--- Day changed Sat Jun 19 2010
00:12 < jrayhawk> the h+ hivemind has deemed you worthy; prepare yourself for the subsumption
00:12 < jrayhawk> you cannot escape
00:33 < QuantumG> kanzure: please do this because I'm lazy?  fucking what?
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10:03 < kanzure> hi parolang 
10:04 < parolang> hi
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13:17 < Yocttar> sup with the silence today?
13:17 < Yocttar> >.<
13:18 < jrayhawk> bryan got subsumed by the h+ hivemind
13:24 < kanzure> aka email
13:25 < Yocttar> Oo
13:25 < kanzure> cool someone cold called me after seeing my phone number on the youtube video :)
13:26 < Yocttar> heh
13:28 < Yocttar> "Hello, this is john from AT&T, your mobile Internet bill has reached its limit, please note, from this moment on, you Internet service will cost double!"
13:28 < Yocttar> AT&T is some provider in US right? :p
13:33 < jrayhawk> Yeah. One that, in response to increasing bandwidth demands from its network-lock-in of the various iPhones, decided to cut monthly bandwidth limits from 5gig to 2gig and start charging ridiculous amounts for overage.
13:33 < jrayhawk> It's a lot more than "double" though.
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13:39 < kanzure> i'm not sure what my bandwidth limit is on my at&t plan
13:39 < kanzure> i don't have an iphone though
13:39 < kanzure> "bandwidth limit" haha that sounds stupid
13:39 < kanzure> uh, my max downloaded bytes
13:42 < jrayhawk> There was some mention of old plans being grandfathered in, but I haven't really been paying attention.
13:42 < kanzure> the amount of email that my phone downloads is enough to send it over
13:42 < kanzure> some asshole sent me an email today that was just one giant .jpeg image of the text he wrote
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14:50 < kanzure> does anyone recall the difficulties with shrinky dink microfluidics that was reported?
14:51 < kanzure> also, i gave Ian_Daniher a link dump on paper-based microfluidics
14:51 < kanzure> Patterned paper as a platform for inexpensive, low-volume portable
14:51 < kanzure> bioassays - requires photoresist and chromatography paper and UV light
14:51 < kanzure> http://designfiles.org/papers/microfluidics/Patterned%20paper%20as%20a%20platform%20for%20inexpensive,%20low-volume,%20portable%20bioassays%20-%20requires%20photoresist%20and%20chromatography%20paper%20and%20UV%20light%20-%20Whitesides%20-%202006.pdf
14:51 < kanzure> Rapid prototyping of paper-based microfluidics with wax for low-cost portable-bioassay http://designfiles.org/papers/microfluidics/Rapid%20prototyping%20of%20paper-based%20microfluidics%20with%20wax%20for%20low-cost,%20portable%20bioassay.pdf
14:51 < kanzure> Three-dimensional microfluidic devices fabricated in layered paper and tape http://designfiles.org/papers/microfluidics/Three-dimensional%20microfluidic%20devices%20fabricated%20in%20layered%20paper%20and%20tape.pdf
14:51 < kanzure> FLASH: A rapid method for prototyping paper-based microfluidic devices http://designfiles.org/papers/microfluidics/FLASH:%20A%20rapid%20method%20for%20prototyping%20paper-based%20microfluidic%20devices.pdf
14:51 < kanzure> Lab on paper http://designfiles.org/papers/microfluidics/Lab%20on%20paper.pdf
14:53 < kanzure> i should get to this point with microfluidics soon: http://www.youtube.com/watch?v=1HrRuaLFGmY
14:54 < kanzure> at first it looks like the pipette might be providing a force for the liquid to go through the system
14:54 < kanzure> but near the end the pipette is lifted and it looks like it might really be surface tension and capillary action
14:55 < kanzure> heh crazy complexity http://www.youtube.com/watch?v=JvDZh8hmR84 all of /four/ valves
14:55 < kanzure> (well, a little more than that)
14:58 < kanzure> Lifespan-on-a-Chip: microfluidic chambers for performing lifelong observation of C. elegans http://www.youtube.com/watch?v=Bf26CSnVO94
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15:05 < kanzure> heh
15:05 < kanzure> http://phdchallenge.org/call-for-participation
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15:32 < cluckj> ahahahahhahahahahaahhahaha
15:33 < cluckj> well I am looking to publish that paper.....
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18:12 < kanzure> cancer-resistant mouse studies: http://www2.wfubmc.edu/tumorbio/srmouse/index.htm
18:12 < kanzure> something in neutrophils
18:16 < kanzure> the transferring is really weird
18:16 < kanzure> http://www2.wfubmc.edu/tumorbio/srmouse/summary.htm
18:16 < kanzure> http://www.wfubmc.edu/tumorbio/srmouse/publications.htm
18:18 < kanzure> "Does cancer reach a detectable size because these controls have failed? If so, could such controls be identified, and enhanced in patients to provide new therapies?"
18:21 < kanzure> "An important initial question in studying these mice was whether the resistance to cancer only worked against this unusual tumor type (S180 sarcoma), or would work against other types of cancer. Using several different mouse cancer types, such as leukemia, lymphoma, liver cancer, and lung cancer, it was shown that the SR/CR mouse was resistant to all of them. "
18:21 < kanzure> http://www2.wfubmc.edu/tumorbio/srmouse/part1.htm
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18:23 < kanzure> "In some cases, this "spontaneous regression" of cancer (Figure 3) was quite dramatic -- a very large tumor mass disappeared overnight."
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18:27 < kanzure> "adoptive transfer"
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18:37 < kanzure> does anyone have access to this? http://www.newscientist.com/article/mg19526224.800-cancerresistant-people-lend-out-their-killer-cells.html
18:48 < kanzure> so they were doing that work back in 2003
18:48 < kanzure> i'm sort of amazed that they still haven't been able to track down the responsible gene
18:48 < kanzure> it's not that hard..
18:49 < kanzure> especially since the original strain was practically genetically identical
18:49 < kanzure> you get like 30 spots of interest or something
18:50 < kanzure> someone should put up the money to just get 'em sequenced (but failing this, blots and so on surely don't take 7+ years)
18:50 < kanzure> am i missing something
18:51 < kanzure> cluckj: you know, it wouldn't be too hard to sneak in that phrase into the 'materials' section on a molecular biology paper for some fairly standard experiment but applied to a different organism, or something
18:51 < kanzure> the molbio people ignore that stuff all the time
18:51 < kanzure> Transferable anticancer innate immunity in spontaneous regression/complete resistance mice http://www2.wfubmc.edu/NR/rdonlyres/DFCA7212-A0AC-431F-9622-FBA5C19ED18D/0/pnas5806.pdf
18:52 < kanzure> Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice http://www2.wfubmc.edu/NR/rdonlyres/3ABE12F6-0EDE-4600-8C68-25E85F245244/0/pnas52703.pdf
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20:07 < kanzure> well, jokes on me
20:07 < kanzure> http://www.pr.com/press-release/201382
20:07 < kanzure> it was john schloendorn / livly.org
20:08 < kanzure> but why in the fuck was he asking for $100k to sequence a genome in 2009?
20:09 < QuantumG> so kanzure, has the idea of 3d printing of synthetic cells (cells made by a synthetic biology process) appeared in print?
20:09 < kanzure> yeah
20:09 < kanzure> "organ printers", cell printers, ...
20:09 < QuantumG> or are people who think about synthetic biology of multicellular organisms still thinking about making organisms that go through gestation?
20:09 < kanzure> nah, organ printing and cellular printing is a craze too
20:09 < QuantumG> sure, but they're not synthetic biology.
20:10 < QuantumG> have the two fields been linked in print yet?
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20:10 < kanzure> what do you mean it's not synthetic biology?
20:11 < kanzure> is it because they don't have drew endy plastering his name all over it?
20:11 < QuantumG> well, I define synthetic biology as forward engineering of biology... and I'm just curious if there are people out there who are saying don't bother trying to forward engineer a gestation process, cause we gotz 3d printers
20:12 < kanzure> i see
20:12 < kanzure> i don't think anyone in synthetic biology has been focusing on engineering gestation really
20:12 < kanzure> so that might be a moot point?
20:13 < QuantumG> I imagine that will be a grand challenge
20:13 < QuantumG> assuming anyone considers it worthwhile and doesn't just fall back on cribbing from nature
20:29 < kanzure> i'm really upset about the livly.org / cancer-resistant mouse thing
20:29 < kanzure> first of all, livly.org is not biocurious.org (as is claimed in that PR release)
20:29 < kanzure> second, $100k to sequence the mouse? in 2009?
20:29 < kanzure> and third, taking 7 years and they still haven't figured out even /which/ chromosome the mutation is on? wtf
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20:31 < QuantumG> this is why competitions are awesome
20:32 < kanzure> okay, sure, but this is john schloendorn
20:32 < kanzure> he's supposed to be defeating aging with diybio in eri's garage or something
20:32 < kanzure> this just looks awful from my point of view
20:33 < genehacker> why's organ printing a craze?
20:34 < kanzure> huh? i mean people are excited about it
20:34 < QuantumG> and that multiple people are working on it
20:34 < genehacker> we can make organs that nature can't probably
20:34 < genehacker> oh wait
20:34 < genehacker> nature doesn't use conventional manufacturing
20:34 < QuantumG> sure
20:34 < kanzure> btw, one of the current challenges with the organ printers (like organovo) is the tubing/pumping and chemical maintenance for the organ
20:34 < kanzure> great, you have an organ! now keep it alive and working :P
20:35 < kanzure> perfusion chambers?
20:35 < kanzure> what are those things called anyway
20:35 < QuantumG> the fact that they're using natural cells (or even modified natural cells) is somewhat limiting
20:35 < kanzure> i wonder why john isn't in here
20:35 < genehacker> well you don't need to keep it alive forever
20:35 < kanzure> anyway someone wanted to sell perfusion chambers with me :P for organovo clients
20:35 < genehacker> once you finish building it you can remove the support and pump blood into
20:35 < kanzure> lots of weird networking problems ot solve, like if you have 10 tanks on a network
20:35 < kanzure> and then you want to make sure downstream/upstream regulation of chemicals is synched
20:36 < genehacker> so keeping it alive is a problem?
20:36 < kanzure> ultimately it was a scheme proposed to me for doing brain-in-a-jar for a multibillionaire who didn't want to die or do cryonics
20:36 < genehacker> we don't have artificial blood?
20:36 < kanzure> sure we do
20:36 < QuantumG> once organs are being printed regularly, and every organ in a mammal can be printed, I think an interesting grand challenge would: print a whole mammal.
20:36 < kanzure> but there's no standard for hooking up artificial organs in some perfusion pumped system
20:36 < genehacker> oh you were talking about that other thing
20:36 < genehacker> whoa
20:36 < QuantumG> would be*
20:36 < genehacker> really?
20:37 < genehacker> he was serious about that?
20:37 < kanzure> .. yes.
20:37 < genehacker> there has been some success with that
20:37 < genehacker> for monkeys
20:37 < kanzure> you mean whole body transplants?
20:37 < genehacker> just the head
20:37 < genehacker> alive
20:37 < kanzure> yes, but it wasn't a head in a jar
20:38 < kanzure> well tbh it probably involved a jar during the surgery
20:38 < kanzure> so that it doesn't role away
20:38 < kanzure> STOP THAT MONKEYHEAD
20:38 < genehacker> they only lasted for a couple days though
20:38 < genehacker> ran out of resources or something
20:38 < kanzure> iirc the monkeys died
20:38 < genehacker> I guess one could keep a multibillionare going
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20:40 < genehacker> yikes someone has a working head transplant method
20:41 < kanzure> dr. white? or the russians
20:42 < genehacker> the russians
20:42 < genehacker> fuck someones done the head in the jar thing in the 1880s
20:42 < kanzure> 'we transplant head, yes?'
20:42 < genehacker> and had some success too
20:43 < genehacker> http://en.wikipedia.org/wiki/Isolated_brain
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21:33 < kanzure> open science summit 2010 http://p2pfoundation.ning.com/profiles/blogs/invitation-for-the-open
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21:55 < kanzure> http://bootstrappingmypersonalsingularity.posterous.com/ok-not-too-dumb-without-googlenet
21:55 < kanzure> http://www.oscon.com/oscon2010/public/schedule/topic/Health/?cmp=il-radar-conf-oscon10-mattman
21:55 < kanzure> ouch, joseph jackson got scooped
21:56 < kanzure> jrayhawk: you should go to that
21:59 < kanzure> why is melanie swan speaking there?
21:59 < kanzure> blah i don't understand how these people get around so quickly
21:59 < kanzure> am i missing some black magic trick?
22:00 < AJollyLife> teleportation, clearly.
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22:01 < kanzure> no, i mean, am i not whoring myself out enough?
22:02 < QuantumG> its who you know
22:02 < QuantumG> and yes, how willing you are to say "hey Bob, you've got this event coming up have you arranged a speaker yet?  Can I get in on that gig?"
22:02 < kanzure> a lot of people? http://designfiles.org/~bryan/meetlog/meetlog.txt 
22:02 < kanzure> i see.
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22:23 < jrayhawk> the medical industry is like africa: no matter how good the work you do to improve the situation is, they'll still find some way to make it worse
22:26 < kanzure> wtf does that have to do with africa
22:26 < kanzure> hah
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22:47 < kanzure> venture funding for personalized medicine http://www.haaretz.com/magazine/week-s-end/taking-it-personally-1.2969632
22:47 < kanzure> "Even though, since 1971 - when [U.S. president] Richard Nixon declared the war on cancer as a national goal - more than $105 billion has been invested in research, hardly any progress has been achieved."
22:48 < kanzure> "gentris"
22:48 < kanzure> http://sciencelife.uchospitals.edu/2010/06/18/linkage-618-the-personalized-medicine-highway-more-world-cup/
22:49 < kanzure> http://glasscityjungle.com/wordpress/2010/06/ohio-state-university-projectone-ground-breaking-held-today-6000-indirect-jobs/
22:49 < kanzure> http://rupindhamankar.wordpress.com/2010/06/18/personalized-medicine-what-is-it/
22:49 < kanzure> http://xtrakin.wordpress.com/2010/06/19/direct-primary-care-direct-care-and-concierge-medicine-defined/
22:50 < kanzure> http://www.scientistsolutions.com/t14768-advances+in+pediatric+personalized+medicine.html
22:50 < kanzure> http://sciencelife.uchospitals.edu/2010/06/18/linkage-618-the-personalized-medicine-highway-more-world-cup/
22:50 < kanzure> er, irssi error :/
22:50 < QuantumG> cancer = understanding-of-the-genome-complete
22:50 < QuantumG> I wonder if that widespread opinion is correct
22:53 < kanzure> uh, that's a widespread opinion?
22:53 < kanzure> i can't figure out why anyone would use this
22:53 < kanzure> http://developers.facebook.com/docs/reference/plugins/like
22:53 < QuantumG> isn't it?
22:54 < kanzure> it doesn't let you capture the data on your own
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23:50 < kanzure> god you know something's wrong when you search for stuff on facebook development documentation, and you get all this "blackhat seo" shit
23:50 < kanzure> http://www.blackhatworld.com/blackhat-seo/facebook/182290-comment-box-fbml.html
23:50  * kanzure is trying to figure out what fbjs_event is from
23:59  * genehacker ponders making bacteria capable of producing snake venom
23:59 < genehacker> or at least the antivenom