--- Log opened Sat Aug 13 00:00:24 2016 00:07 -!- rusty2 [~rusty@pdpc/supporter/bronze/rusty] has quit [Ping timeout: 252 seconds] 00:09 -!- blackwraith [~priidu@unaffiliated/priidu] has joined #bitcoin-wizards 00:11 -!- priidu [~priidu@unaffiliated/priidu] has quit [Ping timeout: 258 seconds] 00:27 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has quit [Ping timeout: 244 seconds] 00:34 -!- bildramer [~bildramer@ppp-94-67-122-42.home.otenet.gr] has quit [Ping timeout: 244 seconds] 00:38 -!- bildramer [~bildramer@ppp-94-67-122-146.home.otenet.gr] has joined #bitcoin-wizards 00:41 -!- kmels [~kmels@190.106.223.48] has joined #bitcoin-wizards 00:54 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has joined #bitcoin-wizards 01:01 -!- cyphase [~cyphase@unaffiliated/cyphase] has quit [Ping timeout: 252 seconds] 01:06 -!- cyphase [~cyphase@unaffiliated/cyphase] has joined #bitcoin-wizards 01:06 -!- satwo [~satwo@c-71-228-209-154.hsd1.tn.comcast.net] has joined #bitcoin-wizards 01:13 -!- Guyver2 [~Guyver2@guyver2.xs4all.nl] has joined #bitcoin-wizards 01:15 -!- xsdfdfsa [~x@unaffiliated/sdfgsdfg] has joined #bitcoin-wizards 01:19 -!- dEBRUYNE [~dEBRUYNE@unaffiliated/debruyne] has joined #bitcoin-wizards 01:32 -!- MoALTz [~no@78-11-183-124.static.ip.netia.com.pl] has joined #bitcoin-wizards 01:40 -!- bildramer [~bildramer@ppp-94-67-122-146.home.otenet.gr] has quit [Ping timeout: 260 seconds] 01:44 -!- sausage_factory [~priidu@unaffiliated/priidu] has joined #bitcoin-wizards 01:46 -!- blackwraith [~priidu@unaffiliated/priidu] has quit [Ping timeout: 240 seconds] 01:46 -!- bildramer [bildramer@2a02:582:5860:9600:1094:7b83:1b52:ec5a] has joined #bitcoin-wizards 01:47 -!- pro [~pro@unaffiliated/pro] has joined #bitcoin-wizards 01:49 -!- dEBRUYNE [~dEBRUYNE@unaffiliated/debruyne] has quit [Ping timeout: 250 seconds] 01:59 -!- Ylbam [uid99779@gateway/web/irccloud.com/x-oabpoaavyqktxugy] has joined #bitcoin-wizards 02:01 -!- [7] [~quassel@rockbox/developer/TheSeven] has quit [Ping timeout: 258 seconds] 02:01 -!- TheSeven [~quassel@rockbox/developer/TheSeven] has joined #bitcoin-wizards 02:06 -!- cjcj [2e3b026a@gateway/web/freenode/ip.46.59.2.106] has quit [Ping timeout: 264 seconds] 02:21 -!- murch [~murch@p4FDB7080.dip0.t-ipconnect.de] has joined #bitcoin-wizards 02:26 -!- Guyver2 [~Guyver2@guyver2.xs4all.nl] has quit [Quit: :)] 02:31 -!- moli [~molly@unaffiliated/molly] has quit [Ping timeout: 240 seconds] 02:36 -!- satwo [~satwo@c-71-228-209-154.hsd1.tn.comcast.net] has quit [Remote host closed the connection] 02:38 -!- gielbier [~giel____@unaffiliated/gielbier] has quit [Quit: Leaving] 02:50 -!- xsdfdfsa [~x@unaffiliated/sdfgsdfg] has quit [Remote host closed the connection] 03:15 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has quit [Ping timeout: 240 seconds] 03:26 -!- dEBRUYNE [~dEBRUYNE@unaffiliated/debruyne] has joined #bitcoin-wizards 03:29 -!- satwo [~satwo@c-71-228-209-154.hsd1.tn.comcast.net] has joined #bitcoin-wizards 03:34 -!- proslogion [~proslogio@2.217.2.220] has joined #bitcoin-wizards 04:12 -!- EasyAt [~easy@unaffiliated/easyat] has quit [Read error: Connection reset by peer] 04:14 -!- satwo [~satwo@c-71-228-209-154.hsd1.tn.comcast.net] has quit [Remote host closed the connection] 04:28 -!- asynk [aknix@gateway/vpn/mullvad/x-dthraoctnrhqbbmu] has quit [Ping timeout: 250 seconds] 04:32 -!- dEBRUYNE [~dEBRUYNE@unaffiliated/debruyne] has quit [Quit: Leaving] 04:33 -!- dEBRUYNE [~dEBRUYNE@unaffiliated/debruyne] has joined #bitcoin-wizards 04:41 -!- asynk [~aknix@65.78.54.2] has joined #bitcoin-wizards 05:05 -!- Ylbam [uid99779@gateway/web/irccloud.com/x-oabpoaavyqktxugy] has quit [Quit: Connection closed for inactivity] 05:09 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has joined #bitcoin-wizards 05:35 -!- moli [~molly@unaffiliated/molly] has joined #bitcoin-wizards 05:53 -!- dEBRUYNE [~dEBRUYNE@unaffiliated/debruyne] has quit [Quit: Leaving] 06:07 * nsh isn't quite sure still why sender/recipient non-ZKness of rangeproof prevents MW tx aggregation 06:20 -!- dEBRUYNE [~dEBRUYNE@unaffiliated/debruyne] has joined #bitcoin-wizards 06:23 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has quit [Quit: Quitte] 06:56 -!- thesnark [~mike@unaffiliated/thesnark] has quit [Quit: Leaving] 07:04 -!- AaronvanW [~ewout@unaffiliated/aaronvanw] has quit [Remote host closed the connection] 07:09 < kanzure> anything to interrogate scott aaronson about? 07:22 -!- Noldorin [~noldorin@unaffiliated/noldorin] has joined #bitcoin-wizards 07:42 -!- dnaleor [~dnaleor@78-23-74-78.access.telenet.be] has quit [Read error: Connection reset by peer] 08:03 -!- Ylbam [uid99779@gateway/web/irccloud.com/x-fnticsyqhsjfayyt] has joined #bitcoin-wizards 08:03 < instagibbs> nsh, huh 08:07 < Alanius> you're meeting scott aaronson? O_o 08:10 -!- Chris_Stewart_5 [~Chris_Ste@unaffiliated/chris-stewart-5/x-3612383] has joined #bitcoin-wizards 08:11 < Alanius> how about whether the many-worlds interpretation applies to classical probabilistics as well, since after all the only real difference is the L1 norm versus the L2 norm of quantum mechanics 08:12 -!- laurentmt [~Thunderbi@176.158.157.202] has joined #bitcoin-wizards 08:12 -!- laurentmt [~Thunderbi@176.158.157.202] has quit [Client Quit] 08:12 -!- Noldorin [~noldorin@unaffiliated/noldorin] has quit [Ping timeout: 240 seconds] 08:15 < kanzure> Alanius: apparently scott aaronson has moved from mit.edu to utexas.edu because the former refused to give his wife tenure or something and the latter said sure 08:15 < kanzure> i mentioned the dan boneh doc to him and a few minutes ago he was telling me about seeing dan earlier this week here in austin because usenix 08:32 < kanzure> "CVE-2016-5696 and its effects on tor" https://blog.patternsinthevoid.net/cve-2016-5696-and-its-effects-on-tor.html 08:32 < kanzure> https://github.com/torvalds/linux/commit/75ff39ccc1bd5d3c455b6822ab09e533c551f758 08:34 < fluffypony> I love how the official Linux kernel source tree is on his personal GH account 08:34 < fluffypony> right next to "subsurface - Advanced multi-platform divelog based on Qt" 08:35 < kanzure> iirc he does not consider github anything official for his purposes? 08:36 -!- mryandao [~mryandaoI@45.32.191.82] has quit [Changing host] 08:36 -!- mryandao [~mryandaoI@unaffiliated/mryandao] has joined #bitcoin-wizards 08:37 < _r0ach_> I'd like to see fluffy take the place of Linus when he dies and just get boozed up on wine in the basement and say, "this weeks kernel will include..." 08:38 < fluffypony> hah hah 08:38 < fluffypony> kanzure: I was just teasing, official sources are kernel.org, and I'm 80% certain they run their own git server on it 08:39 < fluffypony> I've only ever fetched sources via rsync / ftp from there, though 08:39 < kanzure> i have submitted the boneh bitcoin crypto transcript to HN if anyone wants to upvote that :P https://news.ycombinator.com/newest 08:44 < kanzure> hrmm looks like someone is claiming to be auctioning off some malware from equation group http://pastebin.com/NDTU5kJQ 08:55 < kanzure> petertodd: did you ever review the "darkleaks" stuff by any chance? 08:58 -!- afk11 [~afk11@109.255.154.81] has joined #bitcoin-wizards 08:58 -!- afk11 [~afk11@109.255.154.81] has quit [Changing host] 08:58 -!- afk11 [~afk11@unaffiliated/afk11] has joined #bitcoin-wizards 09:00 -!- satwo [~satwo@c-71-228-209-154.hsd1.tn.comcast.net] has joined #bitcoin-wizards 09:03 -!- blackwraith [~priidu@unaffiliated/priidu] has joined #bitcoin-wizards 09:06 -!- sausage_factory [~priidu@unaffiliated/priidu] has quit [Ping timeout: 276 seconds] 09:16 -!- kmels [~kmels@190.106.223.48] has quit [Read error: Connection reset by peer] 09:24 -!- NewLiberty [~NewLibert@2602:306:b8e0:8160:c57d:8753:11e7:7506] has joined #bitcoin-wizards 09:41 -!- JHistone [~JHistone@cpc104808-sgyl39-2-0-cust135.18-2.cable.virginm.net] has joined #bitcoin-wizards 09:54 < kanzure> someone has asked me to pester him about busy beaver functions and http://www.scottaaronson.com/blog/?p=2725 09:55 -!- sausage_factory [~priidu@unaffiliated/priidu] has joined #bitcoin-wizards 09:56 -!- blackwraith [~priidu@unaffiliated/priidu] has quit [Ping timeout: 250 seconds] 09:56 < kanzure> maybe i should ask him about tromp's binary lambda calculus stuff? 09:59 -!- Chris_Stewart_5 [~Chris_Ste@unaffiliated/chris-stewart-5/x-3612383] has quit [Ping timeout: 252 seconds] 10:02 < Alanius> ask him why the many-worlds interpretation does not apply to classical randomness 10:03 < kanzure> i refuse to ask anything about MWI 10:05 < kanzure> hm looks like i can pester him about probabilistically checkable proofs and PCP theorem things 10:08 < kanzure> http://scottaaronson.com/papers/ 10:09 -!- bitcoin-wizards7 [5002b9e7@gateway/web/freenode/ip.80.2.185.231] has joined #bitcoin-wizards 10:10 < kanzure> "Oracles are subtle but not malicious" http://www.scottaaronson.com/papers/subtle.pdf 10:10 < kanzure> "The complexity of agreement" http://www.scottaaronson.com/papers/agree-econ.pdf 10:11 < kanzure> "Why philosophers should care about computational complexity" http://www.scottaaronson.com/papers/philos.pdf 10:11 < Alanius> oh, don't forget the freebits paper 10:13 < kanzure> this looks like some nonsense in favor of consciousness. i'll pass on that. 10:13 < Alanius> free will rather 10:14 < kanzure> like a free will lunch theorem? 10:15 < kanzure> http://no-free-lunch.org/ 10:19 < Alanius> if I recall correctly, the clue is that even if we live in a deterministic world, it might still be impossible for any part of the rest of the universe to predict your choices without changing them 10:19 -!- molz [~molly@unaffiliated/molly] has joined #bitcoin-wizards 10:20 < kanzure> what would be bad about prediction though? 10:20 -!- bitcoin-wizards7 [5002b9e7@gateway/web/freenode/ip.80.2.185.231] has quit [Ping timeout: 264 seconds] 10:22 -!- moli [~molly@unaffiliated/molly] has quit [Ping timeout: 252 seconds] 10:22 < Alanius> well, I guess any assignment of meaning to life and the universe implicitly assigns an active role to us human beings, but that would be impossible if all our actions were already set in stone 10:24 < kanzure> for philosophical questions i refer you to http://diyhpl.us/~bryan/papers2/physics/astrophysics/The%20meaning%20of%20life%20in%20a%20cosmological%20perspective%20-%20Clement%20Vidal.pdf 10:24 -!- EasyAt [~easy@70.41.80.232] has joined #bitcoin-wizards 10:24 -!- EasyAt [~easy@70.41.80.232] has quit [Client Quit] 10:25 < Alanius> holy crap, why didn't I read this 10 years ago? 10:25 < Alanius> thanks! 10:26 < kanzure> it is difficult to figure out who to route certain information to... so that is why this process is extremely inefficient. 10:27 < Alanius> uh, yeah, that seems like a particularly relevant fact about computation and information theory 10:31 -!- bildramer1 [bildramer@2a02:582:5860:9600:f0d8:8569:ff03:9298] has joined #bitcoin-wizards 10:32 < kanzure> also it has been requested that i pester scott about quantum crypto safety topics. so i will do this. 10:32 -!- bildramer [bildramer@2a02:582:5860:9600:1094:7b83:1b52:ec5a] has quit [Disconnected by services] 10:32 -!- bildramer1 is now known as bildramer 10:39 < Alanius> if scott aaronson has an already well formed opinion on the alleged quantum security of isogeny-based crypto, I'd be very much interested to learn about that 10:48 -!- laurentmt [~Thunderbi@176.158.157.202] has joined #bitcoin-wizards 10:50 -!- bildramer1 [~bildramer@2001:0:9d38:6ab8:2c16:2552:a1bc:8a35] has joined #bitcoin-wizards 10:53 -!- bildramer [bildramer@2a02:582:5860:9600:f0d8:8569:ff03:9298] has quit [Ping timeout: 258 seconds] 10:56 -!- hashtag [~hashtagg_@cpe-174-97-254-80.ma.res.rr.com] has quit [Ping timeout: 244 seconds] 10:57 -!- bildramer [bildramer@2a02:582:5860:9600:196a:166d:a5c7:1ed4] has joined #bitcoin-wizards 10:57 -!- bildramer1 [~bildramer@2001:0:9d38:6ab8:2c16:2552:a1bc:8a35] has quit [Ping timeout: 258 seconds] 10:57 -!- Giszmo [~leo@178-83-12-152.dynamic.hispeed.ch] has joined #bitcoin-wizards 11:06 < kanzure> someone has asked that i request from him "a quantum-hard version of confidential transactions" 11:10 < proslogion> lol 11:11 < proslogion> santa aaronson 11:23 < nsh> kanzure, when are you meeting scott? 11:23 < kanzure> sadly... http://lesswrong.com/meetups/1pl 11:24 < nsh> oh 11:24 < nsh> i wouldn't bother trying ot talk about anything intelligent with pop philo groupies in the room 11:25 < pigeons> tell them roku's basilisk says hi 11:26 < nsh> but if you get him somewhere safe have a chat about quantum zero-knowledge proof and pseudo-telepathy games for distributed [no-signalling] computation 11:27 < nsh> also what he thinks about recasting general quantum superposition/entanglement/uncertainy experiments into the context QMA proof schemes 11:32 -!- blackwraith [~priidu@unaffiliated/priidu] has joined #bitcoin-wizards 11:32 -!- laurentmt [~Thunderbi@176.158.157.202] has quit [Quit: laurentmt] 11:34 -!- sausage_factory [~priidu@unaffiliated/priidu] has quit [Ping timeout: 250 seconds] 11:43 -!- gigq [~gigq@45-20-197-26.lightspeed.austtx.sbcglobal.net] has quit [Ping timeout: 250 seconds] 11:44 -!- gigq [~gigq@2602:302:d14c:51a0:3ac9:86ff:fe0e:683d] has joined #bitcoin-wizards 11:57 -!- Tenhi_ [~tenhi@static.177.80.201.138.clients.your-server.de] has joined #bitcoin-wizards 11:58 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has joined #bitcoin-wizards 12:00 -!- satwo [~satwo@c-71-228-209-154.hsd1.tn.comcast.net] has quit [Remote host closed the connection] 12:05 -!- Ylbam [uid99779@gateway/web/irccloud.com/x-fnticsyqhsjfayyt] has quit [Quit: Connection closed for inactivity] 12:08 -!- Tenhi_ [~tenhi@static.177.80.201.138.clients.your-server.de] has quit [K-Lined] 12:26 < kanzure> "A bunch of cryptographic protocol oddities" http://blog.bjrn.se/2016/08/cabinet-of-curiosities-bunch-of.html 12:37 -!- berndj [~berndj@197.242.93.84] has quit [Quit: ZNC - http://znc.in] 12:40 -!- Guyver2 [~Guyver2@guyver2.xs4all.nl] has joined #bitcoin-wizards 12:45 -!- Ylbam [uid99779@gateway/web/irccloud.com/x-dxhgobguatuczwfu] has joined #bitcoin-wizards 12:45 -!- berndj [~berndj@197.242.93.84] has joined #bitcoin-wizards 12:55 -!- jps [~Jud@cpe-68-173-72-120.nyc.res.rr.com] has joined #bitcoin-wizards 13:07 < kanzure> "Computational phenomena in physics" https://www.youtube.com/watch?v=boZyu6NhAcI 13:13 < nsh> also ask SA if he expects that we can prove certain physical scenarios are unlikely through computational complexity arguments more generally than in the context of pathological GR manifolds 13:13 < nsh> which i think was just a good place to first trial the arguments 13:13 < nsh> (firewall paradox stuff) 13:14 < nsh> really i need to get him and susskind in a room at once 13:15 < kanzure> "Pairings in cryptography" https://www.youtube.com/watch?v=8WDOpzxpnTE 13:16 < kanzure> "Algebraic multilinear maps" https://www.youtube.com/watch?v=YK0RXF0YDm0 13:17 < kanzure> "Non-abelian groups in cryptography" https://www.youtube.com/watch?v=m4lv0lXI5uU 13:20 -!- jps [~Jud@cpe-68-173-72-120.nyc.res.rr.com] has quit [Quit: jps] 13:30 -!- pro [~pro@unaffiliated/pro] has quit [Quit: Leaving] 13:35 -!- jps [~Jud@cpe-68-173-72-120.nyc.res.rr.com] has joined #bitcoin-wizards 13:41 < kanzure> about reputation systems and negative attestation http://nbviewer.jupyter.org/url/canonical.org/~kragen/sw/dev3/pagerank-extensions.ipynb 13:44 -!- Sosumi [~Leon@bl10-113-190.dsl.telepac.pt] has joined #bitcoin-wizards 13:51 -!- edvorg [~edvorg@14.169.57.10] has joined #bitcoin-wizards 13:57 < kanzure> "Quantum money from hidden subspaces" http://www.scottaaronson.com/papers/money.pdf 13:58 -!- pro [~pro@unaffiliated/pro] has joined #bitcoin-wizards 14:03 -!- hashtag [~hashtagg_@cpe-174-97-254-80.ma.res.rr.com] has joined #bitcoin-wizards 14:19 -!- JHistone [~JHistone@cpc104808-sgyl39-2-0-cust135.18-2.cable.virginm.net] has quit [Ping timeout: 265 seconds] 14:31 -!- jgarzik [~jgarzik@unaffiliated/jgarzik] has quit [Quit: This computer has gone to sleep] 14:41 -!- Guyver2 [~Guyver2@guyver2.xs4all.nl] has quit [Read error: Connection reset by peer] 14:41 -!- jps [~Jud@cpe-68-173-72-120.nyc.res.rr.com] has quit [Quit: jps] 14:52 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 14:54 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 15:04 -!- JHistone [~JHistone@cpc104808-sgyl39-2-0-cust135.18-2.cable.virginm.net] has joined #bitcoin-wizards 15:10 -!- LeMiner [LeMiner@unaffiliated/leminer] has quit [Read error: Connection reset by peer] 15:13 -!- JHistone [~JHistone@cpc104808-sgyl39-2-0-cust135.18-2.cable.virginm.net] has quit [Ping timeout: 258 seconds] 15:15 -!- JHistone [~JHistone@cpc104808-sgyl39-2-0-cust135.18-2.cable.virginm.net] has joined #bitcoin-wizards 15:30 < instagibbs> kanzure, nice thanks for the video, can listen on the go 15:55 -!- berndj [~berndj@197.242.93.84] has quit [Quit: ZNC - http://znc.in] 15:55 -!- berndj [~berndj@197.242.93.84] has joined #bitcoin-wizards 16:07 -!- JHistone [~JHistone@cpc104808-sgyl39-2-0-cust135.18-2.cable.virginm.net] has quit [Quit: Leaving] 16:07 -!- JHistone [~JHistone@cpc104808-sgyl39-2-0-cust135.18-2.cable.virginm.net] has joined #bitcoin-wizards 16:13 -!- murch [~murch@p4FDB7080.dip0.t-ipconnect.de] has quit [Quit: Leaving.] 16:33 < kanzure> oh right his significant other is pcp theorem expert. how convenient. 16:44 <@gmaxwell> kanzure: well if you're going to talk about pcp theorem stuff, https://eprint.iacr.org/2016/021 16:45 <@gmaxwell> also, https://eprint.iacr.org/2016/324 16:48 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ZZZzzz…] 18:30 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 18:39 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 18:41 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 18:49 -!- Chris_Stewart_5 [~Chris_Ste@unaffiliated/chris-stewart-5/x-3612383] has quit [Ping timeout: 258 seconds] 19:05 -!- pro [~pro@unaffiliated/pro] has quit [Quit: Leaving] 19:08 -!- Chris_Stewart_5 [~Chris_Ste@unaffiliated/chris-stewart-5/x-3612383] has joined #bitcoin-wizards 19:33 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 19:35 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 19:39 -!- davec [~davec@cpe-24-243-251-52.hot.res.rr.com] has quit [Ping timeout: 258 seconds] 19:59 -!- jgarzik [~jgarzik@unaffiliated/jgarzik] has joined #bitcoin-wizards 20:01 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 20:03 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 20:27 -!- davec [~davec@cpe-24-243-251-52.hot.res.rr.com] has joined #bitcoin-wizards 20:40 -!- LeMiner [LeMiner@unaffiliated/leminer] has joined #bitcoin-wizards 20:44 -!- mdavid613 [~Adium@cpe-172-251-161-231.socal.res.rr.com] has joined #bitcoin-wizards 20:47 -!- Chris_Stewart_5 [~Chris_Ste@unaffiliated/chris-stewart-5/x-3612383] has quit [Ping timeout: 252 seconds] 20:47 -!- orville [~orville@c-73-170-124-69.hsd1.ca.comcast.net] has joined #bitcoin-wizards 20:51 -!- jgarzik [~jgarzik@unaffiliated/jgarzik] has quit [Quit: Leaving] 20:55 -!- sausage_factory [~priidu@unaffiliated/priidu] has quit [Ping timeout: 240 seconds] 21:01 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 21:03 -!- mdavid613 [~Adium@cpe-172-251-161-231.socal.res.rr.com] has quit [Quit: Leaving.] 21:03 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 21:08 < kanzure> nsh: next time i'll use astral projection to get you a live feed or somthing, sorry about that 21:11 < kanzure> it is interesting how many computer science grad students are not aware of merkle trees 21:11 -!- Emcy [~MC@unaffiliated/mc1984] has quit [Ping timeout: 260 seconds] 21:14 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has joined #bitcoin-wizards 21:22 -!- orville [~orville@c-73-170-124-69.hsd1.ca.comcast.net] has left #bitcoin-wizards [] 21:31 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 21:33 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 21:42 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 21:44 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 21:46 < kanzure> [re: why biology is not like software engineering] "... there is no source, the bytecode has multiple reentrent abstractions, is unstable and has a very low signal to noise ratio, the runtime is unbootstrappable, the execution is nondeterministic, it tries to randomly integrate and execute code from other computers... multiple reentrant and self-modifying abstractions. absolutely everything has subtle side effects." 21:47 < kanzure> "Abstractions work in machine code because we built the machines to make abstractions possible. Natural cells don't work like that. The closest thing to cells in the machine code world are demoscene x86 assembly blobs -- filled with insane hacks to make something awesome work in a small amount of space, with lots of weird code and data reuse and generative magic." 21:47 < kanzure> "It's worse than that though. Never forget that the true "compiler" of DNA is Physics, specifically that of protein folding, conformational dynamics, and catalysis. It won't be simulated anytime soon with anything approaching useful kinetic accuracy. (It's not clear if we'll ever get kT-accurate quantum simulations of correlated electron wavefunctions that scale to protein-sized systems, though there is some hope in the far future ... 21:47 < kanzure> ... with exotic computing architectures.)" 21:47 < kanzure> "So ultimately what software useful for synthetic biology is going to do is help us curate all of our brute-force efforts to build and screen libraries of pseudorational libraries of proteins, pathways, and cells. -Not- provide shitty abstraction layers that rest upon our incredibly shaky understanding of what's going on circa 2012. Think of curating an incredibly complicated genetic-programming run across a hundred-thousand ... 21:48 < kanzure> ... clusters -- that gives a better sense of the flavor of what's needed." 21:48 < kanzure> "We invented the light-build long before we understood QFT. We'll be building amazing cellular machines long before we really understand them quantitatively. Synbio's (and diybio's) biggest sin is repeatedly elevating the convenient metaphors with EE/CS into a slick-looking action plan that doesn't respect the fundamental differences between these machine architectures." 21:48 < kanzure> "Let me reemphasize the point here. Programmers can exist because WE built computers -explicitly- to support those abstraction layers. The Wizards of EE formed a powerful magical convenant that protects all the gentle digital denizens from concerning themselves with the horrors of physical reality that lays sealed beneath the woven lithography. It took them decades and a trillion dollars to build those magical seals." 21:49 < kanzure> "In biology we haven't even begun to form powerful enough magic to seal away the chaos of physical reality. Over the next few decades we'll almost certainly rebuild simple microbial cells (piecemeal, haltingly, not all at once) with an increasingly modularized set of signaling components and metabolic cores whose behavior we'll have -evolved- to be isolated and predictable. It will take bajillions of manhours to do that, and it will ... 21:49 < kanzure> ... almost entirely be done by limited guesswork and brute-force screening (i.e. traditional engineering). Only once we've untangled the gordian knot of the cell will we be able to construct these magical abstraction layers atop it.... and they'll probably be leaky layers at that." 21:49 < kanzure> "Yes, but what -isn't- hackable? Look, my gripe here is that cells are really -nothing- like a von neumann machine. They're both nonlinear dynamical systems that happen to carry lots of "code" that controls their evolution in time. That's the strongest similarity. Cells deserve more than crappy metaphors to other kinds of systems. If y'all really want to improve how we engineer cells, it's worth taking a few years to begin ... 21:49 < kanzure> ... understanding how they really work." 21:50 < kanzure> "Those of you who have not done biology can't realize how primitive things still are. A CS analogy is that we're trying to reverse engineer a non-deterministic alien architecture from the future via a remote debugger over a noisy line that has no error correction and runs at a fraction of a millibaud, where every peek or poke costs hundreds to thousands of dollars. With the advent of high-throughput sequencing we just figured out how ... 21:50 < kanzure> ... to get noisy ROM/RAM dumps (genotype), but still have precious little ability to quickly interact with the biological systems under study (phenotype). Biology is much more like hacking and reverse engineering than it is like physics or mathematics. A working exploit is worth much more than general pontification. The transformative events in biology these days are the clever hacks that enable whole new classes of fast experiments to ... 21:50 < kanzure> ... be done: quick homologous recombination induced by CRISPR, optical interrogation of neural systems using light-sensitive ion channels, the development of adeno-associated viruses for rapid introduction of genetic material, etc. In the coming decades the combination of such clever hacks with cheaper automation and sensors will hopefully bring a flood of new data that will make a predictive, quantitative science of biology possible. ... 21:50 < kanzure> ... With cheap and plentiful data, perhaps clever minds might discover general quantitative principles that we can't see yet. But the data is what's lacking, not cleverness." 21:50 < kanzure> https://groups.google.com/d/msg/diybio/GxRTESzUWUI/zd5MpKNzBzgJ 21:50 < kanzure> https://groups.google.com/d/msg/diybio/GxRTESzUWUI/IS-zLDlUu_YJ 21:51 < kanzure> https://news.ycombinator.com/item?id=8832407 21:51 < kanzure> here are some refs from the conversation with scott aaronson and others (requested refs, at least) https://groups.google.com/d/msg/austin-less-wrong/_cJU8awXMLM/PhM_WuXnAAAJ 21:54 < cjd> ;;monologue 21:54 < gribble> Your current monologue is at least 1 line long. 21:54 < kanzure> mumblelogue 21:55 < cjd> it looks interesting though... 22:06 -!- RoboTeddy [~roboteddy@c-67-188-40-206.hsd1.ca.comcast.net] has joined #bitcoin-wizards 22:18 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 22:20 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 22:23 -!- YOU-JI [~youyouyou@FL1-122-135-10-55.chb.mesh.ad.jp] has quit [Quit: Leaving...] 22:29 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 22:31 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 22:39 -!- slackircbridge [~slackircb@45.55.41.36] has quit [Remote host closed the connection] 22:40 -!- slackircbridge1 [~slackircb@45.55.41.36] has joined #bitcoin-wizards 22:41 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 22:43 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 23:01 -!- RoboTeddy [~roboteddy@c-67-188-40-206.hsd1.ca.comcast.net] has quit [] 23:02 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has quit [Ping timeout: 258 seconds] 23:26 -!- murch [~murch@p4FDB7CD8.dip0.t-ipconnect.de] has joined #bitcoin-wizards 23:42 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 23:43 -!- ThomasV [~ThomasV@unaffiliated/thomasv] has joined #bitcoin-wizards 23:44 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards 23:53 -!- Alopex [~bitcoin@cyber.dealing.ninja] has quit [Remote host closed the connection] 23:55 -!- Alopex [~bitcoin@cyber.dealing.ninja] has joined #bitcoin-wizards --- Log closed Sun Aug 14 00:00:25 2016