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| fenn | B12 can act as a methyl donor, same as methyl folate | 00:36 |
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| fenn | i think this can affect hormone levels and fatty acid oxidation (in the case of deficiency) | 00:40 |
| fenn | a cheaper source of methyl groups would be choline, TMG, or betaine, though SAMe seems to be popular for some reason: http://www.raysahelian.com/methyl.html | 00:41 |
| fenn | oh TMG is betaine | 00:42 |
| fenn | "The synthesis of SAMe is intimately linked with folate and vitamin B12 metabolism, and deficiencies of both these vitamins have been found to reduce central nervous system SAMe concentrations." | 00:45 |
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| nmz787_ | fenn: good diversion | 02:00 |
| nmz787_ | kanzure: yeah I forgot about that, what happened to those guys? | 02:00 |
| nmz787_ | just got some for of slicing implemented in my BRL-CAD wrapper... and here is a nice animated GIF of slices: https://raw.githubusercontent.com/nmz787/python-brlcad-tcl/master/examples/output/microfluidic_pump_slices_manually_created_animation.gif | 02:01 |
| nmz787_ | now to figure out NIRT and getting a raster, to hopefully get g-code (especially if abetusk ever re-appears) | 02:02 |
| * nmz787_ sleeps now though | 02:02 | |
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| kanzure | https://www.youtube.com/watch?v=MXaONlkQp_E | 07:29 |
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| kanzure | .title http://ai2016.foresight.org/ | 08:05 |
| yoleaux | Foresight Institute Artificial Intelligence for Scientific Progress | 08:05 |
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| CaptHindsight | http://lasergen.com/wp-content/uploads/2013/06/Litosh-NAR-January-2011.pdf | 09:21 |
| CaptHindsight | http://lasergen.com/wp-content/uploads/2013/06/Gardner2012Paper.pdf | 09:21 |
| CaptHindsight | they don't see the big picture | 09:22 |
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| kanzure | "Amplification of RNA by an RNA polymerase ribozyme" http://www.pnas.org/content/early/2016/08/10/1610103113 | 10:10 |
| kanzure | "Here, we report the in vitro evolution of an improved RNA polymerase ribozyme that is able to synthesize structured functional RNAs, including aptamers and ribozymes, and replicate short RNA sequences in a protein-free form of the PCR. Thus, the replication of RNA and the expression of functional RNA can be accomplished with RNA alone. Combining and improving these activities may enable the self-sustained evolution of RNA and offers a ... | 10:10 |
| kanzure | ... potential route to a synthetic form of RNA life." | 10:10 |
| kanzure | ".. the polymerase can replicate nucleic acids, amplifying short RNA templates by more than 10,000-fold in an RNA-catalyzed form of the PCR" | 10:10 |
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| esmerelda | Holy crap that's amazing. | 11:29 |
| nmz787_ | it seems business as usual to me | 11:38 |
| esmerelda | Business as usual is amazing these days. I love the future | 11:41 |
| nmz787_ | the problem seems to be the universe is so big/complex... there could be years of this before we get anywhere that isn't akin to "poserville" | 11:42 |
| nmz787_ | of course I still reserve myself to be amazed... it is just hard when you see things happening in the world that remind me it could all crumble if politics screw up and some disenfranchised group starts smashing things | 11:43 |
| esmerelda | What? I'm just talking about being excited that RNA world seems even more likely now | 11:43 |
| nmz787_ | the RNA world was always as likely though, I guess... it just has some evidence now | 11:44 |
| nmz787_ | CaptHindsight: well at least /someone/ is working on better nucleotide chemistry | 11:46 |
| nmz787_ | oh, this is the lasergen peole | 11:47 |
| nmz787_ | I am stupid for not reading the URL | 11:47 |
| * nmz787_ wonders if this means there are other academics in the Houston area, should I desire to pursue PhD in nucleotide chem/applied-chem | 11:47 | |
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| CaptHindsight | or move to China and get continual funding as you trickle out new synthesis methods | 12:00 |
| CaptHindsight | China is a lot like Texas | 12:00 |
| nmz787_ | I really only consider Texas because I have a friend who might end up being a Medical Doctor around there... and who doesn't need a doctor as a drinking buddy? | 12:07 |
| nmz787_ | also, weather in all places but here seems all messed up... Oregon is pretty sweet | 12:07 |
| * nmz787_ has told in-laws I'll be driving them to see the blown-out Mt. St. Helens now | 12:08 | |
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| kanzure | pasky: how is multi-gpu distributed training supposed to work? | 12:35 |
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| kanzure | "Deep learning with Elastic Averaging SGD" http://arxiv.org/abs/1412.6651 | 12:49 |
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| kanzure | well, i don't think i mean placing separate layers on seperate devices (seems like a good way to get bottlenecked on training) | 12:51 |
| kanzure | *during training | 12:51 |
| kanzure | i'm also not sure about "just average the weights once you're done" | 12:51 |
| kanzure | https://github.com/mila-udem/platoon | 12:54 |
| kanzure | welp looks like they really do just "average the weights yo" | 12:54 |
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| kanzure | nope, people are doing literal summing not even averaging https://github.com/fchollet/keras/issues/106#issuecomment-157130117 | 13:12 |
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| kanzure | oh that's an average. nevermind. | 13:13 |
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| jcorgan | integration wipes away all sins | 13:41 |
| ybit | http://joss.theoj.org/papers.atom | 13:50 |
| ybit | http://joss.theoj.org/ | 13:51 |
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| ybit | anyone have access to | 15:05 |
| ybit | http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.6b00530?journalCode=nalefd | 15:05 |
| ybit | http://www.nature.com/nature/journal/v523/n7561/full/nature14586.html | 15:05 |
| ybit | http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.5b05139 | 15:05 |
| ybit | someone was nice enough to download a paper for me just now: https://www.reddit.com/r/Scholar/comments/4yrfpw/article_eukaryotic_dna_polymerases/ | 15:06 |
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| ybit | guess i'll bundle them into a single request on r/scholar | 15:16 |
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| yashgaroth | is there something wrong with sci-hub | 15:18 |
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| xentrac | nmz787_: congratulations on your slicing! | 15:19 |
| yashgaroth | and the second one is online, no? http://www.hogberglab.net/media/publications/benson2015mc.pdf | 15:19 |
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| ybit | ah, i needed to select "scientific articles" underneath the input form | 15:26 |
| ybit | thanks yashgaroth | 15:26 |
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| maaku | https://www.doc.ic.ac.uk/~mpsha/ECExplained.pdf | 15:38 |
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| kanzure | .title http://www.symmetrymagazine.org/article/the-100-muon-detector | 20:24 |
| yoleaux | The $100 muon detector | symmetry magazine | 20:24 |
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| kanzure | tor is still busy imploding :| | 22:18 |
| ebowden | In what way is tor imploding? | 22:18 |
| anoncicada | :c | 22:19 |
| jcorgan | excess drama | 22:19 |
| superkuh | Lots of members being kicked out, leaving because someone was kicked out, leaving for no stated reason, being replaced in mass. | 22:19 |
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| nmz787_ | xentrac: thanks! | 23:47 |
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| --- Log closed Sun Aug 21 00:00:31 2016 | ||
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