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| jrayhawk | Updated, though it'll be broken for some browsers until the OCSP server updates. | 03:57 |
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| jrayhawk | Which can take a day with startcom. | 03:58 |
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| kanzure | thanks | 04:51 |
| fenn | it's difficult to measure executive function loss due to temporal lobe damage vs "i can't see" or "i can't move my left arm" so the side effects of surgery magically go away :D | 05:07 |
| kanzure | gah who taught you neurosurgery | 05:19 |
| kanzure | wha? https://github.com/bitcoin/bips/pull/242/files | 05:20 |
| archels | might not be so difficult, there's probably not many standardised tasks for it though | 05:37 |
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| kanzure | http://vknight.org/unpeudemath/code/2015/11/15/Visualising-markov-chains/ | 05:58 |
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| kanzure | jrayhawk: "A new piny account ``newuser'' has been created" | 06:24 |
| kanzure | dunno if this is a hole | 06:24 |
| kanzure | eh probably not | 06:24 |
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| justanotheruser | http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.5b03764 | 08:27 |
| justanotheruser | .title | 08:27 |
| yoleaux | An Error Occurred Setting Your User Cookie | 08:27 |
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| fenn | "Biologists Announce They’re All Done With Rodents ‘There Is Nothing About Them That Requires Further Scientific Inquiry,’ Say Scientists" | 08:58 |
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| kanzure | "Mouse Biologist Says Disregard Last Statement" | 09:04 |
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| kanzure | what's the correct name for "microphone"? | 09:32 |
| chris_99 | whatcha mean? i guess it's a type of transducer | 09:33 |
| kanzure | micro-phone is a pretty bad name heh | 09:33 |
| chris_99 | heh | 09:33 |
| kanzure | "acoustic sensor" or "acousto-electric transducer" or "sound recorder" or something.. any of those would be better. | 09:34 |
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| FourFire | "Phonon moderator" | 09:54 |
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| jrayhawk | oh, i think i send out that email regardless of whether or not the creation was successful because i am actually a moron | 10:47 |
| jrayhawk | there is one legitimate hole i should really take care of | 10:47 |
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| jrayhawk | Stskeeps: Is there a comparison of the feature scope of libhybris and ARC somewhere? | 11:46 |
| Stskeeps | jrayhawk: they're not really related. sortof. | 11:46 |
| Stskeeps | jrayhawk: ARC actually implements the entire bionic library using NaCL from what i can tell | 11:47 |
| jrayhawk | That's ambitious. | 11:47 |
| Stskeeps | but only for NDK stuff | 11:47 |
| Stskeeps | i think | 11:47 |
| Stskeeps | libhybris has to use insane android drivers and their weird bits like TLS slots, so .. :) | 11:47 |
| Stskeeps | bit different audience | 11:47 |
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| jrayhawk | Like at this point if someone tells me "I want to run Android apps on my computer" I have no idea whether to attempt to set up libhybris, ARC, or an Android VM for them because I don't really understand the tradeoffs. | 11:54 |
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| ButaTine | jrayhawk, perhaps just ask what the application is and suggest an easier to impliment soluton to the problem | 11:55 |
| jrayhawk | What's good for development? What's good for speed? What's good for security? What's good for weird hardware integration like GPS and accelerometers and such? No idea! | 11:57 |
| andares | How do people map all these complex gene regulatory networks and model their interactions? | 11:58 |
| andares | Just millions of hours in the lab? | 11:58 |
| Stskeeps | jrayhawk: a virtual machine is usually the sanest | 11:59 |
| Stskeeps | jrayhawk: ARC is emerging but not generic | 11:59 |
| kanzure | my life improved dramatically when i started using android-x86 vm for development reasons | 12:01 |
| kanzure | andares: yep, plus lots and lots of inference. and modeling. and speculation. | 12:01 |
| andares | I can't even begin to imagine a computational approach | 12:01 |
| andares | Given all the different ways genes can interact | 12:02 |
| kanzure | it's important to build islands of stability and repeatable stuff that you can use, and then hopefully ignore all the noise | 12:03 |
| kanzure | for example, molecular nanostructures made out of proteins or related byproducts | 12:03 |
| jrayhawk | http://scholar.google.com/scholar?q=measuring+transcription is a big start, but, yeah, we're still quantifying means by which genes are expressed | 12:04 |
| kanzure | not just regulatory network interaction but also protein-protein interaction too | 12:04 |
| jrayhawk | we're still discovering new DNA bases | 12:04 |
| kanzure | protein-protein or cofactor stuff or whatever the hell antibiotics often do to ribosomes | 12:04 |
| andares | Bases? You mean like SNPs or new genes? | 12:05 |
| kanzure | nucleotides | 12:05 |
| nmz787_i | nucleotides? | 12:05 |
| jrayhawk | 5-formyl cytosine was discovered in, what, 2014? | 12:05 |
| nmz787_i | are these just epigenetically different? | 12:05 |
| kanzure | nucleobases | 12:05 |
| andares | Besides agtc? Whoa | 12:06 |
| nmz787_i | oh, yeah, seems epigenetically related | 12:06 |
| nmz787_i | nah it's just a modified C | 12:06 |
| kanzure | "adenosine, BUT WITH A METHYL TAG" | 12:06 |
| andares | Ah | 12:06 |
| andares | Are all nucleotides methylatable? | 12:06 |
| ButaTine | kanzure, why weren't all of these variants hypotheasized in 1952? | 12:06 |
| kanzure | that's more of a question for jrayhawk at the moment, i am too deep in socket programming to know my snd from my recv's | 12:07 |
| nmz787_i | ButaTine: that's like asking why all the different computer science datatypes weren't hypothesized in 1900 or something | 12:08 |
| nmz787_i | "and some day, we'll need a thing called a qubit" | 12:08 |
| nmz787_i | and a uint_8_t | 12:08 |
| kanzure | all two of them? pointer and pointer pointer? | 12:08 |
| jrayhawk | andares: At least for eukaryotes, we've got a g t c 5mc 5hmc 5cac and 5fc as "normal" bases, quite a lot of others considered "damaged" by "abnormal" processes, and a lot of others besides in prokaryotes. | 12:09 |
| kanzure | and then various artificial synthesized nucleobases and backbone substitutes | 12:09 |
| nmz787_i | and then the synthetic analogues | 12:09 |
| nmz787_i | XNA and such | 12:09 |
| nmz787_i | damnit kanzure | 12:09 |
| nmz787_i | quit winning at typing my thoughts | 12:09 |
| andares | Hehe | 12:09 |
| kanzure | http://diyhpl.us/~bryan/papers2/DNA/ | 12:09 |
| jrayhawk | I don't actually pay much attention to non-tet-mediated base mutations, so I couldn't tell you what sorts of things can happen to stuff other than cytosine. | 12:11 |
| jrayhawk | I fined it entirely plausible that "abnormal" "damage" and "repair" will wind up having genetic semantics for legitimate adaptive purposes in a lot of cases. | 12:12 |
| jrayhawk | So the field is still wide open. | 12:12 |
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| kanzure | we should really get around to making mutantpedia happen | 12:25 |
| jrayhawk | andares: another fun fact: we still haven't sequenced the human genome | 12:25 |
| jrayhawk | PCR can only do short segments and even using extremely sophisticated statistical trickery we just can't fill in the gaps of repeating sections. | 12:26 |
| jrayhawk | SMRT is getting pretty close, though. | 12:26 |
| jrayhawk | We'll probably be able to sequence it in the next five years. | 12:26 |
| jrayhawk | I suppose there's a much better way to answer the question "11:58 < andares> How do people map all these complex gene regulatory networks and model their interactions?" | 12:32 |
| jrayhawk | "Badly." | 12:33 |
| jrayhawk | https://en.wikipedia.org/wiki/File:Genome_sequencing_costs,_May_2012.jpg this chart is often thrown around; the precipitous drop is where we gave up on any sort of accuracy standard and just assumed we could correct everything in statistics. | 12:38 |
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| kanzure | "Observation of thermal Hawking radiation and its entanglement in an analogue black hole" http://arxiv.org/abs/1510.00621 | 13:13 |
| kanzure | "Realization of a Sonic Black Hole Analog in a Bose-Einstein Condensate" http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.105.240401 | 13:13 |
| kanzure | "Observation of Dirac monopoles in a synthetic magnetic field" http://www.nature.com/nature/journal/v505/n7485/full/nature12954.html | 13:14 |
| kanzure | from https://news.ycombinator.com/item?id=10573138 about gravity | 13:14 |
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| kanzure | .title http://lists.linuxfoundation.org/pipermail/lightning-dev/2015-November/000309.html | 13:40 |
| yoleaux | [Lightning-dev] Better privacy with SNARKs | 13:40 |
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| kanzure | https://en.wikipedia.org/wiki/Grandiose_delusions | 13:50 |
| kanzure | "Other common grandiose delusions in schizophrenia include religious delusions such as the belief that one is Jesus Christ.[24]" | 13:51 |
| kanzure | "For example, the person may possibly declare to own IBM and kindly offer to write a hospital staff member a check for $5 million if they would only help them escape from the hospital.[23]" | 13:51 |
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| nmz787_i | .title http://www.explainshell.com/ | 15:44 |
| yoleaux | explainshell.com - match command-line arguments to their help text | 15:45 |
| nmz787_i | "This site contains 29761 parsed manpages from sections 1 and 8 found in Ubuntu's manpage repository. A lot of heuristics were used to extract the arguments of each program, and there are errors here and there, especially in manpages that have a non-standard layout." | 15:45 |
| kanzure | https://github.com/BBBSnowball/python-solvespace | 16:24 |
| kanzure | http://www.mattkeeter.com/projects/constraints/ | 16:25 |
| kanzure | .title https://www.youtube.com/watch?v=2r8Y4tOeYZQ | 16:25 |
| yoleaux | Using SolveSpace to draw Sonex flap detent - YouTube | 16:25 |
| kanzure | .title https://github.com/ruevs/solvespace/commit/9963d9bb25d1e17ed5d5bbe8cd42fc73c8326f7c | 16:25 |
| yoleaux | Added a new constraint "Length Difference" · ruevs/solvespace@9963d9b · GitHub | 16:25 |
| nmz787_i | huh, neat | 16:28 |
| nmz787_i | I wonder what benefit I could gain from using this with BRLCAD | 16:29 |
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| kanzure | what was the nature/nurture stuff about, again? that you could only optimize in one of the two dimensions ? or what | 17:34 |
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| kanzure | beep boop | 18:46 |
| kanzure | "a more technical explanation of constraint solving in sketchflat (solvespace’s predecessor)" http://cq.cx/dl/sketchflat-internals.pdf | 18:47 |
| kanzure | http://www.japanesebugfights.com/ | 19:07 |
| kanzure | uh, nevermind | 19:08 |
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| --- Log closed Wed Nov 18 00:00:28 2015 | ||
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