| --- Log opened Wed Feb 10 00:00:22 2016 | ||
| --- Day changed Wed Feb 10 2016 | ||
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| nsh | what's a few V between besties | 00:45 |
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| archels | switching 60A? that's a beefy load | 01:44 |
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| kanzure | ugh https://www.technologyreview.com/s/600774/top-us-intelligence-official-calls-gene-editing-a-wmd-threat/ | 06:57 |
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| cluckj | lol | 07:10 |
| archels | that box on the top left makes me feel like this is a game of Cards Against Humanity | 07:12 |
| archels | the headline probably contributes, too | 07:12 |
| chris_99 | heh | 07:14 |
| yoleaux | 06:35Z <nmz787_i> chris_99: Vc would seem to be Voltage-at-collector, which would be 12, not 3.3 | 07:14 |
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| archels | oh, yeah, the transistor circuit | 07:15 |
| archels | chris_99: so you're switching a 60A @ 12V load? that's pretty whopping | 07:15 |
| chris_99 | sorry i may have poorly explained it, the 12V is wrong actually. I only need to output 5A across a PCB trace, i've done some more calculations on the bottom of https://github.com/anfractuosity/pcbdisplay it's 5A @ ~1.21V I posted on reddit yesterday, and from what they mention the MCU wouldn't actually provide the current needed to get 5A from the transistor i was looking at (they mentioned something like a darlington pair). | 07:18 |
| chris_99 | But someone else mentioned a MOSFET you can drive from a logic level of 3.3V | 07:18 |
| archels | that's possible, but logic-level MOSFETs are considerably more expensive and generally have worse performance | 07:19 |
| chris_99 | http://www.farnell.com/datasheets/136097.pdf is the one they suggested | 07:19 |
| archels | it's easy to make a little buffer circuit to switch the FET with 12V, then you can get cheapo IRFZ44 or so | 07:19 |
| chris_99 | http://uk.farnell.com/international-rectifier/irf3708pbf/mosfet-n-30v-62a-to-220/dp/8648158 is only £0.63 in the quantities i need though. What would be the advantage of a buffer over a logic level one? | 07:20 |
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| archels | ah, well if you can get away with using a logic-level FET then run with it. greater simplicity | 07:21 |
| chris_99 | yeah that's the thing i was thinking, it would save on extra components. The thing i'm slightly unsure about is the resistors, as from what i understand, as they're voltage rather than current dependant, maybe i could get away without one? although i read something about 'ringing' - http://electronics.stackexchange.com/questions/68748/question-about-mosfet-gate-resistor | 07:23 |
| archels | yeah, put a 33 to 100 Ohm resistor in series with the gate | 07:24 |
| chris_99 | what do you think about the pull-down resistor? | 07:24 |
| archels | and a pulldown resistor (don't rely on your MCU to keep the gate lines low) | 07:25 |
| chris_99 | aha ok, cheers! | 07:25 |
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| JayDugger | Good morning, everyone. | 08:16 |
| kanzure | everyone hates on weapons of mass destruction; i think there should be a support group. | 08:17 |
| kanzure | without a support group, who are you going to call when you run into a wmd? | 08:17 |
| JayDugger | I'm all for it. Weekend shoots just to stay in practice. | 08:17 |
| kanzure | right, an untested process is a broken process, and all that | 08:17 |
| JayDugger | Let's see...we could do theme detonations, or just save it all for July 4th, and do the 1812 Overture with Davy Crockett rounds vice cannon. | 08:18 |
| JayDugger | But that's unfair to WMDs other than atomic explosives. | 08:19 |
| JayDugger | We'd need a SIG or two for chemcial and biological. | 08:19 |
| JayDugger | (I can say that here, right? We're on speaking terms with the FBI this week?) | 08:20 |
| kanzure | yea it's cool | 08:20 |
| JayDugger | (Hi Feds!) | 08:20 |
| kanzure | my deal with them was only re: reporting people with unhealthy chickenshit/egg kinks coming on to irc | 08:20 |
| JayDugger | I'll just misspell them on purpose in case they don't use a more sophisticated monitor. | 08:20 |
| JayDugger | Eueww... | 08:21 |
| kanzure | well it was because eggs are a wmd or something | 08:21 |
| kanzure | i forget the details | 08:21 |
| JayDugger | There's a pun somewhere in this about a NEST knocking at my door, but I am too tired to make the joke work. | 08:21 |
| kanzure | i think that nectome would be better off focusing on brain simulation and emulation, rather than promising high-fidelity human brain uploading | 08:22 |
| kanzure | there is more money in replacing large chunks of the labor force compared to the money in rescuing people from old age healthcare costs | 08:22 |
| JayDugger | Nectome? The group from the winner of the Small Mammal prize? | 08:22 |
| kanzure | plus on the way to working human brain uploading and emulation you're going to have working human brain "prototype" software anyway, which is essentially ai or agi or whatever | 08:23 |
| JayDugger | I feel more sympathy for the latter than the former, but you're probably right. | 08:23 |
| kanzure | the resolution or fidelity of initial uploading is going to be somewhat pathetic compared to what everyone is hoping | 08:23 |
| kanzure | so you're basically going to end up with not-quite-human agi anyway | 08:23 |
| kanzure | better to spin it like that rather than overpromise about human uploading | 08:24 |
| JayDugger | Yeah, the whole "Is an emulation me?" is oversold compared to "is an emulation a draft animal?" | 08:24 |
| kanzure | otherwise you will get all sorts of boring cultural artifacts resulting from that, like "frankenstein's zombie" but even more boring and more mundane | 08:24 |
| cluckj | like "should an AI pay taxes?" | 08:24 |
| JayDugger | That went past me. Let me think about it for a bit. | 08:24 |
| kanzure | cluckj: if not, the company running the agi would definitely have to pay taxes | 08:25 |
| JayDugger | More likely the latter. | 08:25 |
| JayDugger | Horses drawing carts didn't pay taxes. Their owners did. | 08:25 |
| cluckj | would the agi need to get healthcare under the ACA or face a penalty? | 08:25 |
| kanzure | JayDugger: "frankenstein's monster" was a story about reanimation and it was boring and obvious in a bunch of places. they will say the same thing about uploads ("omg it's only 1% of a preson~~~~") and we will have to endure the cringe for 20-40 years and it will be awful. | 08:25 |
| JayDugger | We will probably have machines smart as horses before machines as smart as men. | 08:25 |
| JayDugger | The speculation about horse-smart isn't as much fun. | 08:26 |
| kanzure | cluckj: thankfully human history has shown that we're perfectly willing to classify unique things as non-human, so my guess would be no :) | 08:26 |
| kanzure | cluckj: although you could ask the same question about autonomous self-driving cars :D | 08:26 |
| cluckj | and actual humans as non-humans too | 08:26 |
| kanzure | "do autonomous cars have to join organ donation programs?" | 08:26 |
| cluckj | we don't have a good track record at this | 08:26 |
| JayDugger | Yes! and they should be scored and rewarded for how many organ donors each automonous car delivers to the hospital. | 08:27 |
| cluckj | do autonomous cars need to pay for their own insurance? | 08:27 |
| JayDugger | Yes! out of the finder's fees for delivering organs ready for donation. | 08:27 |
| kanzure | well i was more thinking along the lines of autonomous cars donating their own parts in the event of an accident, but deliverance of organs to hospitals sounds like it could work too | 08:27 |
| cluckj | will autonomous cars be considered employees, property, or "independent contractors" under labor laws? | 08:28 |
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| JayDugger | I was thinking more along the lines of encouraging the right kinds of accidents to arrange organ donations. But I think y'all are treated the subject with more seriousness. | 08:28 |
| JayDugger | I'm to bed. I can't even type straight. Good night. | 08:29 |
| cluckj | I have literally asked zero serious questions | 08:29 |
| cluckj | or rather I have asked literally zero serious questions | 08:30 |
| cluckj | whatever | 08:30 |
| JayDugger | https://www.ncbi.nlm.nih.gov/pubmed/24508152 | 08:33 |
| JayDugger | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677127/ | 08:36 |
| JayDugger | Fun project for later... | 08:36 |
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| catern | hey, kanzure, you're a cool cypherpunk, do you know any papers or articles about the use of digital currencies in accounting for network resources at a per-packet level? | 09:22 |
| kanzure | catern: http://diyhpl.us/~bryan/papers2/bitcoin/ | 09:24 |
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| catern | oh boy | 09:24 |
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| catern | i don't know if any of these actually are what i'm looking for but i guess i should use grep | 09:39 |
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| kanzure | bsm117532: welcome. | 10:06 |
| bsm117532 | Neat | 10:07 |
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| bsm117532 | Hahaa there's a lot of overlap between the people here and #bitcoin-wizards ;-) | 10:07 |
| kanzure | yea all of the bitcoiners are immortalists | 10:08 |
| adlai | "Strangely, sorting by log size per day returns relatively high-signal content" << why 'strangely'? | 10:08 |
| kanzure | it's one of those "open secrets" | 10:08 |
| kanzure | adlai: because size shouldn't have anything to do with signal-noise ratio | 10:09 |
| kanzure | adlai: it's a ridiculous correlation | 10:09 |
| bsm117532 | kanzure: Huh? large log size means discussion, and presumably, signal, no? | 10:09 |
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| adlai | it makes sense if people pitch in when they see high-signal discussion, and opt out rather than enflame trolls or just idle chatter | 10:09 |
| kanzure | you're welcome to remove the statement, it's a wiki after all | 10:10 |
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| * adlai doesn't think he has an account? and either the correlation is strange, or the strangeness, so the statement should remain | 10:10 | |
| adlai | buh: http://diyhpl.us/wiki/bitcoin/big-pile/ | 10:11 |
| adlai | that needs a few man-years of constructive mania curation | 10:11 |
| kanzure | jgarzik asked me to release that content somewhere "release early release often" | 10:12 |
| kanzure | actually that file was the result of me spending a week before scalingbitcoin montreal reading all forum posts and all bitcoin-dev email traffic | 10:12 |
| adlai | what's the first token in the links? | 10:12 |
| * bsm117532 raids his mail archives for the Transhumanism mailing list... | 10:12 | |
| kanzure | jotmuch slug https://github.com/davidlazar/jotmuch | 10:13 |
| kanzure | bsm117532: i have the mailing list archives over here http://diyhpl.us/~bryan/irc/extropians/ and http://extropians.weidai.com/ | 10:13 |
| adlai | kanzure: thank you. somebody linked me to this thing before but i never paid much attention... will leave tab open ^_^ | 10:14 |
| * adlai meanwhile goes teach humans go, before it becomes another worthless pastime | 10:14 | |
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| kanzure | https://embracepith.wordpress.com/2015/09/11/on-gell-mann-amnesia-effect-or-how-crichton-pens-more-than-a-novel/ | 10:15 |
| kanzure | http://isearch.nhtsa.gov/files/Google%20--%20compiled%20response%20to%2012%20Nov%20%2015%20interp%20request%20--%204%20Feb%2016%20final.htm | 10:16 |
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| catern | what would have seemed more likely in retrospect to me is not a digital currency eventually being used for paying for packets, but rather network resource accounting methods eventually being used as a digital currency | 10:20 |
| catern | kanzure: is there a better channel than this for discussion of cypherpunk-ish-things | 10:20 |
| kanzure | bitcoin-wizards is better for cryptocurrency theoretical speculation, this channel is pretty good for extropian content | 10:24 |
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| catern | what exactly is "extropian content", then? | 10:29 |
| catern | does what i've brought up fall into the case of extropian content or cryptocurrency theoretical speculation? | 10:29 |
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| kanzure | catern: that's a good question; in my experience, the -wizards folks are much better at privacy tech than the folks in here. | 11:22 |
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| kanzure | brain connectivity matrices http://umcd.humanconnectomeproject.org/ | 11:32 |
| kanzure | .wik DLG4 | 11:33 |
| yoleaux | "PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene." — https://en.wikipedia.org/wiki/DLG4 | 11:33 |
| kanzure | "PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.[1] PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all ... | 11:34 |
| kanzure | ... MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons,[4] and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.[5] It plays an important role ... | 11:34 |
| kanzure | ... in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.[6]" | 11:34 |
| kanzure | "[gephyrin] is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers." | 11:35 |
| kanzure | "Recently, a novel approach based on recombinant fibronectin intrabodies generated by mRNA display (FingRs) has been introduced for use in tissue culture and in mouse brain slices7. FingRs are antibody-like proteins that have been selected to target endogenous synaptic proteins including postsynaptic density 95 (PSD-95) and Gephyrin (GPHN). PSD-95 is a scaffolding protein localized to the postsynaptic density of excitatory synapses8, and ... | 11:37 |
| kanzure | ... GPHN is a component of the postsynaptic protein network of inhibitory synapses9. FingRs have several advantages over current methods: they are recombinant and can be expressed in cell types of interest; they can be fused to a fluorophore to permit visualization of synapses in vivo; and finally, they have an auto-feedback mechanism to limit overexpression that could affect synapse properties as well as obscure precise imaging. " | 11:37 |
| kanzure | from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700522/ | 11:37 |
| kanzure | optogenetic fusion proteins ("luminopsins") (something about fusing channelrhodopsins with luciferase?) http://www.pnas.org/content/113/3/E358.full | 11:40 |
| kanzure | not really sure what to do with that one | 11:40 |
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| kanzure | aldehyde vitrification on hacker news too https://news.ycombinator.com/item?id=11070528 | 12:01 |
| kanzure | scihub and libgen stuff too https://news.ycombinator.com/item?id=11070192 | 12:02 |
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| kanzure | http://scienceblogs.com/pharyngula/2016/01/29/how-can-you-protect-a-brain-by-destroying-it/ | 12:48 |
| archels | any good comments? | 12:56 |
| archels | also why is everybody always so down on capitalism | 12:56 |
| archels | oh wait the comments section isn't actually longer than the article. | 12:57 |
| kanzure | it's because capitalism doesn't have a PR team, duh | 13:10 |
| archels | so given that the cell membranes stay perfectly intact, how about cell-bound proteins and vesicles? | 13:26 |
| archels | post-synaptic densities? | 13:27 |
| kanzure | i think that vacuoles and vesicles might be intact | 13:28 |
| kanzure | or definitely in some of the variants of the CLARITY method | 13:28 |
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| archels | sequencing DNA/RNA is probably out | 13:30 |
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| fenn | "The current explosive Zika virus epidemic in the Americas is, however, causing great concern because of what looks to be a sudden, dramatic increase in the incidence of microcephaly (small brain/head size) in newborns." | 19:17 |
| fenn | i guess a sudden dramatic increase in microcephaly isn't newsworthy on its own? | 19:17 |
| kanzure | another article said that there is no microcephaly from zika virus :( | 19:18 |
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| xentrac_ | fenn: yes, it was, before Zika was identified as a candidate | 19:21 |
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| --- Log closed Thu Feb 11 00:00:29 2016 | ||
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