--- Log opened Wed Dec 15 00:00:08 2010
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02:33 < kanzure> http://www.lifetechnologies.com/news-gallery/press-releases/2010/life-techologies-lauches-io-pgm-sequecer.html
02:34 < kanzure> that link sucks..
02:34 < kanzure> http://www.lifetechnologies.com/content/lifetech/en/home/about-life-technologies/grand-challenges.html
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02:35 < kanzure> hm nope.. it doesn't even list the challenges
02:54 < kanzure> MrClif: no i'm not still up
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06:18 < JayDugger> Good morning everyone.
06:20 < Utopiah> I listened to http://www.franceculture.com/emission-le-champ-des-possibles-les-imprimantes-3d-vont-elles-remplacer-les-usines-2010-12-10.html yesterday and they mentionned http://www.organovo.com (already shared here) but also a (french I think) startup dedicated to bringing 3d printer to the masses by allowing shared design on a website, I didn't find its name so far though
06:32 < archels> http://www.kurzweilai.net/distributed-biological-computation-imitates-logic-gate-circuits
06:32 < archels> A one-bit adder with carry? *chuckle*
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07:06 < archels> kanzure: "May be able to provide funding and a work space"? For what, building an MRI machine?
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07:17 < archels> also lol @ out-of-office autoreply to e-mail lists.
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08:08 < kanzure> hi jmil 
08:09 < kanzure> venter's stuff was oligonucleotide-synthesized, as i recall..
08:17 < kanzure> "Epoch of Plasticity: the metaverse as a vehicle for cognitive enhancement" http://www.atypon-link.com/INT/doi/pdf/10.1386/mvcr.1.1.69_1
08:17 < kanzure> that's natasha's latest.. weird.. article
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08:44 < kanzure> "Counter Biology" http://danielgrushkin.com/images/articles/Articles_Volume_Interview.pdf
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09:05 < jmil> kanzure: ah interesting
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09:12 < kanzure> jmil: unless you read it more thoroughly than i did-- it's entirely possible that i'm talking out of my ass
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09:23 < jmil> i never actually read it, just heard about it and thought they said they had a new way to do something in that paper
09:23 < kanzure> there were many novel things in that paper and the previous papers, 
09:24 < kanzure> like transplanting entire chromosomes or chemically constructing chromosomes
09:24 < MrClif> Has anyone here started a hackerspace / fab lab recently? I'm curious how that is going.
09:24 < jmil> coolio
09:25 < jmil> MrClif: ya we have Hive76
09:25 < jmil> started last year
09:25 < jmil> it's going great!
09:25 < MrClif> cool.
09:25 < jmil> some growing pains but we are trying to get 501c3 status in the next year or so
09:25 < jmil> it's a very slow process
09:25 < kanzure> jmil: atx hackerspace opted to be an llc first and then go for 501c3 (they say it's easier that way)
09:26 < MrClif> is there a site where I can read up on it? I'm toying with the idea of starting one in Eugene.
09:26 < kanzure> MrClif: http://hackerspaces.org/ :P
09:26 < kanzure> MrClif: you mean portland?
09:26 < kanzure> oops i should have said oregon of course
09:26 < MrClif> Yes I know of that one.
09:26 < kanzure> http://brainsilo.org/
09:27 < kanzure> http://watershedpdx.com/
09:27 < kanzure> ok.
09:27 < MrClif> are they all exactly the same or do people use different models?
09:27 < kanzure> some people use different models
09:27 < kanzure> http://hackerspaces.org/wiki/List_of_Hacker_Spaces
09:27 < kanzure> some of them are their own entities (LLCs, 501c3s, etc.)
09:28 < kanzure> others are franchises (TechShop).. which i guess isn't really the same thing precisely
09:28 < kanzure> fablabs are via academic grants and are probably owned by universities (or something)
09:28 < MrClif> i know there is one in portland havn't visited them yet.
09:29 < kanzure> brainsilo and watershedpdx are both in portland
09:29 < MrClif> there are two now, cool!
09:29 < kanzure> there's also PSAS which does some crazy stuff that jrayhawk might attest to
09:29 < kanzure> jrayhawk: are you even alive anymore
09:30 < MrClif> so do people every try to bring in some small money makeing projects to keep the members busy if they are looking for something to do? 
09:31 < MrClif> eg you might crank out a few sets of reprap parts and sell them on ebay. 
09:31 < kanzure> yeah i'm pretty sure that happens often
09:32 < kanzure> fenn wanted to sell reprap parts on ebay.. dunno what happened to that plan
09:32 < MrClif> Nice... is that structured into the bylaws?
09:32 < kanzure> each space has different bylaws (unless they copied them from somewhere)
09:33 < kanzure> atx hackerspace copied a number of its bylaws from noisebridge iirc
09:33 < MrClif> Maybe the market dropped out of reprap parts I've been trying to ascertain what they're going for these days.
09:34 < MrClif> do you know of any good howtos on how to set up and structure hackerspaces?
09:36 < jmil> MrClif: market is still strong check ebay
09:36 < jmil> it will drop precipitously though now that ToM are in the wild
09:37 < jmil> thing-o-matic from makerbot
09:37 < MrClif> hmmm isn't ToM a web site?
09:38 < MrClif> ah its a new makerbot hmmmm.... How does it compare to the Mendel?
09:41 < kanzure> if anyone would retweet this i'd <3 you forever http://twitter.com/kanzure/statuses/15090547714695168
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09:45  * dbolser puts in a claim for infiniate <3s
09:55 < kanzure> MrClif: lookup "hackerspace design patterns"
09:56 < MrClif> ok thanks
09:56 < kanzure> 1996 Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists http://ws1.izbi.uni-leipzig.de/pdf/mcga-96-93-13555-oligosynth.pdf
09:57 < kanzure> hm..
09:57 < MrClif> I was just checking out thing-o-matic, I didn't find a vid yet of the eject process.
09:57 < MrClif> are there people working on something liike that for reprap?
09:59 < jmil> there's a printable one on thingiverse
10:00 < MrClif> ok I'll check it out.
10:00 < jmil> http://wiki.makerbot.com/abpv1
10:00 < jmil> has movies
10:01 < MrClif> Thanks :-)
10:06 < MrClif> It seems like the heated platform means you no longer have to build rafts.
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10:15 < jrayhawk> no i am dead
10:15 < jrayhawk> wooo i am a ghost
10:18 < kanzure> do you go away if i spray you with garlic
10:28 < MrClif> Hi Jrayhawk, can you give me a link to PSAS so I can check it out?
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10:41 < jrayhawk> http://psas.pdx.edu/
10:42 < jrayhawk> http://psas.pdx.edu/news/2010-10-17-2/ being interesting
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11:14 < kanzure> this is good:
11:14 < kanzure> A short history of oligonucleotide synthesis
11:14 < kanzure> http://www.trilinkbiotech.com/tech/oligo_history.pdf
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12:08 < MrClif> Thanks  jrayhawk, very interesting.
12:14 < kanzure> "hey, so how hard do you think it would be to fab a, say 150 kw, electric motor?"
12:15 < MrClif> How much steel and copper would that take?
12:15 < archels> kanzure: Incidentally, I'm thinking of building a linear motor.
12:16 < MrClif> usually the cases for big motors are cast no?
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12:20 < kanzure> drew sez "there was a project to move to a two step peroxide based synthesis cycle ~2001-2003 involving people descended from the Boulder CO groups who had pioneered phosphoramidites."
12:20 < kanzure> that's not very encouraging
12:20 < kanzure> hrm.
12:20 < kanzure> yo drew endy, you're supposed to be into dna synthesis
12:22 < kanzure> hektor / wall-drawing alternative http://www.kickstarter.com/projects/notever/the-drawing-machine
12:25 < kanzure> pics: http://web.me.com/sami6877/unanything/000/000.html
12:29 < kanzure> memory enhancement via neuropeptide S http://www.eurekalert.org/pub_releases/2010-12/uoc--urf121410.php
12:30 < kanzure> "Neuropeptide S Enhances Memory During the Consolidation Phase and Interacts with Noradrenergic Systems in the Brain"
12:30 < kanzure> abstract: Neuropeptide S Enhances Memory During the Consolidation Phase and Interacts with Noradrenergic Systems in the Brain
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14:00 < kanzure> i don't get it
14:00 < kanzure> http://www.sloning.com/index.php?option=com_content&task=view&id=9&Itemid=32
14:00 < kanzure> it looks like DNA libraries + ligation
14:01 < kanzure> except they don't use ssDNA
14:01 < kanzure> but they claim it's not just a library plus ligation?
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14:15 < kanzure> cool erik finished his thesis
14:15 < kanzure> Thesis on the viability of open source development for the design of physical objects  
14:15 < kanzure> http://groups.google.com/group/openmanufacturing/browse_thread/thread/75a079b45bc8c649
14:19 < kanzure> intro to open source hardware http://blog.upverter.com/electronics/intro-to-open-source-hardware/
14:19 < kanzure> mobile sensing platform took the wrong domain name >:o http://openrtms.org/
14:24 < kanzure> funny: http://kevinw.github.com/2010/12/15/this-is-your-brain-on-vim/
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14:59 < kanzure> hi jrabbit 
14:59 < jrabbit> hi
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15:39 < kanzure> hi thesnark 
15:39 < kanzure> hi QuantumG 
15:39 < thesnark> hey kanzure
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15:40 < QuantumG> hey, kinda sick of my internet falling out
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15:41 < kanzure> QuantumG: you should use a server and just connect to the server
15:41 < QuantumG> kanzure: ever looked at metal spraying?
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15:42 < QuantumG> http://www.metalspraysupplies.com/about/what-is-metal-spraying.htm
15:42 < QuantumG> http://www.metalspraysupplies.com/applications.htm
15:42 < QuantumG> for example
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15:44 < kanzure> QuantumG: no
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15:46 < QuantumG> was thinking of asking them if some reprap printed parts could be sprayed without heat deformation
16:05 < kanzure> hi NAK 
16:08 < kanzure> QuantumG: why would you want to metal spray on top of reprap parts?
16:10 < QuantumG> well, my interest is in making thin walled highly detailed metal parts
16:10 < kanzure> isn't there some sort of foam casting that can do this too
16:11 < QuantumG> reprap makes it fast/easy to make the high detail.. metal spraying to build up a layer looks like a cheap way to get high accuracy
16:11 < QuantumG> casting is horrible accuracy
16:13 < NAK> hi kanzure
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16:15 < kanzure> oh oops.. for anyone following along at home the reference that drew endy gave turns out to be this:
16:15 < kanzure> Solid-Phase Oligodeoxynucleotide Synthesis: A Two-Step Cycle Using Peroxy Anion Deprotection
16:15 < kanzure> http://pubs.acs.org/doi/abs/10.1021/ja030376n
16:16 < kanzure> more papers listed here: http://groups.google.com/group/diybio/browse_thread/thread/67ae072bd9d161a9
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17:49 < kanzure> http://www.kurzweilai.net/the-pace-and-proliferation-of-biological-technologies-2
17:49 < kanzure> "By 2010 a single person will be able to sequence or synthesize 10^10 bases a day."
17:50 < kanzure> so it costs about $0.30 per bp at the moment to synthesize DNA
17:50 < kanzure> that's about $3 billion dollars for 10^10 bp
17:50 < kanzure> i should send an invoice to rob carlson
17:50 < kanzure> care of ray kurzweil.
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17:54 < delinquentme> rob carlson?
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17:58 < kanzure> delinquentme: he's a bit of a dick in the synthetic biology community
17:58 < kanzure> rips people off for lots of $$$
17:59 < delinquentme> principal @ biodesic?
17:59 < kanzure> that just means he's a consultant
18:00 < delinquentme> haha quite a title... who did he rip off recently
18:00 < delinquentme> and is hes done this many time s?
18:00 < kanzure> the lava amp guys
18:00 < kanzure> they gave him $100k to build a prototype- they should have given him only $2k
18:04 < delinquentme> lava lamp?
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18:09 < kanzure> delinquentme: a weird thermocycler project that joseph jackson and guido took on
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18:39 < jrayhawk> kurzweil and his cadre of exponential growth futurists seem to screw up biology predictions a lot more than compsci predictions
18:41 < QuantumG> curvology
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18:51 < jrayhawk> I wonder how much of that is due to onerous regulation in the field of medicine.
18:51 < kanzure> wait, what's carlson's relationship to kurzweil?
18:51 < kanzure> i thought they hated each other (or something)
18:52 < kanzure> also, "a weight lifter almost never lifts weights in training" is news to me. from http://www.engin.brown.edu/courses/en123/Lectures/HillEqn.htm
18:55 < delinquentme> yeah thats interesting
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20:24 < kanzure> ouch, denied
20:24 < kanzure> i asked my old molecular biology / synthetic biology professor about next-generation DNA synthesis
20:24 < kanzure> he says: "We run our own DNA Fab, making ca. 100x 1 kb / week.  I don't think there are any options for DIY, which is pretty much as it should be."
20:25 < kanzure> i wasn't even talking about DIYable methods
20:25 < kanzure> although he did blog negatively about diybio once or twice
20:46 < NAK> dang
20:46 < NAK> it
20:47 < NAK> link to his blog?
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20:48 < kanzure> NAK: http://ellingtonlab.org/blog/?p=104
20:48 < kanzure> NAK: http://ellingtonlab.org/blog/?p=153
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20:56 < kanzure> hm that's not so negative now that i look
21:06 < kanzure> human augmentation http://ellingtonlab.org/blog/?p=49
21:06 < kanzure> i'm not really sure why transhumanists spontaneously gather around his lab
21:07 < kanzure> videos from the agi 2010 conference http://vimeo.com/channels/agi10
21:07 < kanzure> (that was from march 2010)
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21:33 < jmil> micromilling for lung engineering assist devices: http://pubs.rsc.org/en/Content/ArticleLanding/2011/LC/C0LC00158A
21:34 < jmil> lemme know if you want the paper, pm me your email address
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21:43 < kanzure> jmil: i do i do
21:44 < jmil> sent
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22:37 < joshcryer> http://www.youtube.com/watch?v=cuMzFNsvOVk
22:44 < kanzure> git push origin master
22:44 < kanzure> fatal: The remote end hung up unexpectedly
22:44 < kanzure> jrayhawk: i blame you
22:44 < NAK> hey, I liked the one one ingenuity
22:44 < NAK> so far
22:44 < NAK> that's the only one Ive read
22:46 < kanzure> jrayhawk: shouldn't push work via git:// ?
22:53 < mayko_> so
22:53 < mayko_> protip
22:53 < mayko_> parafilm melts in a pressure cooker
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23:38 < jrayhawk> that's rather odd
23:38 < jrayhawk> try it with -v?
23:38 < jrayhawk> oh no not via git://
23:38 < jrayhawk> I have no useful means of authenticating that
23:39 < jrayhawk> I guess that's not strictly true; joeyh has a hook that determines if a push involves files that are supposed to be publicly editable anyway and refuses to update the ref otherwise
23:40 < jrayhawk> Which I'm not really sure I like the concept of either.
--- Log closed Thu Dec 16 00:00:07 2010