chris_99 | it seems that would screw the fuses reading the HaD article | 11:56 |
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| FourFire | JayDugger1, explaining a joke is like dissecting a frog... | 12:10 |
| kanzure | .. a good way to spend friday night? | 12:12 |
| FourFire | kanzure, I think I know what my future seedbox is going to be doing | 12:12 |
| FourFire | now I just need to hack that first gen Mac Pro I've got at the office to support newer OSes | 12:13 |
| FourFire | and order some 4TB Spinning rusts | 12:13 |
| kanzure | would be better served torrenting libgen instead of that other stuff | 12:19 |
| FourFire | well is there any easy way to do that? | 12:20 |
| kanzure | torrents? | 12:24 |
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| FourFire | ok. | 12:32 |
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| kanzure | http://lesswrong.com/r/discussion/lw/mo9/yudkowskys_brain_is_the_pinnacle_of_evolution/ | 14:23 |
| kanzure | needs better troll | 14:23 |
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| kanzure | was removed, see http://pastebin.com/v870piDm | 14:43 |
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| delinquentme | TIL people run CFD on bioreactors | 14:59 |
| kanzure | yep | 14:59 |
| kanzure | i did that for a few | 14:59 |
| gradstudentbot | You can't guarantee that. | 15:02 |
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| kanzure | http://www.infinityplus.co.uk/nonfiction/speedofdark.htm | 15:40 |
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| fenn | http://fennetic.net/irc/elizabeth_moon_-_the_speed_of_dark.pdf | 15:48 |
| kanzure | the religious aspects make me very not wanting to read this | 15:48 |
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| superkuh | I don't remember any religious aspects. | 16:19 |
| superkuh | It was an enjoyable read. | 16:20 |
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| kanzure | seanph: howdy | 16:49 |
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| kanzure | "Effect of Simulated Microgravity on Human Brain Gray Matter and White Matter – Evidence from MRI" http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135835 | 20:10 |
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| kanzure | "The point isn’t that hydrocephaly itself would be selected for, rather that if all that brain matter isn’t actually needed, then why are so many humans spending 20% of their energy on a mostly useless organ – not to mention the selection pressure of mothers not dying in childbirth that would come from smaller heads. There are so many negative effects of the larger brain/head that there must have been some immense selection ... | 20:22 |
| kanzure | ... pressure for more brain matter to even get to this point. That pressure seems to be strongly at odds with the claim that a human can be normal with only 5% of the tissue." | 20:22 |
| kanzure | "I won’t speculate on the childbirth factor, but as for the energy usage, well, have there been any studies of the metabolism of VNBs? Maybe it costs just as much energy to run a brain at 126-IQ-level processing power regardless of how much gray matter you’re running it on?" | 20:22 |
| kanzure | or.. the strength of the selective pressure wasn' relevant to whether hydrocephaly-related mutations were found. | 20:22 |
| jrayhawk | that is a very interesting set of paradoxes | 20:28 |
| kanzure | "i think we need to eat more meat to figure out an answer" | 20:34 |
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| kanzure | boring | 21:38 |
| nmz787 | sup | 21:46 |
| nmz787 | I think I will need a PCR thingamabob sometime in the next year... I wonder which one is the best these days | 21:47 |
| nmz787 | i guess openpcr or the openrtpcr | 21:47 |
| delinquentme | is qtpcr even released yet? | 21:48 |
| nmz787 | ya for a while | 21:49 |
| nmz787 | idk if it is actually fully open or not | 21:49 |
| nmz787 | https://www.chaibio.com/openqpcr | 21:49 |
| nmz787 | i actually still don't want to pay that much | 21:50 |
| erasmus | you gotta pay if you want to play. | 22:16 |
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| nmz787 | nah i don't really need that... to start I just need to check length... gonna make a capillary gel system with microcapillary tubes | 22:44 |
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| --- Log closed Tue Aug 25 00:00:51 2015 | ||
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