| --- Log opened Tue Nov 24 00:00:34 2015 | ||
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| kanzure | re: selection for cryoprotectant cryotoxicity resistance. there are two ways to do this.. the default way is (1) inject cryotoxin at whatever "normal" dosage and then select for the organisms that seem to survive this, or recover better from this, or have higher cell survival rates after injection. the second method that occurred to me today, which is obvious in retrospect, is gradual increase of cryotoxin amount over a number of ... | 04:48 |
|---|---|---|
| kanzure | ... generations, because selection to resistance to cryotoxicity at 1% of blood is probably much easier and much more likely than finding something that has high resistance to 100% blood volume as cryoprotectant. | 04:48 |
| kanzure | also, where did that microbubble respirocyte idea go? that was a thing that existed, right? | 05:05 |
| kanzure | complex anatomy and complex cellular structures that are not easily vitrified should be selected against. no reason to sacrifice vitrifiability for the sake of complex shape especialy when simpler shapes can perform the same jobs. | 05:23 |
| FourFire | kanzure, yeah that effect, is what inspired me to want to engineer an oxygen storage organelle | 05:40 |
| FourFire | "you don't evolve to survive > 50% bloodloss" | 05:41 |
| kanzure | zooko would like http://ieeexplore.ieee.org/xpl/articleDetails.jsp?reload=true&arnumber=7255216&punumber%3D7235962%26filter%3DAND%28p_IS_Number%3A7255186%29%26pageNumber%3D2 | 05:43 |
| FourFire | kanzure, you mean http://www.nature.com/news/rabbits-kept-alive-by-oxygen-injections-1.10899 | 05:49 |
| FourFire | afaik it's a product you can buy | 05:49 |
| FourFire | I should really get some actually, once I commit to carrying a first aid kit everywhere | 05:50 |
| FourFire | http://www.jove.com/video/51467/manufacture-concentrated-lipid-based-oxygen-microbubble-emulsions | 05:57 |
| FourFire | Damnit, I need some proper medical training if I want to actually do any good, having something like this on me. | 05:59 |
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| kanzure | "KLEE: Unassisted and Automatic Generation of High-Coverage Tests for Complex Systems Programs" http://llvm.org/pubs/2008-12-OSDI-KLEE.html (klee stuff) | 06:37 |
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| poppingtonic | Neat project! | 07:09 |
| kanzure | "bank for international settlements report on digital currencies" http://www.bis.org/cpmi/publ/d137.pdf | 07:15 |
| kanzure | "single show signature" http://gnusha.org/bitcoin-wizards/2015-11-24.log | 07:15 |
| kanzure | blockchain sharding http://www.reddit.com/r/Bitcoin/comments/3u1m36/why_arent_we_as_a_community_talking_about/cxbamhn | 07:15 |
| kanzure | .title https://www.youtube.com/watch?v=Y3g8DGcAUH4 | 07:25 |
| yoleaux | A cell moving through a matrix - YouTube | 07:25 |
| kanzure | .title https://www.youtube.com/watch?v=bz1U6WCcVtY | 07:26 |
| yoleaux | Muscle Contractions in C. Elegans - YouTube | 07:26 |
| kanzure | .title https://www.youtube.com/watch?v=xXsjBgYkhZE | 07:26 |
| yoleaux | Sonogenetics - YouTube | 07:26 |
| kanzure | "Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution" http://www.sciencemag.org/content/346/6208/1257998 | 07:27 |
| kanzure | "Lattice light-sheet microscopy. An ultrathin structured light sheet (blue-green, center) excites fluorescence (orange) in successive planes as it sweeps through a specimen (gray) to generate a 3D image. The speed, noninvasiveness, and high spatial resolution of this approach make it a promising tool for in vivo 3D imaging of fast dynamic processes in cells and embryos, as shown here in five surrounding examples." | 07:28 |
| kanzure | "By implementing either superresolution structured illumination or by dithering the lattice to create a uniform light sheet, we imaged cells and small embryos in three dimensions, often at subsecond intervals, for hundreds to thousands of time points at the diffraction limit and beyond." | 07:28 |
| kanzure | "We demonstrated the technique on 20 different biological processes spanning four orders of magnitude in space and time, including the binding kinetics of single Sox2 transcription factor molecules, 3D superresolution photoactivated localization microscopy of nuclear lamins, dynamic organelle rearrangements and 3D tracking of microtubule plus ends during mitosis, neutrophil motility in a collagen mesh, and subcellular protein ... | 07:28 |
| kanzure | ... localization and dynamics during embryogenesis in Caenorhabditis elegans and Drosophila melanogaster. Throughout, we established the performance advantages of lattice light-sheet microscopy compared with previous techniques and highlighted phenomena that, when seen at increased spatiotemporal detail, may hint at previously unknown biological mechanisms." | 07:29 |
| kanzure | mitosis http://images.vice.com/motherboard/content-images/contentimage/no-id/1414093598470322.png | 07:32 |
| kanzure | prophase/anaphase http://images.vice.com/motherboard/content-images/contentimage/no-id/1414093625999519.png | 07:32 |
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| nmz787_i1 | so a photocell is a light-controlled resistor | 09:27 |
| nmz787_i1 | which means if you PWM an LED in front of it, you now have a digital potentiometer | 09:27 |
| chris_99 | hmm | 09:29 |
| chris_99 | yeah you'd want to filter the PWM | 09:29 |
| chris_99 | i guess | 09:29 |
| nmz787_i1 | yeah | 09:31 |
| nmz787_i1 | this idea should let me hook up an arduino to an LM317 to make a constant current driver, well I guess constant voltage... but with a laser I don't think the current will change much through time | 09:32 |
| chris_99 | lm317 is an op-amp? | 09:33 |
| chris_99 | or.. | 09:33 |
| nmz787_i1 | if i had another sensor for the laser, then I would be able to do closed-loop feedback on the laser brightness... which would be best for reliable photoresist exposure | 09:33 |
| nmz787_i1 | lm317 is a linear power supply | 09:33 |
| nmz787_i1 | regulator | 09:33 |
| chris_99 | aha | 09:33 |
| nmz787_i1 | i think it has an opamp in it | 09:34 |
| nmz787_i1 | or a few | 09:34 |
| nmz787_i1 | kanzure: this reminded me of you ('the credible hulk') http://i.imgur.com/3KfXfFt.jpg | 09:35 |
| cluckj | hahaha | 09:35 |
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| kanzure | indeed, that's why i am known as the information theoretic hulk http://themisescircle.org/wp-content/uploads/2014/01/1920x1080_hulk_smash-1213215-636x310.jpg | 09:42 |
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| kanzure | "A map of 1,089,837 scientific papers from the arXiv." http://paperscape.org/ | 10:35 |
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| kanzure | vitrifiability or vitrifieasibility? | 12:16 |
| kanzure | an update from pboyer about brep in verbnurbs: https://github.com/pboyer/verb/issues/16#issuecomment-159386488 | 12:17 |
| kanzure | "At this point, I think BReps won't come until 3.0.0, which probably won't surface any earlier than Q3 2016." | 12:19 |
| kanzure | https://github.com/pboyer/verb/tree/topo/src/verb/topo | 12:19 |
| kanzure | "I've already finished BRep splitting, volume/area calcs, tessellation and the core data structures (Face, HalfEdge, Solid). Almost done with booleans... In the first incarnation this will only support planar faces and I'll expand from there." | 12:20 |
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| kanzure | "hacker news becomes fascinated by short papers" https://news.ycombinator.com/item?id=10622660 | 14:14 |
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| ButaTine | I wonder what oxygen source they use here: http://www.outerplaces.com/science/item/9754-new-device-resuscitates-hearts-removed-from-dead-bodies | 14:23 |
| kanzure | what was the better-than-blood blood substitute that we knew about at one point? | 14:25 |
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| nmz787_i | wasn't there some movie where some nerd got their rat drowned in such 'breathing' fluid... and the nerd was super pissed that the 'jock' was upsetting his rat, even though the rat was fine after it started 'breathing' the liquid | 15:16 |
| kanzure | i don't know what movies you're watching or what cinema universe you're from, but i think i like it | 15:17 |
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| cluckj | the abyss? | 15:19 |
| nmz787_i | was that something about underwater... something... | 15:20 |
| nmz787_i | I think that was it though | 15:20 |
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| cluckj | it was totes the abyss | 16:27 |
| cluckj | also woo, done with the major writing in the dissertation | 16:27 |
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| kanzure | andytoshi: we left out me/you from the list | 18:58 |
| kanzure | crescendo: andytoshi mentioned your name over dinner.... he didn't know you hang around these parts. | 18:58 |
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| --- Log closed Wed Nov 25 00:00:35 2015 | ||
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