--- Log opened Thu Mar 01 00:00:32 2012
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02:53 < strangewarp> ...I didn't expect Boingboing commenters, en masse, would have such readily available proofs that transhumanism is false and silly.
02:53 < strangewarp> Need to just.. stop reading blog comments. They tend to be infuriating
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04:07 < foucist> strangewarp: orly, what are they saying?
04:07 < foucist> which part of transhumanism are they attacking anyways?  isn't transhumanism an umbrella term? heh
04:39 < strangewarp> Yeah, basically they were railing against the stupidity of that thing they thought transhumanism is: you know, with the singularity and the rapture rhetoric and whatnot
04:42 < joshcryer> It's contrasted with a distopian future.
04:42 < joshcryer> People are pessimists, the negativity fed to them on a regular basis.
04:42 < strangewarp> indeed
04:42 < joshcryer> Don't get me wrong, I can be a major alarmist.
04:42 < joshcryer> But that only makes it more compelling to seek a better future.
04:43 < joshcryer> The article if foucist is interested: http://boingboing.net/2012/02/29/a-pessimist-and-an-optimist-ta.html
04:43 < joshcryer> (Don't have time to watch both videos now so it being in the log is also a plus.)
04:44 < strangewarp> (Also, I now feel a little silly for getting mad at a couple blog comments, especially since I vented elsewhere instead of replying to them directly, but it was before my daily coffee so meh)
04:47 < joshcryer> I don't see much substance here, in any event.
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06:24 < splicer> ns identify smurfpunk
06:26 < vrs> must... resist
06:26 < splicer> do ;)
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06:27 < vrs> ehehe
06:27 < vrs> sorry
06:27 < vrs> update your pw :)
06:30 < splicer> hmmm... wtf is <key> ?
06:34 < vrs> help setpass
06:34 < vrs> set your email first I guess
06:34 < splicer> solved it
06:35 < splicer> thanks for resisting.... was sweating there
06:48 < vrs> actually I didn't resist
06:48 < vrs> I ghosted you once
06:48 < splicer> noticed that
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08:47 < archels> so this build has been sitting for hours at
08:47 < archels> [100%] Building CXX object dolfin/swig/CMakeFiles/_cpp.dir/dolfinPYTHON_wrap.cxx.o
08:47 < archels> using 100% CPU and thrashing my HDD
08:47 < archels> Do I assume it's doing something useful, or do I kill it and start an incredibly tedious process of troubleshooting?
08:58 < kanzure> magic eight ball says yes
08:58 < kanzure> put it into the foreground and zombie it
08:59 < kanzure> ...background
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09:04 < archels> grm, any way I could monitor its filesystem I/O?
09:04 < archels> (Debian)
09:12 < ThomasEgi> iotop ?
09:17 < archels> Hm, I guess I'd like a combination of iotop and lsof.
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09:22 < archels> alright fuck it, this is stupid.
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10:36 < delinquentme> KNOW WHICH LANGUAGES TO USE FOR WHAT TASKS
10:36 < delinquentme> ^^
10:36 < delinquentme> ... on being irreplaceable .. thoughts? comments?
10:42 < ThomasEgi> spylanguage? :D
10:42 < ThomasEgi> asm?
10:44 < delinquentme> ThomasEgi, so I mean like you shouldn't be doing massive processing in something like Ruby
10:45 < delinquentme> drop that into a CRuby instance .. IDK it just seems like the # of programming languages is on a steady upward trend
10:45 < delinquentme> sooo use them accordingly
10:46 < ThomasEgi> hm. my combination of python. and c/c++ worked out very well so far
10:46 < eudoxia> everyone's out to create the Programming Language to End All Programming Languages
10:46 < ThomasEgi> python for all the slam-together stuff with fast prototyping speed, and doubles as script language for automation.
10:46 < ThomasEgi> and c for microcontrollers. and c++ for desktop when you really need sped
10:46 < ThomasEgi> *speed
10:48 < kanzure> pfft clearly we should be writing all of our microcontroller code in haskell
10:50 < delinquentme> true and prototyping speed is a consideration
10:51 < ThomasEgi> bout 90% of my code is python tho.
10:52 < delinquentme> but in the credo of doing shit ... it seems that outside of a job environment ( maybe in some ) you'd want a few tools
10:55 < ThomasEgi> not sure what you intend to say. but python is a very powerful tool, especially since there are countless libraries with pythonbindings out there
10:56 < ThomasEgi> from interfacing to serial ports , over making SIP calls, up to creating 3d games. pretty much nothing that wouldnt be possible with python.
11:03 < delinquentme> true ^
11:04 < delinquentme> stilla theory in testing :D
11:05 < ThomasEgi> well at least for me it does a wonderful job
11:19  * delinquentme skrilly lovemaking music
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11:37 < delinquentme> MEH i think ec2 is .. lagging?
11:38 < sylph_mako> http://www.bbc.co.uk/news/health-17177251 I just found a motivation to start examining the genes of my friends/mates/self.
11:38 < sylph_mako> Too valuable.
11:38 < delinquentme> ? thats about excercise?
11:38 < delinquentme> ohh ic ic
11:39 < sylph_mako> [a gene marker that indicates an ability to get fit off of but 3 minutes of intense exercise a week.]
11:40 < sylph_mako> [as opposed to wasting serveral hours of your time.]
12:05 < delinquentme> so you're then going to aquire the genes how?
12:14 < sylph_mako> I'm not. I'm going to commit eugenics.
12:15 < sylph_mako> I know it's kind of silly.
12:15 < sylph_mako> Considering how little time there is to make an impact.
12:15 < sylph_mako> Oh you mean the samples?
12:19 < delinquentme> sylph_mako, umm so wait
12:19 < delinquentme> haha you're picking out your girlfriend in this manner?
12:19 < delinquentme> like who am I to tell anyone how to do that but ...
12:20 < kanzure> what?
12:20 < kanzure> i think sylph_mako was making a joke about killing everyone
12:21 < ThomasEgi> oh. if he really intends to do so. i have i wishlist with people of top-priority ;)
12:23 < sylph_mako> hahaha, It was more making a joke about how eugenics sounds like genocide to most people.
12:23 < kanzure> eugenics basically is genocide
12:23 < sylph_mako> What I'm hoping is that there's a human breeding program going on somewhere.
12:24 < sylph_mako> Oh I suppose it is.
12:24 < kanzure> animal husbandry/breeding sounds tremendously more descriptive
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12:24 < sylph_mako> Mind that it's also the opposite.
12:25 < sylph_mako> \converse
12:25 < kanzure> see, i didn't know if you meant "eugenics as in kill all the people" or "eugenics as in something about genetics generically"
12:25 < kanzure> i guess this is like hackers vs. hackers
12:25 < Stee|> eugenics can be comprised of three different degrees, more or less
12:25 < kanzure> except nobody supports using the word 'eugenics' for anything
12:25 < Stee|> 1) Encourage good genes to breed
12:25 < delinquentme> dogs == longest running human lead eugenics experiment in the entirety of history
12:26 < sylph_mako> No no no no no I just mean to sterilize the people.
12:26 < Stee|> 2) stop bad genes from breeding (The US did this)
12:26 < Stee|> (which is what sylph_mako suggested)
12:26 < Stee|> 3) Murder people with bad genes
12:26 < Stee|> I support #1.
12:26 < kanzure> who defines good
12:26 < kanzure> see, this is the problem that WTA ran into
12:26 < sylph_mako> Stee|... I was sugguesting (1) more than (2)..
12:26 < kanzure> they wanted to do this political thing about defining good
12:26 < Stee|> you can find the minimum gradient of bad
12:27 < sylph_mako> but with the current population.. you'd at least have to do both 1 and 2 at once.
12:27 < kanzure> i just strongly discourage you from using the word 'eugenics'
12:27 < kanzure> please just say 'murder everyone' if that's what you mean
12:27 < sylph_mako> is human breeding a clean enough term?
12:27 < Stee|> but that's not what most people mean with it, kanzure
12:28 < kanzure> sylph_mako: no you have to also explain what you mean
12:28 < Stee|> nazi eugenics is not the only form of eugenics
12:28 < kanzure> sylph_mako: "human breeding" could mean "forced human breeding labor camps"
12:28 < sylph_mako> the maturation of the human species?
12:28 < kanzure> or you could simply mean "i want to fuck up my genes before injecting my genomes into embryos, yo"
12:29 < kanzure> the hell does that mean?
12:29 < Stee|> what about 'encouragement of people with specific genes breeding'
12:29 < kanzure> sounds fascist
12:29 < Stee|> nah, that would be sterilization
12:29 < sylph_mako> it's kind of a dune quote.
12:29 < kanzure> i also don't see why you would force people to breed, in this day and age
12:30 < kanzure> since we have the bioinformatics anyway
12:30 < kanzure> fuck karyotype charts
12:30 < kanzure> well, wait
12:30 < kanzure> what's the chart that takes into account your ancestry
12:31 < kanzure> erm, the one that people use for determining an nth-generation trait in their family
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12:31 < Juul> kanzure, seen this: http://shapesmith.net/ ?
12:31 < kanzure> Juul: yeah
12:31 < kanzure> that's ben nortier
12:31 < Juul> ah
12:31 < kanzure> he has opencascade wired up
12:31 < kanzure> and then has a javascript client transmit shit back to his server
12:31 < kanzure> to do the boolean operations
12:31 < Juul> oh
12:31 < Juul> :)
12:31 < kanzure> then he tessellates and sends it to the client for webgl rendering
12:32 < kanzure> he made a peculiar choice for the backend.. it was something like lisp or scala
12:33 < kanzure> erl
12:33 < delinquentme> working under the gun
12:33  * delinquentme feels good man
12:33 < kanzure> erlang, right.
12:33 < kanzure> i knew it was something
12:34 < delinquentme> i think you're confusing euthanasia with eugenics kanz
12:34 < delinquentme> eugenics is simply selective breeding no?
12:34 < Stee|> depending on what country did it
12:34 < delinquentme> like only talking to the hot girls @ the bar
12:35 < delinquentme> haha ok context yes
12:35 < Stee|> nazi germany also did sterilization
12:35 < kanzure> delinquentme: no eugenics is not "simply selective breeding"
12:35 < kanzure> it means a lot of things
12:35 < delinquentme> anyone want to take bets whether im going to break this small EC2 instance?
12:35 < delinquentme> im thinking i will
12:35 < Stee|> however, it doesn't necessarily imply genocide or murder at all
12:35 < delinquentme> Eugenics is the "applied science or the bio-social movement which advocates the use of practices aimed at improving the genetic composition of a population", usually referring to the manipulation of human populations
12:35 < sylph_mako> If you're selecting against a gene, I think that would be genocide.
12:36 < sylph_mako> It's probably not going to be particularly racially focal. Or violent in any way.
12:36 < delinquentme> sure if you want to add some kind of sinister context feel free to
12:36 < eudoxia> people select against genes all the time
12:36 < delinquentme> perhaps in the vernacular use
12:36 < Juul> kanzure, do you know anything about homomorphic encryption?
12:36 < delinquentme> eudoxia, exactly!
12:36 < kanzure> Juul: no
12:36 < eudoxia> when they don't talk to the ugly girls at the bar I guass
12:36 < kanzure> haha yes it's well known you can twist words to mean whatever
12:37 < kanzure> but mostly when you say 'eugenics' to someone they think of government-intervention for things like sterilizing large populations
12:37 < kanzure> or killing large populations of people
12:37 < delinquentme> eudoxia, hahaha
12:37 < sylph_mako> Because they're fucking dogs.
12:37 < delinquentme> #win
12:37 < sylph_mako> Judgemental, traumatized dogs.
12:37 < Stee|> yes, but we're not talking to normal people here are we
12:37 < kanzure> yes you can say "talking to the hot girls at bars is eugenics"
12:37 < kanzure> but you could also say "it's genetics"
12:37 < kanzure> so fucking what?
12:37 < delinquentme> Stee|, <<<<<
12:37 < eudoxia> I dunno
12:37 < kanzure> Stee|: i'm saying "eugenics" is not a high-information-bandwidth word
12:37 < Stee|> genetics is an even worse one
12:37 < kanzure> say something more meaningful..
12:38  * delinquentme thinks we're regressing
12:38 < delinquentme> r/askshityscience
12:38 < kanzure> delinquentme: we regressed the moment someone brought up the god damn word 'eugenics'
12:38 < delinquentme> :D
12:38 < delinquentme> semantics
12:38 < Stee|> nah, I think everyone here is fine with the word but you kanzure :P
12:38 < delinquentme> nah like ill agree w kanzure
12:38 < delinquentme> its like a loaded term
12:39 < delinquentme> but thats within societal context
12:39 < delinquentme> annnd most of society is well _______
12:39 < delinquentme> you fill in the blank
12:39 < Stee|> it's a loaded term to most people, but everyone here got what was meant in sentence context
12:39 < delinquentme> ^^^
12:39 < kanzure> not really
12:39 < kanzure> i still don't know if you're pro-killing-people
12:39 < sylph_mako> No why the hell would that be a good idea.
12:39 < Stee|> I clarified it like 3 times?
12:39 < Stee|> goddamn, humanist is in the name dude
12:40 < kanzure> Stee|: you already said "encouraging certain people to breed".... which is easily implemented as "discouraging everyone else"
12:40 < Stee|> note that I listed three levels, of which discouraging was the second one.
12:40 < Stee|> in addition, discouraging is STILL different from killing people
12:40 < kanzure> why can't you just say "i prefer to be in control of my own genes, thanks"
12:41 < eudoxia> "discouraging" is rather vague
12:41 < kanzure> instead of calling it eugenics
12:41 < kanzure> eudoxia: exactly
12:41 < Stee|> what if I'm talking about on a societal level?
12:41 < Stee|> and not about my own genes?
12:41 < kanzure> Stee|: that's the bad form of eugenics :P
12:41 < kanzure> the one where you impose your will on everyone else
12:41 < Stee|> which, AGAIN, is what I think sylph_mako was talking about
12:41 < Stee|> don't make it law, offer incentives :P
12:42 < kanzure> see? you said you disagree with the popular notion of 'eugenics'
12:42 < kanzure> but these statements make me think you do *not* disagree
12:42 < Stee|> popular view of eugenics involves murder and sterilization
12:42 < kanzure> this is why we should be more careful with words
12:42 < Stee|> I explained this above
12:42 < Stee|> you are the one having issues here :P
12:42 < kanzure> Stee|: specifically they involve murder, sterilization and government intervention
12:42 < Stee|> I got what sylph_mako was saying
12:42 < kanzure> you just said "incentivizes" - that's government intervention on its population again
12:43 < Stee|> yes, I'm okay with this
12:43 < kanzure> how is that any different from the form that you purportedly claim to me that you disagree with
12:43 < Stee|> because one is murder and sterilization and one is not
12:43 < Stee|> keep in mind I'm not a libertarian
12:43 < kanzure> the murder/sterilization is a political issue, iirc
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12:44 < kanzure> i.e. why should the government kill its citizens
12:44 < Stee|> it's an ethical issue
12:44 < sylph_mako> kanzure, but it's NOT my will I want to impose. I don't want to be the guy making the decisions on what to breed for. Ideally it wouldn't even be a guy, it would be a process.
12:44 < kanzure> so my point is, creating incentives on top of a population that you are ruling, without their consent, sorta goes against the politis thing
12:44 < kanzure> *politics
12:44 < kanzure> now! if you want to start a new government and a new population
12:44 < Stee|> but if I don't have a political issue, but an ethical issue, then it's fine
12:44 < kanzure> where you impose your genetic will and design
12:44 < sylph_mako> yes!
12:44 < kanzure> then go right ahead
12:45 < kanzure> but fuck you if you touch my genes without my authorization
12:45 < sylph_mako> I so will.
12:45 < sylph_mako> [go right ahead]
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12:45 < Stee|> kanzure: I also believe in forced retroviral removal of genetic disease laden genes, and forced immortality
12:46 < kanzure> yeah, so again, you *do* agree with the populist notions of eugenics
12:46 < ThomasEgi> believe is good. engineering is better.
12:46 < Stee|> kanzure: Neither of these involve murder or sterilization
12:46 < Stee|> jesus christ
12:46 < kanzure> "forcing people to change against their will" is a pretty firm axiom of the popular notion of eugenics
12:46 < Stee|> no, the murder and sterilization parts are the big thing
12:46 < kanzure> because... that's against their will
12:47 < Juul> Stee|, forced immortaility? your a scary motherfucker
12:47 < kanzure> lots of people support i.e. assistive suicide
12:47 < Juul> *you're
12:47 < Stee|> Juul: I support forced posthumanism in general, but not if it involves uplifting :P
12:47 < eudoxia> what
12:48 < Stee|> err, uploading
12:48 < Stee|> rather
12:48 < delinquentme> suicide = the point where humans should intervene and help that kid out
12:48 < eudoxia> oh right
12:48 < delinquentme> positive psychology is real shit
12:48 < delinquentme> or more concrete .. positive focus / distractions from that bad stimulus
12:49 < Juul> forced consciousness seems like a scary proposition to anyone with any kind of imagination
12:49 < ThomasEgi> delinquentme, arent there countries that have death sentence on attempted suicide?
12:49 < kanzure> so again, i think the scary form of eugenics is the same one that Stee| likes
12:49 < kanzure> even though Stee| does not support murder and sterilization
12:49 < Stee|> kanzure, unfortunately you're wrong
12:49 < kanzure> so wait
12:49 < Stee|> because the murder and sterilization part is bigger than the gov part in most peoples minds
12:49 < delinquentme> ThomasEgi, lolol people
12:50 < delinquentme> jesus we're all so fucking ignorant
12:50 < kanzure> Stee|: ok so you claim that popular eugenics is scary not because it's a forced thing, but because..?
12:50 < delinquentme> seriously we're going to look back at pre life extension times
12:50 < Stee|> OF DEATH AND MUTILATION
12:50 < delinquentme> and be like WTF .. how did they even live
12:50 < Juul> delinquentme, at least some of us realize it :)
12:50 < kanzure> Stee|: ok.. we support abortions, that's death... who cars?
12:50 < kanzure> *cares
12:50 < Stee|> most people don't consider it death tho
12:50 < delinquentme> Juul, =] im glad I've got friend who are of sound mind
12:50 < Stee|> (I'm not pro-abortion, I'm pro-putting fetuses into artificial wombs)
12:51 < eudoxia> I'm pro putting blastulae in liquid nitrogen until somebody gives a fuck
12:51 < kanzure> ok so you claim that eugenics is scary simply because murder is not a friendly concept?
12:51 < Stee|> pretty much, and that's what people associate with it
12:51 < Stee|> that and nazis
12:52 < Stee|> *and sterilization, dudes are protective of their sperm
12:52 < kanzure> ok i posit that the popular notion of eugenics is 'scary' because governments/authorities
12:52 < Juul> delinquentme, you're sane?!
12:52  * ThomasEgi checks the sane-o-meter in the channel..
12:52 < Stee|> empty, ThomasEgi
12:53 < ThomasEgi> uh.. it indicates chilling levels indeed
12:53 < kanzure> why would i want to allow you to control whether or not i build offspring
12:54 < Stee|> note that I said incentive
12:54 < delinquentme> Juul, its a stretch man =]
12:55 < delinquentme> hanging by thread
12:57 < sylph_mako> Because limits on the individuals' reproduction is an easy way to ant-style altruism? I havn't read any Rand yet, and I'm not american[in fact I live in one of the least corrupt countries in the world], so there's probably a lot I don't understand about your feelings about government's power.
12:58 < Stee|> (I'm not fond of ant style altruism, and I agree with incentivizing certain genetic combinations for other reasons)
12:59 < Juul> i think people aren't wearing enough hats
13:01 < sylph_mako> Stee|, I havn't come across a clearer models of a stable super-altruistic evolutionary strategy. It just always seems like there's some limit on breeding whenever groups get social. Sometimes they're entirely mental, sometimes they're pheremonal castration.
13:02 < Stee|> I dislike it because I'm a greedy bastard and want to ditch all y'all
13:02 < Stee|> anyway, airport, bbl
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13:05  * delinquentme so many angry tweets!
13:06 < delinquentme> TITS!
13:06 < delinquentme> parser runs on a ec2 large
13:06 < delinquentme> tiddayssss
13:06 < delinquentme> no! ec2 small 32 bit
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14:29 < delinquentme> LOLLLL causing more hell on twatter
14:29 < delinquentme> who the fuck becomes a bioethicist anyways
14:38 < kanzure> http://www.npr.org/blogs/krulwich/2012/02/24/147367644/six-legged-giant-finds-secret-hideaway-hides-for-80-years?sc=fb&cc=fp
14:38 < kanzure> didn't even realize this was npr
14:39 < delinquentme> kanzure, you're not tweeting
14:40 < delinquentme> we're here trying to change the world!
14:40 < delinquentme> step up your twattering!
14:41 < uniqanomaly_> delinquentme: its like with religious people
14:41 < uniqanomaly_> if you could reason with them they wouldnt be religious
14:42 < uniqanomaly_> humble theory about those bioethics fucks
14:42 < uniqanomaly_> ^^
14:42 < delinquentme> https://twitter.com/#!/delinquentme/status/175346930061295616
14:42 < delinquentme> dey see me trollin
14:44 < uniqanomaly_> also humanist = can't do science
14:44 < uniqanomaly_> but its obvious
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14:46 < delinquentme> humanist?
14:46 < delinquentme> humanity*?
14:46 < kanzure> delinquentme: to download a zip from the command line just use wget or curl..
14:47 < delinquentme> yeah wget did it
14:47 < delinquentme> i gotta figure how to setup the ec2 env for the API nao
14:55 < uniqanomaly_> dammit, I meant humanities
14:58 < uniqanomaly_> like in: whats one's excuse when they can't fill tax forms? - i'm a humanities major
15:01 < delinquentme> lol
15:02 < delinquentme> conscious objector?
15:04 < delinquentme> its ANOTHER ONE BOWM. BROWWWWow!
15:04 < delinquentme> guh
15:05 < delinquentme> when I live to b e 1000 im going to be a DJ
15:05 < delinquentme> im just saying .. you guys are all invited to my shows
15:05 < delinquentme> why do I want to live longer? because there WAY more cool shit this life has to offer than we can fit into a "normal" life span :D
15:06 < kanzure> you're preaching to the choir
15:07 < kanzure> this is the silliest place to preach about the benefits of life extension and immortality
15:07 < kanzure> also you shouldn't wait that long to start djing :x
15:07 < kanzure> klafka has some experience in this department, i hear
15:10 < delinquentme> yeah I was thinking that :D
15:10 < splicer> delinquentme: you want to live longer because there is a selection pressure against people who get themselves killed before they spawn.
15:11 < delinquentme> whut?
15:11 < delinquentme> lol
15:11 < delinquentme> that almost makes sense?
15:11 < uniqanomaly_> delinquentme: yeah why wait, you should make some transhuman dubstep right now
15:11 < delinquentme> hah!
15:12 < delinquentme> I'm programming ec2 .. while absorbing the nuances *studying* dubsteps
15:12 < delinquentme> love you guys so fucking Xcore
15:14 < delinquentme> ( hardcore ) :P
15:14 < sylph_mako> Truth
15:14 < uniqanomaly_> delinquentme: or you could just convert skrillex and others to transhumanism, they could put some subliminal stimuli shit in future works
15:14 < uniqanomaly_> haha
15:14 < delinquentme> ^^^^^^^^^^^^^^ hot
15:19 < uniqanomaly_> transhuman conversion taskforce
15:20 < delinquentme> some quote about not telling someone to get the bricks and the mortar .. but instead teaching them how to yearn for what is to come?
15:20 < delinquentme> like the evolution of music is nuts .. give that shit 200 years .. no man I cant even BEGIN to take a stab
15:25 < sylph_mako> Why does dubstep seem like a necessary step forward to me. It's like I heard traces of it in the music of the past and thought; we need to do more of That, whatever it is. If only we knew how.
15:27 < sylph_mako> A lot of things went like that.
15:27 < delinquentme> sylph_mako, I like the part where we've got music w tangible fury in it .... and mainstream is adopting it
15:27 < delinquentme> that blows my mind
15:27 < sylph_mako> genres/
15:27 < delinquentme> like he got 3 grammys
15:27 < delinquentme> and hes like a metalhead convert .. its just nuts
15:27 < delinquentme> human unity? << just speculation
15:28 < sylph_mako> furious has a lot of meanings. "Furious violining". Pretty sure that was always a revered thing.
15:29 < uniqanomaly_> hmm, algos actually evolving music would be crazy
15:29 < delinquentme> ^^^
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15:29 < delinquentme> some guy made a shell program to do just that
15:29 < delinquentme> sylph_mako, paganinni
15:30 < delinquentme> revered as being possessed for his skills
15:30 < sylph_mako> Anyone used electric sheep? It evolves ridiculous fractal screensavers based on upvotes and downvotes from every user.
15:31 < sylph_mako> If you could do a similar thing for music.. you could make a station based on that shit.
15:31 < uniqanomaly_> http://darwintunes.org/evolve-music
15:32 < delinquentme> machines.
15:34 < sylph_mako> omg
15:34 < uniqanomaly_> http://tones.wolfram.com/ :<
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16:58 < uniqanomaly_> http://www.sadistic.pl/pics/2_d8e5544669aa.jpg
16:58 < uniqanomaly_> :D
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18:28 < delinquentme> http://www.fightaging.org/archives/2012/03/more-background-on-the-russia-2045-initiative.php
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18:35 < kanzure> hi yashgaroth
18:35 < kanzure> saw the email.
18:35 < yashgaroth> ah yes, thanks for crosspostin'
18:35 < yashgaroth> I'm thinking of posting it biohack, but they're a little insane over there...not necessarily in a bad way though
18:36 < yashgaroth> *to/on biohack
18:40 < kanzure> i'm a little surprised nobody has complained that you're destroying humanity on the diybio list yet
18:41 < kanzure> there used to be complaints about our somewhat more niche interests
18:41 < kanzure> glad it's gone down :)
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18:41 < kanzure> the longevity groupies are probably helping there
18:42 < yashgaroth> I'm telling you, all the founders of DIYbio Seattle were big fans of transhumanism
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19:01 < joshcryer> How is he destroying humanity? (I enjoy drama with the best of 'em.)
19:17 < kanzure> joshcryer: oh just bogus bullshit
19:17 < kanzure> don't pay attention to those people
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19:34 < sylph_mako> This story made me happy https://en.wikipedia.org/wiki/Repository_for_Germinal_Choice but it's regrettably concluded.
19:39 < kanzure> yashgaroth: what's wrong with blood injections, again?
19:39 < kanzure> zacharycohn: hey how do you know nathan?
19:40 < yashgaroth> injections of plasmid, protein, or other blood?
19:40 < kanzure> i was thinking protein
19:41 < yashgaroth> I have seriously considered it...for follistatin, you want to at least try to limit the off-target effects
19:41 < yashgaroth> but a myostatin propeptide-Fc fusion would be a strong candidate
19:43 < kanzure> fc?
19:43 < kanzure> so wasn't one of the clinical trials for a propeptide?
19:43 < yashgaroth> that one never made it to trials
19:43 < kanzure> hrm. i'm not misremembering am i?
19:43 < kanzure> i know follistatin did
19:43 < yashgaroth> Fc is antibody backbone, it's added to increase half-life from a few hours to a few weeks
19:44 < yashgaroth> follistatin, anti-myostatin monoclonal, and acvr2b fc fusion have all been in trials
19:44 < yashgaroth> Fc fusion also makes it a fuckton easier to produce
19:44 < kanzure> my knowledge of trial results is current up to 2009
19:44 < kanzure> or, rather, "current and fuzzy because it was 2009"
19:45 < yashgaroth> follistatin's the only one currently trialing, I think they're injecting the AAV now-ish
19:45 < yashgaroth> acvr2b was a couple years ago I think
19:46 < zacharycohn> kanzure: haha, yeah! How do you know nathan?
19:46 < kanzure> this conversation needs more clinicaltrails.gov links
19:46 < kanzure> zacharycohn: he hangs out in here
19:47 < kanzure> what you talkin about
19:47 < yashgaroth> folli: http://clinicaltrials.gov/ct2/show/NCT01519349?term=follistatin&rank=1
19:47 < zacharycohn> kanzure: haha, really? What's his handle?
19:47 < kanzure> nmz787 (he seems to be off irc at the moment)
19:48 < yashgaroth> acvr2b was http://clinicaltrials.gov/ct2/show/NCT01099761?term=acvr2b&rank=4
19:48 < yashgaroth> I'm chatting with nmz787 in the diybio topic right now, so he's online-ish
19:48 < kanzure> yashgaroth: yeah he's on jabber
19:48 < zacharycohn> kanzure: yeah, he and i worked together when we went to school
19:48 < kanzure> hmmm suspicious
19:49 < zacharycohn> How did you know we knew each other?
19:49 < kanzure> i checked out his facebook profile to figure out how the fuck to spell bhowmik
19:49 < zacharycohn> haha
19:49 < kanzure> and you're on there
19:50 < zacharycohn> tadaaa
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19:53 < nmz787> zach, /YOU/ hang out here?
19:53 < kanzure> zacharycohn: there we go
19:53 < zacharycohn> nmz787: :)
19:53 < nmz787> small world, I guess
19:53 < nmz787> lol
19:53 < zacharycohn> I mostly hang out on #startups
19:53 < zacharycohn> but i started hanging out here about a week ago
19:53 < nmz787> yeah so kanzure is the collaborator i am looking to do the synbio startup with
19:54 < zacharycohn> no matter what you do don't trust him
19:54 < zacharycohn> >.>
19:54 < nmz787> he's kind of a jerk of all trades
19:54 < kanzure> aw shucks
19:54 < zacharycohn> hahah
19:54 < kanzure> that's how i know you really care about me
19:55 < nmz787> he can transcribe lectures in real-time though
19:55 < kanzure> nmz787: inkscape still making you its bitch?
19:55 < nmz787> i think he's a mechanical turk for google
19:55 < zacharycohn> kanzure: <3
19:55 < nmz787> kanzure: its coming along
19:55 < nmz787> kanzure: slowly
19:58 < nmz787> zach, do you still have that army backpack?
19:59 < zacharycohn> nmz787: hellll yeah
20:00 < nmz787> you're in WA now?
20:00 < zacharycohn> That hookup was like, one of the best parts of working at FAST
20:00 < zacharycohn> Yep, in Seattle.
20:00 < yashgaroth> oh hey I'm from seattle, good choice
20:00 < nmz787> did you go to BANFF film fest?
20:00 < zacharycohn> yashgaroth: oh yeah? Where? I'm in Belltown
20:00 < nmz787> we just had it here like a week ago i think
20:00 < zacharycohn> nmz787: uuugghhh no. I tried but it sold out within a day.
20:01 < zacharycohn> Then I tried to get a press pass
20:01 < yashgaroth> I lived by the UW for like 15 years, but I live in san diego now for work
20:01 < zacharycohn> but they couldn't do it. They said they had already exceeded the number of people legally allowed in the building.
20:01 < zacharycohn> (I'm not with press, but they didn't know that... :p)
20:01 < nmz787> zacharycohn: ohhh, it was pretty sweet, I went to all 3 (3 hr) sessions here
20:01 < zacharycohn> man, I really wanted to go.
20:01 < zacharycohn> next time!
20:02 < nmz787> there was some sick urban skiing
20:02 < zacharycohn> yashgaroth: Ah, nice. I just moved here about 2 years ago
20:02 < yashgaroth> heh I moved to SD 2 years ago, though I do hope to move back when my current company gets bought or goes under
20:02 < zacharycohn> good exit strategy.
20:03 < yashgaroth> good jobs in biotech are hard to find
20:03 < nmz787> yashagaroth: how do you expect electroporating muscle without uneven transfection?
20:03 < yashgaroth> did you see my most recent reply?
20:03 < nmz787> yashagaroth: I've seen some microneedle matrices lately, but they were for allergy tests
20:04 < nmz787> yashagaroth: i did, but didn't think it mentioned uneven expression
20:04 < nmz787> are you saying the plasmid/protein would diffuse between cells?
20:04 < zacharycohn> i've heard seattle has a good biotech scene
20:04 < yashgaroth> sure it did, the plasmid spreads along the entire fiber, and the follistatin's effect extends to nearby fibers, not just the transfected ones
20:04 < zacharycohn> i don't know anything about it though
20:05 < nmz787> but how many fibers are there in a square centimeter of meat?
20:05 < yashgaroth> zach: it does, but apparently it's very insular, and still tiny compared to SD/bay area/cambridge
20:05 < zacharycohn> ah
20:05 < yashgaroth> I've no idea how many fibers there are, lemme find the mean diameter
20:06 < zacharycohn> nmz787: I just bought 4lbs of steak. I'll go find out for you.
20:06 < nmz787> is a muscle fiber a single cell (multinucleated as it may be)
20:06 < zacharycohn> kanzure: You going to SXSW (or more specifically, any of the SXSW parties?)
20:07 < yashgaroth> so like 50-100 micrometers
20:07 < yashgaroth> it's sort of a single cell, depending on how you define a cell
20:07 < nmz787> hmm, ok so plausibly one cell
20:07 < nmz787> one outer membrane
20:07 < yashgaroth> then yes, they're single cells
20:07 < nmz787> but i doubt the plasmid would diffuse between fibers
20:07 < yashgaroth> no, but the protein would
20:08 < nmz787> how would it get shuttled between? e.coli don't share beta-lactamase
20:08 < yashgaroth> beta-lactamase acts intracellularly anyway, this is a secreted product
20:09 < yashgaroth> the myostatin target is also extracellular
20:10 < yashgaroth> also why would e.coli want to share antibiotic resistance, they're selfish bastards
20:11 < kanzure> zacharycohn: i might be in SF actually
20:11 < kanzure> zacharycohn: i don't know yet
20:11 < kanzure> i might crash a party or two
20:11 < zacharycohn> Ah. Well if you're in Austin, let me know. the whole Startup Weekend crew is coming down
20:12 < zacharycohn> next wed-mon, I think
20:12 < kanzure> i live in austin
20:12 < kanzure> i have a room available actually
20:13 < kanzure> having a room during sxsw this makes me king of the world basically
20:14 < nmz787> yashagaroth: so the myostatin binds extracellularly?
20:14 < kanzure> myostatin is a negative regulator of muscle mass
20:14 < yashgaroth> it acts on cell-surface receptors, yes
20:14 < kanzure> so if you bind and neutralize myostatin then you decrease its effect of prohibiting muscle growth
20:14 < yashgaroth> ^
20:15 < kanzure> s/prohibiting/limiting
20:15 < kanzure> whatever
20:15 < kanzure> Just lots of down and up arrows
20:15 < yashgaroth> \/
20:15 < kanzure> http://diyhpl.us/~bryan/papers2/myostatin/
20:15 < nmz787> wikipedia says whippets are a 'null'
20:15 < nmz787> any idea what that means?
20:15 < nmz787> its just NO2
20:15 < kanzure> http://diyhpl.us/~bryan/papers2/myostatin/myostatin_inhibition.txt
20:16 < yashgaroth> yes, they lack a functional gene for myostatin
20:16 < yashgaroth> same with belgian blue cattle, as well as a few other breeds
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20:16 < yashgaroth> if you knock out the gene, or otherwise mutate it into non-functionality, you get the double muscling
20:17 < nmz787> wait, whippets are different than inhaled 'whip-its'
20:17 < nmz787> ?
20:17 < yashgaroth> heh
20:17 < nmz787> e.g. nitrous oxide
20:17 < nmz787> lol
20:17 < nmz787> derr
20:17 < nmz787> :P
20:18 < zacharycohn> kanzure: airbnb that shit!
20:18 < zacharycohn> you could make a killing
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20:34 < kanzure> hi splicer.
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20:58 < delinquentme> you guys have any idea if I need to restart my EC2 servers for the security group changes to take effect?
21:03 < kanzure> o.o i forget sorry man
21:03 < kanzure> all i know is that s3 security has always been a pain in the butt for me
21:20 < delinquentme> oh damn!
21:21 < delinquentme> i failed to show it off in here
21:21 < delinquentme> turns out no restarts are required when you edit a security group that a particular instance belongs to
21:23 < joshcryer> What are you guys using it for?
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22:03 < joshcryer> Paul Gilding = full of shit snoozefest
22:04 < joshcryer> I hope Diamandis is at least moderately more interesting in making his case.
22:07 < joshcryer> strangewarp, heh, I just started Diamandis' talk and he said exactly what I said in the first few mins, weird!
22:07 < joshcryer> (I had not seen it when I made that statement)
22:07 < kanzure> bleh
22:07 < kanzure> implementing interval arithmetic
22:07 < kanzure> why doesn't sympy do this already
22:07 < kanzure> all i want is to substitute x with [1,5]
22:07 < yashgaroth> diamandis said that gilding is full of shit?
22:08 < yashgaroth> or you just mean his talk took the opposite position
22:11 < joshcryer> No, no, yesterday I said:
22:11 < joshcryer> 04:42 < joshcryer> It's contrasted with a distopian future.
22:11 < joshcryer> 04:42 < joshcryer> People are pessimists, the negativity fed to them on a regular basis.
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22:11 < joshcryer> And Diamandis started his talk with that.
22:11 < Juul> ach, dna annotation scripts are tedious business
22:12 < yashgaroth> ahh okay
22:22 < joshcryer> Diamandis was far more convincing.
22:22 < joshcryer> I mean, truly night and day.
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22:39 < Stee|> hey
22:39 < yashgaroth> whatup
22:41 < Stee|> I actually consulted for diamandis new book
22:41 < joshcryer> Stee|m very cool. :)
22:41 < joshcryer> s/m/,
22:41 -!- Stee| is now known as Steel_
22:42 < Steel_> hm
22:45 < joshcryer> Hmm, "Abundance: The Future Is Better Than You Think"
22:45 < Steel_> yeah
22:45 < joshcryer> Does the book devel much into the 3D printing aspect?
22:46 < Steel_> rather, I 'am' consulting on the continuation of the work that went into the book, not what's currently in it
22:46 < Steel_> my work more involves empirical ways to track increased energy/food/water/freedom/education/shelter, etc.
22:46 < Steel_> I'm assigned to energy
22:46 < yashgaroth> hey bro have you heard about thorium? ron paul
22:47 < joshcryer> lol thorium
22:47 < Steel_> I like thorium but not ron paul
22:47 < Steel_> :(
22:48 < yashgaroth> haha me too
22:48 < joshcryer> Steel_, what say you about that MIT professors projection that solar will be $0.05 per kwh in 8 years?
22:49 < Steel_> I haven't researched enough into future solar. I think that the price won't go down as much, much more likely you'll see reduced subsidies
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23:54 < Steel_> I swear to god one of the people on my forum is my great aunt, but I can't say for sure
23:55 < joshcryer> lol
23:55 < joshcryer> What kind of forum would you have to attract a great aunt?
23:57 < Steel_> I have a transhumanism forum that I'm trying to get going, and my great aunt is a neuropsychiatrist
--- Log closed Fri Mar 02 00:00:33 2012