| --- Log opened Fri Nov 13 00:00:24 2015 | ||
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| JayDugger | Awesome. Do you keep a master tag list? | 00:04 |
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| kanzure | http://www.nature.com/nature/journal/v490/n7419/fig_tab/nature11495_F2.html | 00:11 |
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| kanzure | .title http://www.nature.com/nature/journal/v490/n7419/full/nature11495.html | 00:13 |
| yoleaux | Complex brain and optic lobes in an early Cambrian arthropod : Nature : Nature Publishing Group | 00:13 |
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| archels | .title http://www.chrisharrison.net/index.php/Research/Tomo | 05:31 |
| yoleaux | Chris Harrison | Tomo | 05:31 |
| archels | gesture recognition using electrical impedance tomography | 05:31 |
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| fenn | kewl | 06:05 |
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| kanzure | http://www.brainpreservation.org/shawn-mikula-on-brain-preservation-protocols-and-extensions/ | 06:07 |
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| kanzure | yosarian2 claims "grindhouse wetware" should be forgiven for being obnoxious because bodymod community will be coerced to do surgeries in the near future even if they are not bodymod surgeries, as result of giving them blinking led implants. but i'm not so sure. | 06:13 |
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| fenn | hold still while i soak your brain in a solution of osmium, uranium, and lead, then fire multiple relativistic electron beams at it | 06:19 |
| kanzure | is it going to hurt? | 06:20 |
| fenn | that's still an open ended philosophical question, unfortunately | 06:20 |
| kanzure | will i still be myself after the surgery? | 06:21 |
| fenn | yes, but you'll be dead | 06:21 |
| kanzure | is this covered by my deductible? | 06:21 |
| kanzure | your excerpt is bad, most of the tags are missing | 06:22 |
| kanzure | .tell quonk which particular misleading things are you concerned about? | 06:23 |
| yoleaux | kanzure: I'll pass your message to quonk. | 06:23 |
| kanzure | .tell Jawmare why are the quantum dots melting your parafilm? | 06:24 |
| yoleaux | kanzure: I'll pass your message to Jawmare. | 06:24 |
| fenn | is yoleaux an automated teller machine? | 06:24 |
| kanzure | nah it's just dpk hiding in a cardboard box | 06:24 |
| fenn | .tell yoleaux what she said | 06:24 |
| yoleaux | fenn: Thanks for the message. | 06:24 |
| dpk | beep blorp boop | 06:25 |
| fenn | oh europe is awake now | 06:26 |
| kanzure | "Here we report exceptional preservation of the brain and optic lobes of a stem-group arthropod from 520 million years ago (Myr ago), Fuxianhuia protensa5, exhibiting the most compelling neuroanatomy known from the Cambrian. The protocerebrum of Fuxianhuia is supplied by optic lobes evidencing traces of three nested optic centres serving forward-viewing eyes. Nerves from uniramous antennae define the deutocerebrum, and a stout pair of ... | 06:27 |
| kanzure | ... more caudal nerves indicates a contiguous tritocerebral component. Fuxianhuia shares a tripartite pre-stomodeal brain and nested optic neuropils with extant Malacostraca and Insecta2, 6, demonstrating that these characters were present in some of the earliest derived arthropods. ... The early origin of sophisticated brains provides a probable driver for versatile visual behaviours, a view that accords with compound eyes from the ... | 06:27 |
| kanzure | ... early Cambrian that were, in size and resolution, equal to those of modern insects and malacostracans3." | 06:27 |
| kanzure | maaku: ^ | 06:27 |
| fenn | they ain't no sich animal | 06:28 |
| kanzure | shouldn't this be slice-scanned immediately? | 06:29 |
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| kanzure | "early origin of sophisticated brains" can't explain that | 06:30 |
| fenn | welp it's either a brain or a heart: http://www.nature.com/nature/journal/v490/n7419/fig_tab/nature11495_F2.html | 06:34 |
| fenn | might be a space alien though, hard to say | 06:34 |
| fenn | definitely has the face hugger look http://www.nature.com/nature/journal/v490/n7419/fig_tab/nature11495_F1.html | 06:37 |
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| kanzure | http://www.3dcadworld.com/the-failed-promise-of-parametric-cad/ | 06:54 |
| kanzure | a strongly parametric model requires a lot of upfront thinking though. not sure you can coerce users into doing all that work. | 06:55 |
| fenn | that's like saying "reusable code requires a lot of upfront thinking" | 06:56 |
| kanzure | well it does | 06:57 |
| kanzure | sketching some random lines is not necessarily going to give you something that is parametric in any meaningful sense | 06:57 |
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| kanzure | .title http://www.nature.com/ncomms/2015/151110/ncomms9791/full/ncomms9791.html | 07:16 |
| yoleaux | Targeted drug delivery using genetically engineered diatom biosilica : Nature Communications : Nature Publishing Group | 07:16 |
| kanzure | "The diatom Thalassiosira pseudonana is genetically engineered to display an IgG-binding domain of protein G on the biosilica surface, enabling attachment of cell-targeting antibodies. Neuroblastoma and B-lymphoma cells are selectively targeted and killed by biosilica displaying specific antibodies sorbed with drug-loaded nanoparticles. Treatment with the same biosilica leads to tumour growth regression in a subcutaneous mouse xenograft ... | 07:17 |
| kanzure | ... model of neuroblastoma. These data indicate that genetically engineered biosilica frustules may be used as versatile ‘backpacks’ for the targeted delivery of poorly water-soluble anticancer drugs to tumour sites." | 07:17 |
| kanzure | "drug-loaded nanoparticles" but why would that work? just because you have antibodies doesn't mean they will find what you're looking for. and why wouldn't drug release happen before antibody binding? | 07:18 |
| fenn | drug release happens before binding but the diatom is moving around and due to diffusion and dilution the drug payload doesn't hurt anything | 07:20 |
| kanzure | ok so timed release maybe? need to have some left over for when binding actually happens... | 07:21 |
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| fenn | the half life can be whatever you want | 07:23 |
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| kanzure | also, is this assuming immune suppression, or are there algaes that can float around in blood with minimal immune system aggitation? | 07:24 |
| fenn | pretty sure silica causes "agitation" heh | 07:24 |
| fenn | .wik adjuvant | 07:24 |
| yoleaux | "An adjuvant (from Latin, adjuvare: to aid) is a pharmacological and/or immunological agent that modifies the effect of other agents. Adjuvants may be added to vaccine to modify the immune response by boosting it such as to give a higher amount of antibodies and a longer-lasting protection, thus minimizing the amount of injected foreign material." — https://en.wikipedia.org/wiki/Adjuvant | 07:24 |
| kanzure | .title http://www.rense.com/general77/dblooder.htm | 07:27 |
| yoleaux | All Human Blood is Infected with Bacteria | 07:27 |
| fenn | infected! gaacktblphgh | 07:27 |
| kanzure | .title http://www.ncbi.nlm.nih.gov/pmc/articles/PMC421412/ | 07:28 |
| yoleaux | Novel bacterial structures in human blood: cultural isolation. | 07:28 |
| fenn | it's hard to take seriously anything on rense.com | 07:28 |
| kanzure | why's that ? | 07:29 |
| fenn | high crackpot quotient | 07:29 |
| kanzure | ah. hm. | 07:29 |
| kanzure | viral content of blood is high, why not microbial content? | 07:29 |
| kanzure | .title http://jcm.asm.org/content/39/5/1956.full | 07:30 |
| yoleaux | Does Blood of Healthy Subjects Contain Bacterial Ribosomal DNA? | 07:30 |
| fenn | because there's no such thing as an endogenous bacterium, whereas there are endogenous retroviruses | 07:30 |
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| kanzure | http://www.computerhistory.org/atchm/first-steps-lectures-from-the-dawn-of-computing/ | 07:34 |
| kanzure | .title https://www.youtube.com/watch?v=MG5H-f6ydPg | 07:35 |
| yoleaux | Designing and Developing Z1 through Z4, lecture by Konrad Zuse - YouTube | 07:35 |
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| kanzure | .title https://www.youtube.com/watch?v=zQTfuI-9jIo | 07:43 |
| yoleaux | von Neumann probes, Dyson spheres, exploratory engineering and the Fermi paradox - YouTube | 07:43 |
| kanzure | "bacteremia" | 07:47 |
| kanzure | "Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics" http://www.nature.com/nmeth/journal/v12/n4/abs/nmeth.3292.html | 07:49 |
| kanzure | "High-resolution, high-throughput imaging with a multibeam scanning electron microscope" http://onlinelibrary.wiley.com/doi/10.1111/jmi.12224/epdf | 07:49 |
| kanzure | "Mapping synapses by conjugate light-electron array tomography" http://www.jneurosci.org/content/35/14/5792.short | 07:50 |
| kanzure | "Toward large-scale connectome reconstructions" http://www.sciencedirect.com/science/article/pii/S095943881400035X | 07:50 |
| kanzure | "Cellular-resolution connectomics: challenges of dense neural circuit reconstruction" http://www.nature.com/nmeth/journal/v10/n6/full/nmeth.2476.html | 07:51 |
| kanzure | "Volume electron microscopy for neuronal circuit reconstruction" http://www.ncbi.nlm.nih.gov/pubmed/22119321 | 07:51 |
| kanzure | matrioshka brain stuff http://web.archive.org/web/20020124150049/http://www.aeiveos.com/~bradbury/MatrioshkaBrains/index.html | 07:53 |
| kanzure | "planetary disassembly" http://web.archive.org/web/20011218091635/http://www.aeiveos.com/~bradbury/MatrioshkaBrains/PlntDssmbly.html | 07:54 |
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| maaku | kanzure: interesting | 08:18 |
| archels | OpenWorm journal club/discussion on whole-brain emulation in a couple hours | 08:21 |
| archels | .t https://plus.google.com/u/0/events/cv9l18020h2cc0doj62h29errn0 | 08:21 |
| yoleaux | archels: Sorry, I don't know what timezone that is. If in doubt, see https://en.wikipedia.org/wiki/List_of_tz_database_time_zones for a list of options. | 08:21 |
| kanzure | wonder if they will actually remember any of the questions they were submitted | 08:23 |
| archels | .title https://groups.google.com/forum/?hl=en#!topic/openworm-discuss/yfTBVpGXuUc | 08:24 |
| yoleaux | Google Groups | 08:24 |
| archels | is their IRC channel active at all? I haven't joined for a while | 08:25 |
| kanzure | afaik no | 08:25 |
| kanzure | i left the channel after like 8 months of inactivity | 08:25 |
| kanzure | i don't think they even remember that | 08:26 |
| archels | hm so this is the first time I'm joining this Google hangouts time deal. I don't have to sign up for anything, right? Just click play. | 08:33 |
| archels | s/time/type | 08:33 |
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| kanzure | i believe you need a google account of some kind | 08:38 |
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| archels | should be good to go on that front | 08:50 |
| kanzure | about gangs stealing nuclear weapons from ukraine and other ex-ussr countries https://news.ycombinator.com/item?id=10554744 | 08:58 |
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| kanzure | archels: this doesn't seem to be working for me. | 09:04 |
| archels | yeah I was just about to say, getting nothing here | 09:04 |
| kanzure | i hate video | 09:05 |
| archels | oh, here we go | 09:06 |
| kanzure | this is watch-only? wtf | 09:06 |
| kanzure | what a pile of shit | 09:06 |
| kanzure | i hate everyone | 09:06 |
| archels | haha | 09:06 |
| archels | you should have applied to be a "panelist" | 09:06 |
| kanzure | fuck that | 09:06 |
| kanzure | openworm is the worst thing ot ever happen in the history of forever | 09:06 |
| kanzure | "you can ask us question through twitter" these people need to seriously fucking die | 09:08 |
| nmz787_i | openworm is bad? | 09:08 |
| nmz787_i | last night I had a realization that twitter is just a bunch of #PythonComments | 09:09 |
| maaku | kanzure: holy fuck that's some scary shit (re: post-ussr nuclear material) | 09:09 |
| kanzure | openworm is terrible. they left irc for this bullshit. i hate them; they want questions through fucking twitter? who the shit runs an academic group like that. that's a terrible idea. | 09:10 |
| nmz787_i | I wonder what source file would get the most followers if it tweeted a comment, say every 1 to few hours | 09:10 |
| nmz787_i | seems like we could build an IRC-twitter bridge | 09:10 |
| kanzure | why would you want to do that? | 09:11 |
| maaku | please don't do that | 09:11 |
| nmz787_i | haha | 09:11 |
| kanzure | this is the worst way to handle communication on the internet | 09:11 |
| nmz787_i | so we can keep chatting as usual with openworm (Which i never did) | 09:11 |
| kanzure | they aren't interested in communication, clearly | 09:11 |
| nmz787_i | you could troll them by applying for a phd in their dept | 09:12 |
| kanzure | they are obv. aiming for a view count, not actual collaboration with people over the internet | 09:12 |
| nmz787_i | and then drop the offer at the last moment saying that, idk, openslug, gave you a better offer | 09:12 |
| kanzure | i think you mean nemaload | 09:13 |
| nmz787_i | oh | 09:13 |
| nmz787_i | yeah, that one | 09:13 |
| nmz787_i | hmm, http://www.accelerated-designs.com/binaryreaders/ULADI_Reader.exe "Import and Export various CAD tool libraries including: Cadence Concept, Capture, Orcad Layout andAllegro, Mentor DA, Padslogic, PADs, Viewdraw/DX Designer, Boardstation and Expedition as well asCadstar, P-CAD, Protel, and others." | 09:17 |
| nmz787_i | "Ultra Librarian comes in a free reader format, that will read data stored at a manufacturer or distributor web site. The reader will not allow users to make any changes to the data, but will allow them to export the collected data to many different CAD tools free of charge." | 09:18 |
| nmz787_i | neat, it has a kicad export format! | 09:19 |
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| kanzure | archels: so what happened | 11:32 |
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| jcluck | kanzure, they suck because they're unstructured | 12:03 |
| yoleaux | 12 Sep 2015 22:11Z <kanzure> jcluck: there is a good anthropology presentation at the end of the scalingbitcoin workshop day 1 | 12:03 |
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| maaku | kanzure: was it a good talk? I wasn't in the room, is it worth watching? | 12:08 |
| kanzure | i wasn't watching either, i have no idea | 12:10 |
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| Aurelius_Work2 | kanzure : hypothes.is now supports private groups | 12:32 |
| pasky | i tried, but it was too boring to keep my attention | 12:44 |
| kanzure | what were they talking about? | 12:44 |
| pasky | (off mucking with rdf) | 12:44 |
| pasky | kanzure: sort of generic stuff, basic methods and what are the general challenges (everything in the area) | 12:45 |
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| pasky | maybe i missed the good parts | 12:45 |
| kanzure | maybe not though :-) | 12:45 |
| kanzure | people who use video are notoriously low-signal anyway, so this isn't surprising | 12:47 |
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| kanzure | https://i.ytimg.com/vi/G4iRTdXVIMY/hqdefault.jpg | 13:45 |
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| Jawmare | kanzure: the solvent evaporates and melted it | 14:49 |
| yoleaux | 14:24Z <kanzure> Jawmare: why are the quantum dots melting your parafilm? | 14:49 |
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| kanzure | "Thirty-seven patients in Mexico and Costa Rica have successfully undergone a special laser procedure to change the colour of their irises from brown to blue. Conducted by a California-based company called Stroma Medical, the procedure costs $5,000. The laser treatment lasts just 20 seconds, and then the patient has to wait a few weeks for their body to remove the dead pigmented tissue, says Poppick. "People with blue eyes have a ... | 15:36 |
| kanzure | ... completely colourless stroma with no pigment at all, and it also contains no excess collagen deposits. This means that all the light that enters it is scattered back into the atmosphere and as a result of the Tyndall effect, creates a blue hue." | 15:36 |
| kanzure | .title https://news.ycombinator.com/item?id=10553331 | 15:37 |
| yoleaux | How Insects Breathe | Hacker News | 15:37 |
| kanzure | "Can a decrease in oxygen from 35% down to 21% really explain a decrease in insect size from eight-and-a-half feet down to just 3 inches? Is there an interesting mathematical relationship here, or are there more factors at work?" | 15:37 |
| kanzure | "Great questioN! We spoke to Jon Harrison about this (the scientist we interviewed who studies insect growth & respiration). He says that the truth of the matter is we don't know the answer, it's still a hypothesis that the way insects breathe keep them small. There are other competing explanations, like that it's insect's exoskeletons that constrain their size, or ecological arguments (fewer predators means they can grow bigger). Also ... | 15:37 |
| kanzure | ... spiders don't use trachea to breathe but are also small." | 15:37 |
| kanzure | "One piece of evidence favoring the oxygen hypothesis is research that shows that the fossil record on giant insect size correlates with the oxygen levels in the past, all the way up until birds evolved (and wiped out the ecological niche for giant flying insects) http://blogs.discovermagazine.com/notrocketscience/2012/06/04/giant-insects-disappeared-thanks-to-falling-oxygen-levels-and-agile-birds/#.VkYYYWSrRhA " | 15:37 |
| kanzure | "So to really understand this you'd need to breed insects in high oxygen over many, many generations, and have them evolve in this new environment. That takes a lot of time and money. Jon's lab has done it with fruit flies, and they do grow bigger over the generations." | 15:38 |
| kanzure | .title http://irl.cs.ucla.edu/papers/right-size.html | 15:40 |
| yoleaux | kanzure: Sorry, that command (.title) took too long to process. | 15:40 |
| kanzure | "Such are a very few of the considerations which show that for every type of animal there is an optimum size. Yet although Galileo demonstrated the contrary more than three hundred years ago, people still believe that if a flea were as large as a man it could jump a thousand feet into the air. As a matter of fact the height to which an animal can jump is more nearly independent of its size than proportional to it. A flea can jump about ... | 15:40 |
| kanzure | ... two feet, a man about five. To jump a given height, if we neglect the resistance of air, requires an expenditure of energy proportional to the jumper’s weight. But if the jumping muscles form a constant fraction of the animal’s body, the energy developed per ounce of muscle is independent of the size, provided it can be developed quickly enough in the small animal. As a matter of fact an insect’s muscles, although they can ... | 15:40 |
| kanzure | ... contract more quickly than our own, appear to be less efficient; as otherwise a flea or grasshopper could rise six feet into the air." | 15:40 |
| * kanzure types in an order for a batch of moon-bouncing dogs | 15:41 | |
| kanzure | .title https://www.youtube.com/watch?v=MCs5OvhV9S4 | 15:47 |
| yoleaux | David Beazley - Python Concurrency From the Ground Up: LIVE! - PyCon 2015 - YouTube | 15:47 |
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| Guest5372 | Hello Is there anybody in there? | 16:30 |
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| kanzure | nope | 16:37 |
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| archels | kanzure: I only listened in for about an hour before I had to run off, so mostly got Koene giving some superficial updates on techiques and mostly shrug at the more direct questions | 17:06 |
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| kanzure | i see. | 17:17 |
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| jdqx | hello *world | 19:09 |
| kanzure | hi jdqx | 19:10 |
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| nmz787_i | sup | 21:00 |
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| nmz787_i | reading this: http://techno-fandom.org/~hobbit/cars/mfd/ "The two leads continue through to the other side of the board and end at pins 5 and 6 of a small chip labeled CA0008. Googling this returns surprisingly few substantial hits -- just a lot of noise from the datasheet pirates that try to keyword up anything that even remotely looks like an electronic part number, those fucking parasite bastards." | 21:25 |
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