--- Log opened Sat Aug 06 00:00:12 2011
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09:00 < kanzure> ok i've settled on arghparser
09:10 < foucist> kanzure: for parsing what
09:28 < kanzure> arghparser is a wrapper around argparse for python command line parsing
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10:49 < kanzure> https://github.com/tbuser/openscad.tmbundle
10:49 < kanzure> for textmate lusers
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11:18 < kanzure> hi Tyrant_
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11:55 < delinquentme> uniqanomaly, thanks for the heads up on the human metabolic pathways
11:56 < delinquentme> kanzure, so seriously whos making the big progress in aging research?
11:57 < uniqanomaly> just and idea but I think it can have really enormous applications
11:57 < uniqanomaly> can/will
11:57 < delinquentme> i just looked up the article and the girl thiel sponsored for 100g ... but I think its gonna need to be a bit more than that... her name is " Laura Deming "
11:58 < uniqanomaly> delinquentme: especially in the world where human experimentation is illegal ;)
11:59 < delinquentme> uniqanomaly, i got a little sister im volunteering
11:59 < delinquentme> and a puppy
11:59 < delinquentme> oh, wait..
12:00 < uniqanomaly> delinquentme: ok but I mean like testing *any possible* chemical compound
12:00 < delinquentme> Tyrant_, so im looking at this Gilson machine you were talking about .. definitely seems a little more robust... The focus of the one i built was around an open protocol ... as in i wanted it to be able to "teather" up against another machine and have that machine run it
12:00 < uniqanomaly> something goes wrong, you reset simulation and start again with something else
12:00 < uniqanomaly> well, you can even test combinations of drugs
12:01 < uniqanomaly> like 5 drugs acting on different stuff
12:01 < delinquentme> uniqanomaly, so this is kind of like ... take model of human ... endocrine system?  toss a few drugs into the model
12:01 < delinquentme> and using physical / chemical models
12:01 < uniqanomaly> yeah
12:01 < delinquentme> attempt to predict the effects
12:02 < delinquentme> derp not endocrine system .. but yeah biological system
12:02 < uniqanomaly> simulating different feedbacks etc
12:04 < uniqanomaly> and you can do with it anything as far as human related biological knowledge goes without limitations of human testing
12:37 < delinquentme> uniqanomaly, just out of curiosity .. for the model to represent an actual human model correctly .. wouldnt we need to test it on one ?
12:38 < delinquentme> or are we just talking about chemical reactions which we've studied sufficiently indepth that they're kind of .. standard / static chemical reactions?
13:00 < uniqanomaly> you can use actual know data as tests for systems reaction
13:00 < uniqanomaly> known*
13:01 < uniqanomaly> of course it won't be 100% accurate human model from start
13:02 < uniqanomaly> you add more and more stuff thats missing and at some point you supposedly get results very similar to actual drug action
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14:12 < delinquentme> ohhhh i seeee
14:12 < delinquentme> uniqanomaly, what do you do for a living?
14:12  * delinquentme currently watching transcendent man
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14:33 < delinquentme> open question to all: are there any labs / business which are openly studying the pursuit of aging with high power computing?
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16:39 < Tyrant_> delinquentme, sorry I was afk. I'll be making mine with an open interface as well but mine is geared more towards reducing the cost of the equipment for biotechs
16:39 < Tyrant_> thats why im going for the three axis gantry
16:39 < Tyrant_> What was the accuracy on your LH001 liquid wise?
16:39 < delinquentme> untested
16:40 < delinquentme> i was aiming for .1 uL
16:40 < Tyrant_> ah. how did you pump the liquid?
16:40 < delinquentme> peristaltic pump with pull compression
16:40 < delinquentme> bad idea
16:40 -!- Tyrant_ is now known as Tyrant
16:40 < delinquentme> do direct compression
16:40 < delinquentme> i mean sandwitch that tube between two hard objects
16:40 < delinquentme> i swear to god to get it pump it took like 100 lbs of force
16:41 < Tyrant> I'm looking at using a linear actuator pumping a glass tube ala tecans
16:42 < Tyrant> actuators with .1mm precision are pretty cheap and using a sealed piston gives you great control
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17:07 < delinquentme> Tyrant, yeah my design off the biotek liquid handler peristaltic pump was bc i thought it was novel
17:08 < delinquentme> and if you want really cheap .. you can go with regular syringes
17:33 < Tyrant> delinquentme, cheap but difficult to control and not as long lasting
17:37 < delinquentme> yeah just a suggestion .. i was looking at the pumps used in tecans as well
17:37 < delinquentme> however i did have a really big question as to how the "flow thru" technology actually removed all the biological particulate
17:38 < delinquentme> basically they some how wash and blow out the pipette tips which allow them to jump between different substances
17:38 < delinquentme> AND if you want to get REALLYYY nuts
17:38 < delinquentme> ....
17:39 < delinquentme> http://www.labcyte.com/Acoustic_Droplet_Ejection_ADE/Default.270.html
17:39 < delinquentme> the technical term for this is "the tits"
17:39 < delinquentme> aka AED .. AKA acoustic droplet ejection
17:44 < delinquentme> Tyrant, ^^ hah
18:03 < kanzure> http://www.letsremake.info/PDFs/inflatocookbook.pdf
18:03 < Tyrant> You mean for their fixed tips?
18:04 < Tyrant> delinquentme, I'm going to just add in the feature to pick up and drop disposable tips
18:05 < delinquentme> Tyrant, yeah but what about high volume
18:06 < Tyrant> how high?
18:06 < Tyrant> having a system that flushes if necessary isn't too difficult
18:07 < Tyrant> ill figure that out once the major functions are working
18:07 < Tyrant> right now my linear stage is giving me a lot of trouble. off the shelf stepper controllers kinda suck
18:31 < delinquentme> what're u using?
18:41 < delinquentme> so im thinking they have flow through of liter capacity
18:42 < delinquentme> but the magic is in how does flushing it ... make it sterile .. or pretty close to sterile?
18:42 < delinquentme> i dont know ?
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19:45 < Tyrant> You mean they can hold a liter of a sample? No way. Not a single one I've seen has that capability. Usually only the expensive LHs have anything about milli
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20:19 < ybit> weeee!
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--- Log closed Sun Aug 07 00:00:14 2011